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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 797-800

Tricyclic 3,4-dihydropyrimidine-2-thione derivatives as potent TRPA1 antagonists

(6) Gijsen, Harrie J M a Berthelot, Didier a De Cleyn, Michel A J a Geuens, Ivo a Brône, Bert a Mercken, Marc a

a JANSSEN RESEARCH AND DEVELOPMENT (Belgium)

Author keywords

Antagonist; Biginelli; TRPA1

Indexed keywords

4 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDROINDENO[1,2 D]PYRIMIDIN 5 ONE; THIOUREA DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1 ANTAGONIST; TRANSIENT RECEPTOR POTENTIAL CHANNEL AFFECTING AGENT; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BIGINELLI REACTION; DERIVATIZATION; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG PROTEIN BINDING; ENANTIOMER; HIGH THROUGHPUT SCREENING; IC 50; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; CALCIUM CHANNELS; HUMANS; MOLECULAR STRUCTURE; NERVE TISSUE PROTEINS; PYRIMIDINES; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIONES; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPC CATION CHANNELS;

RATTUS;

EID: 84855668536 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.12.068 Document Type: Article

Times cited : (51)

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