TRP channels: Emerging targets for respiratory disease

Pharmacology and Therapeutics

Volumn 130, Issue 3, 2011, Pages 371-384

  Banner, Katharine Helen ^a   Igney, Frederik ^b   Poll, Chris ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Asthma; Calcium; COPD; Cough; TRP channels

Indexed keywords

1 (2 BROMOPHENYL) 3 [1 (5 TRIFLUOROMETHYL 2 PYRIDINYL) 3 PYRROLIDINYL]UREA; ANKYRIN; AZD 1386; CALCIUM ION; CAPSAICIN; CHEMOKINE; CIS CAPSAICIN; CYTOKINE; MATRIX METALLOPROTEINASE; MCP 101; POLYCYSTIN; SYL 040012; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL 7; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL AFFECTING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; TRANSIENT RECEPTOR POTENTIAL CHANNEL M4; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 2; VANILLOID RECEPTOR 4;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CALCIUM TRANSPORT; CELL TYPE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL (TOPIC); COUGHING; DRUG TARGETING; GASTROESOPHAGEAL REFLUX; GLAUCOMA; HUMAN; INFLAMMATORY CELL; MEDIATOR RELEASE; MEMBRANE POTENTIAL; MUCUS SECRETION; MUSCULOSKELETAL PAIN; NEUROPATHIC PAIN; NONHUMAN; OSMOTIC STRESS; OVERACTIVE BLADDER; PAIN; PATHOGENESIS; PHENOTYPE; POSTHERPETIC NEURALGIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT DISEASE; RESPIRATORY TRACT INFLAMMATION; RHINITIS; SENSORY NERVE; SEQUENCE HOMOLOGY; TEMPERATURE;

EID: 79955581526     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.03.005     Document Type: Review

References (192)

1. N. Agopyan, J. Head, S. Yu, and S.A. Simonm TRPV1 receptors mediate particulate matter-induced apoptosis Am J Physiol Lung Cell Mol Physiol 286 3 2004 L563 L572
2. D.F. Alvarez, J.A. King, D. Weber, E. Addison, W. Liedtke, and M.I. Townsley Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury Circ Res 99 9 2006 988 995 (Pubitemid 44657802)
3. S. Amadesi, J. Nie, N. Vergnolle, G.S. Cottrell, E.F. Grady, and M. Trevisani Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia J Neurosci 24 18 2004 4300 4312 (Pubitemid 38608141)
4. E. Andre, B. Campi, S. Materazzi, M. Trevisani, S. Amadesi, and D. Massi Cigarette smoke-induced neurogenic inflammation is mediated by α, β-unsaturated aldehydes and the TRPA1 receptor in rodents J Clin Invest 118 2008 2574 2582 (Pubitemid 351949784)
5. E. Andre, R. Gatti, M. Trevisani, D. Preti, P.G. Baraldi, and R. Patacchini Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents Br J Pharmacol 158 2009 1621 1628
6. 2+ mishandling to CFTR channel dysfunction in cystic fibrosis Am J Respir Cell Mol Biol 2010, Mar 4 (E pub ahead of print)
7. Y. Araki, H. Sugihara, and T. Hattori The free radical scavengers edaravone and tempol suppress experimental dextran sulfate sodium-induced colitis in mice Int J Mol Med 17 2006 331 334
8. M. Azzawi, B. Bradley, and P.K. Jeffery Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma Am Rev Respir Dis 142 1990 1407 1413
9. B.M. Babior Phagocytes and oxidative stress Am J Med 109 2000 33 44 (Pubitemid 30608735)
10. M. Baggiolini Chemokines in pathology and medicine J Intern Med 250 2001 91 104 (Pubitemid 32868689)
11. G. Barbet, M. Demion, I.C. Moura, N. Serafini, T. Léger, and F. Vrtovsnik The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells Nat Immunol 9 10 2008 1148 1156 Epub 2008 Aug 31
12. P.J. Barnes Macrophages as orchestrators of COPD COPD 1 2004 59 70
13. P.J. Barnes New targets for asthma Trends Mol Med 12 2006 515 520
14. P.J. Barnes Immunology of asthma and chronic obstructive pulmonary disease Nat Rev Immunol 8 2008 183 192 (Pubitemid 351323287)
15. P.J. Barnes, and T. Hansel Prospects for new drugs for chronic obstructive pulmonary disease Lancet 364 2004 985 996 (Pubitemid 39208462)
16. D.M. Bautista, S.E. Jordt, T. Nikai, P.R. Tsuruda, A.J. Read, and J. Poblete TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents Cell 124 2006 1269 1282
17. A. Bhattacharya, B.P. Scott, N. Nasser, H. Ao, M.P. Maher, and A.E. Dubin Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)- piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs J Pharmacol Exp Ther 323 2 2007 665 674 (Pubitemid 350005126)
18. M.A. Birrell, M.G. Belvisi, M. Grace, L. Sadofsky, S. Faruqi, and D.J. Hele TRPA1 agonists evoke coughing in guinea pig and human volunteers Am J Respir Crit Care Med 180 2009 1042 1047
19. A.C. Blackburn, W.F. Doe, and G.D. Buffinton Salicylate hydroxylation as an indicator of hydroxyl radical generation in dextran sulfate-induced colitis Free Radic Biol Med 25 1998 305 313 (Pubitemid 28326205)
20. C.J. Bohlen, A. Priel, S. Zhou, D. King, J. Siemens, and D. Julius A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain Cell 141 5 2010 834 845
21. C.E. Brightling, P. Bradding, F.A. Symon, S.T. Holgate, A.J. Wardlaw, and I.D. Pavord Mast cell infiltration of airway smooth muscle in asthma N Engl J Med 346 2002 1699 1705 (Pubitemid 34547483)
22. B.S. Brown, R. Keddy, R.J. Perner, S. DiDomenico, J.R. Koenig, and T.K. Jinkerson Discovery of TRPV1 antagonist ABT-116 Bioorg Med Chem Lett 20 11 2010 3291 3294
23. C.A. Butler, S. McQuaid, T. Warke, M. Stevenson, L.G. Heaney, and L. McGarvey The sensory receptor TRPV1 is expressed in human bronchial epithelium and upregulated in refractory (steroid resistant) asthma Am J Respir Crit Care Med 181 2010 A2490
24. A.I. Caceres, M. Brackmann, M.D. Elia, B.F. Bessac, D. Camino, and M. D'Armours A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma PNAS 106 2009 9099 9104
25. G. Cantero-Recasens, J.R. Gonzalez, C. Fandos, E. Duran-Tauleria, L.A. Smit, and F. Kauffmann Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma J Biol Chem 285 36 2010 27532 27535
26. K.H. Carlsen, and K.C. Carlsen Exercise-induced asthma Paediatr Respir Rev 3 2002 154 160 (Pubitemid 35331512)
27. M.J. Carr, M. Kollarik, S.N. Meeker, and B.J. Undem A role for TRPV1 in bradykinin-induced excitation of vagal airway afferent nerve terminals J Pharmacol Exp Ther 304 3 2003 1275 1279 (Pubitemid 36254441)
28. M.J. Caterina, A. Leffler, A.B. Malmberg, W.J. Martin, J. Trafton, and K.R. Petersen-Zeitz Impaired nociception and pain sensation inmice lacking the capsaicin receptor Science 288 5464 2000 306 313 (Pubitemid 30226186)
29. M.J. Caterina, T.A. Rosen, M. Tominaga, A.J. Brake, and D. Julius A capsaicin-receptor homologue with a high threshold for noxious heat Nature 398 6726 1999 436 441 (Pubitemid 29180377)
30. M.J. Caterina, M.A. Schumacher, M. Tominaga, T.A. Rosen, J.D. Levine, and D. Julius The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature 389 6653 1997 816 824 (Pubitemid 27462969)
31. B.R. Celli, and P.J. Barnes Exacerbations of chronic obstructive pulmonary disease Eur Respir J 29 2007 1224 1238 (Pubitemid 46895385)
32. B.A. Chizh, M.B. O'Donnell, A. Napolitano, J. Wang, A.C. Brooke, and M.C. Aylott The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans Pain 132 1-2 2007 132 141 (Pubitemid 47494566)
33. N.B. Choudry, R.W. Fuller, and N.B. Pride Sensitivity of the human cough reflex: effect of inflammatory mediators prostaglandin E2, bradykinin, and histamine Am Rev Respir Dis 140 1 1989 137 141 (Pubitemid 19177094)
34. H.H. Chuang, E.D. Prescott, H. Kong, S. Shields, S.E. Jordt, and A.I. Basbaum Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition Nature 411 6840 2001 957 962 (Pubitemid 32601493)
35. D.E. Clapham TRP channels as cellular sensors Nature 426 6966 2003 517 524 (Pubitemid 37522633)
36. D.E. Clapham, L.W. Runnels, and C. Strubing The TRP ion channel family Nat Rev Neurosci 2 2001 387 396 (Pubitemid 33674795)
37. J.G. Collier, and R.W. Fuller Capsaicin inhalation in man and the effects of sodium cromoglycate Br J Pharmacol 81 1984 113 117 (Pubitemid 14148322)
38. B. Colsoul, B. Nilius, and R. Vennekens On the putative role of transient receptor potential cation channels in asthma Clin Exp Allergy 39 10 2009 1456 1466
39. R.L. Corteling, S. Li, J. Giddings, J. Westwick, C. Poll, and I.P. Hall Expression of transient receptor potential C6 and related transient receptor potential family members in human airway smooth muscle and lung tissue Am J Respir Cell Mol Biol 30 2004 145 154 (Pubitemid 38147199)
40. C. Costa, R. Rufino, S.L. Traves, J.R.L. Silva, and P.J. Barnes CXCR3 and CCR5 chemokines in the induced sputum from patients with COPD Chest 133 2008 26 33
41. E. Cuypers, A. Yanagihara, E. Karlsson, and J. Tytgat Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels FEBS Lett 580 24 2006 5728 5732 (Pubitemid 44500677)
42. Y. Dai, S. Wang, M. Tominaga, S. Yamamoto, T. Fukuoka, and T. Higashi Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain J Clin Invest 117 7 2007 1979 1987 (Pubitemid 47036332)
43. N. Damann, G. Owsianik, S. Li, C. Poll, and B. Nilius The calcium-conducting ion channel transient receptor potential canonical 6 is involved in macrophage inflammatory protein-2-induced migration of mouse neutrophils Acta Physiol 195 2009 3 11
44. L. De Petrocellis, S. Harrison, T. Bisogno, M. Tognetto, I. Brandi, and G.D. Smith The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase J Neurochem 77 6 2001 1660 1663 (Pubitemid 32574501)
45. N.S. Delany, M. Hurle, P. Facer, T. Alnadaf, C. Plumpton, and I. Kinghorn Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2 Physiol Genomics 4 3 2001 165 174 (Pubitemid 33676692)
46. M.J. Doherty, R. Mister, M.G. Pearson, and P.M. Calverley Capsaicin induced cough in cryptogenic fibrosing alveolitis Thorax 55 12 2000 1028 1032
47. F.G. Eyal, C.R. Hamm, and J.C. Parker Reduction in alveolar macrophages attenuates acute ventilator induced lung injury in rats Intensive Care Med 33 7 2007 1212 1218 (Pubitemid 47036890)
48. 2+ channels Eur Respir J 33 2009 1105 1112
49. T.K. Finney-Hayward, M.O. Popa, P. Bahra, S. Li, C.T. Poll, and M. Gosling Expression of transient receptor potential C6 channels in human lung macrophages Am J Respir Cell Mol Biol 43 2010 296 304
50. J.R. Fozard, F. Baur, C. Wolber, and S.P. Collingwood Inhibition by viozan of extravasation induced in rat trachea by capsaicin is mediated exclusively by beta 2-adrenoceptors Naunyn-Schmiedebergs Arch Pharmacol 364 6 2001 570 572 (Pubitemid 33145098)
51. J.A. Frank, C.M. Wray, D.F. McAuley, R. Schwendener, and M.A. Matthay Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury Am J Physiol Lung Cell Mol Physiol 291 6 2006 L1191 L1198
52. R.W. Fuller, C.M. Dixon, and P.J. Barnes Bronchoconstrictor response to inhaled capsaicin in humans J Appl Physiol 58 4 1985 1080 1084 (Pubitemid 15033216)
53. A. Gamberucci, E. Giurisato, P. Pizzo, M. Tassi, R. Giunti, and D.P. MacIntosh Diacylglycrol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving TRP6 gene products Biochem J 364 2002 245 254 (Pubitemid 34538968)
54. R. Gatti, E. Andre, S. Amadesi, T.Q. Dinh, A. Fischer, and N.W. Bunnett Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs J Appl Physiol 101 2 2006 506 511 (Pubitemid 44162360)
55. M. Goel, W.G. Sinkins, and W.P. Schilling Selective association of TRPC channel subunits in rat brain synaptosomes J Biol Chem 277 2002 48303 48310 (Pubitemid 35470784)
56. D.A. Groneberg, A. Niimi, Q.T. Dinh, B. Cosio, M. Hew, and A. Fischer Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough Am J Respir Crit Care Med 170 12 2004 1276 1280 (Pubitemid 39657190)
57. S. Grumelli, D.B. Song, L. Green, J. Huh, J. Hacken, and R. Espada An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema PLoS Med 1 2004 75 83
58. Q. Gu, K. Kwong, and L.Y. Lee Ca2+ transient evoked by chemical stimulation is enhanced by PGE2 in vagal sensory neurons: role of cAMP/PKA signaling pathway J Neurophysiol 89 4 2003 1985 1993 (Pubitemid 36444253)
59. M.J. Gunthorpe, and B.A. Chizh Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway Drug Discov Today 14 1-2 2009 56 67
60. K. Hamanaka, M.Y. Jian, M.I. Townsley, J.A. King, W. Liedtke, and D.S. Weber TRPV4 channels augment macrophage activation and ventilator-induced lung injury Am J Physiol Lung Cell Mol Physiol 299 3 2010 L353 L362
61. K. Hamanaka, M.Y. Jian, D.S. Weber, D.F. Alvarez, M.I. Townsley, and A.B. Al-Mehdi TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs Am J Physiol Lung Cell Mol Physiol 293 4 2007 L923 L932
62. Q. Hamid, M. Azzawi, and S. Ying Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma J Clin Invest 87 1991 1541 1546
63. 2+-permeable channel activated by changes in redox status confers susceptibility to cell death Mol Cell 18 2002 61 69
64. I.H. Heijink, H.F. Kauffman, E. Vellenga, C.A. Veltman-Starkenburg, D.S. Postma, and J.G. de Monchy Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma Int Arch Allergy Immunol 145 2 2008 111 121
65. I. Heiner, J. Eisfeld, C.R. Halaszovich, E. Wehage, E. Jungling, and C. Zitt Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP ribose and NAD Biochem J 371 2003 1045 1053 (Pubitemid 36578904)
66. I. Heiner, N. Radukina, J. Eisfeld, F. Kuhn, and A. Luckhoff Regulation of TRPM2 channels in neutrophil granulocytes, by ADP-ribose: a promising pharmacological target Naunyn-Schmiedebergs Arch Pharmacol 371 2005 325 333 (Pubitemid 40905087)
67. Z. Helyes, K. Elekes, J. Németh, G. Pozsgai, K. Sándor, and L. Kereskai Role of transient receptor potential vanilloid 1 receptors in endotoxin-induced airway inflammation in the mouse Am J Physiol Lung Cell Mol Physiol 292 5 2007 L1173 L1181
68. T. Higenbottam Chronic cough and the cough reflex in common lung diseases Pulm Pharmacol Ther 15 2002 241 247 (Pubitemid 34754113)
69. J.G. Hoenderop, T. Voets, S. Hoefs, F. Weidema, J. Prenen, and B. Nilius Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6 EMBO J 22 4 2003 776 785 (Pubitemid 36227780)
70. T. Hofmann, A.G. Obukhov, M. Scaefer, C. Harteneck, T. Gudermann, and G. Scultz Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol Nature 397 1999 259 263
71. T. Hofmann, M. Schaefer, G. Schultz, and T. Gudermann Subunit composition of mammalian transient receptor potential channels in living cells Proc Natl Acad Sci 99 2002 7461 7466 (Pubitemid 34568713)
72. S.T. Holgate Pathogenesis of asthma Clin Exp Allergy 153 2008 872 897
73. P. Holzer Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides Neuroscience 24 3 1988 739 768
74. Y. Hu, Q. Gu, R.L. Lin, R. Kryscio, and L.Y. Lee Calcium transient evoked by TRPV1 activators is enhanced by tumor necrosis factor-α in rat pulmonary sensory neurons Am J Physiol Lung Cell Mol Physiol 299 4 2010 L483 L492 Epub 2010 Jul 16
75. S.M. Huang, T. Bisogno, M. Trevisani, A. Al-Hayani, L. De Petrocellis, and F. Fezza An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors Proc Natl Acad Sci 99 12 2002 8400 8405 (Pubitemid 34651064)
76. M. Humbert, S.R. Durham, and S. Ying IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and non atopic asthma: evidence against "intrinsic asthma" being a distinct immunopathologic entity Am J Respir Crit Care Med 1996 1497 1504 (Pubitemid 26391204)
77. S.W. Hwang, H. Cho, J. Kwak, S.Y. Lee, C.J. Kang, and J. Jung Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances Proc Natl Acad Sci 97 11 2000 6155 6160 (Pubitemid 30367539)
78. D. Jaquemar, T. Schenker, and B. Trueb An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts J Biol Chem 274 1999 7325 7333
79. A. Jatakanon, C. Uasuf, M. Wazim, S. Lim, Fan Chung, and P.J. Barnes Neutrophilic inflammation in severe persistent asthma Am J Respir Crit Care Med 160 1999 1532 1539
80. P.K. Jeffery Structural and inflammatory changes in COPD: a comparison with asthma Thorax 53 1998 129 136 (Pubitemid 28212140)
81. Y. Jia, and L.Y. Lee Role of TRPV receptors in respiratory diseases Biochim Biophys Acta 1772 8 2007 915 927 (Pubitemid 47176369)
82. Y. Jia, X. Wang, L. Varty, C.A. Rizzo, R. Yang, and C.C. Correll Functional TRPV4 channels are expressed in human airway smooth muscle cells Am J Physiol Lung Cell Mol Physiol 287 2 2004 L272 L278
83. M.Y. Jian, J.A. King, A.B. Al-Mehdi, W. Liedtke, and M.I. Townsley High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4 Am J Respir Cell Mol Biol 38 4 2008 386 392 (Pubitemid 351758684)
84. L.H. Jiang, W. Yang, J. Zou, and D.J. Beech TRPM2 channel properties, functions and therapeutic potentials Expert Opin Ther Targets 14 2010 1 16
85. G.F. Joos, J.C. Kips, R.A. Peleman, and R.A. Pauwels Tachykinin antagonists and the airways Arch Int Pharmacodyn Ther 329 1 1995 205 219
86. S.E. Jordt, D.M. Bautista, H.H. Chuang, D.D. McKemy, P.M. Zygmunt, and E.D. Hogestatt Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 Nature 427 2004 260 265 (Pubitemid 38112043)
87. Y. Kajihara, M. Murakami, T. Imagawa, K. Otsuguro, S. Ito, and T. Ohta Histamine potentiates acid-induced responses mediating transient receptor potential V1 in mouse primary sensory neurons Neuroscience 166 1 2010 292 304
88. H. Karmouty-Quintana, C. Cannet, R. Sugar, J.R. Fozard, C.P. Page, and N. Beckmann Capsaicin-induced mucus secretion in rat airways assessed in vivo and non-invasively by magnetic resonance imaging Br J Pharmacol 150 8 2007 1022 1030 (Pubitemid 46625088)
89. A.B. Kay The role of T-lymphocytes in asthma Chem Immunol Allergy 91 2006 59 75
90. V.M. Keatings, P.D. Collins, D.M. Scott, and P.J. Barnes Differences in interleukin-8 and tumour necrosis factor-α in induced sputum in patients with chronic obstructive pulmonary disease or asthma Am J Respir Crit Care Med 153 1996 530 534
91. S.R. Kim, and Y.K. Rhee Overlap between asthma and COPD: where the two diseases converge Allergy Asthma Immunol Res 2 4 2010, Oct 209 214
92. T. Kobori, G.D. Smith, R. Sandford, and J.M. Edwardson The transient receptor potential channels TRPP2 and TRPC1 form a heterotetramer with a 2:2 stoichiometry and an alternating subunit arrangement J Biol Chem 284 51 2009 35507 35513
93. O.M. Kon, and A.B. Kay T cells and chronic asthma Int Arch Allergy Immunol 118 1999 133 135 (Pubitemid 29195487)
94. T. Kowase, Y. Nakazato, H. Yoko-O, A. Morikawa, and I. Kojima Immunohistochemical localization of growth factor-regulated channel (GRC) in human tissues Endocr J 49 3 2002 349 355 (Pubitemid 34832308)
95. R. Kraft, C. Grimm, Frenzel, and C. Harteneck Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)antrhanilic acid Br J Pharmacol 148 2006 264 273 (Pubitemid 43801173)
96. K. Kwong, and L.Y. Lee PGE(2) sensitizes cultured pulmonary vagal sensory neurons to chemical and electrical stimuli J Appl Physiol 93 4 2002 1419 1428
97. K. Kwong, C. Nassenstein, L. de Garavilla, S. Meeker, and B.J. Undem Thrombin and trypsin directly activate vagal C-fibres in mouse lung via protease-activated receptor-1 J Physiol 588 Pt 7 2010 1171 1177
98. U.G. Lalloo, A.J. Fox, M.G. Belvisi, K.F. Chung, and P.J. Barnes Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs J Appl Physiol 79 4 1995 1082 1087
99. L. Lemonnier, M. Trebak, and J.W. Putney Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5- bisphosphate Cell Calcium 43 2008 506 514 (Pubitemid 351524606)
100. Z. Li, H. Jiang, W. Xie, Z. Zhang, A.V. Smrcka, and D. Wu Roles of PLC-beta2-beta3 and PI3Kgamma in chemoattractant-mediated signal transduction Science 287 2000 1046 1049 (Pubitemid 30094361)
101. 2+ influx channels in leukocytes: a therapeutic target? Trends Pharmacol Sci 23 2002 63 70 (Pubitemid 34119327)
102. S.W. Li, J. Westwick, and C. Poll Transient receptor potential (TRP) as potential drug targets in respiratory disease Cell Calcium 33 2003 551 558 (Pubitemid 36748677)
103. W. Liedtke, Y. Choe, M.A. Martí-Renom, A.M. Bell, C.S. Denis, and A. Sali Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor Cell 103 3 2000 525 535
104. W. Liedtke, and J.M. Friedman Abnormal osmotic regulation in trpv4-/- mice Proc Natl Acad Sci 100 23 2003 13698 13703 (Pubitemid 37444802)
105. W. Liedtke, and S.A. Simon A possible role for TRPV4 receptors in asthma Am J Physiol Lung Cell Mol Physiol 287 2 2004 L269 L271
106. Y.S. Lin, R.L. Lin, M.Y. Bien, C.Y. Ho, and Y.R. Kou Sensitization of capsaicin-sensitive lung vagal afferents by anandamide in rats: role of transient receptor potential vanilloid 1 receptors J Appl Physiol 106 4 2009 1142 1152
107. T.M. Link, U. Park, B.M. Vonakis, D.M. Raben, M.J. Soloski, and M.J. Caterina TRPV2 has a pivotal role in macrophage particle binding and phagocytosis Nat Immunol 11 3 2010 232 239
108. I.M. Lorenzo, W. Liedtke, M.J. Sanderson, and M.A. Valverde TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells Proc Natl Acad Sci 105 34 2008 12611 12616
109. J.M. Lundberg, L. Lundblad, A. Saria, and A. Anggård Inhibition of cigarette smoke-induced oedema in the nasal mucosa by capsaicin pretreatment and a substance P antagonist Naunyn-Schmiedebergs Arch Pharmacol 326 2 1984 181 185 (Pubitemid 14091359)
110. X. Ma, J. Cao, J. Luo, B. Nilius, Y. Huang, and I.S. Ambudkar Depletion of intracellular Ca2+ stores stimulates the translocation of vanilloid transient receptor potential 4-c1 heteromeric channels to the plasma membrane Arterioscler Thromb Vasc Biol 30 11 2010, Nov 2249 2255
111. L.J. Macpherson, B. Xiao, K.Y. Kwan, M.J. Petrus, A.E. Dubin, and S.W. Hwang An ion channel essential for sensing chemical damage J Neurosci 27 42 2007, October 17 11412 11415 (Pubitemid 47621302)
112. S.A. Maher, M.A. Birrell, and M.G. Belvisi Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy Am J Respir Crit Care Med 180 10 2009 923 928
113. S.A. Maher, M.S. Grace, M.A. Birrell, and M.G. Belvisi Prostaglandin E2-induced sensory nerve activation is mediated by TRPA1 and TRPV1 ATS poster 802 2010
114. S.A. Maher, M.S. Grace, M.A. Birrell, and M.G. Belvisi Prostaglandin E2-induced sensory nerve activation is mediated by TRPA1 and TRPV1 Am J Respir Crit Care Med 181 2010 A5541
115. D.M. Manino, and A.S. Buist Global burden of COPD: risk factors, prevalence and future trends Lancet 370 2007 765 773 (Pubitemid 47321908)
116. D. McHugh, R. Flemming, S.Z. Xu, A.L. Perraud, and D.J. Beech Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation J Biol Chem 278 13 2003, Mar 28 11002 11006 (Pubitemid 36792648)
117. D.D. McKemy, W.M. Neuhausser, and D. Julius Identification of a cold receptor reveals a general role for TRP channels in thermosensation Nature 416 6876 2002 52 58 (Pubitemid 34215395)
118. R.L. McLeod, X. Fernandez, C.C. Correll, T.P. Phelps, Y. Jia, and X. Wang TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs Cough 2 2006 10
119. S.R. McMeekin, I. Dransfield, A.G. Rossi, C. Haslett, and T.R. Walker E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils Blood 107 2006 4938 4945 (Pubitemid 43882648)
120. S.A. Mendoza, J. Fang, D.D. Gutterman, D.A. Wilcox, A.H. Bubolz, and R. Li TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress Am J Physiol Heart Circ Physiol 298 2 2010 H466 H476
121. M. Mertens, W. Yin, W. Liedtke, S. Uhlig, and W.M. Kuebler TRPV4-deficiency protects overventilated mice from lung edema but not inflammation Am J Respir Crit Care Med 181 2010 A1676
122. E.H. Meyer, R.H. DeKruyff, and D.T. Umetsu T cells and NKT cells in the pathogenesis of asthma Annu Rev Med 59 2008 281 292 (Pubitemid 351287938)
123. J.E. Mitchell, A.P. Campbell, N.E. New, L.R. Sadofsky, J.A. Kastelik, and S.A. Mulrennan Expression and characterization of the intracellular vanilloid receptor (TRPV1) in bronchi from patients with chronic cough Exp Lung Res 31 3 2005 295 306 (Pubitemid 40463471)
124. J.A. Nadel, and K. Takeyama Mechanisms of hypersecretion in acute asthma, proposed cause of death and novel therapy Pediatr Pulmonol Suppl 18 1999 54 55 (Pubitemid 29140306)
125. K. Nagata, A. Duggan, G. Kumar, and J. Garcia-Anoveros Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing J Neurosci 25 2005 4052 4061 (Pubitemid 40563380)
126. C. Nassenstein, K. Kwong, T. Taylor-Clark, M. Kollarik, D.M. Macglashan, and A. Braun Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs J Physiol 586 6 2008, Mar 15 1595 1604 (Pubitemid 351404963)
127. M.P. Neeper, Y. Liu, T.L. Hutchinson, Y. Wang, C.M. Flores, and N. Qin Activation properties of heterologously expressed mammalian TRPV2: evidence for species dependence J Biol Chem 282 21 2007 15894 15902 (Pubitemid 47093309)
128. B. Nilius, G. Oswianik, T. Voets, and J.A. Peters Transient receptor potential cation channels in disease Physiol Rev 87 2007 165 217 (Pubitemid 46207713)
129. B. Nilius, and G. Owsianik Channelopathies converge on TRPV4 Nat Genet 42 2 2010 98 100
130. + T-lymphocytes with FEV1 Am J Respir Crit Care Med 155 1997 852 857 (Pubitemid 27133393)
131. 2+ influx pathways in human neutrophil granulocytes Naunyn-Schmiedebergs Arch Pharmacol 380 2009 497 507
132. S. Partida-Sanchez, A. Gasser, R. Fliegert, C.C. Siebrands, W. Dammermann, and G. Shi Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by ADP-ribose, the major product generated by the CD38 enzyme reaction J Immunol 179 2007 7827 7839
133. A.M. Patwardhan, A.N. Akopian, N.B. Ruparel, A. Diogenes, S.T. Weintraub, and C. Uhlson Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents J Clin Invest 120 5 2010 1617 1626
134. N. Pearce Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC) Thorax 62 2007 758 766
135. S.F. Pedersen, G. Oswianik, and B. Nilius TRP channels: an overview Cell Calcium 38 2005 233 252 (Pubitemid 41283262)
136. A.M. Peier, A. Moqrich, A.C. Hergarden, A.J. Reeve, D.A. Andersson, and G.M. Story A TRP channel that senses cold stimuli and menthol Cell 108 2002 705 715 (Pubitemid 34241429)
137. A. Penna, V. Juvin, J. Chemin, V. Compan, M. Monet, and F.A. Rassendren PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane Cell Calcium 39 6 2006 495 507
138. R.J. Perner, J.R. Koenig, S. Didomenico, A. Gomtsyan, R.G. Schmidt, and C.H. Lee Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists Bioorg Med Chem 18 13 2010 4821 4829 Epub 2010 May 10
139. A.L. Perraud, A. Fleig, C.A. Dunn, L.A. Bagley, P. Launay, and C. Shmitz ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology Nature 411 2001 595 599 (Pubitemid 32531407)
140. L.S. Premkumar, and G.P. Ahern Induction of vanilloid receptor channel activity by protein kinase C Nature 408 6815 2000 985 990 (Pubitemid 32101646)
141. K. Raemdonck, J. De Alba, M.A. Birrell, and M.G. Belvisi A role for airway sensory nerves in the allergen induced late asthmatic response in a rat model of allergic asthma ATS poster 803 2010
142. S. Ramsey, M. Delling, and D.E. Clapham An introduction to TRP channels Annu Rev Physiol 68 2006 619 647
143. C.A. Reilly, J.L. Taylor, D.L. Lanza, B.A. Carr, D.J. Crouch, and G.S. Yost Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors Toxicol Sci 73 1 2003 170 181 (Pubitemid 36609099)
144. I. Retamales, W.M. Elliott, B. Meshi, H.O. Coxson, P.D. Pare, and F.C. Sciurba Amplification of inflammation in emphysema and its association with latent adenoviral infection Am J Respir Crit Care Med 164 2001 469 473 (Pubitemid 32778218)
145. T. Rohacs Phosphoinositide regulation of non-canonical transient receptor potential channels Cell Calcium 45 6 2009, Jun 554 565
146. T. Rohacs, B. Thyagarajan, and V. Lukacs Phospholipase C mediated modulation of TRPV1 channels Mol Neurobiol 37 2-3 2008 153 163
147. A.S. Sabnis, C.A. Reilly, J.M. Veranth, and G.S. Yost Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures Am J Physiol Lung Cell Mol Physiol 295 2008 L194 L200
148. A.S. Sabnis, M. Shadid, G.S. Yost, and C.A. Reilly Human lung epithelial cells express a functional cold-sensing TRPM8 variant Am J Respir Cell Mol Biol 39 2008 466 474
149. + T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease Am J Respir Crit Care Med 157 1998 822 826
150. M. Saetta, M. Mariani, P. Panina-Bordignon, G. Turato, C. Buonsanti, and S. Baraldo Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease Am J Respir Crit Care Med 165 2002 1404 1409 (Pubitemid 34522945)
151. 2+ influx system mediated by LTRPC2 Science 293 2001 1327 1330 (Pubitemid 32777424)
152. M.A. Schumacher, and H. Eilers TRPV1 splice variants: structure and function Front Biosci 15 2010 872 882
153. S. Sel, B.R. Rost, A.O. Yildirim, B. Sel, H. Kalwa, and H. Fehrenbach Loss of classical transient receptor potential 6 channel reduces allergic airway response Clin Exp Allergy 38 2008 1548 1558
154. S.D. Shapiro Elastolytic metalloproteinases produced by human mononuclear phagocytes. Potential roles in destructive lung disease Am J Respir Crit Care Med 150 1994 S160 S164
155. T. Shimizu, G. Oswianik, M. Freichel, V. Flockerzi, B. Nilius, and R. Vennekens TRPM4 regulates migration of mast cells in mice Cell Calcium 45 2009 226 232
156. A. Stokes, C. Wakano, M. Kloban-Huberson, C.N. Adra, A. Fleig, and H.
157. G.M. Story, A.M. Peier, A.J. Reeve, S.R. Eid, J. Mosbacher, and T.R. Hricik ANKTM1, a TRP-like channel expressed in nociceptive neurons is activated by cold temperatures Cell 112 2003 819 829 (Pubitemid 36378884)
158. R. Strotmann, C. Harteneck, K. Nunnenmacher, G. Schultz, and T.D. Plant OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity Nat Cell Biol 2 10 2000 695 702
159. K. Suresh, O. Rentsendorj, C. Undem, L.A. Shimoda, L.E. Servinsky, and R.N. Willette TRPV4 activation increases endothelial permeability and [Ca2+]i in human lung microvascular endothelial cells Am J Respir Crit Care Med 181 2010 A3425
160. M. Suzuki, A. Mizuno, K. Kodaira, and M. Imai Impaired pressure sensation in mice lacking TRPV4 J Biol Chem 278 25 2003 22664 22668 (Pubitemid 36830325)
161. A. Szallasi, and P.M. Blumberg Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper Neuroscience 30 2 1989 515 520 (Pubitemid 19168499)
162. A. Szallasi, D.N. Cortright, C.A. Blum, and S.R. Eid The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept Nat Rev Drug Discov 6 5 2007 357 372 (Pubitemid 46705200)
163. M. Takemura, D. Quarcoo, A. Niimi, Q.T. Dinh, P. Geppetti, A. Fischer, K.F. Chung, and D.A. Groneberg Is TRPV1 a useful target in respiratory diseases Pulm Pharmacol Ther 21 6 2008 833 839 Epub 2008 Oct 17
164. K.C. Thomas, A.S. Sabnis, M.E. Johansen, D.L. Lanza, P.J. Moos, and G.S. Yost Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells J Pharmacol Exp Ther 321 3 2007 830 838 (Pubitemid 46762717)
165. M. Tominaga, M.J. Caterina, A.B. Malmberg, T.A. Rosen, H. Gilbert, and K. Skinner The cloned capsaicin receptor integrates multiple pain-producing stimuli Neuron 21 3 1998 531 543 (Pubitemid 28475505)
166. S.L. Traves, S.J. Smith, P.J. Barnes, and L.E. Donnelly Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2 J Leukoc Biol 76 2004 441 450 (Pubitemid 39006959)
167. Trevisani M., J. Siemens, S. Materazzi, D.M. Bautista, R. Nassini, and B. Campi 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1 PNAS 104 33 2007 13519 13524 (Pubitemid 47293977)
168. F. Tsuji, M. Murai, K. Oki, H. Inoue, M. Sasano, and H. Tanaka Effects of SA13353, a transient receptor potential vanilloid 1 agonist, on leukocyte infiltration in lipopolysaccharide-induced acute lung injury and ovalbumin-induced allergic airway inflammation J Pharmacol Sci 112 4 2010 487 490
169. K. Venkatachalam, and C. Montell TRP channels Annu Rev Biochem 76 2007 387 417
170. R. Vennekens, J. Olausson, M. Meissner, W. Bloch, I. Mathar, and S.E. Philipp Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4 Nat Immunol 8 3 2007 312 320 (Pubitemid 46745381)
171. N. Vergnolle, N. Cenac, C. Altier, L. Cellars, K. Chapman, and G.W. Zamponi A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation Br J Pharmacol 159 5 2010 1161 1173
172. F. Vincent, A. Acevedo, M.T. Nguyen, M. Dourado, J. DeFalco, and A. Gustafson Identification and characterization of novel TRPV4 modulators Biochem Biophys Res Commun 389 3 2009 490 494
173. T. Voets, G. Droogmans, U. Wissenbach, A. Janssens, V. Flockerzi, and B. Nilius The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels Nature 430 7001 2004 748 754 (Pubitemid 39071340)
174. P.A. Wark, and P.G. Gibson Asthma exacerbations 3: pathogenesis Thorax 61 2006 909 915
175. H. Watanabe, J.B. Davis, D. Smart, J.C. Jerman, G.D. Smith, and P. Hayes Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives J Biol Chem 277 16 2002 13569 13577 (Pubitemid 34967954)
176. N. Watanabe, S. Horie, G.J. Michael, S. Keir, D. Spina, and C.P. Page Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system Neuroscience 141 3 2006 1533 1543 (Pubitemid 44128670)
177. H. Watanabe, J. Vriens, J. Prenen, G. Droogmans, T. Voets, and B. Nilius Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels Nature 424 6947 2003 434 438 (Pubitemid 36917492)
178. H. Watanabe, J. Vriens, S.H. Suh, C.D. Benham, G. Droogmans, and B. Nilius Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells J Biol Chem 277 49 2002 47044 47051 (Pubitemid 36159212)
179. E. Wehage, J. Eisfeld, I. Heiner, E. Jungling, Zitt, and A. Luckhoff Activation of the cation channel long transient receptor channel 2 (LTRPC2) by hydrogen peroxide: a splice variant reveals a mode of activation independentof ADP-ribose J Biol Chem 277 26 2002 23150 23156 (Pubitemid 34952140)
180. J. Wehrhahn, R. Kraft, C. Harteneck, and S. Hauschildt Transient receptor potential melastatin 2 is required for lipopolysaccharide-induced cytokine production in human monocytes J Immunol 184 2010 2386 2393
181. P.D. Wes, J. Chevesich, A. Jeromin, C. Rosenberg, G. Stetten, and C. Montell TRPC1, a human homolog of a Drosophila store-operated channel Proc Natl Acad Sci 92 1995 9652 9656
182. R.N. Willette, W. Bao, S. Nerurkar, T.L. Yue, C.P. Doe, and G. Stankus Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2 J Pharmacol Exp Ther 326 2 2008 443 452
183. S. Wu, M.Y. Jian, Y.C. Xu, C. Zhou, A.B. Al-Mehdi, and W. Liedtke Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium Am J Physiol Lung Cell Mol Physiol 297 4 2009 L650 L657
184. H. Xing, J.X. Ling, M. Chen, R.D. Johnson, M. Tominaga, and C.-Y. Wang TRPM8 mechanism of autonomic nerve response to cold in respiratory airway Mol Pain 4 2008 22
185. Y. Yamamoto, Y. Sato, and K. Taniguchi Distribution of TRPV1- and TRPV2-immunoreactive afferent nerve endings in rat trachea J Anat 211 6 2007 775 783 (Pubitemid 350182605)
186. 2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration Nat Med 14 7 2008 738 747 (Pubitemid 351953041)
187. X.R. Yang, M.J. Lin, L.S. McIntosh, and J.S. Sham Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle Am J Physiol Lung Cell Mol Physiol 290 6 2006 L1267 L1276
188. J. Yin, J. Hoffmann, S.M. Kaestle, N. Neye, L. Wang, and J. Baeurle Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4 Circ Res 102 8 2008 966 974 (Pubitemid 351591552)
189. J. Yin, and W.M. Kuebler Mechanotransduction by TRP channels: general concepts and specific role in the vasculature Cell Biochem Biophys 56 1 2010 1 18
190. S. Yoshihara, P. Geppetti, M. Hara, A. Linden, F.L. Ricciardolo, and B. Chan Cold air-induced bronchoconstriction is mediated by tachykinin release in guinea pigs Eur J Pharmacol 296 3 1996 291 296 (Pubitemid 26045463)
191. G. Zhang, R.L. Lin, M. Wiggers, D.M. Snow, and L.Y. Lee Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat J Physiol 586 2008 5771 5786
192. G. Zhu, I.C.G.N. Investigators, A. Gulsvik, P. Bakke, S. Ghatta, and W. Anderson Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease Hum Mol Genet 18 11 2009 2053 2062