A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet

Liver International

Volumn 31, Issue 4, 2011, Pages 542-551

  Ogasawara, Mitsunari ^a   Hirose, Akira ^a   Ono, Masafumi ^a   Aritake, Kosuke ^b   Nozaki, Yasuko ^a   Takahashi, Masaya ^a   Okamoto, Nobuto ^a   Sakamoto, Shuji ^a   Iwasaki, Shinji ^a   Asanuma, Taketoshi ^c   Taniguchi, Taketoshi ^a   Urade, Yoshihiro ^b   Onishi, Saburo ^a   Saibara, Toshiji ^a   Oben, Jude A ^d,e  

^a KOCHI MEDICAL SCHOOL   (Japan)

^b OSAKA BIOSCIENCE INSTITUTE   (Japan)

^c UNIVERSITY OF MIYAZAKI   (Japan)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Animal models; Gold thioglucose; Hyperphagia; NASH; Obesity

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; AUROTHIOGLUCOSE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1;

ABDOMINAL OBESITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE SEVERITY; GLUCOSE TOLERANCE TEST; HISTOPATHOLOGY; HYPERPHAGIA; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; LIPID DIET; LIVER METABOLISM; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PHENOTYPE; ZONA INCERTA;

ADIPONECTIN; ADIPOSE TISSUE; ANIMALS; AUROTHIOGLUCOSE; DIETARY FATS; DISEASE MODELS, ANIMAL; FATTY LIVER; GLUCOSE TOLERANCE TEST; HYPOTHALAMUS; INJECTIONS, INTRAPERITONEAL; INSULIN RESISTANCE; LIVER; MICE; MICE, INBRED C57BL; PPAR GAMMA; RECEPTORS, ADIPONECTIN; STATISTICS, NONPARAMETRIC; TOMOGRAPHY, X-RAY COMPUTED;

EID: 79952462806     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2010.02443.x     Document Type: Article

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