Titration of hepatitis B virus infectivity in the sera of pre-acute and late acute phases of HBV infection: Transmission experiments to chimeric mice with human liver repopulated hepatocytes

Journal of Medical Virology

Volumn 80, Issue 12, 2008, Pages 2064-2068

  Tabuchi, Ayako ^a   Tanaka, Junko ^a   Katayama, Keiko ^a   Mizui, Masaaki ^b   Matsukura, Harumichi ^c   Yugi, Hisao ^d   Shimada, Takashi ^e   Miyakawa, Yuzo ^f   Yoshizawa, Hiroshi ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b JAPANESE RED CROSS SOCIETY   (Japan)

^c OSAKA RED CROSS HOSPITAL   (Japan)

^d Japanese Red Central Blood Center   (Japan)

^e PhoenixBio USA Corporation   (Japan)

^f Miyakawa Memorial Research Foundation   (Japan)

Author keywords

Acute HBV infection; Chimeric mice; Experimental transmission of HBV; HBV DNA; HBV serum markers; Hepatitis B virus (HBV); Minimum infectious HBV dose

Indexed keywords

AMINOTRANSFERASE; HEPATITIS B CORE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; VIRUS DNA;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CELL POPULATION; CHIMERA; CHIMPANZEE; CONTROLLED STUDY; EXPERIMENTAL INFECTION; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; INOCULATION; LIVER CELL; MALE; MOUSE; NONHUMAN; VIREMIA; VIRUS INFECTIVITY; VIRUS PATHOGENESIS; VIRUS TITRATION; VIRUS TRANSMISSION;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HEPATITIS B; HEPATITIS B ANTIBODIES; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; MALE; MICE; MICE, SCID; MICE, TRANSGENIC; PAN TROGLODYTES; SERUM;

ANIMALIA; HEPATITIS B VIRUS; MUS; PAN; PRIMATES;

EID: 57349167340     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21320     Document Type: Article

References (16)

1. Dandri M, Burda MR, Torok E, Pollok JM, Iwanska A, Sommer G, Rogiers X, Rogler CE, Gupta S, Will H, Greten H, Petersen J. 2001. Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus. Hepatology 33:981-988.
2. Dienstag JL. 1983. Non-A, non-B hepatitis. II. Experimental transmission, putative virus agents and markers, and prevention. Gastroenterology 85:743-768.
3. Heckel JL, Sandgren EP, Degen JL, Palmiter RD, Brinster RL. 1990. Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator. Cell 62:447-456.
4. Komiya Y, Katayama K, Yugi H, Mizui M, Matsukura H, Tomoguri T, Miyakawa Y, Tabuchi A, Tanaka J, Yoshizawa H. 2008. Minimum infectious dose of hepatitis Bvirus in chimpanzees and difference in the dynamics of viremia between genotype A and genotype C. Transfusion 48:286-294.
5. Ling CM, Mushahwar IK, Overby LR, Berquist KR, Maynard JE. 1979. Hepatitis B e-antigen and its correlation with other serological markers in chimpanzees. Infect Immun 24:352-356.
6. Mercer DF, Schiller DE, Elliott JF, Douglas DN, Hao C, Rinfret A, Addison WR, Fischer KP, Churchill TA, Lakey JR, Tyrrell DL, Kneteman NM. 2001. Hepatitis C virus replication in mice with chimeric human livers. Nat Med 7:927-933.
7. Meuleman P, Libbrecht L, De Vos R, de Hemptinne B, Gevaert K, Vandekerckhove J, Roskams T, Leroux-Roels G. 2005. Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera. Hepatology 41:847-856.
8. Murray JM, Wieland SF, Purcell RH, Chisari FV. 2005. Dynamics of hepatitis B virus clearance in chimpanzees. Proc Natl Acad Sci USA 102:17780-17785.
9. Prince AM, Brotman B. 2001. Perspectives on hepatitis B studies with chimpanzees. Ilar J 42:85-88.
10. Prince AM, Lee DH, Brotman B. 2001. Infectivity of blood from PCR-positive, HBsAg-negative, anti-HBs-positive cases of resolved hepatitis B infection. Transfusion 41:329-332.
11. Rhim JA, Sandgren EP, Degen JL, Palmiter RD, Brinster RL. 1994. Replacement of diseased mouse liver by hepatic cell transplantation. Science 263:1149-1152.
12. Rizzetto M, Canese MG, Purcell RH, London WT, Sly LD, Gerin JL. 1981. Experimental HBV and delta infections of chimpanzees: Occurrence and significance of intrahepatic immune complexes of HBcAg and delta antigen. Hepatology 1:567-574.
13. Sugiyama M, Tanaka Y, Sakamoto T, Maruyama I, Shimada T, Takahashi S, Shirai T, Kato H, Nagao M, Miyakawa Y, Mizokami M. 2007. Early dynamics of hepatitis B virus in chimeric mice carrying human hepatocytes monoinfected or coinfected with genotype G. Hepatology 45:929-937.
14. Tateno C, Yoshizane Y, Saito N, Kataoka M, Utoh R, Yamasaki C, Tachibana A, Soeno Y, Asahina K, Hino H, Asahara T, Yokoi T, Furukawa T, Yoshizato K. 2004. Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am J Pathol 165:901-912.
15. Tsuge M, Hiraga N, Takaishi H, Noguchi C, Oga H, Imamura M, Takahashi S, Iwao E, Fujimoto Y, Ochi H, Chayama K, Tateno C, Yoshizato K. 2005. Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis B virus. Hepatology 42:1046-1054.
16. Yugi H, Mizui M, Tanaka J, Yoshizawa H. 2006. Hepatitis B Virus (HBV) screening strategy to ensure the safety of blood for transfusion through a combination of immunological testing and nucleic acid amplification testing - Japanese experience. J Clin Virol S36:S56-S64.