메뉴 건너뛰기




Volumn 18, Issue 19, 2012, Pages 2300-2308

Animal models of nonalcoholic fatty liver disease/ nonalcoholic steatohepatitis

Author keywords

Animal model; Histopathology; Metabolic syndrome; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis

Indexed keywords

DIET; EDITORIAL; GENETIC DISORDER; HISTOPATHOLOGY; HYPERLIPIDEMIA; INCIDENCE; LIVER CARCINOMA; LIVER CIRRHOSIS; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PREVALENCE;

EID: 84861738395     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v18.i19.2300     Document Type: Editorial
Times cited : (436)

References (80)
  • 1
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-1231
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 2
    • 84861751270 scopus 로고    scopus 로고
    • Pathology of nonalcoholic steatohepatitis
    • In: Trivandrum: Research Media
    • Takahashi Y, Fukusato T. Pathology of nonalcoholic steatohepatitis. In: Current Research in Hepatology 2. Trivandrum: Research Media, 2008: 99-112
    • (2008) Current Research in Hepatology , vol.2 , pp. 99-112
    • Takahashi, Y.1    Fukusato, T.2
  • 3
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
    • Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 1990; 11: 74-80
    • (1990) Hepatology , vol.11 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3    Searle, J.4    Halliday, J.W.5    Powell, L.W.6
  • 4
    • 0141510580 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: A clinical histopathological study
    • Harrison SA, Torgerson S, Hayashi PH. The natural history of nonalcoholic fatty liver disease: a clinical histopathological study. Am J Gastroenterol 2003; 98: 2042-2047
    • (2003) Am J Gastroenterol , vol.98 , pp. 2042-2047
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.H.3
  • 5
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: Old questions and new insights
    • Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: old questions and new insights. Science 2011; 332: 1519-1523
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 8
    • 29244444549 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis and the metabolic syndrome
    • Neuschwander-Tetri BA. Nonalcoholic steatohepatitis and the metabolic syndrome. Am J Med Sci 2005; 330: 326-335
    • (2005) Am J Med Sci , vol.330 , pp. 326-335
    • Neuschwander-Tetri, B.A.1
  • 9
    • 77952562217 scopus 로고    scopus 로고
    • Animal models of non-alcoholic steatohepatitis: Of mice and man
    • Schattenberg JM, Galle PR. Animal models of non-alcoholic steatohepatitis: of mice and man. Dig Dis 2010; 28: 247-254
    • (2010) Dig Dis , vol.28 , pp. 247-254
    • Schattenberg, J.M.1    Galle, P.R.2
  • 10
    • 78651089694 scopus 로고    scopus 로고
    • Animal models of nonalcoholic fatty liver disease
    • Hebbard L, George J. Animal models of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 2011; 8: 35-44
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , pp. 35-44
    • Hebbard, L.1    George, J.2
  • 11
    • 70350421812 scopus 로고    scopus 로고
    • Alcoholic and non-alcoholic fatty liver disease
    • In: Odze RD, Goldblum JR, Crawford JM, editors. Philadelphia: Saunders
    • Brunt EM, Tiniakos DG. Alcoholic and non-alcoholic fatty liver disease. In: Odze RD, Goldblum JR, Crawford JM, editors. Pathology of the GI Tract, Liver, Biliary Tract and Pancreas. Philadelphia: Saunders, 2009: 1087-1114
    • (2009) Pathology of the GI Tract, Liver, Biliary Tract and Pancreas , pp. 1087-1114
    • Brunt, E.M.1    Tiniakos, D.G.2
  • 15
    • 84861130135 scopus 로고    scopus 로고
    • Histopathological characteristics of non-alcoholic fatty liver disease in children: Comparison with adult cases
    • Takahashi Y, Inui A, Fujisawa T, Takikawa H, Fukusato T. Histopathological characteristics of non-alcoholic fatty liver disease in children: Comparison with adult cases. Hepatol Res 2011; 41: 1066-1074
    • (2011) Hepatol Res , vol.41 , pp. 1066-1074
    • Takahashi, Y.1    Inui, A.2    Fujisawa, T.3    Takikawa, H.4    Fukusato, T.5
  • 17
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology 1998; 114: 842-845
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 18
    • 78649393986 scopus 로고    scopus 로고
    • Pediatric nonalcoholic fatty liver disease: Overview with emphasis on histology
    • Takahashi Y, Fukusato T. Pediatric nonalcoholic fatty liver disease: overview with emphasis on histology. World J Gastroenterol 2010; 16: 5280-5285
    • (2010) World J Gastroenterol , vol.16 , pp. 5280-5285
    • Takahashi, Y.1    Fukusato, T.2
  • 19
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006; 43: S99-S112
    • (2006) Hepatology , vol.43
    • Farrell, G.C.1    Larter, C.Z.2
  • 20
  • 21
    • 4344589923 scopus 로고    scopus 로고
    • Lipid metabolism in hepatic steatosis
    • Bradbury MW, Berk PD. Lipid metabolism in hepatic steatosis. Clin Liver Dis 2004; 8: 639-671
    • (2004) Clin Liver Dis , vol.8 , pp. 639-671
    • Bradbury, M.W.1    Berk, P.D.2
  • 22
    • 33644955272 scopus 로고    scopus 로고
    • Mouse models in non-alcoholic fatty liver disease and steatohepatitis research
    • Anstee QM, Goldin RD. Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. Int J Exp Pathol 2006; 87: 1-16
    • (2006) Int J Exp Pathol , vol.87 , pp. 1-16
    • Anstee, Q.M.1    Goldin, R.D.2
  • 23
    • 0036454882 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: Definitions and pathogenesis
    • Day CP, Saksena S. Non-alcoholic steatohepatitis: definitions and pathogenesis. J Gastroenterol Hepatol 2002; 17 Suppl 3: S377-S384
    • (2002) J Gastroenterol Hepatol , vol.17 , Issue.SUPPL. 3
    • Day, C.P.1    Saksena, S.2
  • 25
    • 0032532152 scopus 로고    scopus 로고
    • Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized lipodystrophy
    • Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL, Brown MS. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 1998; 12: 3182-3194
    • (1998) Genes Dev , vol.12 , pp. 3182-3194
    • Shimomura, I.1    Hammer, R.E.2    Richardson, J.A.3    Ikemoto, S.4    Bashmakov, Y.5    Goldstein, J.L.6    Brown, M.S.7
  • 26
    • 33947264902 scopus 로고    scopus 로고
    • Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis
    • Nakayama H, Otabe S, Ueno T, Hirota N, Yuan X, Fukutani T, Hashinaga T, Wada N, Yamada K. Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis. Metabolism 2007; 56: 470-475
    • (2007) Metabolism , vol.56 , pp. 470-475
    • Nakayama, H.1    Otabe, S.2    Ueno, T.3    Hirota, N.4    Yuan, X.5    Fukutani, T.6    Hashinaga, T.7    Wada, N.8    Yamada, K.9
  • 27
    • 0018756428 scopus 로고
    • Hypothalamic and genetic obesity in experimental animals: An autonomic and endocrine hypothesis
    • Bray GA, York DA. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev 1979; 59: 719-809
    • (1979) Physiol Rev , vol.59 , pp. 719-809
    • Bray, G.A.1    York, D.A.2
  • 28
    • 29144523498 scopus 로고    scopus 로고
    • Lessons from animal models of NASH
    • Diehl AM. Lessons from animal models of NASH. Hepatol Res 2005; 33: 138-144
    • (2005) Hepatol Res , vol.33 , pp. 138-144
    • Diehl, A.M.1
  • 30
    • 0001513966 scopus 로고    scopus 로고
    • Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis
    • Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci USA 1997; 94: 2557-2562
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2557-2562
    • Yang, S.Q.1    Lin, H.Z.2    Lane, M.D.3    Clemens, M.4    Diehl, A.M.5
  • 31
    • 0036022846 scopus 로고    scopus 로고
    • Leptin is essential for the hepatic fibrogenic response to chronic liver injury
    • Leclercq IA, Farrell GC, Schriemer R, Robertson GR. Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J Hepatol 2002; 37: 206-213
    • (2002) J Hepatol , vol.37 , pp. 206-213
    • Leclercq, I.A.1    Farrell, G.C.2    Schriemer, R.3    Robertson, G.R.4
  • 32
    • 0034927064 scopus 로고    scopus 로고
    • Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals
    • Ikejima K, Honda H, Yoshikawa M, Hirose M, Kitamura T, Takei Y, Sato N. Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals. Hepatology 2001; 34: 288-297
    • (2001) Hepatology , vol.34 , pp. 288-297
    • Ikejima, K.1    Honda, H.2    Yoshikawa, M.3    Hirose, M.4    Kitamura, T.5    Takei, Y.6    Sato, N.7
  • 35
    • 50949127370 scopus 로고    scopus 로고
    • The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet
    • Wortham M, He L, Gyamfi M, Copple BL, Wan YJ. The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet. Dig Dis Sci 2008; 53: 2761-2774
    • (2008) Dig Dis Sci , vol.53 , pp. 2761-2774
    • Wortham, M.1    He, L.2    Gyamfi, M.3    Copple, B.L.4    Wan, Y.J.5
  • 36
    • 7044241291 scopus 로고    scopus 로고
    • Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: Role of short-form leptin receptors and osteopontin
    • Sahai A, Malladi P, Pan X, Paul R, Melin-Aldana H, Green RM, Whitington PF. Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin. Am J Physiol Gastrointest Liver Physiol 2004; 287: G1035-G1043
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Sahai, A.1    Malladi, P.2    Pan, X.3    Paul, R.4    Melin-Aldana, H.5    Green, R.M.6    Whitington, P.F.7
  • 42
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    • Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 1999; 103: 1489-1498
    • (1999) J Clin Invest , vol.103 , pp. 1489-1498
    • Kersten, S.1    Seydoux, J.2    Peters, J.M.3    Gonzalez, F.J.4    Desvergne, B.5    Wahli, W.6
  • 43
    • 0035425824 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpharesponsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice
    • Cook WS, Jain S, Jia Y, Cao WQ, Yeldandi AV, Reddy JK, Rao MS. Peroxisome proliferator-activated receptor alpharesponsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice. Exp Cell Res 2001; 268: 70-76
    • (2001) Exp Cell Res , vol.268 , pp. 70-76
    • Cook, W.S.1    Jain, S.2    Jia, Y.3    Cao, W.Q.4    Yeldandi, A.V.5    Reddy, J.K.6    Rao, M.S.7
  • 44
    • 34249681974 scopus 로고    scopus 로고
    • Pathogenesis of NASH: Animal models
    • London RM, George J. Pathogenesis of NASH: animal models. Clin Liver Dis 2007; 11: 55-74, viii
    • (2007) Clin Liver Dis , vol.11
    • London, R.M.1    George, J.2
  • 45
    • 0035826898 scopus 로고    scopus 로고
    • Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation
    • Lu SC, Alvarez L, Huang ZZ, Chen L, An W, Corrales FJ, Avila MA, Kanel G, Mato JM. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci USA 2001; 98: 5560-5565
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5560-5565
    • Lu, S.C.1    Alvarez, L.2    Huang, Z.Z.3    Chen, L.4    An, W.5    Corrales, F.J.6    Avila, M.A.7    Kanel, G.8    Mato, J.M.9
  • 47
    • 0025183076 scopus 로고
    • Reduction in VLDL, but not HDL, in plasma of rats deficient in choline
    • Yao ZM, Vance DE. Reduction in VLDL, but not HDL, in plasma of rats deficient in choline. Biochem Cell Biol 1990; 68: 552-558
    • (1990) Biochem Cell Biol , vol.68 , pp. 552-558
    • Yao, Z.M.1    Vance, D.E.2
  • 48
    • 0034092716 scopus 로고    scopus 로고
    • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
    • Leclercq IA, Farrell GC, Field J, Bell DR, Gonzalez FJ, Robertson GR. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J Clin Invest 2000; 105: 1067-1075
    • (2000) J Clin Invest , vol.105 , pp. 1067-1075
    • Leclercq, I.A.1    Farrell, G.C.2    Field, J.3    Bell, D.R.4    Gonzalez, F.J.5    Robertson, G.R.6
  • 50
    • 48449096011 scopus 로고    scopus 로고
    • MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes
    • Larter CZ, Yeh MM, Williams J, Bell-Anderson KS, Farrell GC. MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes. J Hepatol 2008; 49: 407-416
    • (2008) J Hepatol , vol.49 , pp. 407-416
    • Larter, C.Z.1    Yeh, M.M.2    Williams, J.3    Bell-Anderson, K.S.4    Farrell, G.C.5
  • 52
    • 27744458510 scopus 로고    scopus 로고
    • NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis
    • Dela Peña A, Leclercq I, Field J, George J, Jones B, Farrell G. NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. Gastroenterology 2005; 129: 1663-1674
    • (2005) Gastroenterology , vol.129 , pp. 1663-1674
    • dela Peña, A.1    Leclercq, I.2    Field, J.3    George, J.4    Jones, B.5    Farrell, G.6
  • 53
    • 2342644813 scopus 로고    scopus 로고
    • Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice
    • Ip E, Farrell G, Hall P, Robertson G, Leclercq I. Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology 2004; 39: 1286-1296
    • (2004) Hepatology , vol.39 , pp. 1286-1296
    • Ip, E.1    Farrell, G.2    Hall, P.3    Robertson, G.4    Leclercq, I.5
  • 54
    • 56549117448 scopus 로고    scopus 로고
    • Animal models of NASH: Getting both pathology and metabolic context right
    • Larter CZ, Yeh MM. Animal models of NASH: getting both pathology and metabolic context right. J Gastroenterol Hepatol 2008; 23: 1635-1648
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 1635-1648
    • Larter, C.Z.1    Yeh, M.M.2
  • 55
    • 7044264899 scopus 로고    scopus 로고
    • Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease
    • Gao D, Wei C, Chen L, Huang J, Yang S, Diehl AM. Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease. Am J Physiol Gastrointest Liver Physiol 2004; 287: G1070-G1077
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Gao, D.1    Wei, C.2    Chen, L.3    Huang, J.4    Yang, S.5    Diehl, A.M.6
  • 56
    • 67549113925 scopus 로고    scopus 로고
    • Commonly used animal models of nonalcoholic steatohepatitis
    • Fan JG, Qiao L. Commonly used animal models of nonalcoholic steatohepatitis. Hepatobiliary Pancreat Dis Int 2009; 8: 233-240
    • (2009) Hepatobiliary Pancreat Dis Int , vol.8 , pp. 233-240
    • Fan, J.G.1    Qiao, L.2
  • 58
    • 0346689994 scopus 로고    scopus 로고
    • The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance
    • Rinella ME, Green RM. The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. J Hepatol 2004; 40: 47-51
    • (2004) J Hepatol , vol.40 , pp. 47-51
    • Rinella, M.E.1    Green, R.M.2
  • 60
    • 33645891166 scopus 로고    scopus 로고
    • Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine-and choline-deficient diet
    • Nagasawa T, Inada Y, Nakano S, Tamura T, Takahashi T, Maruyama K, Yamazaki Y, Kuroda J, Shibata N. Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine-and choline-deficient diet. Eur J Pharmacol 2006; 536: 182-191
    • (2006) Eur J Pharmacol , vol.536 , pp. 182-191
    • Nagasawa, T.1    Inada, Y.2    Nakano, S.3    Tamura, T.4    Takahashi, T.5    Maruyama, K.6    Yamazaki, Y.7    Kuroda, J.8    Shibata, N.9
  • 61
    • 33845788135 scopus 로고    scopus 로고
    • Intrahepatic insulin resistance in a murine model of steatohepatitis: Effect of PPARgamma agonist pioglitazone
    • Leclercq IA, Lebrun VA, Stärkel P, Horsmans YJ. Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARgamma agonist pioglitazone. Lab Invest 2007; 87: 56-65
    • (2007) Lab Invest , vol.87 , pp. 56-65
    • Leclercq, I.A.1    Lebrun, V.A.2    Stärkel, P.3    Horsmans, Y.J.4
  • 63
    • 33746299139 scopus 로고    scopus 로고
    • High-fat emulsion-induced rat model of nonalcoholic steatohepatitis
    • Zou Y, Li J, Lu C, Wang J, Ge J, Huang Y, Zhang L, Wang Y. High-fat emulsion-induced rat model of nonalcoholic steatohepatitis. Life Sci 2006; 79: 1100-1107
    • (2006) Life Sci , vol.79 , pp. 1100-1107
    • Zou, Y.1    Li, J.2    Lu, C.3    Wang, J.4    Ge, J.5    Huang, Y.6    Zhang, L.7    Wang, Y.8
  • 67
    • 34548565932 scopus 로고    scopus 로고
    • Involvement of sex, strain and age factors in high fat dietinduced obesity in C57BL/6J and BALB/cA mice
    • Nishikawa S, Yasoshima A, Doi K, Nakayama H, Uetsuka K. Involvement of sex, strain and age factors in high fat dietinduced obesity in C57BL/6J and BALB/cA mice. Exp Anim 2007; 56: 263-272
    • (2007) Exp Anim , vol.56 , pp. 263-272
    • Nishikawa, S.1    Yasoshima, A.2    Doi, K.3    Nakayama, H.4    Uetsuka, K.5
  • 71
    • 18244375243 scopus 로고    scopus 로고
    • Fructose-induced fatty liver disease: Hepatic effects of blood pressure and plasma triglyceride reduction
    • Ackerman Z, Oron-Herman M, Grozovski M, Rosenthal T, Pappo O, Link G, Sela BA. Fructose-induced fatty liver disease: hepatic effects of blood pressure and plasma triglyceride reduction. Hypertension 2005; 45: 1012-1018
    • (2005) Hypertension , vol.45 , pp. 1012-1018
    • Ackerman, Z.1    Oron-Herman, M.2    Grozovski, M.3    Rosenthal, T.4    Pappo, O.5    Link, G.6    Sela, B.A.7
  • 72
    • 18844371710 scopus 로고    scopus 로고
    • Thymosin alpha 1 attenuates lipid peroxidation and improves fructose-induced steatohepatitis in rats
    • Armutcu F, Coskun O, Gürel A, Kanter M, Can M, Ucar F, Unalacak M. Thymosin alpha 1 attenuates lipid peroxidation and improves fructose-induced steatohepatitis in rats. Clin Biochem 2005; 38: 540-547
    • (2005) Clin Biochem , vol.38 , pp. 540-547
    • Armutcu, F.1    Coskun, O.2    Gürel, A.3    Kanter, M.4    Can, M.5    Ucar, F.6    Unalacak, M.7
  • 73
    • 70350075402 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice
    • Spruss A, Kanuri G, Wagnerberger S, Haub S, Bischoff SC, Bergheim I. Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. Hepatology 2009; 50: 1094-1104
    • (2009) Hepatology , vol.50 , pp. 1094-1104
    • Spruss, A.1    Kanuri, G.2    Wagnerberger, S.3    Haub, S.4    Bischoff, S.C.5    Bergheim, I.6
  • 75
    • 84856756928 scopus 로고    scopus 로고
    • The role of fructose-enriched diets in mechanisms of nonalcoholic fatty liver disease
    • Nomura K, Yamanouchi T. The role of fructose-enriched diets in mechanisms of nonalcoholic fatty liver disease. J Nutr Biochem 2012; 23: 203-208
    • (2012) J Nutr Biochem , vol.23 , pp. 203-208
    • Nomura, K.1    Yamanouchi, T.2
  • 76
    • 0038643427 scopus 로고    scopus 로고
    • Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice
    • Ip E, Farrell GC, Robertson G, Hall P, Kirsch R, Leclercq I. Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Hepatology 2003; 38: 123-132
    • (2003) Hepatology , vol.38 , pp. 123-132
    • Ip, E.1    Farrell, G.C.2    Robertson, G.3    Hall, P.4    Kirsch, R.5    Leclercq, I.6
  • 77
    • 4644370807 scopus 로고    scopus 로고
    • Lack of peroxisome proliferatoractivated receptor alpha in mice enhances methionine and choline deficient diet-induced steatohepatitis
    • Kashireddy PV, Rao MS. Lack of peroxisome proliferatoractivated receptor alpha in mice enhances methionine and choline deficient diet-induced steatohepatitis. Hepatol Res 2004; 30: 104-110
    • (2004) Hepatol Res , vol.30 , pp. 104-110
    • Kashireddy, P.V.1    Rao, M.S.2
  • 78
    • 11244348954 scopus 로고    scopus 로고
    • A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats
    • Carmiel-Haggai M, Cederbaum AI, Nieto N. A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats. FASEB J 2005; 19: 136-138
    • (2005) FASEB J , vol.19 , pp. 136-138
    • Carmiel-Haggai, M.1    Cederbaum, A.I.2    Nieto, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.