International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: Transient Receptor Potential Channels

Pharmacological Reviews

Volumn 55, Issue 4, 2003, Pages 591-596

  Clapham, David E ^a   Montell, Craig ^b   Schultz, Guenter ^c   Julius, David ^d  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; CALCIUM ION; CATION CHANNEL; GUANINE NUCLEOTIDE BINDING PROTEIN; ION CHANNEL; MESSENGER RNA; VANILLOID RECEPTOR; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; CAENORHABDITIS ELEGANS; CELL TYPE; DROSOPHILA; MAMMAL; NOMENCLATURE; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; RECEPTOR POTENTIAL; REVIEW;

ANIMALS; CALCIUM CHANNELS; ION CHANNEL GATING; MOLECULAR BIOLOGY; TRPC CATION CHANNELS;

EID: 0345059360     PISSN: 00316997     EISSN: None     Source Type: Journal    
DOI: 10.1124/pr.55.4.6     Document Type: Review

References (68)

1. Alessandri-Haber N, Yeh JJ, Boyd AE, Parada CA, Chen X, Reichling DB, and Levine JD (2003) Hypotonicity induces TRPV4-mediated nociception in rat. Neuron 39:497-511.
2. Birder LA, Nakamura Y, Kiss S, Nealen ML, Barrick S, Kanai AJ, Wang E, Ruiz G, De Groat WC, Apodaca G, et al. (2002) Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci 5:856-860.
3. Caterina MJ and Julius D (2001) The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci 24:487-517.
4. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, and Julius D (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science (Wash DC) 288:306-313.
5. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, and Julius D (1999) A capsaicin-receptor homologue with a high threshold for noxious heat. Nature (Lond) 398:436-441.
6. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, and Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature (Lond) 389:816-824.
7. Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, and Julius D (2001) Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature (Lond) 411:957-962.
8. Clapham DE (1995) Calcium signaling. Cell 80:259-268.
9. Clapham DE, Runnels LW, and Strubing C (2001) The TRP ion channel family. Nat Rev Neurosci 2:387-396.
10. + conduction and selectivity. Science (Wash DC) 280:69-77.
11. Duncan LM, Deeds J, Hunter J, Shao J, Holmgren LM, Woolf EA, Tepper RI, and Shyjan AW (1998) Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res 58:1515-1520.
12. Grimm C, Kraft R, Sauerbruch S, Schultz G, and Harteneck C (2003) Molecular and functional characterization of the melastatin-related cation channel TRPM3. J Biol Chem 278:21493-21501.
13. Guler AD, Lee H, Iida T, Shimizu I, Tominaga M, and Caterina M (2002) Heatevoked activation of the ion channel, TRPV4. J Neurosci 22:6408-6414.
14. Hardie RC (2003) Regulation of TRP channels via lipid second messengers. Annu Rev Physiol 65:735-759.
15. Harteneck C, Plant TD, and Schultz G (2000) From worm to man: three subfamilies of TRP channels. Trends Neurosci 23:159-166.
16. Hoenderop JG, van der Kemp AW, Hartog A, van de Graaf SF, van Os CH, Willems PH, and Bindels RJ (1999) Molecular identification of the apical Ca2+ channel in 1,25-dihydroxyvitamin D3-responsive epithelia. J Biol Chem 274:8375-8378.
17. Hofmann T, Chubanov V, Gudermann T, and Montell C (2003) TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel. Curr Biol 13:1153-1158.
18. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, and Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature (Lond) 397:259-263.
19. Hofmann T, Schaefer M, Schultz G, and Gudermann T (2000) Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. Biochem J 351:115-122.
20. Hoth M and Penner R (1992) Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature (Lond) 355:353-356.
21. Inoue R, Okada T, Onoue H, Hara Y, Shimizu S, Naitoh S, Ito Y, and Mori Y (2001) The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+) -permeable cation channel. Circ Res 88:325-332.
22. Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, and Kinet JP (2002) TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell 109:397-407.
23. Lee N, Chen J, Sun L, Wu S, Gray KR, Rich A, Huang M, Lin JH, Feder JN, Janovitz EB, et al. (2003) Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3). J Biol Chem 278:20890-20897.
24. Lewis RS (1999) Store-operated calcium channels. Adv Second Messenger Phosphoprotein Res 33:279-307.
25. Liedtke W, Choe Y, Marti-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, and Heller S (2000) Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103:525-535.
26. Liman ER, Corey DP, and Dulac C (1999) TRP2: a candidate transduction channel for mammalian pheromone sensory signaling. Proc Natl Acad Sci USA 96:5791-5796.
27. Lintschinger B, Balzer-Geldsetzer M, Baskaran T, Graier WF, Romanin C, Zhu MX, and Groschner K (2000) Coassembly of trp1 and trp3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels. J Biol Chem 275:27799-27805.
28. McKemy DD, Neuhausser WM, and Julius D (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature (Lond) 416:52-58.
29. Mizuno A, Matsumoto N, Imai M, and Suzuki M (2003) Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol 285:C96-C101.
30. Montell C (1999) Visual transduction in Drosophila. Annu Rev Cell Dev Biol 15:231-268.
31. Montell C, Birnbaumer L, and Flockerzi V (2002) The TRP channels, a remarkably functional family. Cell 108:595-598.
32. Nadler MJ, Hermosura MC, Inabe K, Perraud AL, Zhu Q, Stokes AJ, Kurosaki T, Kinet JP, Penner R, Scharenberg AM, and Fleig A (2001) LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. Nature (Lond) 411:590-595.
33. Nagamine K, Kudoh J, Minoshima S, Kawasaki K, Asakawa S, Ito F, and Shimizu N (1998) Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain. Genomics 54:124-131.
34. Nilius B, Prenen J, Droogmans G, Voets T, Vennekens R, Freichel M, Wissenbach U, and Flockerzi V (2003) Voltage dependence of the Ca2+ activated cation channel TRPM4. J Biol Chem 278:30813-30820.
35. Nilius B, Vennekens R, Prenen J, Hoenderop JG, Bindels RJ, and Droogmans G (2000) Whole-cell and single channel monovalent cation currents through the novel rabbit epithelial Ca2+ channel ECaC. J Physiol 527:239-248.
36. Okada T, Inoue R, Yamazaki K, Maeda A, Kurosaki T, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K, Imoto K, and Mori Y (1999) Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem 274:27359-27370.
37. Okada T, Shimizu S, Wakamori M, Maeda A, Kurosaki T, Takada N, Imoto K, and Mori Y (1998) Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. J Biol Chem 273:10279-10287.
38. Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, and Patapoutian A (2002a) A TRP channel that senses cold stimuli and menthol. Cell 108:705-715.
39. Peier AM, Reeve AJ, Andersson DA, Moqrich A, Earley TJ, Hergarden AC, Story GM, Colley S, Hogenesch JB, McIntyre P, et al. (2002b) A heat-sensitive TRP channel expressed in keratinocytes. Science (Wash DC) 296:2046-2049.
40. Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, et al. (2001) ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature (Lond) 411:595-599.
41. Prescott ED and Julius D (2003) A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science (Wash DC) 300:1284-1288.
42. Putney JW Jr (1977) Muscarinic, alpha-adrenergic and peptide receptors regulate the same calcium influx sites in the parotid gland. J Physiol 268:139-149.
43. Runnels LW, Yue L, and Clapham DE (2001) TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science (Wash DC) 291:1043-1047.
44. Runnels LW, Yue L, and Clapham DE (2002) The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol 4:329-336.
45. Saitou N and Nei M (1987) The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4:406-425.
46. Sano Y, Inamura K, Miyake A, Mochizuki S, Yokoi H, Matsushime H, and Furuichi K (2001) Immunocyte Ca2+ influx system mediated by LTRPC2. Science (Wash DC) 293:1327-1330.
47. Schaefer M, Plant TD, Obukhov AG, Hofmann T, Gudermann T, and Schultz G (2000) Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. J Biol Chem 275:17517-17526.
48. Schlingmann KP, Weber S, Peters M, Niemann Nejsum L, Vitzthum H, Klingel K, Kratz M, Haddad E, Ristoff E, Dinour D, et al. (2002) Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet 31:166-170.
49. Schmitz C, Perraud AL, Johnson CO, Inabe K, Smith MK, Penner R, Kurosaki T, Fleig A, and Scharenberg AM (2003) Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell 114:191-200.
50. Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin JP, Ooi L, et al. (2002) TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature (Lond) 418:186-190.
51. Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, et al. (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112:819-829.
52. Stowers L, Holy TE, Meister M, Dulac C, and Koentges G (2002) Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science (Wash DC) 195:1493-1500.
53. Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, and Plant TD (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2:695-702.
54. Strubing C, Krapivinsky G, Krapivinsky L, and Clapham DE (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29:646-655.
55. Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, and Zhu MX (2000) Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J Biol Chem 275:37559-37564.
56. Tsavaler L, Shapero MH, Morkowski S, and Laus R (2001) Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res 61:3760-3769.
57. Tsien RW, Hess P, McCleskey EW, and Rosenberg RL (1987) Calcium channels: mechanisms of selectivity, permeation and block. Annu Rev Biophys Chem 16:265-290.
58. Vannier B, Peyton M, Boulay G, Brown D, Qin N, Jiang M, Zhu X, and Birnbaumer L (1999) Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel. Proc Natl Acad Sci USA 96:2060-2064.
59. Vennekens R, Hoenderop JG, Prenen J, Stuiver M, Willems PH, Droogmans G, Nilius B, and Bindels RJ (2000) Permeation and gating properties of the novel epithelial Ca(2+) channel. J Biol Chem 275:3963-3969.
60. Walder RY, Landau D, Meyer P, Shalev H, Tsolia M, Borochowitz Z, Boettger MB, Beck GE, Englehardt RK, Carmi R, and Sheffield VC (2002) Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. Nat Genet 31:171-174.
61. Wes PD, Chevesich J, Jeromin A, Rosenberg C, Stetten G, and Montell C (1995) TRPC1, a human homolog of a Drosophila store-operated channel. Proc Natl Acad Sci USA 92:9652-9656.
62. Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, et al. (2002) TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature (Lond) 418:181-186.
63. Xu XZ, Li HS, Guggino WB, and Montell C (1997) Coassembly of TRP and TRPL produces a distinct store-operated conductance. Cell 89:1155-1164.
64. Yamaguchi H, Matsushita M, Nairn AC, and Kuriyan J (2001) Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity. Mol Cell 7:1047-1057.
65. Yue L, Peng JB, Hediger MA, and Clapham DE (2001) CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature (Lond) 410:705-709.
66. Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, and Ryba NJ (2003) Coding of sweet, bitter and umami tastes: different receptor cells sharing similar signaling pathways. Cell 112:293-301.
67. Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E, and Birnbaumer L (1996) trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell 85:661-671.
68. Zitt C, Zobel A, Obukhov AG, Harteneck C, Kalkbrenner F, Luckhoff A, and Schultz G (1996) Cloning and functional expression of a human Ca2+- permeable cation channel activated by calcium store depletion. Neuron 16:1189-1196.