Comparison of three research models of portal hypertension in mice: Macroscopic, histological and portal pressure evaluation

International Journal of Experimental Pathology

Volumn 89, Issue 4, 2008, Pages 251-263

  Geerts, Anja M ^a   Vanheule, Eline ^a   Praet, Marleen ^a   Van Vlierberghe, Hans ^a   De Vos, Martine ^a   Colle, Isabelle ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Bile duct ligation; Carbon tetrachloride; Cirrhosis; Mice models; Partial portal vein ligation; Portal hypertension

Indexed keywords

CARBON TETRACHLORIDE;

ALCOHOL LIVER CIRRHOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCITES; BILE DUCT LIGATION; BILIARY CIRRHOSIS; BLOOD SAMPLING; CONTROLLED STUDY; HISTOPATHOLOGY; KNOCKOUT MOUSE; LIVER CIRRHOSIS; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ANIMALS; ASCITES; CARBON TETRACHLORIDE; COMMON BILE DUCT; DISEASE PROGRESSION; HYPERTENSION, PORTAL; INJECTIONS, SUBCUTANEOUS; LIGATION; LIVER; LIVER CIRRHOSIS, BILIARY; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MICE; MICE, INBRED STRAINS; MICROSCOPY, ELECTRON; MODELS, ANIMAL; PORTAL PRESSURE; PORTAL VEIN; STAINING AND LABELING;

EID: 47649116115     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/j.1365-2613.2008.00597.x     Document Type: Article

References (34)

1. Abraldes J.C., Marcos P., Garcia-Pagan J.C. (2006) Animal models of portal hypertension. World J. Gastroenterol. 12, 6577 6584.
2. Bedossa P. Poynard T. (1996) An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 24, 289 293.
3. Benson J.M., Tibbetts B.M., Thrall K.D., Springer D.L. (2001) Uptake, tissue distribution, and fate of inhaled carbon tetrachloride: comparison of rat, mouse, and hamster. Inhal. Toxicol. 13, 207 217.
4. Biecker E., Neef M., Sagesser H., Shaw S., Koshy A., Reichen J. (2004) Nitric oxide synthase 1 is partly compensating for nitric oxide synthase 3 deficiency in nitric oxide synthase knock-out mice and is elevated in murine and human cirrhosis. Liver Int. 24, 345 353.
5. Canbay A., Higuchi H., Bronk S.F., Taniai M., Sebo T., Gores G. (2002) Fas enhanced fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis. Gastroenterology 123, 1323 1330.
6. Castaneda B., Debernardi-Venon W., Bandi J.C. et al. (2000) The role of portal pressure in the severity of bleeding in portal hypertensive rats. Hepatology 31, 581 586.
7. Chang M.L., Yeh C.T., Chang P.Y., Chen J.C. (2005) Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation. World J. Gastroenterol. 11, 4167 4172.
8. Colle I., De Vriese A., Van Vlierberghe H., Lameire N., De Vos M. (2004a) Systemic and splanchnic haemodynamic effects of sildenafil in an in vivo animal model of cirrhosis, support for a risk in cirrhotic patients. Liver Int. 24, 63 68.
9. Colle I., De Vriese A., Van Vlierberghe H., Lameire N., De Vos M. (2004b) Vascular hyporesponsiveness in the mesenteric artery of rats with cirrhosis and portal hypertension: an in vivo study. Eur. J. Gastroenterol. Hepatol. 16, 139 145.
10. Colombato L.A., Albillos A., Groszmann R.J. (1992) Temporal relationship of peripheral plasma volume expansion and the hyperdynamic circulatory state in portal hypertensive rats. Hepatology 15, 323 328.
11. Fernandez M., Vizzutti F., Garcia-Pagan J.C., Rodes J., Bosch J. (2004) Anti-VEGF receptor-2 monoclonal antibody prevents portal-systemic collateral vessel formation in portal hypertensive mice. Gastroenterology 126, 886 894.
12. Franco D., Gigou M., Szekely A.M., Bismuth H. (1979) Portal hypertension after bile duct obstruction: effect of bile diversion on portal pressure in the rat. Arch. Surg. 114, 1064 1067.
13. Garro A.J. Lieber C.S. (1990) Alcohol and cancer. Annu. Rev. Pharmacol. Toxicol. 30, 219 249.
14. Georgiev P., Navarini A.A., Eloranta J.J. et al. (2007) Cholestasis protects the liver from ischaemic injury and post-ischaemic inflammation in the mouse. Gut 56, 121 128.
15. Groszmann R.J., Vorobioff J., Riley E. (1982) Splanchnic hemodynamics in portal hypertensive rats: measurements with gamma-labeled microspheres. Am. J. Physiol. 242, G156 G160.
16. Iwakiri Y., Cadelina G., Sessa W.C., Groszmann R.J. (2002) Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension. Am. J. Physiol. Gastrointest. Liver Physiol. 283, G1074 G1081.
17. Janakat S. Al-Merie H. (2002) Optimization of the dose and route of injection, and characterisation of the time course of carbon tetrachloride-induced hepatotoxicity in the rat. J. Pharmacol. Toxicol. Methods 48, 41 44.
18. Jimenez W., Claria J., Arroyo V., Rodes J. (1992) Carbon tetrachloride induced cirrhosis in rats: a useful tool for investigating the pathogenesis of ascites in chronic liver disease. J. Gastroenterol. Hepatol. 7, 90 97.
19. Katsuta Y., Zhang X.J., Ohsuga M. et al. (2005) Hemodynamic feature of advanced cirrhosis due to chronic bile duct ligation. J. Nippon Med. Sch. 72, 217 225.
20. Koop D.R. Coon M.J. (1986) Ethanol oxidation and toxicity: role of alcohol P-450 oxygenase. Alcohol. Clin. Exp. Res. 10, 44S 49S.
21. Kountouras J., Billing B.H., Scheuer P.J. (1984) Prolonged bile duct obstruction: a new experimental model for cirrhosis in rat. Br. J. Exp. Pathol. 65, 305 311.
22. Lee S.S., Girod C., Braillon A. et al. (1986) Hemodynamic characterization of chronic bile-duct ligated rats: effect of phenobarbital sodium. Am. J. Physiol. 251, G176 G180.
23. Lieber C.S. (1984) Alcohol and the liver: 1984 update. Hepatology 4, 1243 1260.
24. Mennon A., Soroka C.J., Cai S.Y. et al. (2006) Mrp 4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Hepatology 43, 1013 1021.
25. Natsume M., Tsuji H., Harada A. et al. (1999) Attenuated liver fibrosis and depressed serum albumin levels in carbon-tetrachloride IL-6-deficient mice. J. Leukoc. Biol. 66, 601 608.
26. Niggemann P., Murata S., Naito Z., Kumazaki T. (2004) A comparative study of the microcirculatory changes in the developing liver cirrhosis between the central and peripheral parts of the main lobe in mice. Hepatol Res. 28, 41 48.
27. 4 and adequate model of human cirrhosis? Hepatology 3, 112 120.
28. Proctor E. Chatamra K. (1982) High yield micronodular cirrhosis in the rat. Gastroenterology 83, 1181 1190.
29. Sikuler E., Buchs A.E., Yaari A., Keynan A. (1991) Hemodynamic characterization of conscious and ketamine-anesthetized bile duct-ligated rats. Am. J. Physiol. 260, G161 G166.
30. Stewart S.F. Day C.P. (2003) The management of alcoholic liver disease. J. Hepatol. 38, 2 13.
31. Van de Casteele M., Sägesser H., Zimmermann H., Reichen J. (2001) Characterisation of portal hypertension models by microspheres in aneasthtised rats: a comparison of flow. Pharmacol. Ther. 35, 35 43.
32. Vorobioff J., Bredfeldt J.E., Groszmann R.J. (1983) Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension. Am. J. Physiol. 244, G52 G57.
33. Vorobioff J., Bredfeldt J.E., Groszmann R.J. (1994) Increased blood flow through the portal system in cirrhotic rats. Gastroenterology 87, 1120 1126.
34. Zimmerman H.J. (1986) Effects of alcohol on other hepatotoxins. Alcohol. Clin. Exp. Res. 10, 3 15.