The hepatitis B virus-trimera mouse: A model for human HBV infection and evaluation of anti-HBV therapeutic agents

Hepatology

Volumn 29, Issue 2, 1999, Pages 553-562

  Ilan, Ehud ^a   Burakova, Tatjana ^d   Dagan, Shlomo ^a   Nussaum, Ofer ^a   Lubin, Ido ^a   Eren, Rachel ^a   Ben Moshe, Ofer ^a   Arazi, Joseph ^a   Berr, Shoshana ^a   Neville, Lewis ^a   Yuen, Leonard ^b   Mansour, Tarek S ^b   Gillard, John ^b   Eid, Ahamed ^c   Jurim, Oded ^c   Shouval, Daniel ^c   Reisner, Yair ^d   Galun, Eithan ^c  

^a XTL Biopharmaceuticals Ltd Israel   (Israel)

^b Shire Canada   (Canada)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^d WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' DIDEOXY 5 FLUOROCYTIDINE; LAMIVUDINE; POLYCLONAL ANTIBODY; RNA DIRECTED DNA POLYMERASE INHIBITOR; ZALCITABINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; HEPATITIS B VIRUS; HUMAN; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RADIATION PROTECTION; SIMULATION; VIREMIA; VIRUS REPLICATION;

ANIMALS; ANTIBODIES, VIRAL; ANTIVIRAL AGENTS; DEOXYCYTIDINE; DISEASE MODELS, ANIMAL; DNA, VIRAL; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; KIDNEY; LAMIVUDINE; LIVER; LIVER TRANSPLANTATION; MICE; MICE, INBRED NOD; MICE, SCID; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERUM ALBUMIN; VIREMIA;

EID: 0033030127     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510290228     Document Type: Article

References (17)

1. Tiollais P, Buendia MA. Hepatitis B virus. Sci Am 1991;264:116-123.
2. Szmuness W. Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association. Prog Med Virol 1978;24:40-69.
3. Hadziyannis SJ. Hepatocellular carcinoma and type B hepatitis. Clin Gastroenterol 1980;9:117-134.
4. Beasley RP, Hwang LY, Lin CC, Chien CS. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22,707 men in Taiwan. Lancet 1981;2:1129-1133.
5. Takahashi H, Fujimoto J, Hanada S, Isselbacher KJ. Acute hepatitis in rats expressing human hepatitis B virus transgenes. Proc Natl Acad Sci USA 1995;92:1470-1474.
6. Zhai WR, Vajta G, Acs G, Paronetto E A nude mouse model for the in vivo production of hepatitis B virus. Gastroenterology 1990;98:470-477.
7. Chisari, FV, Filippi P, McLachlan A, Milich DR, Riggs M, Lee S, Palmiter RD, et al. Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol 1986;60:880-887.
8. Chisari FV, Klopchin K, Moriyama T, Pasquinelli C, Dunsford HA, Sell S, Pinkert CA, et al. Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 1989;59:1145-1156.
9. Yamamura K, Araki K, Hino O, Tomita N, Miyazaki J, Matsubara K. HBV production in transgenic mice. Gastroenterol Jpn 1990;25:49-52.
10. Condreay LD, Jansen RW, Powdrill TF, Johnson LC, Selleseth DW, Paff MT, Daluge SM, et al. Evaluation of the potent anti-hepatitis B virus agent FTC in a novel in vivo model. Antimicrob Agents Chemother 1994;38:616-619.
11. Caselmann WH. HBV and HDV replication in experimental models: effect of interferon. Antiviral Res 1994;24:121-129.
12. Lubin I, Faktorowich Y, Lapidot T, Gan Y, Eshhar Z, Gazit E, Levite M, et al. Engraftment and development of human T and B cells in mice after bone marrow transplantation. Science 1991;252:427-431.
13. Lubin I, Segall H, Marcus H, David M, Kulova L, Steinitz M, Erlich P, et al. Engraftment of human peripheral blood lymphocytes in normal strains of mice. Blood 1994;83:2368-2381.
14. Galun E, Burakova T, Ketzinel M, Lubin I, Shezen E, Kahana Y, Eid A, et al. Hepatitis C virus viremia in SCID→BNX mouse chimera. J Infect Dis 1995;172:25-30.
15. Dekel B, Burakova T, Marcus H, Shezen E, Polack S, Canaan A, Passwell J, et al. Engraftment of human kidney tissue in SCID/rat radiation chimera I. A new model of human kidney allograft rejection. Transplantation 1997;64:1541-1550.
16. Dekel B, Burakova T, Ben-Hur H, Marcus H, Oren R, Laufer J, Reisner Y. Engraftment of human kidney tissue in SCID/rat radiation chimera II. Human fetal kidney display reduced immunogenecity to adoptively transferred human PBMC and exhibit rapid growth and development. Transplantation 1997;64:1550-1558.
17. Zoulim, F, Dannaoui E, Borel C, Hantz O, Lin TS, Liu SH, Trepo C, et al. 2′,3′-dideoxy-beta-L-5-fluorocytidine inhibits duck hepatitis B virus reverse transcription and suppresses viral DNA synthesis in hepatocytes, both in vitro and in vivo. Antimicrob Agents Chemother 1996;40:448-453.