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Volumn 48, Issue 5, 2008, Pages 858-879

Experimental models of hepatocellular carcinoma

Author keywords

Cirrhosis; Genetically engineered mice; Hepatocellular carcinoma; Liver cancer; Mouse models

Indexed keywords

BETA CATENIN; CARBON TETRACHLORIDE; CARCINOGEN; CIPROFIBRATE; DIETHYLNITROSAMINE; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; N (2 FLUORENYL)ACETAMIDE; PHENOBARBITAL; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53; RETINOBLASTOMA PROTEIN; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SOMATOMEDIN; TETRACYCLINE; THIOACETAMIDE; TRANSCRIPTION FACTOR E2F; UROKINASE; VIRUS T ANTIGEN; WNT PROTEIN;

EID: 41249102034     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.01.008     Document Type: Review
Times cited : (200)

References (199)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag H.B., and Rudolph K.L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132 (2007) 2557-2576
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi P.A., and DePinho R.A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 6 (2006) 674-687
    • (2006) Nat Rev Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 3
    • 41249088055 scopus 로고    scopus 로고
    • Focal VEGFA gains and molecular classification of hepatocellular carcinomas
    • Chiang D. Focal VEGFA gains and molecular classification of hepatocellular carcinomas. Hepatology 46 (2007) 530A
    • (2007) Hepatology , vol.46
    • Chiang, D.1
  • 4
    • 34548217651 scopus 로고    scopus 로고
    • Maximizing mouse cancer models
    • Frese K.K., and Tuveson D.A. Maximizing mouse cancer models. Nat Rev Cancer 7 (2007) 654-658
    • (2007) Nat Rev Cancer , vol.7 , pp. 654-658
    • Frese, K.K.1    Tuveson, D.A.2
  • 5
    • 0014649888 scopus 로고
    • Heterotransplantation of a human malignant tumour to "Nude" mice
    • Rygaard J., and Povlsen C.O. Heterotransplantation of a human malignant tumour to "Nude" mice. Acta Pathol Microbiol Scand 77 (1969) 758-760
    • (1969) Acta Pathol Microbiol Scand , vol.77 , pp. 758-760
    • Rygaard, J.1    Povlsen, C.O.2
  • 6
    • 1942422743 scopus 로고    scopus 로고
    • Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development
    • Kelland L.R. Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development. Eur J Cancer 40 (2004) 827-836
    • (2004) Eur J Cancer , vol.40 , pp. 827-836
    • Kelland, L.R.1
  • 7
    • 0019818819 scopus 로고
    • Preclinical drug development: rationale and methods
    • Venditti J.M. Preclinical drug development: rationale and methods. Semin Oncol 8 (1981) 349-361
    • (1981) Semin Oncol , vol.8 , pp. 349-361
    • Venditti, J.M.1
  • 8
    • 84965822602 scopus 로고
    • Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay
    • Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., et al. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 48 (1988) 589-601
    • (1988) Cancer Res , vol.48 , pp. 589-601
    • Alley, M.C.1    Scudiero, D.A.2    Monks, A.3    Hursey, M.L.4    Czerwinski, M.J.5    Fine, D.L.6
  • 9
    • 0025775062 scopus 로고
    • Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
    • Monks A., Scudiero D., Skehan P., Shoemaker R., Paull K., Vistica D., et al. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst 83 (1991) 757-766
    • (1991) J Natl Cancer Inst , vol.83 , pp. 757-766
    • Monks, A.1    Scudiero, D.2    Skehan, P.3    Shoemaker, R.4    Paull, K.5    Vistica, D.6
  • 10
    • 2042458747 scopus 로고    scopus 로고
    • Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials
    • Johnson J.I., Decker S., Zaharevitz D., Rubinstein L.V., Venditti J.M., Schepartz S., et al. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br J Cancer 84 (2001) 1424-1431
    • (2001) Br J Cancer , vol.84 , pp. 1424-1431
    • Johnson, J.I.1    Decker, S.2    Zaharevitz, D.3    Rubinstein, L.V.4    Venditti, J.M.5    Schepartz, S.6
  • 11
    • 0141566685 scopus 로고    scopus 로고
    • Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models
    • Voskoglou-Nomikos T., Pater J.L., and Seymour L. Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models. Clin Cancer Res 9 (2003) 4227-4239
    • (2003) Clin Cancer Res , vol.9 , pp. 4227-4239
    • Voskoglou-Nomikos, T.1    Pater, J.L.2    Seymour, L.3
  • 12
    • 1542436704 scopus 로고    scopus 로고
    • Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: better than commonly perceived-but they can be improved
    • Kerbel R.S. Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: better than commonly perceived-but they can be improved. Cancer Biol Ther 2 (2003) S134-S139
    • (2003) Cancer Biol Ther , vol.2
    • Kerbel, R.S.1
  • 13
    • 0023893153 scopus 로고
    • Pharmacokinetic approach to rational therapeutic doses for human tumor-bearing nude mice
    • Inaba M., Kobayashi T., Tashiro T., and Sakurai Y. Pharmacokinetic approach to rational therapeutic doses for human tumor-bearing nude mice. Jpn J Cancer Res 79 (1988) 509-516
    • (1988) Jpn J Cancer Res , vol.79 , pp. 509-516
    • Inaba, M.1    Kobayashi, T.2    Tashiro, T.3    Sakurai, Y.4
  • 14
    • 0030753407 scopus 로고    scopus 로고
    • Clonal growth of colorectal-carcinoma cell lines transplanted to nude mice
    • De Both N.J., Vermey M., Groen N., Dinjens W.N., and Bosman F.T. Clonal growth of colorectal-carcinoma cell lines transplanted to nude mice. Int J Cancer 72 (1997) 1137-1141
    • (1997) Int J Cancer , vol.72 , pp. 1137-1141
    • De Both, N.J.1    Vermey, M.2    Groen, N.3    Dinjens, W.N.4    Bosman, F.T.5
  • 15
    • 0026513518 scopus 로고
    • The use of molecular genetic markers to demonstrate the effect of organ environment on clonal dominance in a human renal-cell carcinoma grown in nude mice
    • Staroselsky A.N., Radinsky R., Fidler I.J., Pathak S., Chernajovsky Y., and Frost P. The use of molecular genetic markers to demonstrate the effect of organ environment on clonal dominance in a human renal-cell carcinoma grown in nude mice. Int J Cancer 51 (1992) 130-138
    • (1992) Int J Cancer , vol.51 , pp. 130-138
    • Staroselsky, A.N.1    Radinsky, R.2    Fidler, I.J.3    Pathak, S.4    Chernajovsky, Y.5    Frost, P.6
  • 16
    • 20544467225 scopus 로고    scopus 로고
    • Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy
    • Hoffman R.M. Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy. Methods Mol Med 111 (2005) 297-322
    • (2005) Methods Mol Med , vol.111 , pp. 297-322
    • Hoffman, R.M.1
  • 17
    • 34948896045 scopus 로고    scopus 로고
    • Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    • Karnoub A.E., Dash A.B., Vo A.P., Sullivan A., Brooks M.W., Bell G.W., et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449 (2007) 557-563
    • (2007) Nature , vol.449 , pp. 557-563
    • Karnoub, A.E.1    Dash, A.B.2    Vo, A.P.3    Sullivan, A.4    Brooks, M.W.5    Bell, G.W.6
  • 18
    • 34548596706 scopus 로고    scopus 로고
    • Side population cells isolated from mesenchymal neoplasms have tumor initiating potential
    • Wu C., Wei Q., Utomo V., Nadesan P., Whetstone H., Kandel R., et al. Side population cells isolated from mesenchymal neoplasms have tumor initiating potential. Cancer Res 67 (2007) 8216-8222
    • (2007) Cancer Res , vol.67 , pp. 8216-8222
    • Wu, C.1    Wei, Q.2    Utomo, V.3    Nadesan, P.4    Whetstone, H.5    Kandel, R.6
  • 19
    • 0036467484 scopus 로고    scopus 로고
    • Technologically advanced cancer modeling in mice
    • Tuveson D.A., and Jacks T. Technologically advanced cancer modeling in mice. Curr Opin Genet Dev 12 (2002) 105-110
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 105-110
    • Tuveson, D.A.1    Jacks, T.2
  • 20
    • 1342288971 scopus 로고    scopus 로고
    • Opinion: comparative biology of mouse versus human cells: modelling human cancer in mice
    • Rangarajan A., and Weinberg R.A. Opinion: comparative biology of mouse versus human cells: modelling human cancer in mice. Nat Rev Cancer 3 (2003) 952-959
    • (2003) Nat Rev Cancer , vol.3 , pp. 952-959
    • Rangarajan, A.1    Weinberg, R.A.2
  • 21
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
    • Blasco M.A., Lee H.W., Hande M.P., Samper E., Lansdorp P.M., DePinho R.A., et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91 (1997) 25-34
    • (1997) Cell , vol.91 , pp. 25-34
    • Blasco, M.A.1    Lee, H.W.2    Hande, M.P.3    Samper, E.4    Lansdorp, P.M.5    DePinho, R.A.6
  • 22
    • 13644266446 scopus 로고    scopus 로고
    • New approaches for modelling cancer mechanisms in the mouse
    • Maddison K., and Clarke A.R. New approaches for modelling cancer mechanisms in the mouse. J Pathol 205 (2005) 181-193
    • (2005) J Pathol , vol.205 , pp. 181-193
    • Maddison, K.1    Clarke, A.R.2
  • 23
    • 0024283304 scopus 로고
    • Transgenic animals
    • Jaenisch R. Transgenic animals. Science 240 (1988) 1468-1474
    • (1988) Science , vol.240 , pp. 1468-1474
    • Jaenisch, R.1
  • 24
    • 0032954092 scopus 로고    scopus 로고
    • Insights into cancer from transgenic mouse models
    • Macleod K.F., and Jacks T. Insights into cancer from transgenic mouse models. J Pathol 187 (1999) 43-60
    • (1999) J Pathol , vol.187 , pp. 43-60
    • Macleod, K.F.1    Jacks, T.2
  • 27
    • 0022380768 scopus 로고
    • The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    • Adams J.M., Harris A.W., Pinkert C.A., Corcoran L.M., Alexander W.S., Cory S., et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318 (1985) 533-538
    • (1985) Nature , vol.318 , pp. 533-538
    • Adams, J.M.1    Harris, A.W.2    Pinkert, C.A.3    Corcoran, L.M.4    Alexander, W.S.5    Cory, S.6
  • 28
    • 0035476437 scopus 로고    scopus 로고
    • Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1
    • Gannon M., Gamer L.W., and Wright C.V. Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. Dev Biol 238 (2001) 185-201
    • (2001) Dev Biol , vol.238 , pp. 185-201
    • Gannon, M.1    Gamer, L.W.2    Wright, C.V.3
  • 30
    • 0022965278 scopus 로고
    • Germ-line transformation of mice
    • Palmiter R.D., and Brinster R.L. Germ-line transformation of mice. Annu Rev Genet 20 (1986) 465-499
    • (1986) Annu Rev Genet , vol.20 , pp. 465-499
    • Palmiter, R.D.1    Brinster, R.L.2
  • 31
    • 0030989016 scopus 로고    scopus 로고
    • Do transgene arrays form heterochromatin in vertebrates?
    • Dorer D.R. Do transgene arrays form heterochromatin in vertebrates?. Transgenic Res 6 (1997) 3-10
    • (1997) Transgenic Res , vol.6 , pp. 3-10
    • Dorer, D.R.1
  • 33
    • 0036549015 scopus 로고    scopus 로고
    • Conditional mouse models of sporadic cancer
    • Jonkers J., and Berns A. Conditional mouse models of sporadic cancer. Nat Rev Cancer 2 (2002) 251-265
    • (2002) Nat Rev Cancer , vol.2 , pp. 251-265
    • Jonkers, J.1    Berns, A.2
  • 34
    • 0034581163 scopus 로고    scopus 로고
    • Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances
    • Baron U., and Bujard H. Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances. Methods Enzymol 327 (2000) 401-421
    • (2000) Methods Enzymol , vol.327 , pp. 401-421
    • Baron, U.1    Bujard, H.2
  • 36
    • 0034976579 scopus 로고    scopus 로고
    • Conditional gene knockout using Cre recombinase
    • Le Y., and Sauer B. Conditional gene knockout using Cre recombinase. Mol Biotechnol 17 (2001) 269-275
    • (2001) Mol Biotechnol , vol.17 , pp. 269-275
    • Le, Y.1    Sauer, B.2
  • 37
    • 0346503889 scopus 로고    scopus 로고
    • Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice
    • Branda C.S., and Dymecki S.M. Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. Dev Cell 6 (2004) 7-28
    • (2004) Dev Cell , vol.6 , pp. 7-28
    • Branda, C.S.1    Dymecki, S.M.2
  • 38
    • 0028843052 scopus 로고
    • The Flp recombinase of the 2-microns plasmid of Saccharomyces cerevisiae
    • Sadowski P.D. The Flp recombinase of the 2-microns plasmid of Saccharomyces cerevisiae. Prog Nucleic Acid Res Mol Biol 51 (1995) 53-91
    • (1995) Prog Nucleic Acid Res Mol Biol , vol.51 , pp. 53-91
    • Sadowski, P.D.1
  • 40
    • 33646139174 scopus 로고    scopus 로고
    • Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition
    • Feo F., De Miglio M.R., Simile M.M., Muroni M.R., Calvisi D.F., Frau M., et al. Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition. Biochim Biophys Acta 1765 (2006) 126-147
    • (2006) Biochim Biophys Acta , vol.1765 , pp. 126-147
    • Feo, F.1    De Miglio, M.R.2    Simile, M.M.3    Muroni, M.R.4    Calvisi, D.F.5    Frau, M.6
  • 42
    • 33846812600 scopus 로고    scopus 로고
    • Xenografts of human hepatocellular carcinoma: a useful model for testing drugs
    • Huynh H., Soo K.C., Chow P.K., Panasci L., and Tran E. Xenografts of human hepatocellular carcinoma: a useful model for testing drugs. Clin Cancer Res 12 (2006) 4306-4314
    • (2006) Clin Cancer Res , vol.12 , pp. 4306-4314
    • Huynh, H.1    Soo, K.C.2    Chow, P.K.3    Panasci, L.4    Tran, E.5
  • 43
    • 34249980343 scopus 로고    scopus 로고
    • Identification and characterization of tumorigenic liver cancer stem/progenitor cells
    • Ma S., Chan K.W., Hu L., Lee T.K., Wo J.Y., Ng I.O., et al. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 132 (2007) 2542-2556
    • (2007) Gastroenterology , vol.132 , pp. 2542-2556
    • Ma, S.1    Chan, K.W.2    Hu, L.3    Lee, T.K.4    Wo, J.Y.5    Ng, I.O.6
  • 44
    • 40749150740 scopus 로고    scopus 로고
    • CD133(+) HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
    • Ma S., Lee T.K., Zheng B.J., Chan K.W., and Guan X.Y. CD133(+) HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene 27 (2008) 1749-1758
    • (2008) Oncogene , vol.27 , pp. 1749-1758
    • Ma, S.1    Lee, T.K.2    Zheng, B.J.3    Chan, K.W.4    Guan, X.Y.5
  • 45
    • 40949136223 scopus 로고    scopus 로고
    • Accelerated orthotopic HCC growth is linked to increased expression of pro-angiogenic and pro-metastatic factors in murine liver fibrosis
    • Kornek M., Raskopf E., Tolba R., Becker U., Klockner M., Sauerbruch T., et al. Accelerated orthotopic HCC growth is linked to increased expression of pro-angiogenic and pro-metastatic factors in murine liver fibrosis. Liver Int 28 (2008) 509-518
    • (2008) Liver Int , vol.28 , pp. 509-518
    • Kornek, M.1    Raskopf, E.2    Tolba, R.3    Becker, U.4    Klockner, M.5    Sauerbruch, T.6
  • 46
    • 34547576427 scopus 로고    scopus 로고
    • The epidemiology of hepatitis C infection in the United States
    • Rustgi V.K. The epidemiology of hepatitis C infection in the United States. J Gastroenterol 42 (2007) 513-521
    • (2007) J Gastroenterol , vol.42 , pp. 513-521
    • Rustgi, V.K.1
  • 47
    • 0024818649 scopus 로고
    • Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice
    • Chisari F.V., Klopchin K., Moriyama T., Pasquinelli C., Dunsford H.A., Sell S., et al. Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59 (1989) 1145-1156
    • (1989) Cell , vol.59 , pp. 1145-1156
    • Chisari, F.V.1    Klopchin, K.2    Moriyama, T.3    Pasquinelli, C.4    Dunsford, H.A.5    Sell, S.6
  • 48
    • 0028230728 scopus 로고
    • High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice
    • Koike K., Moriya K., Iino S., Yotsuyanagi H., Endo Y., Miyamura T., et al. High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice. Hepatology 19 (1994) 810-819
    • (1994) Hepatology , vol.19 , pp. 810-819
    • Koike, K.1    Moriya, K.2    Iino, S.3    Yotsuyanagi, H.4    Endo, Y.5    Miyamura, T.6
  • 49
    • 0033058294 scopus 로고    scopus 로고
    • Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein
    • Yu D.Y., Moon H.B., Son J.K., Jeong S., Yu S.L., Yoon H., et al. Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein. J Hepatol 31 (1999) 123-132
    • (1999) J Hepatol , vol.31 , pp. 123-132
    • Yu, D.Y.1    Moon, H.B.2    Son, J.K.3    Jeong, S.4    Yu, S.L.5    Yoon, H.6
  • 50
    • 0029870749 scopus 로고    scopus 로고
    • Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene
    • Slagle B.L., Lee T.H., Medina D., Finegold M.J., and Butel J.S. Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene. Mol Carcinog 15 (1996) 261-269
    • (1996) Mol Carcinog , vol.15 , pp. 261-269
    • Slagle, B.L.1    Lee, T.H.2    Medina, D.3    Finegold, M.J.4    Butel, J.S.5
  • 51
    • 0033398633 scopus 로고    scopus 로고
    • Transgenic mouse models of viral hepatitis: insight into viral hepatocarcinogenesis
    • Koike K. Transgenic mouse models of viral hepatitis: insight into viral hepatocarcinogenesis. Viral Hepatitis Rev 5 (1999) 177-203
    • (1999) Viral Hepatitis Rev , vol.5 , pp. 177-203
    • Koike, K.1
  • 52
    • 0023579993 scopus 로고
    • Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice
    • Chisari F.V., Filippi P., Buras J., McLachlan A., Popper H., Pinkert C.A., et al. Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice. Proc Natl Acad Sci USA 84 (1987) 6909-6913
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 6909-6913
    • Chisari, F.V.1    Filippi, P.2    Buras, J.3    McLachlan, A.4    Popper, H.5    Pinkert, C.A.6
  • 53
    • 0025334672 scopus 로고
    • Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice
    • Dunsford H.A., Sell S., and Chisari F.V. Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice. Cancer Res 50 (1990) 3400-3407
    • (1990) Cancer Res , vol.50 , pp. 3400-3407
    • Dunsford, H.A.1    Sell, S.2    Chisari, F.V.3
  • 54
    • 7044272621 scopus 로고    scopus 로고
    • Pathogenesis of hepatitis C-associated hepatocellular carcinoma
    • Liang T.J., and Heller T. Pathogenesis of hepatitis C-associated hepatocellular carcinoma. Gastroenterology 127 (2004) S62-S71
    • (2004) Gastroenterology , vol.127
    • Liang, T.J.1    Heller, T.2
  • 56
    • 14244261930 scopus 로고    scopus 로고
    • Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis
    • Kamegaya Y., Hiasa Y., Zukerberg L., Fowler N., Blackard J.T., Lin W., et al. Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis. Hepatology 41 (2005) 660-667
    • (2005) Hepatology , vol.41 , pp. 660-667
    • Kamegaya, Y.1    Hiasa, Y.2    Zukerberg, L.3    Fowler, N.4    Blackard, J.T.5    Lin, W.6
  • 58
    • 0031712813 scopus 로고    scopus 로고
    • The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
    • Moriya K., Fujie H., Shintani Y., Yotsuyanagi H., Tsutsumi T., Ishibashi K., et al. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 4 (1998) 1065-1067
    • (1998) Nat Med , vol.4 , pp. 1065-1067
    • Moriya, K.1    Fujie, H.2    Shintani, Y.3    Yotsuyanagi, H.4    Tsutsumi, T.5    Ishibashi, K.6
  • 59
    • 0036097130 scopus 로고    scopus 로고
    • Role of hepatitis C virus in the development of hepatocellular carcinoma: transgenic approach to viral hepatocarcinogenesis
    • Koike K., Moriya K., and Kimura S. Role of hepatitis C virus in the development of hepatocellular carcinoma: transgenic approach to viral hepatocarcinogenesis. J Gastroenterol Hepatol 17 (2002) 394-400
    • (2002) J Gastroenterol Hepatol , vol.17 , pp. 394-400
    • Koike, K.1    Moriya, K.2    Kimura, S.3
  • 60
    • 0036158719 scopus 로고    scopus 로고
    • Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus
    • Lerat H., Honda M., Beard M.R., Loesch K., Sun J., Yang Y., et al. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 122 (2002) 352-365
    • (2002) Gastroenterology , vol.122 , pp. 352-365
    • Lerat, H.1    Honda, M.2    Beard, M.R.3    Loesch, K.4    Sun, J.5    Yang, Y.6
  • 61
    • 0034805486 scopus 로고    scopus 로고
    • Increase in the concentration of carbon 18 monounsaturated fatty acids in the liver with hepatitis C: analysis in transgenic mice and humans
    • Moriya K., Todoroki T., Tsutsumi T., Fujie H., Shintani Y., Miyoshi H., et al. Increase in the concentration of carbon 18 monounsaturated fatty acids in the liver with hepatitis C: analysis in transgenic mice and humans. Biochem Biophys Res Commun 281 (2001) 1207-1212
    • (2001) Biochem Biophys Res Commun , vol.281 , pp. 1207-1212
    • Moriya, K.1    Todoroki, T.2    Tsutsumi, T.3    Fujie, H.4    Shintani, Y.5    Miyoshi, H.6
  • 62
    • 0035360859 scopus 로고    scopus 로고
    • Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis
    • Moriya K., Nakagawa K., Santa T., Shintani Y., Fujie H., Miyoshi H., et al. Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res 61 (2001) 4365-4370
    • (2001) Cancer Res , vol.61 , pp. 4365-4370
    • Moriya, K.1    Nakagawa, K.2    Santa, T.3    Shintani, Y.4    Fujie, H.5    Miyoshi, H.6
  • 63
    • 0033802836 scopus 로고    scopus 로고
    • Hepadnaviral hepatocarcinogenesis: in situ visualization of viral antigens, cytoplasmic compartmentation, enzymic patterns, and cellular proliferation in preneoplastic hepatocellular lineages in woodchucks
    • Radaeva S., Li Y., Hacker H.J., Burger V., Kopp-Schneider A., and Bannasch P. Hepadnaviral hepatocarcinogenesis: in situ visualization of viral antigens, cytoplasmic compartmentation, enzymic patterns, and cellular proliferation in preneoplastic hepatocellular lineages in woodchucks. J Hepatol 33 (2000) 580-600
    • (2000) J Hepatol , vol.33 , pp. 580-600
    • Radaeva, S.1    Li, Y.2    Hacker, H.J.3    Burger, V.4    Kopp-Schneider, A.5    Bannasch, P.6
  • 65
    • 0027205094 scopus 로고
    • Coordinate expression of N-myc 2 and insulin-like growth factor II in precancerous altered hepatic foci in woodchuck hepatitis virus carriers
    • Yang D., Alt E., and Rogler C.E. Coordinate expression of N-myc 2 and insulin-like growth factor II in precancerous altered hepatic foci in woodchuck hepatitis virus carriers. Cancer Res 53 (1993) 2020-2027
    • (1993) Cancer Res , vol.53 , pp. 2020-2027
    • Yang, D.1    Alt, E.2    Rogler, C.E.3
  • 66
    • 33646426898 scopus 로고    scopus 로고
    • Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression
    • Farazi P.A., Glickman J., Horner J., and Depinho R.A. Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. Cancer Res 66 (2006) 4766-4773
    • (2006) Cancer Res , vol.66 , pp. 4766-4773
    • Farazi, P.A.1    Glickman, J.2    Horner, J.3    Depinho, R.A.4
  • 67
    • 13444278808 scopus 로고    scopus 로고
    • The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma
    • Lewis B.C., Klimstra D.S., Socci N.D., Xu S., Koutcher J.A., and Varmus H.E. The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma. Mol Cell Biol 25 (2005) 1228-1237
    • (2005) Mol Cell Biol , vol.25 , pp. 1228-1237
    • Lewis, B.C.1    Klimstra, D.S.2    Socci, N.D.3    Xu, S.4    Koutcher, J.A.5    Varmus, H.E.6
  • 68
    • 34548044683 scopus 로고    scopus 로고
    • Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells
    • Chen Y.W., Klimstra D.S., Mongeau M.E., Tatem J.L., Boyartchuk V., and Lewis B.C. Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells. Cancer Res 67 (2007) 7589-7596
    • (2007) Cancer Res , vol.67 , pp. 7589-7596
    • Chen, Y.W.1    Klimstra, D.S.2    Mongeau, M.E.3    Tatem, J.L.4    Boyartchuk, V.5    Lewis, B.C.6
  • 69
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • Xue W., Zender L., Miething C., Dickins R.A., Hernando E., Krizhanovsky V., et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445 (2007) 656-660
    • (2007) Nature , vol.445 , pp. 656-660
    • Xue, W.1    Zender, L.2    Miething, C.3    Dickins, R.A.4    Hernando, E.5    Krizhanovsky, V.6
  • 70
    • 0033602410 scopus 로고    scopus 로고
    • Balancing proliferation and apoptosis in vivo: the Goldilocks theory of E2F/DP action
    • Yamasaki L. Balancing proliferation and apoptosis in vivo: the Goldilocks theory of E2F/DP action. Biochim Biophys Acta 1423 (1999) M9-M15
    • (1999) Biochim Biophys Acta , vol.1423
    • Yamasaki, L.1
  • 72
    • 18844402131 scopus 로고    scopus 로고
    • Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-myc/E2F1 transgenic mouse model of liver cancer
    • Calvisi D.F., Conner E.A., Ladu S., Lemmer E.R., Factor V.M., and Thorgeirsson S.S. Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-myc/E2F1 transgenic mouse model of liver cancer. J Hepatol 42 (2005) 842-849
    • (2005) J Hepatol , vol.42 , pp. 842-849
    • Calvisi, D.F.1    Conner, E.A.2    Ladu, S.3    Lemmer, E.R.4    Factor, V.M.5    Thorgeirsson, S.S.6
  • 73
    • 0035100475 scopus 로고    scopus 로고
    • Cellular transformation by SV40 large T antigen: interaction with host proteins
    • Ali S.H., and DeCaprio J.A. Cellular transformation by SV40 large T antigen: interaction with host proteins. Semin Cancer Biol 11 (2001) 15-23
    • (2001) Semin Cancer Biol , vol.11 , pp. 15-23
    • Ali, S.H.1    DeCaprio, J.A.2
  • 75
    • 0035958001 scopus 로고    scopus 로고
    • Conditional liver-specific expression of simian virus 40 T antigen leads to regulatable development of hepatic neoplasm in transgenic mice
    • Manickan E., Satoi J., Wang T.C., and Liang T.J. Conditional liver-specific expression of simian virus 40 T antigen leads to regulatable development of hepatic neoplasm in transgenic mice. J Biol Chem 276 (2001) 13989-13994
    • (2001) J Biol Chem , vol.276 , pp. 13989-13994
    • Manickan, E.1    Satoi, J.2    Wang, T.C.3    Liang, T.J.4
  • 76
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L., and Moorhead P.S. The serial cultivation of human diploid cell strains. Exp Cell Res 25 (1961) 585-621
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 77
    • 0033835452 scopus 로고    scopus 로고
    • Mice without telomerase: what can they teach us about human cancer?
    • Artandi S.E., and DePinho R.A. Mice without telomerase: what can they teach us about human cancer?. Nat Med 6 (2000) 852-855
    • (2000) Nat Med , vol.6 , pp. 852-855
    • Artandi, S.E.1    DePinho, R.A.2
  • 79
    • 33845790499 scopus 로고    scopus 로고
    • A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis
    • Llovet J.M., Chen Y., Wurmbach E., Roayaie S., Fiel M.I., Schwartz M., et al. A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. Gastroenterology 131 (2006) 1758-1767
    • (2006) Gastroenterology , vol.131 , pp. 1758-1767
    • Llovet, J.M.1    Chen, Y.2    Wurmbach, E.3    Roayaie, S.4    Fiel, M.I.5    Schwartz, M.6
  • 80
    • 33845736952 scopus 로고    scopus 로고
    • Real-time quantification of human telomerase reverse transcriptase mRNA in liver tissues from patients with hepatocellular cancer and chronic viral hepatitis
    • Satra M., Gatselis N., Iliopoulos D., Zacharoulis D., Dalekos G.N., and Tsezou A. Real-time quantification of human telomerase reverse transcriptase mRNA in liver tissues from patients with hepatocellular cancer and chronic viral hepatitis. J Viral Hepat 14 (2007) 41-47
    • (2007) J Viral Hepat , vol.14 , pp. 41-47
    • Satra, M.1    Gatselis, N.2    Iliopoulos, D.3    Zacharoulis, D.4    Dalekos, G.N.5    Tsezou, A.6
  • 81
    • 0031054261 scopus 로고    scopus 로고
    • Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis
    • Miura N., Horikawa I., Nishimoto A., Ohmura H., Ito H., Hirohashi S., et al. Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis. Cancer Genet Cytogenet 93 (1997) 56-62
    • (1997) Cancer Genet Cytogenet , vol.93 , pp. 56-62
    • Miura, N.1    Horikawa, I.2    Nishimoto, A.3    Ohmura, H.4    Ito, H.5    Hirohashi, S.6
  • 82
  • 83
    • 3042780966 scopus 로고    scopus 로고
    • Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma
    • Plentz R.R., Caselitz M., Bleck J.S., Gebel M., Flemming P., Kubicka S., et al. Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma. Hepatology 40 (2004) 80-86
    • (2004) Hepatology , vol.40 , pp. 80-86
    • Plentz, R.R.1    Caselitz, M.2    Bleck, J.S.3    Gebel, M.4    Flemming, P.5    Kubicka, S.6
  • 84
    • 0025029030 scopus 로고
    • Hypervariable ultra-long telomeres in mice
    • Kipling D., and Cooke H.J. Hypervariable ultra-long telomeres in mice. Nature 347 (1990) 400-402
    • (1990) Nature , vol.347 , pp. 400-402
    • Kipling, D.1    Cooke, H.J.2
  • 85
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi S.E., Chang S., Lee S.L., Alson S., Gottlieb G.J., Chin L., et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406 (2000) 641-645
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1    Chang, S.2    Lee, S.L.3    Alson, S.4    Gottlieb, G.J.5    Chin, L.6
  • 86
    • 0025341727 scopus 로고
    • TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas
    • Jhappan C., Stahle C., Harkins R.N., Fausto N., Smith G.H., and Merlino G.T. TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 61 (1990) 1137-1146
    • (1990) Cell , vol.61 , pp. 1137-1146
    • Jhappan, C.1    Stahle, C.2    Harkins, R.N.3    Fausto, N.4    Smith, G.H.5    Merlino, G.T.6
  • 87
    • 0026673779 scopus 로고
    • Development of liver tumors in transforming growth factor alpha transgenic mice
    • Lee G.H., Merlino G., and Fausto N. Development of liver tumors in transforming growth factor alpha transgenic mice. Cancer Res 52 (1992) 5162-5170
    • (1992) Cancer Res , vol.52 , pp. 5162-5170
    • Lee, G.H.1    Merlino, G.2    Fausto, N.3
  • 88
    • 0025297086 scopus 로고
    • Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast
    • Sandgren E.P., Luetteke N.C., Palmiter R.D., Brinster R.L., and Lee D.C. Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell 61 (1990) 1121-1135
    • (1990) Cell , vol.61 , pp. 1121-1135
    • Sandgren, E.P.1    Luetteke, N.C.2    Palmiter, R.D.3    Brinster, R.L.4    Lee, D.C.5
  • 89
    • 19944432263 scopus 로고    scopus 로고
    • Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis
    • Schiffer E., Housset C., Cacheux W., Wendum D., Desbois-Mouthon C., Rey C., et al. Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis. Hepatology 41 (2005) 307-314
    • (2005) Hepatology , vol.41 , pp. 307-314
    • Schiffer, E.1    Housset, C.2    Cacheux, W.3    Wendum, D.4    Desbois-Mouthon, C.5    Rey, C.6
  • 90
    • 9644254191 scopus 로고    scopus 로고
    • Application of comparative functional genomics to identify best-fit mouse models to study human cancer
    • Lee J.S., Chu I.S., Mikaelyan A., Calvisi D.F., Heo J., Reddy J.K., et al. Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat Genet 36 (2004) 1306-1311
    • (2004) Nat Genet , vol.36 , pp. 1306-1311
    • Lee, J.S.1    Chu, I.S.2    Mikaelyan, A.3    Calvisi, D.F.4    Heo, J.5    Reddy, J.K.6
  • 91
    • 0035947770 scopus 로고    scopus 로고
    • Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice
    • Wang R., Ferrell L.D., Faouzi S., Maher J.J., and Bishop J.M. Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol 153 (2001) 1023-1034
    • (2001) J Cell Biol , vol.153 , pp. 1023-1034
    • Wang, R.1    Ferrell, L.D.2    Faouzi, S.3    Maher, J.J.4    Bishop, J.M.5
  • 92
    • 33745253109 scopus 로고    scopus 로고
    • Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
    • Zender L., Spector M.S., Xue W., Flemming P., Cordon-Cardo C., Silke J., et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125 (2006) 1253-1267
    • (2006) Cell , vol.125 , pp. 1253-1267
    • Zender, L.1    Spector, M.S.2    Xue, W.3    Flemming, P.4    Cordon-Cardo, C.5    Silke, J.6
  • 93
    • 0345722740 scopus 로고    scopus 로고
    • Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas
    • Park W.S., Dong S.M., Kim S.Y., Na E.Y., Shin M.S., Pi J.H., et al. Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas. Cancer Res 59 (1999) 307-310
    • (1999) Cancer Res , vol.59 , pp. 307-310
    • Park, W.S.1    Dong, S.M.2    Kim, S.Y.3    Na, E.Y.4    Shin, M.S.5    Pi, J.H.6
  • 94
    • 35448964238 scopus 로고    scopus 로고
    • Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis
    • Takami T., Kaposi-Novak P., Uchida K., Gomez-Quiroz L.E., Conner E.A., Factor V.M., et al. Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Res 67 (2007) 9844-9851
    • (2007) Cancer Res , vol.67 , pp. 9844-9851
    • Takami, T.1    Kaposi-Novak, P.2    Uchida, K.3    Gomez-Quiroz, L.E.4    Conner, E.A.5    Factor, V.M.6
  • 95
    • 0029910845 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers
    • Sakata H., Takayama H., Sharp R., Rubin J.S., Merlino G., and LaRochelle W.J. Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers. Cell Growth Differ 7 (1996) 1513-1523
    • (1996) Cell Growth Differ , vol.7 , pp. 1513-1523
    • Sakata, H.1    Takayama, H.2    Sharp, R.3    Rubin, J.S.4    Merlino, G.5    LaRochelle, W.J.6
  • 96
    • 33750610840 scopus 로고    scopus 로고
    • Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice
    • Apte U., Zeng G., Muller P., Tan X., Micsenyi A., Cieply B., et al. Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice. Hepatology 44 (2006) 992-1002
    • (2006) Hepatology , vol.44 , pp. 992-1002
    • Apte, U.1    Zeng, G.2    Muller, P.3    Tan, X.4    Micsenyi, A.5    Cieply, B.6
  • 98
    • 0028970934 scopus 로고
    • Characterization of double transgenic mice expressing hepatocye growth factor and transforming growth factor alpha
    • Shiota G., Kawasaki H., Nakamura T., and Schmidt E.V. Characterization of double transgenic mice expressing hepatocye growth factor and transforming growth factor alpha. Res Commun Mol Pathol Pharmacol 90 (1995) 17-24
    • (1995) Res Commun Mol Pathol Pharmacol , vol.90 , pp. 17-24
    • Shiota, G.1    Kawasaki, H.2    Nakamura, T.3    Schmidt, E.V.4
  • 99
    • 35548966020 scopus 로고    scopus 로고
    • Distinct pathways of genomic progression to benign and malignant tumors of the liver
    • Tward A.D., Jones K.D., Yant S., Cheung S.T., Fan S.T., Chen X., et al. Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci USA 104 (2007) 14771-14776
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14771-14776
    • Tward, A.D.1    Jones, K.D.2    Yant, S.3    Cheung, S.T.4    Fan, S.T.5    Chen, X.6
  • 100
    • 0026095665 scopus 로고
    • A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
    • Bellacosa A., Testa J.R., Staal S.P., and Tsichlis P.N. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254 (1991) 274-277
    • (1991) Science , vol.254 , pp. 274-277
    • Bellacosa, A.1    Testa, J.R.2    Staal, S.P.3    Tsichlis, P.N.4
  • 101
    • 0017647580 scopus 로고
    • Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma
    • Staal S.P., Hartley J.W., and Rowe W.P. Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma. Proc Natl Acad Sci USA 74 (1977) 3065-3067
    • (1977) Proc Natl Acad Sci USA , vol.74 , pp. 3065-3067
    • Staal, S.P.1    Hartley, J.W.2    Rowe, W.P.3
  • 103
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I., and Sawyers C.L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2 (2002) 489-501
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 104
    • 24944572259 scopus 로고    scopus 로고
    • Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
    • Stanger B.Z., Stiles B., Lauwers G.Y., Bardeesy N., Mendoza M., Wang Y., et al. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 8 (2005) 185-195
    • (2005) Cancer Cell , vol.8 , pp. 185-195
    • Stanger, B.Z.1    Stiles, B.2    Lauwers, G.Y.3    Bardeesy, N.4    Mendoza, M.5    Wang, Y.6
  • 105
    • 0035210374 scopus 로고    scopus 로고
    • Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia
    • Bernal-Mizrachi E., Wen W., Stahlhut S., Welling C.M., and Permutt M.A. Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest 108 (2001) 1631-1638
    • (2001) J Clin Invest , vol.108 , pp. 1631-1638
    • Bernal-Mizrachi, E.1    Wen, W.2    Stahlhut, S.3    Welling, C.M.4    Permutt, M.A.5
  • 107
    • 2942724235 scopus 로고    scopus 로고
    • mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
    • Majumder P.K., Febbo P.G., Bikoff R., Berger R., Xue Q., McMahon L.M., et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 10 (2004) 594-601
    • (2004) Nat Med , vol.10 , pp. 594-601
    • Majumder, P.K.1    Febbo, P.G.2    Bikoff, R.3    Berger, R.4    Xue, Q.5    McMahon, L.M.6
  • 108
    • 85047694402 scopus 로고    scopus 로고
    • Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
    • Horie Y., Suzuki A., Kataoka E., Sasaki T., Hamada K., Sasaki J., et al. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 113 (2004) 1774-1783
    • (2004) J Clin Invest , vol.113 , pp. 1774-1783
    • Horie, Y.1    Suzuki, A.2    Kataoka, E.3    Sasaki, T.4    Hamada, K.5    Sasaki, J.6
  • 109
    • 34249791226 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice
    • Watanabe S., Horie Y., Kataoka E., Sato W., Dohmen T., Ohshima S., et al. Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice. J Gastroenterol Hepatol 22 (2007) S96-S100
    • (2007) J Gastroenterol Hepatol , vol.22
    • Watanabe, S.1    Horie, Y.2    Kataoka, E.3    Sato, W.4    Dohmen, T.5    Ohshima, S.6
  • 110
    • 33745552897 scopus 로고    scopus 로고
    • Dysregulation of growth factor signaling in human hepatocellular carcinoma
    • Breuhahn K., Longerich T., and Schirmacher P. Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene 25 (2006) 3787-3800
    • (2006) Oncogene , vol.25 , pp. 3787-3800
    • Breuhahn, K.1    Longerich, T.2    Schirmacher, P.3
  • 111
    • 0032930759 scopus 로고    scopus 로고
    • Type-2 IGF receptor: a multi-ligand binding protein
    • Braulke T. Type-2 IGF receptor: a multi-ligand binding protein. Horm Metab Res 31 (1999) 242-246
    • (1999) Horm Metab Res , vol.31 , pp. 242-246
    • Braulke, T.1
  • 112
    • 0037099610 scopus 로고    scopus 로고
    • Comparison of gene expression profiles between hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method
    • Iizuka N., Oka M., Yamada-Okabe H., Mori N., Tamesa T., Okada T., et al. Comparison of gene expression profiles between hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method. Cancer Res 62 (2002) 3939-3944
    • (2002) Cancer Res , vol.62 , pp. 3939-3944
    • Iizuka, N.1    Oka, M.2    Yamada-Okabe, H.3    Mori, N.4    Tamesa, T.5    Okada, T.6
  • 113
    • 0026635934 scopus 로고
    • Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth
    • Schirmacher P., Held W.A., Yang D., Chisari F.V., Rustum Y., and Rogler C.E. Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth. Cancer Res 52 (1992) 2549-2556
    • (1992) Cancer Res , vol.52 , pp. 2549-2556
    • Schirmacher, P.1    Held, W.A.2    Yang, D.3    Chisari, F.V.4    Rustum, Y.5    Rogler, C.E.6
  • 114
    • 0028942819 scopus 로고
    • Concomitant and isolated expression of TGF-alpha and EGF-R in human hepatoma cells supports the hypothesis of autocrine, paracrine, and endocrine growth of human hepatoma
    • Yamaguchi K., Carr B.I., and Nalesnik M.A. Concomitant and isolated expression of TGF-alpha and EGF-R in human hepatoma cells supports the hypothesis of autocrine, paracrine, and endocrine growth of human hepatoma. J Surg Oncol 58 (1995) 240-245
    • (1995) J Surg Oncol , vol.58 , pp. 240-245
    • Yamaguchi, K.1    Carr, B.I.2    Nalesnik, M.A.3
  • 115
    • 0028941076 scopus 로고
    • Autocrine mitogen IgEGF cooperates with c-myc or with the Hcs locus during hepatocarcinogenesis in transgenic mice
    • Tonjes R.R., Lohler J., O'Sullivan J.F., Kay G.F., Schmidt G.H., Dalemans W., et al. Autocrine mitogen IgEGF cooperates with c-myc or with the Hcs locus during hepatocarcinogenesis in transgenic mice. Oncogene 10 (1995) 765-768
    • (1995) Oncogene , vol.10 , pp. 765-768
    • Tonjes, R.R.1    Lohler, J.2    O'Sullivan, J.F.3    Kay, G.F.4    Schmidt, G.H.5    Dalemans, W.6
  • 116
    • 33750726092 scopus 로고    scopus 로고
    • Conditional deletion of beta-catenin reveals its role in liver growth and regeneration
    • Tan X., Behari J., Cieply B., Michalopoulos G.K., and Monga S.P. Conditional deletion of beta-catenin reveals its role in liver growth and regeneration. Gastroenterology 131 (2006) 1561-1572
    • (2006) Gastroenterology , vol.131 , pp. 1561-1572
    • Tan, X.1    Behari, J.2    Cieply, B.3    Michalopoulos, G.K.4    Monga, S.P.5
  • 117
    • 29244458336 scopus 로고    scopus 로고
    • Molecular control of liver development
    • McLin V.A., and Zorn A.M. Molecular control of liver development. Clin Liver Dis 10 (2006) 1-25
    • (2006) Clin Liver Dis , vol.10 , pp. 1-25
    • McLin, V.A.1    Zorn, A.M.2
  • 118
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • Thorgeirsson S.S., and Grisham J.W. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 31 (2002) 339-346
    • (2002) Nat Genet , vol.31 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 119
    • 0034088858 scopus 로고    scopus 로고
    • AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
    • Satoh S., Daigo Y., Furukawa Y., Kato T., Miwa N., Nishiwaki T., et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 24 (2000) 245-250
    • (2000) Nat Genet , vol.24 , pp. 245-250
    • Satoh, S.1    Daigo, Y.2    Furukawa, Y.3    Kato, T.4    Miwa, N.5    Nishiwaki, T.6
  • 120
    • 0032525836 scopus 로고    scopus 로고
    • Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3
    • Miyoshi Y., Iwao K., Nagasawa Y., Aihara T., Sasaki Y., Imaoka S., et al. Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res 58 (1998) 2524-2527
    • (1998) Cancer Res , vol.58 , pp. 2524-2527
    • Miyoshi, Y.1    Iwao, K.2    Nagasawa, Y.3    Aihara, T.4    Sasaki, Y.5    Imaoka, S.6
  • 122
    • 0037130449 scopus 로고    scopus 로고
    • Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas
    • Taniguchi K., Roberts L.R., Aderca I.N., Dong X., Qian C., Murphy L.M., et al. Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene 21 (2002) 4863-4871
    • (2002) Oncogene , vol.21 , pp. 4863-4871
    • Taniguchi, K.1    Roberts, L.R.2    Aderca, I.N.3    Dong, X.4    Qian, C.5    Murphy, L.M.6
  • 123
    • 0034995765 scopus 로고    scopus 로고
    • Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis
    • Laurent-Puig P., Legoix P., Bluteau O., Belghiti J., Franco D., Binot F., et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 120 (2001) 1763-1773
    • (2001) Gastroenterology , vol.120 , pp. 1763-1773
    • Laurent-Puig, P.1    Legoix, P.2    Bluteau, O.3    Belghiti, J.4    Franco, D.5    Binot, F.6
  • 124
    • 0035395236 scopus 로고    scopus 로고
    • beta-Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance
    • Wong C.M., Fan S.T., and Ng I.O. beta-Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance. Cancer 92 (2001) 136-145
    • (2001) Cancer , vol.92 , pp. 136-145
    • Wong, C.M.1    Fan, S.T.2    Ng, I.O.3
  • 125
    • 0036725378 scopus 로고    scopus 로고
    • Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, beta-catenin expression, and clinical features
    • Wei Y., Van Nhieu J.T., Prigent S., Srivatanakul P., Tiollais P., and Buendia M.A. Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, beta-catenin expression, and clinical features. Hepatology 36 (2002) 692-701
    • (2002) Hepatology , vol.36 , pp. 692-701
    • Wei, Y.1    Van Nhieu, J.T.2    Prigent, S.3    Srivatanakul, P.4    Tiollais, P.5    Buendia, M.A.6
  • 126
    • 17844372967 scopus 로고    scopus 로고
    • Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression
    • Fukutomi T., Zhou Y., Kawai S., Eguchi H., Wands J.R., and Li J. Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression. Hepatology 41 (2005) 1096-1105
    • (2005) Hepatology , vol.41 , pp. 1096-1105
    • Fukutomi, T.1    Zhou, Y.2    Kawai, S.3    Eguchi, H.4    Wands, J.R.5    Li, J.6
  • 128
    • 0036531817 scopus 로고    scopus 로고
    • Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin
    • Harada N., Miyoshi H., Murai N., Oshima H., Tamai Y., Oshima M., et al. Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin. Cancer Res 62 (2002) 1971-1977
    • (2002) Cancer Res , vol.62 , pp. 1971-1977
    • Harada, N.1    Miyoshi, H.2    Murai, N.3    Oshima, H.4    Tamai, Y.5    Oshima, M.6
  • 129
    • 22344435816 scopus 로고    scopus 로고
    • Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver
    • Tan X., Apte U., Micsenyi A., Kotsagrelos E., Luo J.H., Ranganathan S., et al. Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver. Gastroenterology 129 (2005) 285-302
    • (2005) Gastroenterology , vol.129 , pp. 285-302
    • Tan, X.1    Apte, U.2    Micsenyi, A.3    Kotsagrelos, E.4    Luo, J.H.5    Ranganathan, S.6
  • 130
    • 10344254872 scopus 로고    scopus 로고
    • Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas
    • Colnot S., Decaens T., Niwa-Kawakita M., Godard C., Hamard G., Kahn A., et al. Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci USA 101 (2004) 17216-17221
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 17216-17221
    • Colnot, S.1    Decaens, T.2    Niwa-Kawakita, M.3    Godard, C.4    Hamard, G.5    Kahn, A.6
  • 131
    • 1642535593 scopus 로고    scopus 로고
    • Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations
    • Harada N., Oshima H., Katoh M., Tamai Y., Oshima M., and Taketo M.M. Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations. Cancer Res 64 (2004) 48-54
    • (2004) Cancer Res , vol.64 , pp. 48-54
    • Harada, N.1    Oshima, H.2    Katoh, M.3    Tamai, Y.4    Oshima, M.5    Taketo, M.M.6
  • 132
    • 0036086285 scopus 로고    scopus 로고
    • A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice
    • Nicholes K., Guillet S., Tomlinson E., Hillan K., Wright B., Frantz G.D., et al. A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice. Am J Pathol 160 (2002) 2295-2307
    • (2002) Am J Pathol , vol.160 , pp. 2295-2307
    • Nicholes, K.1    Guillet, S.2    Tomlinson, E.3    Hillan, K.4    Wright, B.5    Frantz, G.D.6
  • 133
    • 0026463692 scopus 로고
    • DNA rearrangement causes hepatocarcinogenesis in albumin-plasminogen activator transgenic mice
    • Sandgren E.P., Palmiter R.D., Heckel J.L., Brinster R.L., and Degen J.L. DNA rearrangement causes hepatocarcinogenesis in albumin-plasminogen activator transgenic mice. Proc Natl Acad Sci USA 89 (1992) 11523-11527
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11523-11527
    • Sandgren, E.P.1    Palmiter, R.D.2    Heckel, J.L.3    Brinster, R.L.4    Degen, J.L.5
  • 135
    • 0017692938 scopus 로고
    • Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis
    • Solt D.B., Medline A., and Farber E. Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. Am J Pathol 88 (1977) 595-618
    • (1977) Am J Pathol , vol.88 , pp. 595-618
    • Solt, D.B.1    Medline, A.2    Farber, E.3
  • 136
    • 0023124846 scopus 로고
    • Hepatocarcinogenesis: a dynamic cellular perspective
    • Farber E., and Sarma D.S. Hepatocarcinogenesis: a dynamic cellular perspective. Lab Invest 56 (1987) 4-22
    • (1987) Lab Invest , vol.56 , pp. 4-22
    • Farber, E.1    Sarma, D.S.2
  • 137
    • 0033999104 scopus 로고    scopus 로고
    • Genetic alterations in liver carcinogenesis: implications for new preventive and therapeutic strategies
    • Feo F., Pascale R.M., Simile M.M., De Miglio M.R., Muroni M.R., and Calvisi D. Genetic alterations in liver carcinogenesis: implications for new preventive and therapeutic strategies. Crit Rev Oncog 11 (2000) 19-62
    • (2000) Crit Rev Oncog , vol.11 , pp. 19-62
    • Feo, F.1    Pascale, R.M.2    Simile, M.M.3    De Miglio, M.R.4    Muroni, M.R.5    Calvisi, D.6
  • 138
    • 0021322170 scopus 로고
    • Oxygen- and carbon-centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitro
    • McCay P.B., Lai E.K., Poyer J.L., DuBose C.M., and Janzen E.G. Oxygen- and carbon-centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitro. J Biol Chem 259 (1984) 2135-2143
    • (1984) J Biol Chem , vol.259 , pp. 2135-2143
    • McCay, P.B.1    Lai, E.K.2    Poyer, J.L.3    DuBose, C.M.4    Janzen, E.G.5
  • 139
    • 0030011821 scopus 로고    scopus 로고
    • The relationship between N-nitrosodimethylamine metabolism and DNA methylation in isolated rat hepatocytes
    • Encell L., Foiles P.G., and Gold B. The relationship between N-nitrosodimethylamine metabolism and DNA methylation in isolated rat hepatocytes. Carcinogenesis 17 (1996) 1127-1134
    • (1996) Carcinogenesis , vol.17 , pp. 1127-1134
    • Encell, L.1    Foiles, P.G.2    Gold, B.3
  • 140
    • 0021827737 scopus 로고
    • A dimethylnitrosamine-induced model of cirrhosis and portal hypertension in the rat
    • Jenkins S.A., Grandison A., Baxter J.N., Day D.W., Taylor I., and Shields R. A dimethylnitrosamine-induced model of cirrhosis and portal hypertension in the rat. J Hepatol 1 (1985) 489-499
    • (1985) J Hepatol , vol.1 , pp. 489-499
    • Jenkins, S.A.1    Grandison, A.2    Baxter, J.N.3    Day, D.W.4    Taylor, I.5    Shields, R.6
  • 141
    • 0020643388 scopus 로고
    • Preneoplastic and neoplastic progression during hepatocarcinogenesis in mice injected with diethylnitrosamine in infancy
    • Goldfarb S., Pugh T.D., Koen H., and He Y.Z. Preneoplastic and neoplastic progression during hepatocarcinogenesis in mice injected with diethylnitrosamine in infancy. Environ Health Perspect 50 (1983) 149-161
    • (1983) Environ Health Perspect , vol.50 , pp. 149-161
    • Goldfarb, S.1    Pugh, T.D.2    Koen, H.3    He, Y.Z.4
  • 142
    • 0020560317 scopus 로고
    • Centrilobular distribution of diethylnitrosamine-induced hepatocellular foci in the mouse
    • Koen H., Pugh T.D., and Goldfarb S. Centrilobular distribution of diethylnitrosamine-induced hepatocellular foci in the mouse. Lab Invest 49 (1983) 78-81
    • (1983) Lab Invest , vol.49 , pp. 78-81
    • Koen, H.1    Pugh, T.D.2    Goldfarb, S.3
  • 144
    • 0033566982 scopus 로고    scopus 로고
    • Different frequencies and patterns of beta-catenin mutations in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats
    • Tsujiuchi T., Tsutsumi M., Sasaki Y., Takahama M., and Konishi Y. Different frequencies and patterns of beta-catenin mutations in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats. Cancer Res 59 (1999) 3904-3907
    • (1999) Cancer Res , vol.59 , pp. 3904-3907
    • Tsujiuchi, T.1    Tsutsumi, M.2    Sasaki, Y.3    Takahama, M.4    Konishi, Y.5
  • 145
    • 0344654862 scopus 로고    scopus 로고
    • Mutational analysis of three tumor suppressor genes in two models of rat hepatocarcinogenesis
    • Gomez-Angelats M., Teeguarden J.G., Dragan Y.P., and Pitot H.C. Mutational analysis of three tumor suppressor genes in two models of rat hepatocarcinogenesis. Mol Carcinog 25 (1999) 157-163
    • (1999) Mol Carcinog , vol.25 , pp. 157-163
    • Gomez-Angelats, M.1    Teeguarden, J.G.2    Dragan, Y.P.3    Pitot, H.C.4
  • 146
    • 0036105275 scopus 로고    scopus 로고
    • Reproducible production of thioacetamide-induced macronodular cirrhosis in the rat with no mortality
    • Li X., Benjamin I.S., and Alexander B. Reproducible production of thioacetamide-induced macronodular cirrhosis in the rat with no mortality. J Hepatol 36 (2002) 488-493
    • (2002) J Hepatol , vol.36 , pp. 488-493
    • Li, X.1    Benjamin, I.S.2    Alexander, B.3
  • 147
    • 18144378768 scopus 로고    scopus 로고
    • Persistence of liver cirrhosis in association with proliferation of nonparenchymal cells and altered location of alpha-smooth muscle actin-positive cells
    • Kang J.S., Morimura K., Salim E.I., Wanibuchi H., Yamaguchi S., and Fukushima S. Persistence of liver cirrhosis in association with proliferation of nonparenchymal cells and altered location of alpha-smooth muscle actin-positive cells. Toxicol Pathol 33 (2005) 329-335
    • (2005) Toxicol Pathol , vol.33 , pp. 329-335
    • Kang, J.S.1    Morimura, K.2    Salim, E.I.3    Wanibuchi, H.4    Yamaguchi, S.5    Fukushima, S.6
  • 148
    • 0015963597 scopus 로고
    • Selective uridine triphosphate deficiency induced by d-galactosamine in liver and reversed by pyrimidine nucleotide precursors
    • Keppler D.O., Pausch J., and Decker K. Selective uridine triphosphate deficiency induced by d-galactosamine in liver and reversed by pyrimidine nucleotide precursors. Effect on ribonucleic acid synthesis. J Biol Chem 249 (1974) 211-216
    • (1974) Effect on ribonucleic acid synthesis. J Biol Chem , vol.249 , pp. 211-216
    • Keppler, D.O.1    Pausch, J.2    Decker, K.3
  • 149
    • 0021025039 scopus 로고
    • The rapid induction of liver cell death in rats fed a choline-deficient methionine-low diet
    • Ghoshal A.K., Ahluwalia M., and Farber E. The rapid induction of liver cell death in rats fed a choline-deficient methionine-low diet. Am J Pathol 113 (1983) 309-314
    • (1983) Am J Pathol , vol.113 , pp. 309-314
    • Ghoshal, A.K.1    Ahluwalia, M.2    Farber, E.3
  • 150
    • 0023575685 scopus 로고
    • Probable free radical effects on rat liver nuclei during early hepatocarcinogenesis with a choline-devoid low methionine diet
    • Rushmore T.H., Ghazarian D.M., Subrahmanyan V., Farber E., and Ghoshal A.K. Probable free radical effects on rat liver nuclei during early hepatocarcinogenesis with a choline-devoid low methionine diet. Cancer Res 47 (1987) 6731-6740
    • (1987) Cancer Res , vol.47 , pp. 6731-6740
    • Rushmore, T.H.1    Ghazarian, D.M.2    Subrahmanyan, V.3    Farber, E.4    Ghoshal, A.K.5
  • 151
    • 0023855370 scopus 로고
    • Liver cell proliferation and incidence of hepatocellular carcinomas in rats fed consecutively a choline-devoid and a choline-supplemented diet
    • Chandar N., and Lombardi B. Liver cell proliferation and incidence of hepatocellular carcinomas in rats fed consecutively a choline-devoid and a choline-supplemented diet. Carcinogenesis 9 (1988) 259-263
    • (1988) Carcinogenesis , vol.9 , pp. 259-263
    • Chandar, N.1    Lombardi, B.2
  • 152
    • 0029159792 scopus 로고
    • Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation
    • Bissell D.M., Wang S.S., Jarnagin W.R., and Roll F.J. Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest 96 (1995) 447-455
    • (1995) J Clin Invest , vol.96 , pp. 447-455
    • Bissell, D.M.1    Wang, S.S.2    Jarnagin, W.R.3    Roll, F.J.4
  • 153
    • 0028953768 scopus 로고
    • Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions
    • Sanderson N., Factor V., Nagy P., Kopp J., Kondaiah P., Wakefield L., et al. Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci USA 92 (1995) 2572-2576
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2572-2576
    • Sanderson, N.1    Factor, V.2    Nagy, P.3    Kopp, J.4    Kondaiah, P.5    Wakefield, L.6
  • 154
    • 0033109090 scopus 로고    scopus 로고
    • TGF-beta1 in liver fibrosis: an inducible transgenic mouse model to study liver fibrogenesis
    • Kanzler S., Lohse A.W., Keil A., Henninger J., Dienes H.P., Schirmacher P., et al. TGF-beta1 in liver fibrosis: an inducible transgenic mouse model to study liver fibrogenesis. Am J Physiol 276 (1999) G1059-G1068
    • (1999) Am J Physiol , vol.276
    • Kanzler, S.1    Lohse, A.W.2    Keil, A.3    Henninger, J.4    Dienes, H.P.5    Schirmacher, P.6
  • 155
    • 2642527018 scopus 로고    scopus 로고
    • Thioacetamide-induced hepatic fibrosis in transforming growth factor beta-1 transgenic mice
    • Schnur J., Olah J., Szepesi A., Nagy P., and Thorgeirsson S.S. Thioacetamide-induced hepatic fibrosis in transforming growth factor beta-1 transgenic mice. Eur J Gastroenterol Hepatol 16 (2004) 127-133
    • (2004) Eur J Gastroenterol Hepatol , vol.16 , pp. 127-133
    • Schnur, J.1    Olah, J.2    Szepesi, A.3    Nagy, P.4    Thorgeirsson, S.S.5
  • 156
    • 0032739624 scopus 로고    scopus 로고
    • Chemical hepatocarcinogenesis in transgenic mice overexpressing mature TGF beta-1 in liver
    • Schnur J., Nagy P., Sebestyen A., Schaff Z., and Thorgeirsson S.S. Chemical hepatocarcinogenesis in transgenic mice overexpressing mature TGF beta-1 in liver. Eur J Cancer 35 (1999) 1842-1845
    • (1999) Eur J Cancer , vol.35 , pp. 1842-1845
    • Schnur, J.1    Nagy, P.2    Sebestyen, A.3    Schaff, Z.4    Thorgeirsson, S.S.5
  • 157
    • 35848951652 scopus 로고    scopus 로고
    • Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation
    • Kitisin K., Ganesan N., Tang Y., Jogunoori W., Volpe E.A., Kim S.S., et al. Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation. Oncogene 26 (2007) 7103-7110
    • (2007) Oncogene , vol.26 , pp. 7103-7110
    • Kitisin, K.1    Ganesan, N.2    Tang, Y.3    Jogunoori, W.4    Volpe, E.A.5    Kim, S.S.6
  • 158
    • 0028170153 scopus 로고
    • Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture
    • Wong L., Yamasaki G., Johnson R.J., and Friedman S.L. Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture. J Clin Invest 94 (1994) 1563-1569
    • (1994) J Clin Invest , vol.94 , pp. 1563-1569
    • Wong, L.1    Yamasaki, G.2    Johnson, R.J.3    Friedman, S.L.4
  • 161
    • 33646014467 scopus 로고    scopus 로고
    • Serum cytokine and soluble cytokine receptor levels in patients with non-alcoholic steatohepatitis
    • Abiru S., Migita K., Maeda Y., Daikoku M., Ito M., Ohata K., et al. Serum cytokine and soluble cytokine receptor levels in patients with non-alcoholic steatohepatitis. Liver Int 26 (2006) 39-45
    • (2006) Liver Int , vol.26 , pp. 39-45
    • Abiru, S.1    Migita, K.2    Maeda, Y.3    Daikoku, M.4    Ito, M.5    Ohata, K.6
  • 162
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler W.E., Sakurai T., Kim S., Maeda S., Kim K., Elsharkawy A.M., et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317 (2007) 121-124
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6
  • 163
    • 35848938907 scopus 로고    scopus 로고
    • Hepatocellular carcinoma and sex
    • Wands J. Hepatocellular carcinoma and sex. N Engl J Med 357 (2007) 1974-1976
    • (2007) N Engl J Med , vol.357 , pp. 1974-1976
    • Wands, J.1
  • 164
    • 0028053044 scopus 로고
    • Hepatocarcinogenesis is the sequel to hepatitis in Z#2 alpha 1-antitrypsin transgenic mice: histopathological and DNA ploidy studies
    • Geller S.A., Nichols W.S., Kim S., Tolmachoff T., Lee S., Dycaico M.J., et al. Hepatocarcinogenesis is the sequel to hepatitis in Z#2 alpha 1-antitrypsin transgenic mice: histopathological and DNA ploidy studies. Hepatology 19 (1994) 389-397
    • (1994) Hepatology , vol.19 , pp. 389-397
    • Geller, S.A.1    Nichols, W.S.2    Kim, S.3    Tolmachoff, T.4    Lee, S.5    Dycaico, M.J.6
  • 165
    • 33646247610 scopus 로고    scopus 로고
    • Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the Mdr2-knockout mice
    • Katzenellenbogen M., Pappo O., Barash H., Klopstock N., Mizrahi L., Olam D., et al. Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the Mdr2-knockout mice. Cancer Res 66 (2006) 4001-4010
    • (2006) Cancer Res , vol.66 , pp. 4001-4010
    • Katzenellenbogen, M.1    Pappo, O.2    Barash, H.3    Klopstock, N.4    Mizrahi, L.5    Olam, D.6
  • 166
    • 0028028436 scopus 로고
    • Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis
    • Mauad T.H., van Nieuwkerk C.M., Dingemans K.P., Smit J.J., Schinkel A.H., Notenboom R.G., et al. Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis. Am J Pathol 145 (1994) 1237-1245
    • (1994) Am J Pathol , vol.145 , pp. 1237-1245
    • Mauad, T.H.1    van Nieuwkerk, C.M.2    Dingemans, K.P.3    Smit, J.J.4    Schinkel, A.H.5    Notenboom, R.G.6
  • 167
    • 0032546929 scopus 로고    scopus 로고
    • Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism
    • Fan C.Y., Pan J., Usuda N., Yeldandi A.V., Rao M.S., and Reddy J.K. Steatohepatitis, spontaneous peroxisome proliferation and liver tumors
    • (1998) J Biol Chem , vol.273 , pp. 15639-15645
    • Fan, C.Y.1    Pan, J.2    Usuda, N.3    Yeldandi, A.V.4    Rao, M.S.5    Reddy, J.K.6
  • 168
    • 33750617327 scopus 로고    scopus 로고
    • Oncogene-specific gene expression signatures at preneoplastic stages in mice define distinct mechanisms of hepatocarcinogenesis
    • Coulouaru C., Gomez-Quiroz L.E., Lee J.S., Kaposi-Novak P., Conner E.A., Goldina T.A., et al. Oncogene-specific gene expression signatures at preneoplastic stages in mice define distinct mechanisms of hepatocarcinogenesis. Hepatology 44 (2006) 1003-1011
    • (2006) Hepatology , vol.44 , pp. 1003-1011
    • Coulouaru, C.1    Gomez-Quiroz, L.E.2    Lee, J.S.3    Kaposi-Novak, P.4    Conner, E.A.5    Goldina, T.A.6
  • 169
    • 33847419143 scopus 로고    scopus 로고
    • Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
    • Guerra C., Schuhmacher A.J., Canamero M., Grippo P.J., Verdaguer L., Perez-Gallego L., et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11 (2007) 291-302
    • (2007) Cancer Cell , vol.11 , pp. 291-302
    • Guerra, C.1    Schuhmacher, A.J.2    Canamero, M.3    Grippo, P.J.4    Verdaguer, L.5    Perez-Gallego, L.6
  • 170
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani S.R., Wang L., Multani A.S., Combs C., Deramaudt T.B., Hruban R.H., et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7 (2005) 469-483
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3    Combs, C.4    Deramaudt, T.B.5    Hruban, R.H.6
  • 171
    • 0031963692 scopus 로고    scopus 로고
    • Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha
    • Santoni-Rugiu E., Jensen M.R., and Thorgeirsson S.S. Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha. Cancer Res 58 (1998) 123-134
    • (1998) Cancer Res , vol.58 , pp. 123-134
    • Santoni-Rugiu, E.1    Jensen, M.R.2    Thorgeirsson, S.S.3
  • 172
    • 34047241387 scopus 로고    scopus 로고
    • Differential gene expression of p27Kip1 and Rb knockout pituitary tumors associated with altered growth and angiogenesis
    • Chien W.M., Garrison K., Caufield E., Orthel J., Dill J., and Fero M.L. Differential gene expression of p27Kip1 and Rb knockout pituitary tumors associated with altered growth and angiogenesis. Cell Cycle 6 (2007) 750-757
    • (2007) Cell Cycle , vol.6 , pp. 750-757
    • Chien, W.M.1    Garrison, K.2    Caufield, E.3    Orthel, J.4    Dill, J.5    Fero, M.L.6
  • 173
    • 0034528807 scopus 로고    scopus 로고
    • An inducible melanoma model implicates a role for RAS in tumor maintenance and angiogenesis
    • Wong A.K., and Chin L. An inducible melanoma model implicates a role for RAS in tumor maintenance and angiogenesis. Cancer Metastasis Rev 19 (2000) 121-129
    • (2000) Cancer Metastasis Rev , vol.19 , pp. 121-129
    • Wong, A.K.1    Chin, L.2
  • 174
    • 0035113825 scopus 로고    scopus 로고
    • Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation
    • Wu X., Wu J., Huang J., Powell W.C., Zhang J., Matusik R.J., et al. Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation. Mech Dev 101 (2001) 61-69
    • (2001) Mech Dev , vol.101 , pp. 61-69
    • Wu, X.1    Wu, J.2    Huang, J.3    Powell, W.C.4    Zhang, J.5    Matusik, R.J.6
  • 175
  • 176
    • 0027939369 scopus 로고
    • Hepatic preneoplasia in hepatitis B virus transgenic mice
    • Toshkov I., Chisari F.V., and Bannasch P. Hepatic preneoplasia in hepatitis B virus transgenic mice. Hepatology 20 (1994) 1162-1172
    • (1994) Hepatology , vol.20 , pp. 1162-1172
    • Toshkov, I.1    Chisari, F.V.2    Bannasch, P.3
  • 178
    • 0030036244 scopus 로고    scopus 로고
    • Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha
    • Santoni-Rugiu E., Nagy P., Jensen M.R., Factor V.M., and Thorgeirsson S.S. Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha. Am J Pathol 149 (1996) 407-428
    • (1996) Am J Pathol , vol.149 , pp. 407-428
    • Santoni-Rugiu, E.1    Nagy, P.2    Jensen, M.R.3    Factor, V.M.4    Thorgeirsson, S.S.5
  • 180
    • 0025053246 scopus 로고
    • Heterologous protein expression by transimmortalized differentiated liver cell lines derived from transgenic mice (hepatomas/alpha 1 antitrypsin/ONC mouse)
    • Dalemans W., Perraud F., Le Meur M., Gerlinger P., Courtney M., and Pavirani A. Heterologous protein expression by transimmortalized differentiated liver cell lines derived from transgenic mice (hepatomas/alpha 1 antitrypsin/ONC mouse). Biologicals 18 (1990) 191-198
    • (1990) Biologicals , vol.18 , pp. 191-198
    • Dalemans, W.1    Perraud, F.2    Le Meur, M.3    Gerlinger, P.4    Courtney, M.5    Pavirani, A.6
  • 181
    • 0025777146 scopus 로고
    • Characterization of trans-immortalized hepatic cell lines established from transgenic mice
    • Perraud F., Dalemans W., Gendrault J.L., Dreyer D., Ali-Hadji D., Faure T., et al. Characterization of trans-immortalized hepatic cell lines established from transgenic mice. Exp Cell Res 195 (1991) 59-65
    • (1991) Exp Cell Res , vol.195 , pp. 59-65
    • Perraud, F.1    Dalemans, W.2    Gendrault, J.L.3    Dreyer, D.4    Ali-Hadji, D.5    Faure, T.6
  • 182
    • 0027245446 scopus 로고
    • Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis
    • Murakami H., Sanderson N.D., Nagy P., Marino P.A., Merlino G., and Thorgeirsson S.S. Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis. Cancer Res 53 (1993) 1719-1723
    • (1993) Cancer Res , vol.53 , pp. 1719-1723
    • Murakami, H.1    Sanderson, N.D.2    Nagy, P.3    Marino, P.A.4    Merlino, G.5    Thorgeirsson, S.S.6
  • 183
    • 0025766290 scopus 로고
    • Selective amplification of periportal transitional cells precedes formation of hepatocellular carcinoma in SV40 large tag transgenic mice
    • Schirmacher P., Held W.A., Yang D., Biempica L., and Rogler C.E. Selective amplification of periportal transitional cells precedes formation of hepatocellular carcinoma in SV40 large tag transgenic mice. Am J Pathol 139 (1991) 231-241
    • (1991) Am J Pathol , vol.139 , pp. 231-241
    • Schirmacher, P.1    Held, W.A.2    Yang, D.3    Biempica, L.4    Rogler, C.E.5
  • 184
    • 0022385932 scopus 로고
    • Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice
    • Messing A., Chen H.Y., Palmiter R.D., and Brinster R.L. Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice. Nature 316 (1985) 461-463
    • (1985) Nature , vol.316 , pp. 461-463
    • Messing, A.1    Chen, H.Y.2    Palmiter, R.D.3    Brinster, R.L.4
  • 185
    • 0024432857 scopus 로고
    • Development of a transgenic mouse system for the analysis of stages in liver carcinogenesis using tissue-specific expression of SV40 large T-antigen controlled by regulatory elements of the human alpha-1-antitrypsin gene
    • Sepulveda A.R., Finegold M.J., Smith B., Slagle B.L., DeMayo J.L., Shen R.F., et al. Development of a transgenic mouse system for the analysis of stages in liver carcinogenesis using tissue-specific expression of SV40 large T-antigen controlled by regulatory elements of the human alpha-1-antitrypsin gene. Cancer Res 49 (1989) 6108-6117
    • (1989) Cancer Res , vol.49 , pp. 6108-6117
    • Sepulveda, A.R.1    Finegold, M.J.2    Smith, B.3    Slagle, B.L.4    DeMayo, J.L.5    Shen, R.F.6
  • 186
    • 0025826837 scopus 로고
    • Time-course development of differentiated hepatocarcinoma and lung metastasis in transgenic mice
    • Dubois N., Bennoun M., Allemand I., Molina T., Grimber G., Daudet-Monsac M., et al. Time-course development of differentiated hepatocarcinoma and lung metastasis in transgenic mice. J Hepatol 13 (1991) 227-239
    • (1991) J Hepatol , vol.13 , pp. 227-239
    • Dubois, N.1    Bennoun, M.2    Allemand, I.3    Molina, T.4    Grimber, G.5    Daudet-Monsac, M.6
  • 187
    • 0028318189 scopus 로고
    • Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice
    • Rogler C.E., Yang D., Rossetti L., Donohoe J., Alt E., Chang C.J., et al. Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice. J Biol Chem 269 (1994) 13779-13784
    • (1994) J Biol Chem , vol.269 , pp. 13779-13784
    • Rogler, C.E.1    Yang, D.2    Rossetti, L.3    Donohoe, J.4    Alt, E.5    Chang, C.J.6
  • 188
    • 0032518796 scopus 로고    scopus 로고
    • Reactivation of the maternally imprinted IGF2 allele in TGFalpha induced hepatocellular carcinomas in mice
    • Harris T.M., Rogler L.E., and Rogler C.E. Reactivation of the maternally imprinted IGF2 allele in TGFalpha induced hepatocellular carcinomas in mice. Oncogene 16 (1998) 203-209
    • (1998) Oncogene , vol.16 , pp. 203-209
    • Harris, T.M.1    Rogler, L.E.2    Rogler, C.E.3
  • 189
    • 0028213841 scopus 로고
    • Hepatocyte growth factor in transgenic mice: effects on hepatocyte growth, liver regeneration and gene expression
    • Shiota G., Wang T.C., Nakamura T., and Schmidt E.V. Hepatocyte growth factor in transgenic mice: effects on hepatocyte growth, liver regeneration and gene expression. Hepatology 19 (1994) 962-972
    • (1994) Hepatology , vol.19 , pp. 962-972
    • Shiota, G.1    Wang, T.C.2    Nakamura, T.3    Schmidt, E.V.4
  • 190
    • 0021912710 scopus 로고
    • Expression of c-Ki-ras, c-Ha-ras, and c-myc in specific cell types during hepatocarcinogenesis
    • Yaswen P., Goyette M., Shank P.R., and Fausto N. Expression of c-Ki-ras, c-Ha-ras, and c-myc in specific cell types during hepatocarcinogenesis. Mol Cell Biol 5 (1985) 780-786
    • (1985) Mol Cell Biol , vol.5 , pp. 780-786
    • Yaswen, P.1    Goyette, M.2    Shank, P.R.3    Fausto, N.4
  • 191
    • 0010452104 scopus 로고
    • c-myc gene amplification during hepatocarcinogenesis by a choline-devoid diet
    • Chandar N., Lombardi B., and Locker J. c-myc gene amplification during hepatocarcinogenesis by a choline-devoid diet. Proc Natl Acad Sci USA 86 (1989) 2703-2707
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 2703-2707
    • Chandar, N.1    Lombardi, B.2    Locker, J.3
  • 192
    • 0023767641 scopus 로고
    • Cellular distribution of c-myc transcripts during chemical hepatocarcinogenesis in rats
    • Nagy P., Evarts R.P., Marsden E., Roach J., and Thorgeirsson S.S. Cellular distribution of c-myc transcripts during chemical hepatocarcinogenesis in rats. Cancer Res 48 (1988) 5522-5527
    • (1988) Cancer Res , vol.48 , pp. 5522-5527
    • Nagy, P.1    Evarts, R.P.2    Marsden, E.3    Roach, J.4    Thorgeirsson, S.S.5
  • 193
    • 0021368812 scopus 로고
    • Inhibitory effect of antioxidants ethoxyquin and 2(3)-tert-butyl-4-hydroxyanisole on hepatic tumorigenesis in rats fed ciprofibrate, a peroxisome proliferator
    • Rao M.S., Lalwani N.D., Watanabe T.K., and Reddy J.K. Inhibitory effect of antioxidants ethoxyquin and 2(3)-tert-butyl-4-hydroxyanisole on hepatic tumorigenesis in rats fed ciprofibrate, a peroxisome proliferator. Cancer Res 44 (1984) 1072-1076
    • (1984) Cancer Res , vol.44 , pp. 1072-1076
    • Rao, M.S.1    Lalwani, N.D.2    Watanabe, T.K.3    Reddy, J.K.4
  • 194
    • 38449117083 scopus 로고    scopus 로고
    • Comparison of mode of action of four hepatocarcinogens: a model-based approach
    • Groos J., Bannasch P., Schwarz M., and Kopp-Schneider A. Comparison of mode of action of four hepatocarcinogens: a model-based approach. Toxicol Sci 99 (2007) 446-454
    • (2007) Toxicol Sci , vol.99 , pp. 446-454
    • Groos, J.1    Bannasch, P.2    Schwarz, M.3    Kopp-Schneider, A.4
  • 195
    • 0016435386 scopus 로고
    • Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes
    • Poirier L.A. Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes. J Natl Cancer Inst 54 (1975) 137-140
    • (1975) J Natl Cancer Inst , vol.54 , pp. 137-140
    • Poirier, L.A.1
  • 196
    • 0031769971 scopus 로고    scopus 로고
    • Nonlinearities in 2-acetylaminofluorene exposure responses for genotoxic and epigenetic effects leading to initiation of carcinogenesis in rat liver
    • Williams G.M., Iatropoulos M.J., Wang C.X., Jeffrey A.M., Thompson S., Pittman B., et al. Nonlinearities in 2-acetylaminofluorene exposure responses for genotoxic and epigenetic effects leading to initiation of carcinogenesis in rat liver. Toxicol Sci 45 (1998) 152-161
    • (1998) Toxicol Sci , vol.45 , pp. 152-161
    • Williams, G.M.1    Iatropoulos, M.J.2    Wang, C.X.3    Jeffrey, A.M.4    Thompson, S.5    Pittman, B.6
  • 197
    • 3042697182 scopus 로고    scopus 로고
    • Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital
    • Calvisi D.F., Ladu S., Factor V.M., and Thorgeirsson S.S. Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital. Carcinogenesis 25 (2004) 901-908
    • (2004) Carcinogenesis , vol.25 , pp. 901-908
    • Calvisi, D.F.1    Ladu, S.2    Factor, V.M.3    Thorgeirsson, S.S.4
  • 198
    • 0034117990 scopus 로고    scopus 로고
    • Paradoxical effects of phenobarbital on mouse hepatocarcinogenesis
    • Lee G.H. Paradoxical effects of phenobarbital on mouse hepatocarcinogenesis. Toxicol Pathol 28 (2000) 215-225
    • (2000) Toxicol Pathol , vol.28 , pp. 215-225
    • Lee, G.H.1
  • 199
    • 0037462502 scopus 로고    scopus 로고
    • Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice
    • Tang Y., Katuri V., Dillner A., Mishra B., Deng C.X., and Mishra L. Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science 299 (2003) 574-577
    • (2003) Science , vol.299 , pp. 574-577
    • Tang, Y.1    Katuri, V.2    Dillner, A.3    Mishra, B.4    Deng, C.X.5    Mishra, L.6


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