TGF-β1 in liver fibrosis: An inducible transgenic mouse model to study liver fibrogenesis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 276, Issue 4 39-4, 1999, Pages

  Kanzler, Stephan ^a   Lohse, Ansgar W ^a   Keil, Andrea ^a   Henninger, Jürgen ^a   Dienes, Hans P ^b   Schirmacher, Peter ^b   Rose John, Stefan ^a   Meyer Zum Büschenfelde, Karl H ^a   Blessing, Manfred ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

C reactive protein promoter; Collagen I; Stellate cell activation; Transforming growth factor 1

Indexed keywords

COMPLEMENTARY DNA; PROCOLLAGEN; TRANSFORMING GROWTH FACTOR BETA1; C REACTIVE PROTEIN; COLLAGEN; HYBRID PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; COLLAGEN SYNTHESIS; FIBROGENESIS; GENE CONTROL; GENE OVEREXPRESSION; LIVER CELL; LIVER FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; EXPERIMENTAL LIVER CIRRHOSIS; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REGULATORY SEQUENCE;

ANIMALS; C-REACTIVE PROTEIN; COLLAGEN; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; LIPOPOLYSACCHARIDES; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MICE; MICE, TRANSGENIC; PROCOLLAGEN; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033109090     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1999.276.4.g1059     Document Type: Article

References (62)

1. Arrick, B. A., M. Korc, and R. Derynck. Differential regulation of expression of three transforming growth factor beta species in human breast cancer cell lines by estradiol. Cancer Res. 50: 299-303, 1990.
2. Bachem, M. G., D. Meyer, R. Melchior, K. M. Sell, and A. M. Gressner. Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis. J. Clin. Invest. 89: 19-27, 1992.
3. Bachem, M. G., K. M. Sell, R. Melchior, J. Kropf, T. Eller, and A. M. Gressner. Tumor necrosis factor alpha (TNF alpha) and transforming growth factor beta 1 (TGF beta 1) stimulate fibronectin synthesis and the transdifferentiation of fat-storing cells in the rat liver into myofibroblasts. Virchows Arch B Cell Pathol. Incl. Mol. Pathol. 63: 123-130, 1993.
4. Bayer, E. M., W. Herr, S. Kanzler, C. Waldmann, K. H. Meyer zum Büschenfelde, H. P. Dienes, and A. W. Lohse. Transforming growth factor-β in autoimmune hepatitis: correlation of liver tissue expression and systemic levels with disease activity. J. Hepatol. 28: 803-811, 1998.
5. Bedossa, P., and V. Paradis. Transforming growth factor-beta (TGF-beta): a key-role in liver fibrogenesis. J. Hepatol. 22: 37-42, 1995.
6. Bissell, D. M., S. S. Wang, W. R. Jarnagin, and F. J. Roll. Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. J. Clin. Invest. 96: 447-455, 1995.
7. Border, W. A., and N. A. Noble. Transforming growth factor beta in tissue fibrosis. N. Engl. J. Med. 331: 1286-1292, 1994.
8. Brenner, D. A., L. Veloz, R. Jaenisch, and J. M. Alcorn. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. Hepatology 17: 287-292, 1993.
9. Brunner, A. M., M. N. Lioubin, H. Marquardt, A. R. Malacko, W. C. Wang, R. A. Shapiro, M. Neubauer, J. Cook, L. Madisen, and A. F. Purchio. Site-directed mutagenesis of glycosylation sites in the transforming growth factor-beta 1 (TGF beta 1) and TGF beta 2 (414) precursors and of cysteine residues within mature TGF beta 1: effects on secretion and bioactivity. Mol. Endocrinol. 6: 1691-1700, 1992.
10. Brunner, A. M., H. Marquardt, A. R. Malacko, M. N. Lioubin, and A. F. Purchio. Site-directed mutagenesis of cysteine residues in the pro region of the transforming growth factor beta 1 precursor. Expression and characterization of mutant proteins. J. Biol. Chem. 264: 13660-13664, 1989.
11. Castilla, A., J. Prieto, and N. Fausto. Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy. N. Engl. J. Med. 324: 933-940, 1991.
12. Chevallier, M., S. Guerret, P. Chossegros, F. Gerard, and J. A. Grimaud. A histological semiquantitative scoring system for evaluation of hepatic fibrosis in needle liver biopsy specimens: comparison with morphometric studies. Hepatology 20: 349-355, 1994.
13. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
14. Church, G. M., and W. Gilbert. Genomic sequencing. Proc. Natl. Acad. Sci. USA 81: 1991-1995, 1984.
15. Ciliberto, G., R. Arcone, E. F. Wagner, and U. Ruther. Inducible and tissue-specific expression of human C-reactive protein in transgenic mice. EMBO J. 6: 4017-4022, 1987.
16. Clouthier, D. E., S. A. Comerford, and R. E. Hammer. Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice. J. Clin. Invest. 100: 2697-2713, 1997.
17. Czaja, M. J., F. R. Weiner, K. C. Flanders, M. A. Giambrone, R. Wind, L. Biempica, and M. A. Zern. In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis. J. Cell Biol. 108: 2477-2482, 1989.
18. Erroi, A., G. Fantuzzi, M. Mengozzi, M. Sironi, S. F. Orencole, B. D. Clark, C. A. Dinarello, A. Isetta, P. Gnocchi, and M. Giovarelli. Differential regulation of cytokine production in lipopolysaccharide tolerance in mice. Infect. Immun. 61: 4356-4359, 1993.
19. Fournie, G. J., M. G. Minh, M. A. Mignon-Conte, S. Hass, P. H. Lambert, and J. J. Conte. Acceleration of glomerulonephritis in NZB x NZW mice by early immunization with DNA and injection of bacterial lipopolysaccharide. Experimental approach to the treatment of lupus nephritis by use of the accelerated model of NZB x NZW mouse disease. J. Clin. Lab. Immunol. 4: 103-106, 1980.
20. Freudenberg, M. A., and C. Galanos. Induction of tolerance to lipopolysaccharide (LPS)-D-galactosamine lethality by pretreatment with LPS is mediated by macrophages. Infect. Immun. 56: 1352-1357, 1988.
21. Friedman, S. L. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic flbrosis. Mechanisms and treatment strategies. N. Engl. J. Med. 328: 1828-1835, 1993.
22. Greenwel, P., and M. Rojkind. Accelerated development of liver fibrosis in CC14-treated rats by the weekly induction of acute phase response episodes: upregulation of alpha1(I) procollagen and tissue inhibitor of metalloproteinase-1 mRNAs. Biochim. Biophys. Acta 1361: 177-184, 1997.
23. Haas, C., B. Car, B. Ryffel, and M. Le Hir. Lipopolysaccharide-induced glomerulonephritis develops in the absence of interferon-gamma signaling. Exp. Nephrol. 4: 222-230, 1996.
24. Harpel, J. G., C. N. Metz, S. Kojima, and D. B. Rifkin. Control of transforming growth factor-beta activity: latency vs. activation. Prog. Growth Factor Res. 4: 321-335, 1992.
25. Hemsley, A., N. Arnheim, M. D. Toney, G. Cortopassi, and D. J. Galas. A simple method for site-directed mutagenesis using the polymerase chain reaction. Nucleic Acids Res. 17: 6545-6551, 1989.
26. Hogan, B. L. M., F. Costatini, and E. Lacy. Manipulating the Mouse Embryo. A Laboratory Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory, 1986.
27. Ikeda, T., M. N. Lioubin, and H. Marquardt. Human transforming growth factor type beta 2: production by a prostatic adenocarcinoma cell line, purification, and initial characterization. Biochemistry 26: 2406-2410, 1987.
28. Iredale, J. P., G. Murphy, R. M. Hembry, S. L. Friedman, and M. J. Arthur. Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver. J. Clin. Invest. 90: 282-287, 1992.
29. Jakowlew, S. B., J. E. Mead, D. Danielpour, J. Wu, A. B. Roberts, and N. Fausto. Transforming growth factor-beta (TGF-beta) isoforms in rat liver regeneration: messenger RNA expression and activation of latent TGF-beta. Cell Regul. 2: 535-548, 1991.
30. Karkar, A. M., and A. J. Rees. Influence of an established acute phase response on the severity of experimental nephritis. Clin. Exp. Immunol. 98: 295-299, 1994.
31. Kingsley, D. M. The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev. 8: 133-146, 1994.
32. Knittel, T., T. Janneck, L. Muller, P. Fellmer, and G. Ramadori. Transforming growth factor beta 1-regulated gene expression of Ito cells. Hepatology 24: 352-360, 1996.
33. Krull, N. B., T. Zimmermann, and A. M. Gressner. Spatial and temporal patterns of gene expression for the proteoglycans biglycan and decorin and for transforming growth factor-beta 1 revealed by in situ hybridization during experimentally induced liver fibrosis in the rat. Hepatology 18: 581-589, 1993.
34. Kuribayashi-Ohta, K., S. Tamatsukuri, M. Hikata, C. Miyamoto, and Y. Furuichi. Application of oligo(dT)30-latex for rapid purification of poly(A)+ mRNA and for hybrid subtraction with the in situ reverse transcribed cDNA. Biochim. Biophys. Acta 1156: 204-212, 1993.
35. Lyons, R. M., and H. L. Moses. Transforming growth factors and the regulation of cell proliferation. Eur. J. Biochem. 187: 467-473, 1990.
36. Massague, J. The transforming growth factor-beta family. Annu. Rev. Cell Biol. 6: 597-641, 1990.
37. Meyer, D. H., M. G. Bachem, and A. M. Gressner. Modulation of hepatic lipocyte proteoglycan synthesis and proliferation by Kupffer cell-derived transforming growth factors type beta 1 and type alpha. Biochem. Biophys. Res. Commun. 171: 1122-1129, 1990.
38. Milani, S., H. Herbst, D. Schuppan, C. Grappone, G. Pellegrini, M. Pinzani, A. Casini, A. Calabro, G. Ciancio, F. Stefanini, A. K. Burroughs, and C. Surrenti. Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am. J. Pathol. 144: 528-537, 1994.
39. Milani, S., H. Herbst, D. Schuppan, H. Stein, and C. Surrenti. Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease. Am. J. Pathol. 139: 1221-1229, 1991.
40. Miwa, Y., P. M. Harrison, F. Farzaneh, P. G. Langley, R. Williams, and R. D. Hughes. Plasma levels and hepatic mRNA expression of transforming growth factor-beta1 in patients with fulminant hepatic failure. J. Hepatol. 27: 780-788, 1997.
41. Murphy, C., J. Beckers, and U. Ruther. Regulation of the human C-reactive protein gene in transgenic mice. J. Biol. Chem. 270: 704-708, 1995.
42. Overall, C. M., J. L. Wrana, and J. Sodek. Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J. Biol. Chem. 264: 1860-1869, 1989.
43. Pepys, M. B. C-reactive protein: the role of an ancient protein in modern rheumatology. Clin. Exp. Rheumatol. 1: 3-7, 1983.
44. Poliard, A., G. Feldmann, and D. Bernuau. Alpha fetoprotein and albumin gene transcripts are detected in distinct cell populations of the brain and kidney of the developing rat. Differentiation 39: 59-65, 1988.
45. Randow, F., U. Syrbe, C. Meisel, D. Krausch, H. Zuckermann, C. Platzer, and H. D. Volk. Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta. J. Exp. Med. 181: 1887-1892, 1995.
46. Roberts, A. B., U. I. Heine, K. C. Flanders, and M. B. Sporn. Transforming growth factor-beta. Major role in regulation of extracellular matrix. Ann. NY Acad. Sci. 580: 225-232, 1990.
47. Roberts, A. B., and M. B. Sporn. Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta). Growth Factors 8: 1-9, 1993.
48. Rosenbaum, J., and S. Blazejewski. Regulation of Ito cell proliferation by soluble factors. J. Hepatol. 22: 65-70, 1995.
49. Roulot, D., H. Durand, T. Coste, J. Rautureau, A. D. Strosberg, R. Benarous, and S. Marullo. Quantitative analysis of transforming growth factor beta 1 messenger RNA in the liver of patients with chronic hepatitis C: absence of correlation between high levels and severity of disease. Hepatology 21: 298-304, 1995.
50. Rüther, U., C. Woodroofe, E. Fattori, and G. Ciliberto. Inducible formation of liver tumors in transgenic mice. Oncogene 8: 87-93, 1993.
51. Samuel, S. K., R. A. Hurta, P. Kondaiah, N. Khalil, E. A. Turley, J. A. Wright, and A. H. Greenberg. Autocrine induction of tumor protease production and invasion by a metallothionein-regulated TGF-beta 1 (Ser223, 225). EMBO J. 11: 1599-1605, 1992.
52. Sanchez-Cantu, L., H. N. Rode, and N. V. Christou. Endotoxin tolerance is associated with reduced secretion of tumor necrosis factor. Arch. Surg. 124: 1432-1435, 1989.
53. Sanderson, N., V. Factor, P. Nagy, J. Kopp, P. Kondaiah, L. Wakefield, A. B. Roberts, M. B. Sporn, and S. S. Thorgeirsson. Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc. Natl. Acad. Sci. USA 92: 2572-2576, 1995.
54. Sato, Y., R. Tsuboi, R. Lyons, H. Moses, and D. B. Rifkin. Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system. J. Cell Biol. 111: 757-763, 1990.
55. Sell, S., M. A. Longley, and J. Boulter. alpha-Fetoprotein and albumin gene expression in brain and other tissues of fetal and adult rats. Brain Res. 354: 49-53, 1985.
56. Sharpies, K., G. D. Plowman, T. M. Rose, D. R. Twardzik, and A. F. Purchio. Cloning and sequence analysis of simian transforming growth factor-beta cDNA. DNA (NY) 6: 239-244, 1987.
57. Short, M. K., D. E. Clouthier, I. M. Schaefer, R. E. Hammer, M.A. Magnuson, andE. G. Beale. Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice. Mol. Cell. Biol. 12: 1007-1020, 1992.
58. Weigle, W. O., L. C. Gahring, C. G. Romball, and M. G. Goodman. The effect of lipopolysaccharide desensitization on the regulation of in vivo induction of immunologic tolerance and antibody production and in vitro release of IL-1. J. Immunol. 142: 1107-1113, 1989.
59. Weinhold, B., and U. Rüther. Interleukin-6-dependent and -independent regulation of the human C-reactive protein gene. Biochem. J. 327: 425-429, 1997.
60. Whitehead, A. S., G. A. Bruns, A. F. Markham, H. R. Colten, and D. E. Woods. Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1. Science 221: 69-71, 1983.
61. Whitehead, A. S., K. Zahedi, M. Rits, R. F. Mortensen, and J. M. Leilas. Mouse C-reactive protein. Generation of cDNA clones, structural analysis, and induction of mRNA during inflammation. Biochem. J. 266: 283-290, 1990.
62. Wrana, J. L., L. Attisano, R. Wieser, F. Ventura, and J. Massague. Mechanism of activation of the TGF-beta receptor. Nature 370: 341-347, 1994.