Transient Receptor Potential A1 (TRPA1) Activity in the Human Urethra-Evidence for a Functional Role for TRPA1 in the Outflow Region

European Urology

Volumn 55, Issue 3, 2009, Pages 696-704

  Gratzke, Christian ^a,b   Streng, Tomi ^a,c   Waldkirch, Eginhard ^d   Sigl, Katja ^b   Stief, Christian ^b   Andersson, Karl Erik ^e   Hedlund, Petter ^a,f  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF TURKU   (Finland)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e WAKE FOREST SCHOOL OF MEDICINE   (United States)

^f LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cinnamaldehyde; Human; Hydrogen sulfide; Interstitial cell; Relaxation; Sensory nerve; TRPA1; TRPV1; Urethra; Urothelium

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; VIMENTIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; URETHRA FUNCTION; UROTHELIUM;

ACROLEIN; CAPSAICIN; FEMALE; HUMANS; ISOTHIOCYANATES; MALE; MIDDLE AGED; SENSORY SYSTEM AGENTS; SULFIDES; TRPC CATION CHANNELS; URETHRA;

EID: 58849127865     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2008.04.042     Document Type: Article

References (32)

1. Andersson K.E., and Wein A.J. Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence. Pharmacol Rev 56 (2004) 581-631
2. Yoshimura N., and de Groat W.C. Neural control of the lower urinary tract. Int J Urol 4 (1997) 111-125
3. Birder L.A., and de Groat W.C. Mechanisms of disease: involvement of the urothelium in bladder dysfunction. Nat Clin Pract Urol 4 (2007) 46-54
4. Nilius B., Owsianik G., Voets T., and Peters J.A. Transient receptor potential cation channels in disease. Physiol Rev 87 (2007) 165-217
5. Szallasi A., and Fowler C.J. After a decade of intravesical vanilloid therapy: still more questions than answers. Lancet Neurol 1 (2002) 167-172
6. Story G.M., Peier A.M., Reeve A.J., et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112 (2003) 819-829
7. Everaerts W., Gevaert T., Nilius B., and De Ridder D. On the origin of bladder sensing: Tr(i)ps in urology. Neurourol Urodyn 27 (2008) 264-273
8. Szallasi A., and Blumberg P.M. Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev 51 (1999) 159-212
9. Jordt S.E., Bautista D.M., Chuang H.H., et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427 (2004) 260-265
10. Bautista D.M., Jordt S.E., Nikai T., et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124 (2006) 1269-1282
11. Bautista D.M., Movahed P., Hinman A., et al. Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci U S A 102 (2005) 12248-12252
12. Streng T., Axelsson H.E., Hedlund P., et al. Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. Eur Urol 53 (2008) 391-400
13. Karashima Y., Damann N., Prenen J., et al. Bimodal action of menthol on the transient receptor potential channel TRPA1. J Neurosci 27 (2007) 9874-9884
14. McNamara C.R., Mandel-Brehm J., Bautista D.M., et al. TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A 104 (2007) 13525-13530
15. Nagata K., Duggan A., Kumar G., and Garcia-Anoveros J. Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci 25 (2005) 4052-4061
16. Du S., Araki I., Yoshiyama M., Nomura T., and Takeda M. Transient receptor potential channel A1 involved in sensory transduction of rat urinary bladder through C-fiber pathway. Urology 70 (2007) 826-831
17. Lazzeri M., Vannucchi M.G., Zardo C., et al. Immunohistochemical evidence of vanilloid receptor 1 in normal human urinary bladder. Eur Urol 46 (2004) 792-798
18. Bschleipfer T., Schukowski K., Weidner W., et al. Expression and distribution of cholinergic receptors in the human urothelium. Life Sci 80 (2007) 2303-2307
19. Gillespie J.I., Markerink-van Ittersum M., and de Vente J. Expression of neuronal nitric oxide synthase (nNOS) and nitric-oxide-induced changes in cGMP in the urothelial layer of the guinea pig bladder. Cell Tissue Res 321 (2005) 341-351
20. Zanardo R.C., Brancaleone V., Distrutti E., et al. Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation. Faseb J 20 (2006) 2118-2120
21. Fallon D., Andrews N., Frodsham D., et al. A comparison of the performance of cystine lactose electrolyte deficient (CLED) agar with Oxoid chromogenic urinary tract infection (CUTI) medium for the isolation and presumptive identification of organisms from urine. J Clin Pathol 55 (2002) 524-529
22. Soutourina J., Blanquet S., and Plateau P. Role of D-cysteine desulfhydrase in the adaptation of Escherichia coli to D-cysteine. J Biol Chem 276 (2001) 40864-40872
23. Nazif O., Teichman J.M., and Gebhart G.F. Neural upregulation in interstitial cystitis. Urology 69 (2007) 24-33
24. Parsons C.L. The role of the urinary epithelium in the pathogenesis of interstitial cystitis/prostatitis/urethritis. Urology 69 (2007) 9-16
25. Apostolidis A., Brady C.M., Yiangou Y., et al. Capsaicin receptor TRPV1 in urothelium of neurogenic human bladders and effect of intravesical resiniferatoxin. Urology 65 (2005) 400-405
26. Liu L., Mansfield K.J., Kristiana I., et al. The molecular basis of urgency: regional difference of vanilloid receptor expression in the human urinary bladder. Neurourol Urodyn 26 (2007) 433-438 discussion 439; discussion 451-3
27. Andrade E.L., Ferreira J., Andre E., and Calixto J.B. Contractile mechanisms coupled to TRPA1 receptor activation in rat urinary bladder. Biochem Pharmacol 72 (2006) 104-114
28. Nishizawa S., Igawa Y., Okada N., and Ohhashi T. Capsaicin-induced nitric-oxide-dependent relaxation in isolated dog urethra. Eur J Pharmacol 335 (1997) 211-219
29. McHale N.G., Hollywood M.A., Sergeant G.P., et al. Organization and function of ICC in the urinary tract. J Physiol 576 (2006) 689-694
30. Lyons A.D., Gardiner T.A., and McCloskey K.D. Kit-positive interstitial cells in the rabbit urethra: structural relationships with nerves and smooth muscle. BJU Int 99 (2007) 687-694
31. Werkstrom V., Persson K., and Andersson K.E. NANC transmitters in the female pig urethra-localization and modulation of release via alpha 2-adrenoceptors and potassium channels. Br J Pharmacol 121 (1997) 1605-1612
32. Schicho R., Krueger D., Zeller F., et al. Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon. Gastroenterology 131 (2006) 1542-1552