Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

Nature Neuroscience

Volumn 11, Issue 7, 2008, Pages 772-779

  Bautista, Diana M ^a,b,c   Sigal, Yaron M ^a,b   Milstein, Aaron D ^b   Garrison, Jennifer L ^b,c,d   Zorn, Julie A ^b   Tsuruda, Pamela R ^a,b,e   Nicoll, Roger A ^a,b   Julius, David ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

^e THERAVANCE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL ISOTHIOCYANATE; CAPSAICIN; CAPSAZEPINE; HYDROXY ALPHA SANSHOOL; NEUROTROPHIN 3 RECEPTOR; NEUROTROPHIN RECEPTOR; PLANT EXTRACT; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KCNK18; POTASSIUM CHANNEL KCNK3; POTASSIUM CHANNEL KCNK9; ZANTHOXYLUM EXTRACT;

ANESTHESIA MECHANISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MOLECULAR MECHANICS; MOUSE; MYELINATION; NONHUMAN; PEPPER; PH MEASUREMENT; PRIORITY JOURNAL; REGULATORY MECHANISM; SENSORY STIMULATION; SOMATOSENSORY CORTEX; SZECHUAN PEPPER; TOOTH PAIN; TRADITIONAL MEDICINE; ZANTHOXYLUM;

AMIDES; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CAPSAICIN; CELLS, CULTURED; ELECTRIC STIMULATION; GANGLIA, SENSORY; GENE EXPRESSION REGULATION; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; NEUROFILAMENT PROTEINS; NEURONS, AFFERENT; PATCH-CLAMP TECHNIQUES; PIPER NIGRUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; POTASSIUM CHLORIDE; RECEPTOR, TRKC; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPV CATION CHANNELS;

EID: 46049085571     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2143     Document Type: Article

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