Fatal Autoimmune Hepatitis Induced by Concurrent Loss of Naturally Arising Regulatory T Cells and PD-1-Mediated Signaling

Gastroenterology

Volumn 135, Issue 4, 2008, Pages 1333-1343

  Kido, Masahiro ^a   Watanabe, Norihiko ^a   Okazaki, Taku ^a,b   Akamatsu, Takuji ^a   Tanaka, Junya ^a   Saga, Kazuyuki ^a   Nishio, Akiyoshi ^a   Honjo, Tasuku ^a   Chiba, Tsutomu ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; DEATH RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; PROTEIN PD 1; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE HEPATITIS; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CELL INFILTRATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FATALITY; LIVER HISTOLOGY; LIVER NECROSIS; LIVER PARENCHYMA; LYMPHOCYTIC INFILTRATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SPLEEN CELL; THYMECTOMY;

EID: 44649144640     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.06.042     Document Type: Article

References (36)

1. Krawitt E.L. Autoimmune hepatitis. N Engl J Med 354 (2006) 54-66
2. Manns M.P., and Vogel A. Autoimmune hepatitis, from mechanisms to therapy. Hepatology 43 (2006) S132-S144
3. Lapierre P., Djilali-Saiah I., Vitozzi S., et al. A murine model of type 2 autoimmune hepatitis: xenoimmunization with human antigens. Hepatology 39 (2004) 1066-1074
4. Christen U., Holdener M., and Hintermann E. Animal models for autoimmune hepatitis. Autoimmun Rev 6 (2007) 306-311
5. Tiegs G., Hentschel J., and Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 90 (1992) 196-203
6. Kaneko Y., Harada M., Kawano T., et al. Augmentation of Vα14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J Exp Med 191 (2000) 105-114
7. Mizuhara H., O'Neill E., Seki N., et al. T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6. J Exp Med 179 (1994) 1529-1537
8. Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22 (2004) 531-562
9. Longhi M.S., Ma Y., Bogdanos D.P., et al. Impairment of CD4(+)CD25(+) regulatory T cells in autoimmune liver disease. J Hepatol 41 (2004) 31-37
10. Longhi M.S., Hussain M.J., Mitry R.R., et al. Functional study of CD4+CD25+ regulatory T cells in health and autoimmune hepatitis. J Immunol 176 (2006) 4484-4491
11. Kim J.M., Rasmussen J.P., and Rudensky A.Y. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 8 (2007) 191-197
12. Ono M., Shimizu J., Miyachi Y., et al. Control of autoimmune myocarditis and multiorgan inflammation by glucocorticoid-induced TNF receptor family-related protein(high), Foxp3-expressing CD25+ and CD25- regulatory T cells. J Immunol 176 (2006) 4748-4756
13. Wildin R.S., Smyk-Pearson S., and Filipovich A.H. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet 39 (2002) 537-545
14. Okazaki T., and Honjo T. The PD-1-PD-L pathway in immunological tolerance. Trends Immunol 27 (2006) 195-201
15. Sharpe A.H., Wherry E.J., Ahmed R., et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol 8 (2007) 239-245
16. Nishimura H., Okazaki T., Tanaka Y., et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291 (2001) 319-322
17. Iwai Y., Terawaki S., Ikegawa M., et al. PD-1 inhibits antiviral immunity at the effector phase in the liver. J Exp Med 198 (2003) 39-50
18. Dong H., Zhu G., Tamada K., et al. B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity 20 (2004) 327-336
19. Shinkai Y., Rathbun G., Lam K.P., et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68 (1992) 855-867
20. Uchida K., Okazaki K., Debrecceni A., et al. Analysis of cytokines in the early development of gastric secondary lymphoid follicles in Helicobacter pylori-infected BALB/c mice with neonatal thymectomy. Infect Immun 69 (2001) 6749-6754
21. Kiriya K., Watanabe N., Nishio A., et al. Essential role of Peyer's patches in the development of Helicobacter-induced gastritis. Int Immunol 19 (2007) 435-446
22. Candon S., McHugh R.S., Foucras G., et al. Spontaneous organ-specific Th2-mediated autoimmunity in TCR transgenic mice. J Immunol 172 (2004) 2917-2924
23. Nishimura H., Minato N., Nakano T., et al. Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B-cell responses. Int Immunol 10 (1998) 1563-1572
24. Asano M., Toda M., Sakaguchi N., et al. Autoimmune disease as a consequence of developmental abnormality of a T-cell subpopulation. J Exp Med 184 (1996) 387-396
25. Alderuccio F., Sentry J.W., Marshall A.C., et al. Animal models of human disease: experimental autoimmune gastritis-a model for autoimmune gastritis and pernicious anemia. Clin Immunol 102 (2002) 48-58
26. Murai M., Yoneyama H., Ezaki T., et al. Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nat Immunol 4 (2003) 154-160
27. Shimizu Y., Murata H., Kashii Y., et al. CC-chemokine receptor 6 and its ligand macrophage inflammatory protein 3α might be involved in the amplification of local necroinflammatory response in the liver. Hepatology 34 (2001) 311-319
28. Nicoletti F., Zaccone P., Xiang M., et al. Essential pathogenetic role for interferon (IFN)-γ in concanavalin A-induced T cell-dependent hepatitis: exacerbation by exogenous IFN-γ and prevention by IFN-γ receptor-immunoglobulin fusion protein. Cytokine 12 (2000) 315-323
29. Diamantis I., and Boumpas D.T. Autoimmune hepatitis: evolving concepts. Autoimmun Rev 3 (2004) 207-214
30. Ichiki Y., Aoki C.A., Bowlus C.L., et al. T-cell immunity in autoimmune hepatitis. Autoimmun Rev 4 (2005) 315-321
31. Suzuki Y., Kobayashi M., Hosaka T., et al. Peripheral CD8+/CD25+ lymphocytes may be implicated in hepatocellular injuries in patients with acute-onset autoimmune hepatitis. J Gastroenterol 39 (2004) 649-653
32. Theofilopoulos A.N., Dummer W., et al. T-cell homeostasis and systemic autoimmunity. J Clin Invest 108 (2001) 335-340
33. Lin S.J., Peacock C.D., Bahl K., et al. Programmed death-1 (PD-1) defines a transient and dysfunctional oligoclonal T-cell population in acute homeostatic proliferation. J Exp Med 204 (2007) 2321-2333
34. Keir M.E., Liang S.C., Guleria I., et al. Tissue expression of PD-L1 mediates peripheral T-cell tolerance. J Exp Med 203 (2006) 883-895
35. Martin-Orozco N., Wang Y.H., Yagita H., et al. Cutting edge: programmed death (PD) ligand-1/PD-1 interaction is required for CD8+ T-cell tolerance to tissue antigens. J Immunol 177 (2006) 8291-8295
36. Keir M.E., Francisco L.M., and Sharpe A.H. PD-1 and its ligands in T-cell immunity. Curr Opin Immunol 19 (2007) 309-314