메뉴 건너뛰기




Volumn 304, Issue 5, 2013, Pages

Animal models of chronic liver diseases

Author keywords

ALD; Autoimmune hepatitis; Fibrosis; HBV; HCV; NASH; PBC; PSC

Indexed keywords

1,4 DIHYDRO 2,4,6 TRIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER; ALCOHOL; BOCEPREVIR; CASPASE 8; CYTOCHROME P450; FK 506 BINDING PROTEIN; FRUCTOSE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; INTERLEUKIN 6; LEPTIN; METHIONINE; MULTIDRUG RESISTANCE PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; PEGINTERFERON ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN BCL XL; RAG2 PROTEIN; RIBAVIRIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; UNINDEXED DRUG; UROKINASE;

EID: 84874600567     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00199.2012     Document Type: Review
Times cited : (176)

References (229)
  • 1
    • 77950324131 scopus 로고    scopus 로고
    • Murine schistosomiasis as a model for human schistosomiasis mansoni: Similarities and discrepancies
    • Abdul-Ghani RA, Hassan AA. Murine schistosomiasis as a model for human schistosomiasis mansoni: similarities and discrepancies. Parasitol Res 107: 1-8, 2010.
    • (2010) Parasitol Res , vol.107 , pp. 1-8
    • Abdul-Ghani, R.A.1    Hassan, A.A.2
  • 2
    • 78751541079 scopus 로고    scopus 로고
    • Fructose at the center of necroinflammation and fibrosis in nonalcoholic steatohepatitis
    • Alisi A, Manco M, Pezzullo M, Nobili V. Fructose at the center of necroinflammation and fibrosis in nonalcoholic steatohepatitis. Hepatology 53: 372-373, 2010.
    • (2010) Hepatology , vol.53 , pp. 372-373
    • Alisi, A.1    Manco, M.2    Pezzullo, M.3    Nobili, V.4
  • 3
    • 33644955272 scopus 로고    scopus 로고
    • Mouse models in non-alcoholic fatty liver disease and steatohepatitis research
    • Anstee QM, Goldin RD. Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. Int J Exp Pathol 87: 1-16, 2006.
    • (2006) Int J Exp Pathol , vol.87 , pp. 1-16
    • Anstee, Q.M.1    Goldin, R.D.2
  • 6
    • 31844448804 scopus 로고    scopus 로고
    • Development of nonhuman adenoviruses as vaccine vectors
    • Bangari DS, Mittal SK. Development of nonhuman adenoviruses as vaccine vectors. Vaccine 24: 849-862, 2006.
    • (2006) Vaccine , vol.24 , pp. 849-862
    • Bangari, D.S.1    Mittal, S.K.2
  • 8
    • 44649093803 scopus 로고    scopus 로고
    • Mouse models for the study of HCV infection and virus-host interactions
    • Barth H, Robinet E, Liang TJ, Baumert TF. Mouse models for the study of HCV infection and virus-host interactions. J Hepatol 49: 134-142, 2008.
    • (2008) J Hepatol , vol.49 , pp. 134-142
    • Barth, H.1    Robinet, E.2    Liang, T.J.3    Baumert, T.F.4
  • 9
    • 0031925283 scopus 로고    scopus 로고
    • Analysis of hepatitis C virusinoculated chimpanzees reveals unexpected clinical profiles
    • Bassett SE, Brasky KM, Lanford RE. Analysis of hepatitis C virusinoculated chimpanzees reveals unexpected clinical profiles. J Virol 72: 2589-2599, 1998.
    • (1998) J Virol , vol.72 , pp. 2589-2599
    • Bassett, S.E.1    Brasky, K.M.2    Lanford, R.E.3
  • 12
    • 80052548485 scopus 로고    scopus 로고
    • Therapy for hepatic fibrosis: Revisiting the preclinical models
    • Bissell DM. Therapy for hepatic fibrosis: revisiting the preclinical models. Clin Res Hepatol Gastroenterol 35: 521-525, 2011.
    • (2011) Clin Res Hepatol Gastroenterol , vol.35 , pp. 521-525
    • Bissell, D.M.1
  • 13
    • 38049164210 scopus 로고    scopus 로고
    • Repopulation of adult and neonatal mice with human hepatocytes: A chimeric animal model
    • Bissig KD, Le TT, Woods NB, Verma IM. Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model. Proc Natl Acad Sci USA 104: 20507-20511, 2007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20507-20511
    • Bissig, K.D.1    Le, T.T.2    Woods, N.B.3    Verma, I.M.4
  • 16
    • 0024400632 scopus 로고
    • Immunopathology of Schistosoma mansoni infection
    • Boros DL. Immunopathology of Schistosoma mansoni infection. Clin Microbiol Rev 2: 250-269, 1989.
    • (1989) Clin Microbiol Rev , vol.2 , pp. 250-269
    • Boros, D.L.1
  • 17
    • 0023730861 scopus 로고
    • Synergism between ethanol and carbon tetrachloride in the generation of liver fibrosis
    • Bosma A, Brouwer A, Seifert WF, Knook DL. Synergism between ethanol and carbon tetrachloride in the generation of liver fibrosis. J Pathol 156: 15-21, 1988.
    • (1988) J Pathol , vol.156 , pp. 15-21
    • Bosma, A.1    Brouwer, A.2    Seifert, W.F.3    Knook, D.L.4
  • 20
    • 11244348954 scopus 로고    scopus 로고
    • A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats
    • Carmiel-Haggai M, Cederbaum AI, Nieto N. A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats. FASEB J 19: 136-138, 2005.
    • (2005) FASEB J , vol.19 , pp. 136-138
    • Carmiel-Haggai, M.1    Cederbaum, A.I.2    Nieto, N.3
  • 21
    • 0022551673 scopus 로고
    • Acetone potentiation of chronic liver injury induced by repetitive administration of carbon tetrachloride
    • Charbonneau M, Tuchweber B, Plaa GL. Acetone potentiation of chronic liver injury induced by repetitive administration of carbon tetrachloride. Hepatology 6: 694-700, 1986.
    • (1986) Hepatology , vol.6 , pp. 694-700
    • Charbonneau, M.1    Tuchweber, B.2    Plaa, G.L.3
  • 23
    • 80052178313 scopus 로고    scopus 로고
    • Conditional gene expression in hepatitis C virus transgenic mice without induction of severe liver injury using a non-inflammatory Cre-expressing adenovirus
    • Chiyo T, Sekiguchi S, Hayashi M, Tobita Y, Kanegae Y, Saito I, Kohara M. Conditional gene expression in hepatitis C virus transgenic mice without induction of severe liver injury using a non-inflammatory Cre-expressing adenovirus. Virus Res 160: 89-97, 2011.
    • (2011) Virus Res , vol.160 , pp. 89-97
    • Chiyo, T.1    Sekiguchi, S.2    Hayashi, M.3    Tobita, Y.4    Kanegae, Y.5    Saito, I.6    Kohara, M.7
  • 24
    • 77952561310 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 as a model antigen
    • Christen U, Holdener M, Hintermann E. Cytochrome P450 2D6 as a model antigen. Dig Dis 28: 80-85, 2010.
    • (2010) Dig Dis , vol.28 , pp. 80-85
    • Christen, U.1    Holdener, M.2    Hintermann, E.3
  • 25
    • 1242270574 scopus 로고    scopus 로고
    • Induction, acceleration or prevention of autoimmunity by molecular mimicry
    • Christen U, von Herrath MG. Induction, acceleration or prevention of autoimmunity by molecular mimicry. Mol Immunol 40: 1113-1120, 2004.
    • (2004) Mol Immunol , vol.40 , pp. 1113-1120
    • Christen, U.1    von Herrath, M.G.2
  • 31
    • 33646339646 scopus 로고    scopus 로고
    • Small animal model systems for studying hepatitis B virus replication and pathogenesis
    • Dandri M, Lutgehetmann M, Volz T, Petersen J. Small animal model systems for studying hepatitis B virus replication and pathogenesis. Semin Liver Dis 26: 181-191, 2006.
    • (2006) Semin Liver Dis , vol.26 , pp. 181-191
    • Dandri, M.1    Lutgehetmann, M.2    Volz, T.3    Petersen, J.4
  • 32
    • 32044433759 scopus 로고    scopus 로고
    • Animal models for the study of HBV replication and its variants
    • Dandri M, Volz TK, Lutgehetmann M, Petersen J. Animal models for the study of HBV replication and its variants. J Clin Virol 34, Suppl 1: S54-S62, 2005.
    • (2005) J Clin Virol , vol.34 , Issue.SUPPL. 1
    • Dandri, M.1    Volz, T.K.2    Lutgehetmann, M.3    Petersen, J.4
  • 34
    • 0033391153 scopus 로고    scopus 로고
    • Concanavalin A-induced hepatitis in mice is prevented by interleukin (IL)-10 and exacerbated by endogenous IL-10 deficiency
    • Di Marco R, Xiang M, Zaccone P, Leonardi C, Franco S, Meroni P, Nicoletti F. Concanavalin A-induced hepatitis in mice is prevented by interleukin (IL)-10 and exacerbated by endogenous IL-10 deficiency. Autoimmunity 31: 75-83, 1999.
    • (1999) Autoimmunity , vol.31 , pp. 75-83
    • Di Marco, R.1    Xiang, M.2    Zaccone, P.3    Leonardi, C.4    Franco, S.5    Meroni, P.6    Nicoletti, F.7
  • 38
    • 80052584948 scopus 로고    scopus 로고
    • Autoimmune liver disease-are there spectra that we do not know?
    • Fallatah HI, Akbar HO. Autoimmune liver disease-are there spectra that we do not know? Comp Hepatol 10: 9, 2011.
    • (2011) Comp Hepatol , vol.10 , pp. 9
    • Fallatah, H.I.1    Akbar, H.O.2
  • 39
    • 67549113925 scopus 로고    scopus 로고
    • Commonly used animal models of non-alcoholic steatohepatitis
    • Fan JG, Qiao L. Commonly used animal models of non-alcoholic steatohepatitis. Hepatobiliary Pancreat Dis Int 8: 233-240, 2009.
    • (2009) Hepatobiliary Pancreat Dis Int , vol.8 , pp. 233-240
    • Fan, J.G.1    Qiao, L.2
  • 40
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 43: S99-S112, 2006.
    • (2006) Hepatology , vol.43
    • Farrell, G.C.1    Larter, C.Z.2
  • 47
    • 0035049639 scopus 로고    scopus 로고
    • Pro-and anti-inflammatory gene expression in the murine small intestine and liver after chronic exposure to alcohol
    • Fleming S, Toratani S, Shea-Donohue T, Kashiwabara Y, Vogel SN, Metcalf ES. Pro-and anti-inflammatory gene expression in the murine small intestine and liver after chronic exposure to alcohol. Alcohol Clin Exp Res 25: 579-589, 2001.
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 579-589
    • Fleming, S.1    Toratani, S.2    Shea-Donohue, T.3    Kashiwabara, Y.4    Vogel, S.N.5    Metcalf, E.S.6
  • 48
    • 0022830407 scopus 로고
    • Ethanol-induced hepatic fibrosis in the rat: Role of the amount of dietary fat
    • French SW, Miyamoto K, Tsukamoto H. Ethanol-induced hepatic fibrosis in the rat: role of the amount of dietary fat. Alcohol Clin Exp Res 10: 13S-19S, 1986.
    • (1986) Alcohol Clin Exp Res , vol.10
    • French, S.W.1    Miyamoto, K.2    Tsukamoto, H.3
  • 50
    • 0028795171 scopus 로고
    • Concanavalin A-induced T-cell-mediated hepatic injury in mice: The role of tumor necrosis factor
    • Gantner F, Leist M, Lohse AW, Germann PG, Tiegs G. Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology 21: 190-198, 1995.
    • (1995) Hepatology , vol.21 , pp. 190-198
    • Gantner, F.1    Leist, M.2    Lohse, A.W.3    Germann, P.G.4    Tiegs, G.5
  • 51
    • 7044264899 scopus 로고    scopus 로고
    • Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease
    • Gao D, Wei C, Chen L, Huang J, Yang S, Diehl AM. Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease. Am J Physiol Gastrointest Liver Physiol 287: G1070-G1077, 2004.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Gao, D.1    Wei, C.2    Chen, L.3    Huang, J.4    Yang, S.5    Diehl, A.M.6
  • 52
    • 47649116115 scopus 로고    scopus 로고
    • Comparison of three research models of portal hypertension in mice: Macroscopic, histological and portal pressure evaluation
    • Geerts AM, Vanheule E, Praet M, Van Vlierberghe H, De Vos M, Colle I. Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation. Int J Exp Pathol 89: 251-263, 2008.
    • (2008) Int J Exp Pathol , vol.89 , pp. 251-263
    • Geerts, A.M.1    Vanheule, E.2    Praet, M.3    van Vlierberghe, H.4    de Vos, M.5    Colle, I.6
  • 53
    • 0034131557 scopus 로고    scopus 로고
    • Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
    • Gorelik L, Flavell RA. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12: 171-181, 2000.
    • (2000) Immunity , vol.12 , pp. 171-181
    • Gorelik, L.1    Flavell, R.A.2
  • 54
    • 0035873731 scopus 로고    scopus 로고
    • Genetic regulation of autoimmune disease: BALB/c background TGF-beta 1-deficient mice develop necroinflammatory IFN-gamma-dependent hepatitis
    • Gorham JD, Lin JT, Sung JL, Rudner LA, French MA. Genetic regulation of autoimmune disease: BALB/c background TGF-beta 1-deficient mice develop necroinflammatory IFN-gamma-dependent hepatitis. J Immunol 166: 6413-6422, 2001.
    • (2001) J Immunol , vol.166 , pp. 6413-6422
    • Gorham, J.D.1    Lin, J.T.2    Sung, J.L.3    Rudner, L.A.4    French, M.A.5
  • 57
    • 77952576055 scopus 로고    scopus 로고
    • Mouse models for experimental autoimmune hepatitis: Limits and chances
    • Hardtke-Wolenski M, Jaeckel E. Mouse models for experimental autoimmune hepatitis: limits and chances. Dig Dis 28: 70-79, 2010.
    • (2010) Dig Dis , vol.28 , pp. 70-79
    • Hardtke-Wolenski, M.1    Jaeckel, E.2
  • 58
    • 79955554762 scopus 로고    scopus 로고
    • Animal models for the study of liver fibrosis: New insights from knockout mouse models
    • Hayashi H, Sakai T. Animal models for the study of liver fibrosis: new insights from knockout mouse models. Am J Physiol Gastrointest Liver Physiol 300: G729-G738, 2011.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300
    • Hayashi, H.1    Sakai, T.2
  • 59
    • 78651089694 scopus 로고    scopus 로고
    • Animal models of nonalcoholic fatty liver disease
    • Hebbard L, George J. Animal models of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 8: 35-44, 2010.
    • (2010) Nat Rev Gastroenterol Hepatol , vol.8 , pp. 35-44
    • Hebbard, L.1    George, J.2
  • 60
    • 0025144417 scopus 로고
    • Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator
    • Heckel JL, Sandgren EP, Degen JL, Palmiter RD, Brinster RL. Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator. Cell 62: 447-456, 1990.
    • (1990) Cell , vol.62 , pp. 447-456
    • Heckel, J.L.1    Sandgren, E.P.2    Degen, J.L.3    Palmiter, R.D.4    Brinster, R.L.5
  • 61
    • 68849118378 scopus 로고    scopus 로고
    • Experimental mouse models for hepatocellular carcinoma research
    • Heindryckx F, Colle I, Van Vlierberghe H. Experimental mouse models for hepatocellular carcinoma research. Int J Exp Pathol 90: 367-386, 2009.
    • (2009) Int J Exp Pathol , vol.90 , pp. 367-386
    • Heindryckx, F.1    Colle, I.2    van Vlierberghe, H.3
  • 62
    • 0036892365 scopus 로고    scopus 로고
    • Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15
    • Hillebrandt S, Goos C, Matern S, Lammert F. Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15. Gastroenterology 123: 2041-2051, 2002.
    • (2002) Gastroenterology , vol.123 , pp. 2041-2051
    • Hillebrandt, S.1    Goos, C.2    Matern, S.3    Lammert, F.4
  • 63
    • 84861214016 scopus 로고    scopus 로고
    • The CYP2D6 animal model: How to induce autoimmune hepatitis in mice
    • doi: 10.3791/3644
    • Hintermann E, Ehser J, Christen U. The CYP2D6 animal model: how to induce autoimmune hepatitis in mice. J Vis Exp (60), e3644, doi: 10.3791/3644, 2012.
    • (2012) J Vis Exp , Issue.60
    • Hintermann, E.1    Ehser, J.2    Christen, U.3
  • 71
    • 0032146551 scopus 로고    scopus 로고
    • Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
    • Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, Hovell C, Arthur MP. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 102: 538-549, 1998.
    • (1998) J Clin Invest , vol.102 , pp. 538-549
    • Iredale, J.P.1    Benyon, R.C.2    Pickering, J.3    McCullen, M.4    Northrop, M.5    Pawley, S.6    Hovell, C.7    Arthur, M.P.8
  • 73
    • 0035083958 scopus 로고    scopus 로고
    • Apoptosis of hepatic stellate cells: Involvement in resolution of biliary fibrosis and regulation by soluble growth factors
    • Issa R, Williams E, Trim N, Kendall T, Arthur MJ, Reichen J, Benyon RC, Iredale JP. Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors. Gut 48: 548-557, 2001.
    • (2001) Gut , vol.48 , pp. 548-557
    • Issa, R.1    Williams, E.2    Trim, N.3    Kendall, T.4    Arthur, M.J.5    Reichen, J.6    Benyon, R.C.7    Iredale, J.P.8
  • 77
  • 79
    • 0032530110 scopus 로고    scopus 로고
    • Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: Implications for gene therapy
    • Kafri T, Morgan D, Krahl T, Sarvetnick N, Sherman L, Verma I. Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy. Proc Natl Acad Sci USA 95: 11377-11382, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11377-11382
    • Kafri, T.1    Morgan, D.2    Krahl, T.3    Sarvetnick, N.4    Sherman, L.5    Verma, I.6
  • 82
    • 4644370807 scopus 로고    scopus 로고
    • Lack of peroxisome proliferator-activated receptor alpha in mice enhances methionine and choline deficient dietinduced steatohepatitis
    • Kashireddy PV, Rao MS. Lack of peroxisome proliferator-activated receptor alpha in mice enhances methionine and choline deficient dietinduced steatohepatitis. Hepatol Res 30: 104-110, 2004.
    • (2004) Hepatol Res , vol.30 , pp. 104-110
    • Kashireddy, P.V.1    Rao, M.S.2
  • 84
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    • Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 103: 1489-1498, 1999.
    • (1999) J Clin Invest , vol.103 , pp. 1489-1498
    • Kersten, S.1    Seydoux, J.2    Peters, J.M.3    Gonzalez, F.J.4    Desvergne, B.5    Wahli, W.6
  • 85
    • 77957946415 scopus 로고    scopus 로고
    • Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3
    • Ki SH, Park O, Zheng M, Morales-Ibanez O, Kolls JK, Bataller R, Gao B. Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology 52: 1291-1300, 2010.
    • (2010) Hepatology , vol.52 , pp. 1291-1300
    • Ki, S.H.1    Park, O.2    Zheng, M.3    Morales-Ibanez, O.4    Kolls, J.K.5    Bataller, R.6    Gao, B.7
  • 86
    • 44649144640 scopus 로고    scopus 로고
    • Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling
    • Kido M, Watanabe N, Okazaki T, Akamatsu T, Tanaka J, Saga K, Nishio A, Honjo T, Chiba T. Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling. Gastroenterology 135: 1333-1343, 2008.
    • (2008) Gastroenterology , vol.135 , pp. 1333-1343
    • Kido, M.1    Watanabe, N.2    Okazaki, T.3    Akamatsu, T.4    Tanaka, J.5    Saga, K.6    Nishio, A.7    Honjo, T.8    Chiba, T.9
  • 89
    • 0034569372 scopus 로고    scopus 로고
    • Development of an intragastric enteral model in the mouse: Studies of alcohol-induced liver disease using knockout technology
    • Kono H, Bradford BU, Rusyn I, Fujii H, Matsumoto Y, Yin M, Thurman RG. Development of an intragastric enteral model in the mouse: studies of alcohol-induced liver disease using knockout technology. J Hepatobiliary Pancreat Surg 7: 395-400, 2000.
    • (2000) J Hepatobiliary Pancreat Surg , vol.7 , pp. 395-400
    • Kono, H.1    Bradford, B.U.2    Rusyn, I.3    Fujii, H.4    Matsumoto, Y.5    Yin, M.6    Thurman, R.G.7
  • 91
    • 0021238490 scopus 로고
    • Prolonged bile duct obstruction: A new experimental model for cirrhosis in the rat
    • Kountouras J, Billing BH, Scheuer PJ. Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. Br J Exp Pathol 65: 305-311, 1984.
    • (1984) Br J Exp Pathol , vol.65 , pp. 305-311
    • Kountouras, J.1    Billing, B.H.2    Scheuer, P.J.3
  • 92
    • 34250634419 scopus 로고    scopus 로고
    • New animal models for hepatitis C viral infection and pathogenesis studies
    • Kremsdorf D, Brezillon N. New animal models for hepatitis C viral infection and pathogenesis studies. World J Gastroenterol 13: 2427-2435, 2007.
    • (2007) World J Gastroenterol , vol.13 , pp. 2427-2435
    • Kremsdorf, D.1    Brezillon, N.2
  • 93
    • 0039469942 scopus 로고
    • alpha-Hydroxylation pathway in the in vitro metabolism of carcinogenic nitrosamines: N-nitrosodimethylamine and N-nitroso-Nmethylaniline
    • Kroeger-Koepke MB, Koepke SR, McClusky GA, Magee PN, Michejda CJ. alpha-Hydroxylation pathway in the in vitro metabolism of carcinogenic nitrosamines: N-nitrosodimethylamine and N-nitroso-Nmethylaniline. Proc Natl Acad Sci USA 78: 6489-6493, 1981.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 6489-6493
    • Kroeger-Koepke, M.B.1    Koepke, S.R.2    McClusky, G.A.3    Magee, P.N.4    Michejda, C.J.5
  • 94
    • 84855691892 scopus 로고    scopus 로고
    • New developments in HCV therapy
    • Kronenberger B, Zeuzem S. New developments in HCV therapy. J Viral Hepat 19, Suppl 1: 48-51, 2012.
    • (2012) J Viral Hepat , vol.19 , Issue.SUPPL. 1 , pp. 48-51
    • Kronenberger, B.1    Zeuzem, S.2
  • 96
    • 0030017301 scopus 로고    scopus 로고
    • Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A
    • Kusters S, Gantner F, Kunstle G, Tiegs G. Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology 111: 462-471, 1996.
    • (1996) Gastroenterology , vol.111 , pp. 462-471
    • Kusters, S.1    Gantner, F.2    Kunstle, G.3    Tiegs, G.4
  • 99
    • 56549117448 scopus 로고    scopus 로고
    • Animal models of NASH: Getting both pathology and metabolic context right
    • Larter CZ, Yeh MM. Animal models of NASH: getting both pathology and metabolic context right. J Gastroenterol Hepatol 23: 1635-1648, 2008.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 1635-1648
    • Larter, C.Z.1    Yeh, M.M.2
  • 101
    • 48449096011 scopus 로고    scopus 로고
    • MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes
    • Larter CZ, Yeh MM, Williams J, Bell-Anderson KS, Farrell GC. MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes. J Hepatol 49: 407-416, 2008.
    • (2008) J Hepatol , vol.49 , pp. 407-416
    • Larter, C.Z.1    Yeh, M.M.2    Williams, J.3    Bell-Anderson, K.S.4    Farrell, G.C.5
  • 102
    • 0036022846 scopus 로고    scopus 로고
    • Leptin is essential for the hepatic fibrogenic response to chronic liver injury
    • Leclercq IA, Farrell GC, Schriemer R, Robertson GR. Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J Hepatol 37: 206-213, 2002.
    • (2002) J Hepatol , vol.37 , pp. 206-213
    • Leclercq, I.A.1    Farrell, G.C.2    Schriemer, R.3    Robertson, G.R.4
  • 103
    • 33845788135 scopus 로고    scopus 로고
    • Intrahepatic insulin resistance in a murine model of steatohepatitis: Effect of PPARgamma agonist pioglitazone
    • Leclercq IA, Lebrun VA, Starkel P, Horsmans YJ. Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARgamma agonist pioglitazone. Lab Invest 87: 56-65, 2007.
    • (2007) Lab Invest , vol.87 , pp. 56-65
    • Leclercq, I.A.1    Lebrun, V.A.2    Starkel, P.3    Horsmans, Y.J.4
  • 104
    • 0020696022 scopus 로고
    • Hepatic fibrosis after long-term administration of ethanol and moderate vitamin A supplementation in the rat
    • Leo MA, Lieber CS. Hepatic fibrosis after long-term administration of ethanol and moderate vitamin A supplementation in the rat. Hepatology 3: 1-11, 1983.
    • (1983) Hepatology , vol.3 , pp. 1-11
    • Leo, M.A.1    Lieber, C.S.2
  • 105
    • 79958268921 scopus 로고    scopus 로고
    • Animal models in the study of hepatitis C virus-associated liver pathologies
    • Lerat H, Higgs M, Pawlotsky JM. Animal models in the study of hepatitis C virus-associated liver pathologies. Expert Rev Gastroenterol Hepatol 5: 341-352, 2011.
    • (2011) Expert Rev Gastroenterol Hepatol , vol.5 , pp. 341-352
    • Lerat, H.1    Higgs, M.2    Pawlotsky, J.M.3
  • 107
    • 0025801063 scopus 로고
    • Biliary tract disease in rats with experimental small bowel bacterial overgrowth
    • Lichtman SN, Keku J, Clark RL, Schwab JH, Sartor RB. Biliary tract disease in rats with experimental small bowel bacterial overgrowth. Hepatology 13: 766-772, 1991.
    • (1991) Hepatology , vol.13 , pp. 766-772
    • Lichtman, S.N.1    Keku, J.2    Clark, R.L.3    Schwab, J.H.4    Sartor, R.B.5
  • 108
    • 0020395484 scopus 로고
    • The feeding of alcohol in liquid diets: Two decades of applications and 1982 update
    • Lieber CS, DeCarli LM. The feeding of alcohol in liquid diets: two decades of applications and 1982 update. Alcohol Clin Exp Res 6: 523-531, 1982.
    • (1982) Alcohol Clin Exp Res , vol.6 , pp. 523-531
    • Lieber, C.S.1    DeCarli, L.M.2
  • 109
  • 112
    • 34249799917 scopus 로고    scopus 로고
    • The physiology of obese-hyperglycemic mice [ob/ob mice]
    • Lindstrom P. The physiology of obese-hyperglycemic mice [ob/ob mice]. ScientificWorldJournal 7: 666-685, 2007.
    • (2007) ScientificWorldJournal , vol.7 , pp. 666-685
    • Lindstrom, P.1
  • 113
    • 34249681974 scopus 로고    scopus 로고
    • Pathogenesis of NASH: Animal models
    • London RM, George J. Pathogenesis of NASH: animal models. Clin Liver Dis 11: 55-74, viii, 2007.
    • (2007) Clin Liver Dis , vol.11
    • London, R.M.1    George, J.2
  • 117
    • 42149161075 scopus 로고    scopus 로고
    • An update on primary sclerosing cholangitis
    • Maggs JR, Chapman RW. An update on primary sclerosing cholangitis. Curr Opin Gastroenterol 24: 377-383, 2008.
    • (2008) Curr Opin Gastroenterol , vol.24 , pp. 377-383
    • Maggs, J.R.1    Chapman, R.W.2
  • 122
    • 0034710792 scopus 로고    scopus 로고
    • Oxidized LDL induces an oxidative stress and activates the tumor suppressor p53 in MRC5 human fibroblasts
    • Maziere C, Meignotte A, Dantin F, Conte MA, Maziere JC. Oxidized LDL induces an oxidative stress and activates the tumor suppressor p53 in MRC5 human fibroblasts. Biochem Biophys Res Commun 276: 718-723, 2000.
    • (2000) Biochem Biophys Res Commun , vol.276 , pp. 718-723
    • Maziere, C.1    Meignotte, A.2    Dantin, F.3    Conte, M.A.4    Maziere, J.C.5
  • 123
    • 0014592402 scopus 로고
    • An improved method for producing cirrhosis of the liver in rats by simultaneous administration of carbon tetrachloride and phenobarbitone
    • Sutton Instant cirrhosis PM
    • McLean EK, McLean AE, Sutton Instant cirrhosis PM. An improved method for producing cirrhosis of the liver in rats by simultaneous administration of carbon tetrachloride and phenobarbitone. Br J Exp Pathol 50: 502-506, 1969.
    • (1969) Br J Exp Pathol , vol.50 , pp. 502-506
    • McLean, E.K.1    McLean, A.E.2
  • 125
    • 56349163205 scopus 로고    scopus 로고
    • The human liver-uPA-SCID mouse: A model for the evaluation of antiviral compounds against HBV and HCV
    • Meuleman P, Leroux-Roels G. The human liver-uPA-SCID mouse: a model for the evaluation of antiviral compounds against HBV and HCV. Antiviral Res 80: 231-238, 2008.
    • (2008) Antiviral Res , vol.80 , pp. 231-238
    • Meuleman, P.1    Leroux-Roels, G.2
  • 130
    • 0023751476 scopus 로고
    • Thioacetamideinduced cirrhosis-like liver lesions in rats-usefulness and reliability of this animal model
    • Muller A, Machnik F, Zimmermann T, Schubert H. Thioacetamideinduced cirrhosis-like liver lesions in rats-usefulness and reliability of this animal model. Exp Pathol (Jena) 34: 229-236, 1988.
    • (1988) Exp Pathol (Jena) , vol.34 , pp. 229-236
    • Muller, A.1    McHnik, F.2    Zimmermann, T.3    Schubert, H.4
  • 133
    • 1642321982 scopus 로고    scopus 로고
    • IL-2, regulatory T cells, and tolerance
    • Nelson BH. IL-2, regulatory T cells, and tolerance. J Immunol 172: 3983-3988, 2004.
    • (2004) J Immunol , vol.172 , pp. 3983-3988
    • Nelson, B.H.1
  • 135
    • 34548565932 scopus 로고    scopus 로고
    • Involvement of sex, strain and age factors in high fat diet-induced obesity in C57BL/6J and BALB/cA mice
    • Nishikawa S, Yasoshima A, Doi K, Nakayama H, Uetsuka K. Involvement of sex, strain and age factors in high fat diet-induced obesity in C57BL/6J and BALB/cA mice. Exp Anim 56: 263-272, 2007.
    • (2007) Exp Anim , vol.56 , pp. 263-272
    • Nishikawa, S.1    Yasoshima, A.2    Doi, K.3    Nakayama, H.4    Uetsuka, K.5
  • 136
    • 0025322603 scopus 로고
    • Synthetic low and high fat diets for the study of atherosclerosis in the mouse
    • Nishina PM, Verstuyft J, Paigen B. Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J Lipid Res 31: 859-869, 1990.
    • (1990) J Lipid Res , vol.31 , pp. 859-869
    • Nishina, P.M.1    Verstuyft, J.2    Paigen, B.3
  • 142
    • 0034954716 scopus 로고    scopus 로고
    • Transplantation of human hepatocytes into tolerized genetically immunocompetent rats
    • Ouyang EC, Wu CH, Walton C, Promrat K, Wu GY. Transplantation of human hepatocytes into tolerized genetically immunocompetent rats. World J Gastroenterol 7: 324-330, 2001.
    • (2001) World J Gastroenterol , vol.7 , pp. 324-330
    • Ouyang, E.C.1    Wu, C.H.2    Walton, C.3    Promrat, K.4    Wu, G.Y.5
  • 144
    • 0021858935 scopus 로고
    • Rapid induction of cirrhosis by administration of carbon tetrachloride plus phospholipase D
    • Ozeki T, Funakoshi K, Iwaki K. Rapid induction of cirrhosis by administration of carbon tetrachloride plus phospholipase D. Br J Exp Pathol 66: 385-390, 1985.
    • (1985) Br J Exp Pathol , vol.66 , pp. 385-390
    • Ozeki, T.1    Funakoshi, K.2    Iwaki, K.3
  • 145
    • 77953986092 scopus 로고    scopus 로고
    • Differential expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in thioacetamide-induced chronic liver injury
    • Park SY, Shin HW, Lee KB, Lee MJ, Jang JJ. Differential expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in thioacetamide-induced chronic liver injury. J Korean Med Sci 25: 570-576, 2010.
    • (2010) J Korean Med Sci , vol.25 , pp. 570-576
    • Park, S.Y.1    Shin, H.W.2    Lee, K.B.3    Lee, M.J.4    Jang, J.J.5
  • 147
    • 60149090028 scopus 로고    scopus 로고
    • Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
    • Ploss A, Evans MJ, Gaysinskaya VA, Panis M, You H, de Jong YP, Rice CM. Human occludin is a hepatitis C virus entry factor required for infection of mouse cells. Nature 457: 882-886, 2009.
    • (2009) Nature , vol.457 , pp. 882-886
    • Ploss, A.1    Evans, M.J.2    Gaysinskaya, V.A.3    Panis, M.4    You, H.5    de Jong, Y.P.6    Rice, C.M.7
  • 148
    • 0016435386 scopus 로고
    • Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes
    • Poirier LA. Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes. J Natl Cancer Inst 54: 137-140, 1975.
    • (1975) J Natl Cancer Inst , vol.54 , pp. 137-140
    • Poirier, L.A.1
  • 149
    • 27744512904 scopus 로고    scopus 로고
    • -/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro-and antifibrogenic genes
    • -/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro-and antifibrogenic genes. J Hepatol 43: 1045-1054, 2005.
    • (2005) J Hepatol , vol.43 , pp. 1045-1054
    • Popov, Y.1    Patsenker, E.2    Fickert, P.3    Trauner, M.4    Schuppan, D.5
  • 151
    • 0015642211 scopus 로고
    • Age-and sex-associated diethylnitrosamine dealkylation activity of the mouse liver and hepatocarcinogenesis
    • Rao KV, Vesselinovitch SD. Age-and sex-associated diethylnitrosamine dealkylation activity of the mouse liver and hepatocarcinogenesis. Cancer Res 33: 1625-1627, 1973.
    • (1973) Cancer Res , vol.33 , pp. 1625-1627
    • Rao, K.V.1    Vesselinovitch, S.D.2
  • 152
    • 0035658444 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal β-oxidation, PPARα, and steatohepatitis
    • Reddy JK. Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal β-oxidation, PPARα, and steatohepatitis. Am J Physiol Gastrointest Liver Physiol 281: G1333-G1339, 2001.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.281
    • Reddy, J.K.1
  • 155
    • 0346689994 scopus 로고    scopus 로고
    • The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance
    • Rinella ME, Green RM. The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. J Hepatol 40: 47-51, 2004.
    • (2004) J Hepatol , vol.40 , pp. 47-51
    • Rinella, M.E.1    Green, R.M.2
  • 156
    • 0036862005 scopus 로고    scopus 로고
    • Effects of ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats: I. Periadolescent exposure
    • Rodd-Henricks ZA, Bell RL, Kuc KA, Murphy JM, McBride WJ, Lumeng L, Li TK. Effects of ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats: I. Periadolescent exposure. Alcohol Clin Exp Res 26: 1632-1641, 2002.
    • (2002) Alcohol Clin Exp Res , vol.26 , pp. 1632-1641
    • Rodd-Henricks, Z.A.1    Bell, R.L.2    Kuc, K.A.3    Murphy, J.M.4    McBride, W.J.5    Lumeng, L.6    Li, T.K.7
  • 158
    • 1642516133 scopus 로고    scopus 로고
    • Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination
    • Safran M, Kim WY, Kung AL, Horner JW, DePinho RA, Kaelin WG Jr. Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination. Mol Imaging 2: 297-302, 2003.
    • (2003) Mol Imaging , vol.2 , pp. 297-302
    • Safran, M.1    Kim, W.Y.2    Kung, A.L.3    Horner, J.W.4    DePinho, R.A.5    Kaelin Jr., W.G.6
  • 159
    • 7044241291 scopus 로고    scopus 로고
    • Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: Role of short-form leptin receptors and osteopontin
    • Sahai A, Malladi P, Pan X, Paul R, Melin-Aldana H, Green RM, Whitington PF. Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin. Am J Physiol Gastrointest Liver Physiol 287: G1035-G1043, 2004.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Sahai, A.1    Malladi, P.2    Pan, X.3    Paul, R.4    Melin-Aldana, H.5    Green, R.M.6    Whitington, P.F.7
  • 162
    • 0025781894 scopus 로고
    • Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene
    • Sandgren EP, Palmiter RD, Heckel JL, Daugherty CC, Brinster RL, Degen JL. Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell 66: 245-256, 1991.
    • (1991) Cell , vol.66 , pp. 245-256
    • Sandgren, E.P.1    Palmiter, R.D.2    Heckel, J.L.3    Daugherty, C.C.4    Brinster, R.L.5    Degen, J.L.6
  • 163
    • 77956572699 scopus 로고    scopus 로고
    • Natural killer cells target HCV core proteins during the innate immune response in HCV transgenic mice
    • Satoh K, Takahashi H, Matsuda C, Tanaka T, Miyasaka M, Zeniya M, Kohara M. Natural killer cells target HCV core proteins during the innate immune response in HCV transgenic mice. J Med Virol 82: 1545-1553, 2010.
    • (2010) J Med Virol , vol.82 , pp. 1545-1553
    • Satoh, K.1    Takahashi, H.2    Matsuda, C.3    Tanaka, T.4    Miyasaka, M.5    Zeniya, M.6    Kohara, M.7
  • 164
    • 77952562217 scopus 로고    scopus 로고
    • Animal models of non-alcoholic steatohepatitis: Of mice and man
    • Schattenberg JM, Galle PR. Animal models of non-alcoholic steatohepatitis: of mice and man. Dig Dis 28: 247-254, 2010.
    • (2010) Dig Dis , vol.28 , pp. 247-254
    • Schattenberg, J.M.1    Galle, P.R.2
  • 167
    • 79958813517 scopus 로고    scopus 로고
    • Pathogenesis of alcohol-induced liver disease: Classical concepts and recent advances
    • Seth D, Haber PS, Syn WK, Diehl AM, Day CP. Pathogenesis of alcohol-induced liver disease: classical concepts and recent advances. J Gastroenterol Hepatol 26: 1089-1105, 2011.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 1089-1105
    • Seth, D.1    Haber, P.S.2    Syn, W.K.3    Diehl, A.M.4    Day, C.P.5
  • 172
    • 79957597421 scopus 로고    scopus 로고
    • Telaprevir: An NS3/4A protease inhibitor for the treatment of chronic hepatitis C
    • Smith LS, Nelson M, Naik S, Woten J. Telaprevir: an NS3/4A protease inhibitor for the treatment of chronic hepatitis C. Ann Pharmacother 45: 639-648, 2011.
    • (2011) Ann Pharmacother , vol.45 , pp. 639-648
    • Smith, L.S.1    Nelson, M.2    Naik, S.3    Woten, J.4
  • 173
    • 0035033218 scopus 로고    scopus 로고
    • Transfer of hepatitis B virus genome by adenovirus vectors into cultured cells and mice: Crossing the species barrier
    • Sprinzl MF, Oberwinkler H, Schaller H, Protzer U. Transfer of hepatitis B virus genome by adenovirus vectors into cultured cells and mice: crossing the species barrier. J Virol 75: 5108-5118, 2001.
    • (2001) J Virol , vol.75 , pp. 5108-5118
    • Sprinzl, M.F.1    Oberwinkler, H.2    Schaller, H.3    Protzer, U.4
  • 174
    • 70350075402 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in the development of fructoseinduced hepatic steatosis in mice
    • Spruss A, Kanuri G, Wagnerberger S, Haub S, Bischoff SC, Bergheim I. Toll-like receptor 4 is involved in the development of fructoseinduced hepatic steatosis in mice. Hepatology 50: 1094-1104, 2009.
    • (2009) Hepatology , vol.50 , pp. 1094-1104
    • Spruss, A.1    Kanuri, G.2    Wagnerberger, S.3    Haub, S.4    Bischoff, S.C.5    Bergheim, I.6
  • 177
    • 19644375041 scopus 로고    scopus 로고
    • Steatohepatitis develops rapidly in transgenic mice overexpressing Abcb11 and fed a methioninecholine-deficient diet
    • Sundaram SS, Whitington PF, Green RM. Steatohepatitis develops rapidly in transgenic mice overexpressing Abcb11 and fed a methioninecholine-deficient diet. Am J Physiol Gastrointest Liver Physiol 288: G1321-G1327, 2005.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Sundaram, S.S.1    Whitington, P.F.2    Green, R.M.3
  • 179
    • 57349167340 scopus 로고    scopus 로고
    • Titration of hepatitis B virus infectivity in the sera of preacute and late acute phases of HBV infection: Transmission experiments to chimeric mice with human liver repopulated hepatocytes
    • Tabuchi A, Tanaka J, Katayama K, Mizui M, Matsukura H, Yugi H, Shimada T, Miyakawa Y, Yoshizawa H. Titration of hepatitis B virus infectivity in the sera of preacute and late acute phases of HBV infection: transmission experiments to chimeric mice with human liver repopulated hepatocytes. J Med Virol 80: 2064-2068, 2008.
    • (2008) J Med Virol , vol.80 , pp. 2064-2068
    • Tabuchi, A.1    Tanaka, J.2    Katayama, K.3    Mizui, M.4    Matsukura, H.5    Yugi, H.6    Shimada, T.7    Miyakawa, Y.8    Yoshizawa, H.9
  • 180
    • 0026333396 scopus 로고
    • Effect of dietary fat on Ito cell activation by chronic ethanol intake. A long-term serial morphometric study on alcohol-fed and control rats
    • Takahashi H, Wong K, Jui L, Nanji AA, Mendenhall CS, French SW. Effect of dietary fat on Ito cell activation by chronic ethanol intake. A long-term serial morphometric study on alcohol-fed and control rats. Alcohol Clin Exp Res 15: 1060-1066, 1991.
    • (1991) Alcohol Clin Exp Res , vol.15 , pp. 1060-1066
    • Takahashi, H.1    Wong, K.2    Jui, L.3    Nanji, A.A.4    Mendenhall, C.S.5    French, S.W.6
  • 181
    • 84861738395 scopus 로고    scopus 로고
    • Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    • Takahashi Y, Soejima Y, Fukusato T. Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J Gastroenterol 18: 2300-2308, 2012.
    • (2012) World J Gastroenterol , vol.18 , pp. 2300-2308
    • Takahashi, Y.1    Soejima, Y.2    Fukusato, T.3
  • 184
    • 70349731726 scopus 로고    scopus 로고
    • A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J
    • Tatematsu K, Tanaka Y, Kurbanov F, Sugauchi F, Mano S, Maeshiro T, Nakayoshi T, Wakuta M, Miyakawa Y, Mizokami M. A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J. J Virol 83: 10538-10547, 2009.
    • (2009) J Virol , vol.83 , pp. 10538-10547
    • Tatematsu, K.1    Tanaka, Y.2    Kurbanov, F.3    Sugauchi, F.4    Mano, S.5    Maeshiro, T.6    Nakayoshi, T.7    Wakuta, M.8    Miyakawa, Y.9    Mizokami, M.10
  • 188
    • 0026643743 scopus 로고
    • A T cell-dependent experimental liver injury in mice inducible by concanavalin A
    • Tiegs G, Hentschel J, Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 90: 196-203, 1992.
    • (1992) J Clin Invest , vol.90 , pp. 196-203
    • Tiegs, G.1    Hentschel, J.2    Wendel, A.3
  • 189
    • 55949085226 scopus 로고    scopus 로고
    • Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases
    • Trauner M, Fickert P, Halilbasic E, Moustafa T. Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases. Wien Med Wochenschr 158: 542-548, 2008.
    • (2008) Wien Med Wochenschr , vol.158 , pp. 542-548
    • Trauner, M.1    Fickert, P.2    Halilbasic, E.3    Moustafa, T.4
  • 192
    • 0021923933 scopus 로고
    • Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet
    • Tsukamoto H, French SW, Benson N, Delgado G, Rao GA, Larkin EC, Largman C. Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet. Hepatology 5: 224-232, 1985.
    • (1985) Hepatology , vol.5 , pp. 224-232
    • Tsukamoto, H.1    French, S.W.2    Benson, N.3    Delgado, G.4    Rao, G.A.5    Larkin, E.C.6    Largman, C.7
  • 193
    • 0025028967 scopus 로고
    • Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: Status report
    • Tsukamoto H, Gaal K, French SW. Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. Hepatology 12: 599-608, 1990.
    • (1990) Hepatology , vol.12 , pp. 599-608
    • Tsukamoto, H.1    Gaal, K.2    French, S.W.3
  • 195
  • 199
    • 84874590808 scopus 로고    scopus 로고
    • Pathological features of new animal models for primary biliary cirrhosis
    • Tsuneyama K, Moritoki Y, Kikuchi K, Nakanuma Y. Pathological features of new animal models for primary biliary cirrhosis. Int J Hepatol 2012: 403954, 2011.
    • (2011) Int J Hepatol , vol.2012 , pp. 403954
    • Tsuneyama, K.1    Moritoki, Y.2    Kikuchi, K.3    Nakanuma, Y.4
  • 201
    • 0038374866 scopus 로고    scopus 로고
    • Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosis
    • Ueberham E, Low R, Ueberham U, Schonig K, Bujard H, Gebhardt R. Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosis. Hepatology 37: 1067-1078, 2003.
    • (2003) Hepatology , vol.37 , pp. 1067-1078
    • Ueberham, E.1    Low, R.2    Ueberham, U.3    Schonig, K.4    Bujard, H.5    Gebhardt, R.6
  • 204
  • 205
    • 0242290378 scopus 로고    scopus 로고
    • Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression
    • Vergnes L, Phan J, Strauss M, Tafuri S, Reue K. Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. J Biol Chem 278: 42774-42784, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 42774-42784
    • Vergnes, L.1    Phan, J.2    Strauss, M.3    Tafuri, S.4    Reue, K.5
  • 207
    • 0034890409 scopus 로고    scopus 로고
    • Animal models for primary sclerosing cholangitis
    • Vierling JM. Animal models for primary sclerosing cholangitis. Best Pract Res Clin Gastroenterol 15: 591-610, 2001.
    • (2001) Best Pract Res Clin Gastroenterol , vol.15 , pp. 591-610
    • Vierling, J.M.1
  • 216
  • 220
    • 0029834440 scopus 로고    scopus 로고
    • Animal models of liver fibrosis
    • Wu J, Norton PA. Animal models of liver fibrosis. Scand J Gastroenterol 31: 1137-1143, 1996.
    • (1996) Scand J Gastroenterol , vol.31 , pp. 1137-1143
    • Wu, J.1    Norton, P.A.2
  • 221
    • 77950355485 scopus 로고    scopus 로고
    • Characterization of high-fat, diet-induced, non-alcoholic steatohepatitis with fibrosis in rats
    • Xu ZJ, Fan JG, Ding XD, Qiao L, Wang GL. Characterization of high-fat, diet-induced, non-alcoholic steatohepatitis with fibrosis in rats. Dig Dis Sci 55: 931-940, 2010.
    • (2010) Dig Dis Sci , vol.55 , pp. 931-940
    • Xu, Z.J.1    Fan, J.G.2    Ding, X.D.3    Qiao, L.4    Wang, G.L.5
  • 222
    • 0037108818 scopus 로고    scopus 로고
    • Hydrodynamic injection of viral DNA: A mouse model of acute hepatitis B virus infection
    • Yang PL, Althage A, Chung J, Chisari FV. Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc Natl Acad Sci USA 99: 13825-13830, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13825-13830
    • Yang, P.L.1    Althage, A.2    Chung, J.3    Chisari, F.V.4
  • 223
    • 84856449557 scopus 로고    scopus 로고
    • A novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein
    • Yimin, Furumaki H, Matsuoka S, Sakurai T, Kohanawa M, Zhao S, Kuge Y, Tamaki N, Chiba H. A novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein. Lab Invest 92: 265-281, 2011.
    • (2011) Lab Invest , vol.92 , pp. 265-281
    • Yimin1    Furumaki, H.2    Matsuoka, S.3    Sakurai, T.4    Kohanawa, M.5    Zhao, S.6    Kuge, Y.7    Tamaki, N.8    Chiba, H.9
  • 227
    • 77955266159 scopus 로고    scopus 로고
    • Effects and regulation of autoreactive CD8+ T cells in a transgenic mouse model of autoimmune hepatitis
    • 986.e1-3
    • Zierden M, Kuhnen E, Odenthal M, Dienes HP. Effects and regulation of autoreactive CD8+ T cells in a transgenic mouse model of autoimmune hepatitis. Gastroenterology 139: 975-986, 986. e1-3, 2010.
    • (2010) Gastroenterology , vol.139 , pp. 975-986
    • Zierden, M.1    Kuhnen, E.2    Odenthal, M.3    Dienes, H.P.4
  • 228
    • 0023616653 scopus 로고
    • Biochemical and morphological studies on production and regression of experimental liver cirrhosis induced by thioacetamide in Uje:WIST rats
    • Zimmermann T, Müller A, Machnik G, Franke H, Schubert H, Dargel R. Biochemical and morphological studies on production and regression of experimental liver cirrhosis induced by thioacetamide in Uje:WIST rats. Z Versuchstierkd 30: 165-180, 1987.
    • (1987) Z Versuchstierkd , vol.30 , pp. 165-180
    • Zimmermann, T.1    Müller, A.2    McHnik, G.3    Franke, H.4    Schubert, H.5    Dargel, R.6
  • 229
    • 33746299139 scopus 로고    scopus 로고
    • High-fat emulsion-induced rat model of nonalcoholic steatohepatitis
    • Zou Y, Li J, Lu C, Wang J, Ge J, Huang Y, Zhang L, Wang Y. High-fat emulsion-induced rat model of nonalcoholic steatohepatitis. Life Sci 79: 1100-1107, 2006.
    • (2006) Life Sci , vol.79 , pp. 1100-1107
    • Zou, Y.1    Li, J.2    Lu, C.3    Wang, J.4    Ge, J.5    Huang, Y.6    Zhang, L.7    Wang, Y.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.