Animal models for the study of HBV replication and its variants

Journal of Clinical Virology

Volumn 34, Issue SUPPL. 1, 2005, Pages

  Dandri, M ^a   Volz, T K ^a   Lutgehetmann M ^a   Petersen, J ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

HBV; Hepadnaviruses; SCID; Transgenic mice; uPA mice

Indexed keywords

BIOLOGICAL MODEL; CHIMERA; CHIMPANZEE; DISEASE MODEL; EXPERIMENTAL ANIMAL; FOWL; HEPADNAVIRUS; HEPATITIS B; HEPATITIS B VIRUS; MAMMAL; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SCANDENTIA; TRANSGENE; VIRUS PATHOGENESIS; VIRUS REPLICATION;

EID: 32044433759     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6532(05)80011-3     Document Type: Article

References (120)

1. Aguesse-Germon S., and Liu S.H. Inhibitory effect of 2′-fluoro-5- methyl-beta-L-arabinofuranosyl-uracil on duck hepatitis B virus replication Antimicrob Agents Chemother 42 2 1998 369 376
2. Ando K., and Moriyama T. Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis J Exp Med 178 5 1993 1541 1554
3. Ando K., and Guidotti L.G. Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo J Immunol 152 7 1994 3245 3253
4. Barker L.F., and Chisari F.V. Transmission of type B viral hepatitis to chimpanzees J Infect Dis 127 6 1973 648 662
5. Baron J.L., and Gardiner L. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection Immunity 16 4 2002 583 594
6. Baumert T.F., and Yang C. Hepatitis B virus mutations associated with fulminant hepatitis induce apoptosis in primary Tupaia hepatocytes Hepatology 41 2 2005 247 456
7. Berthelot P., and Courouce A.M. Hepatitis B vaccine safety monitoring in the chimpanzee: interpretation of results J Med Primatol 13 3 1984 119 133
8. Bertoni R., and Sette A. Human class I supertypes and CTL repertoires extend to chimpanzees J Immunol 161 8 1998 4447 4455
9. Block T.M., and Lu X. Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking Nat Med 4 5 1998 610 614
10. Bocher W.O., and Galun E. Reduced hepatitis B virus surface antigenspecific Thl helper cell frequency of chronic HBV carriers is associated with a failure to produce antigen-specific antibodies in the trimera mouse [In Process Citation] Hepatology 31 2 2000 480 487
11. Bouchard M.J., and Wang L.H. Calcium signaling by HBx protein in hepatitis B virus DNA replication Science 294 5550 2001 2376 2378
12. Breiner K.M., and Urban S. Envelope protein-mediated down-regulation of hepatitis B virus receptor in infected hepatocytes J Virol 75 1 2001 143 150
13. Brown J.J., and Parashar B. A long-term hepatitis B viremia model generated by transplanting nontumorigenic immortalized human hepatocytes in Rag-2-deficient mice Hepatology 31 1 2000 173 181
14. Buendia M.A. Hepatitis B viruses and hepatocellular carcinoma Adv Cancer Res 59 1992 167 226
15. Buendia M.A. Hepatitis B viruses and cancerogenesis Biomed Pharmacother 52 1 1998 34 43
16. Caselmann W.H. HBV and HDV replication in experimental models: effect of interferon Antiviral Res 24 2-3 1994 121 129
17. Chang S.F., and Netter H.J. A new avian hepadnavirus infecting snow geese (Anser caerulescens) produces a significant fraction of virions containing single-stranded DNA Virology 262 1 1999 39 54
18. Chisad F.V., and Pinkert C.A. A transgenic mouse model of the chronic hepatitis B surface antigen carrier state Science 230 4730 1985 1157 1160
19. Chisari F.V., and Filippi P. Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice J Virol 60 3 1986 880 887
20. Colledge D., and Civitico G. In vitro antihepadnaviral activities of combinations of penciclovir, lamivudine, and adefovir [In Process Citation] Antimicrob Agents Chemother 44 3 2000 551 560
21. Cote P.J., and Gerin J.L. In vitro activation of woodchuck lymphocytes measured by radiopurine incorporation and interleukin-2 production: implications for modeling immunity and therapy in hepatitis B virus infection Hepatology 22 3 1995 687 699
22. Cote P.J., and Korba B.E. Effects of age and viral determinants on chronicity as an outcome of experimental woodchuck hepatitis virus infection Hepatology 31 1 2000 190 200
23. Cullen J.M., and Li D.H. Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks Antimicrob Agents Chemother 45 10 2001 2740 2745
24. Dandri M., and Schirmacher P. Woodchuck hepatitis virus X protein is present in chronically infected woodchuck liver and woodchuck hepatocellular carcinomas which are permissive for viral replication J Virol 70 8 1996 5246 5254
25. Dandri M., and Petersen J. Metabolic labeling of woodchuck hepatitis B virus X protein in naturally infected hepatocytes reveals a bimodal halflife and association with the nuclear framework J Virol 72 11 1998 9359 9364
26. Dandri M., and Burda M.R. Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA Hepatology 32 1 2000 139 146
27. (4 Pt 1) Dandri M., and Burda M.R. Woodchuck hepatocytes remain permissive for hepadnavirus infection and mouse liver repopulation after cryopreservation Hepatology 34 2001 824 833
28. Dandri M., and Burda M.R. Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus Hepatology 33 4 2001 981 988
29. Dandri M., and Burda M.R. Chronic infection with hepatitis B viruses and antiviral drug evaluation in uPA mice after liver repopulation with tupaia hepatocytes J Hepatol 42 1 2005 54 60
30. Delmas J., and Schorr O. Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro Antimicrob Agents Chemother 46 2 2002 425 433
31. Dunsford H.A., and Sell S. Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice Cancer Res 50 11 1990 3400 3407
32. Eren R., and Ilan E. Preclinical evaluation of two human antihepatitis B virus (HBV) monoclonal antibodies in the HBV-trimera mouse model and in HBV chronic carrier chimpanzees Hepatology 32 3 2000 588 596
33. Farza H., and Hadchouel M. Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genome J Virol 62 11 1988 4144 4152
34. Feitelson M.A., and Millman I. A newly identified hepatitis B type virus in tree squirrels Proc Natl Acad Sci USA 83 1986 2233 2237
35. Fujisawa Y., and Kuroda S. Protective efficacy of a novel hepatitis B vaccine consisting of M (pre-S2+S) protein particles (a third generation vaccine) Vaccine 8 3 1990 192 198
36. Galibert F., and Chen T.N. Nucleotide sequence of a cloned woodchuck hepatitis virus genome: comparison with the hepatitis B virus sequence J Virol 41 1 1982 51 65
37. Galle P.R., and Hagelstein J. In vitro experimental infection of primary human hepatocytes with hepatitis B virus Gastroenterology 106 3 1994 664 673
38. Ganem D. Hepadnaviridae and their replication Fields B.N. Knipe D.N. Howley P.M. Virology Vol. 2 1996 Lippincott-Raven Philadelphia, PA 2703 2739
39. Ganem D., and Greenbaum L. Virion DNA of ground squirrel hepatitis virus: structural analysis and molecular cloning J Virol 44 1 1982 374 383
40. Ganem D., and Weiser B. Biological characterization of acute infection with ground squirrel hepatitis virus J Virol 44 1 1982 366 373
41. Gong S.S., and Jensen A.D. Loss and acquisition of duck hepatitis B virus integrations in lineages of LMH-D2 chicken hepatoma cells J Virol 70 3 1996 2000 2007
42. Gong S.S., and Jensen A.D. Double-stranded linear duck hepatitis B virus (DHBV) stably integrates at a higher frequency than wild-type DHBV in LMH chicken hepatoma cells J Virol 73 2 1999 1492 1502
43. Gripon P., and Diot C. Reproducible high level infection of cultured adult human hepatocytes by hepatitis B virus: effect of polyethylene glycol on adsorption and penetration Virology 192 2 1993 534 540
44. 24 Gripon P., and Rumin S. Infection of a human hepatoma cell line by hepatitis B virus Proc Natl Acad Sci USA 99 2002 15655 15660
45. Guidotti L.G., and Guilhot S. Interleukin-2 and alpha/beta interferon down-regulate hepatitis B virus gene expression in vivo by tumor necrosis factor-dependent and independent pathways J Virol 68 3 1994 1265 1270
46. Guidotti L.G., and Matzke B. High-level hepatitis B virus replication in transgenic mice J Virol 69 10 1995 6158 6169
47. Guidotti L.G., and Ishikawa T. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes Immunity 4 1 1996 25 36
48. Guidotti L.G., and Matzke B. The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice J Virol 70 10 1996 7056 7061
49. Guidotti L.G., and Rochford R. Viral clearance without destruction of infected cells during acute HBV infection Science 284 5415 1999 825 829
50. Guo J.T., and Zhou H. Apoptosis and regeneration of hepatocytes during recovery from transient hepadnavirus infections J Virol 74 3 2000 1495 1505
51. Gupta S., and Bhargava K.K. Mechanisms of cell engraftment during liver repopulation with hepatocyte transplantation Semin Liver Dis 19 1 1999 15 26
52. Heise T., and Guidotti L.G. Hepatitis B virus RNA-binding proteins associated with cytokine-induced clearance of viral RNA from the liver of transgenic mice J Virol 73 1 1999 474 481
53. Ilan E., and Burakova T. The hepatitis B virus-trimera mouse: a model for human HBV infection and evaluation of anti-HBV therapeutic agents Hepatology 29 2 1999 553 562
54. Isogawa M., and Kakimi K. Differential dynamics of the peripheral and intrahepatic cytotoxic T lymphocyte response to hepatitis B surface antigen Virology 333 2 2005 293 300
55. Iwarson S., and Tabor E. Protection against hepatitis B virus infection by immunization with hepatitis B core antigen Gastroenterology 88 3 1985 763 767
56. Kim C.M., and Koike K. HBx gene of hepatitis B virus induces liver cancer in transgenic mice Nature 351 6324 1991 317 320
57. Kock J., and Schlicht H.J. Analysis of the earliest steps of hepadnavirus replication: genome repair after infectious entry into hepatocytes does not depend on viral polymerase activity J Virol 67 8 1993 4867 4874
58. Kock J., and Nassal M. Efficient infection of primary tupaia hepatocytes with purified human and woolly monkey hepatitis B virus J Virol 75 11 2001 5084 5089
59. Koike K., and Moriya K. High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice Hepatology 19 4 1994 810 819
60. Korba B.E., and Cote P. Treatment of chronic woodchuck hepatitis virus infection in the Eastern woodchuck (Marmota monax) with nucleoside analogues is predictive of therapy for chronic hepatitis B virus infection in humans Hepatology 31 5 2000 1165 1175
61. Korba B.E., and Cote P.J. Clevudine therapy with vaccine inhibits progression of chronic hepatitis and delays onset of hepatocellular carcinoma in chronic woodchuck hepatitis virus infection Antivir Ther 9 6 2004 937 952
62. Lanford R.E., and Chavez D. Isolation of a hepadnavirus from the woolly monkey, a New World primate Proc Natl Acad Sci USA 95 1998 5757 5761
63. Lanford R.E., and Chavez D. Hepadnavirus infection in captive gibbons [In Process Citation] J Virol 74 6 2000 2955 2959
64. Larkin J., and Clayton M. Hepatitis B virus transgenic mouse model of chronic liver disease Nat Mad 5 8 1999 907 912
65. Lenhoff R.J., and Luscombe C.A. Acute liver injury following infection with a cytopathic strain of duck hepatitis B virus Hepatology 29 2 1999 563 571
66. Lin E., and Luscombe C. Long-term therapy with the guanine nucleoside analog penciclovir controls chronic duck hepatitis B virus infection in vivo Antimicrob Agents Chemother 42 8 1998 2132 2137
67. Luscombe C., and Pedersen J. Long-term ganciclovir chemotherapy for congenital duck hepatitis B virus infection in vivo: effect on intrahepatic-viral DNA, RNA, and protein expression Hepatology 24 4 1996 766 773
68. Mandart E., and Kay A. Nucleotide sequence of a cloned duck hepatitis B virus genome: comparison with woodchuck and human hepatitis B virus sequences J Virol 49 3 1984 782 792
69. Marion P.L., and Oshiro L.S. A virus in Beechey ground squirrels that is related to hepatitis B virus of humans Proc Natl Acad Sci USA 77 1980 2941 2945
70. Mason W.S., and Seal G. Virus ofPekin ducks with structural and biological relatedness to human hepatitis B virus J Virol 36 3 1980 829 836
71. Mason W.S., and Aldrich C. Asymmetric replication of duck hepatitis B virus DNA in liver cells: Free minus-strand DNA Proc Natl Acad Sci USA 79 1982 3997 4001
72. Mason W.S., and Cullen J. Characterization of the antiviral effects of 2′ carbodeoxyguanosine in ducks chronically infected with duck hepatitis B virus Hepatology 19 2 1994 398 411
73. Mason W.S., and Cullen J. Lamivudine therapy of WHV-infected woodchucks Virology 245 1 1998 18 32
74. Menne S., and Maschke J. T-Cell response to woodchuck hepatitis virus (WHY) antigens during acute self-limited WHY infection and convalescence and after viral challenge J Virol 72 7 1998 6083 6091
75. Mercer D.F., and Schiller D.E. Hepatitis C virus replication in mice with chimeric human livers Nat Med 7 8 2001 927 933
76. Mignon A., and Guidotti J.E. Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes Nat Med 4 10 1998 1185 1188
77. Millman I., and Southam L. Woodchuck hepatitis virus: experimental infection and natural occurrence Hepatology 4 5 1984 817 823
78. Moraleda G., and Saputelli J. Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus J Virol 71 12 1997 9392 9399
79. Moriyama T., and Guilhot S. Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice Science 248 4953 1990 361 364
80. Ogata N., and Cote P.J. Licensed recombinant hepatitis B vaccines protect chimpanzees against infection with the prototype surface gene mutant of hepatitis B virus Hepatology 30 3 1999 779 786
81. Ohashi K., and Marion P.L. Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses Nat Med 6 3 2000 327 331
82. Ohmura T., and Ohmizu A. Properties of recombinant hepatitis B vaccine Biochem Biophys Res Commun 149 3 1987 1172 1178
83. [see comments] [published erratum appears in Nat Genet 1996 Apr;12(4):458] Overturf K., and Al-Dhalimy M. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I Nat Genet 12 3 1996 266 273
84. Petersen J., and Dandri M. Increase in the frequency of hepadnavirus DNA integrations by oxidative DNA damage and inhibition of DNA repair J Virol 71 7 1997 5455 5463
85. Petersen J., and Dandri M. Liver repopulation with xenogenic hepatocytes in B and T cell-deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma Proc Natl Acad Sci USA 95 1998 310 315
86. Pillot J. Primates in the study of hepatitis viruses Pathol Biol (Paris) 38 3 1990 177 181
87. Purcell R.H. Does non-A, non-B hepatitis cause hepatocellular carcinoma? Cancer Detect Prev 14 2 1989 203 207
88. Purcell R.H., and Satterfield W.C. Experimental hepatitis delta virus infection in the chimpanzee Prog Clin Biol Res 234 1987 27 36
89. Rhim J.A., and Sandgren E.P. Replacement of diseased mouse liver by hepatic cell transplantation Science 263 5150 1994 1149 1152
90. Roggendorf M., and Tolle T.K. The woodchuck: an animal model for hepatitis B virus infection in man Intervirology 38 1-2 1995 100 112
91. Sandgren E.P., and Palmiter R.D. Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene Cell 66 2 1991 245 256
92. Schuster R., and Hildt E. Conserved transactivating and pro-apoptotic functions of hepadnaviral X protein in ortho- and avihepadnaviruses Oncogene 21 43 2002 6606 6613
93. Sells M.A., and Chen M.L. Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA Proc Natl Acad Sci USA 84 1987 1005 1009
94. Shikata T., and Karasawa T. Two distinct types of hepatitis in experimental hepatitis B virus infection Am J Pathol 99 2 1980 353 367
95. Shinkai Y., and Rathbun G. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement Cell 68 5 1992 855 867
96. Shouval D. The role of the chimpanzee in research Eder G. Kaiser E. King F.A. The Role of the Chimpanzee in Research 1994 Karger Philadelphia, PA 175 179
97. Shouval D., and Chakraborty P.R. Chronic hepatitis in chimpanzee carriers of hepatitis B virus: morphologic, immunologic, and viral DNA studies Proc Natl Acad Sci USA 77 1980 6147 6151
98. Sitia G., and Isogawa M. MMPs are required for recruitment of antigennonspecific mononuclear cells into the liver by CTLs J Clin Invest 113 8 2004 1158 1167
99. Slagle B.L., and Lee T.H. Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene Mol Carcinog 15 4 1996 261 269
100. Sprengel R., and Kaleta E.F. Isolation and characterization of a hepatitis B virus endemic in herons J Virol 62 10 1988 3832 3839
101. Sprinzl M.F., and Oberwinkler H. Transfer of hepatitis B virus genome by adenovirus vectors into cultured cells and mice: crossing the species barrier J Virol 75 11 2001 5108 5118
102. Summers J. The replication cycle of hepatitis B viruses Cancer 61 10 1988 1957 1962
103. Summers J., and Smolec J.M. A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks Proc Natl Acad Sci USA 75 1978 4533 4537
104. Takahashi K., and Brotman B. Full-genome sequence analyses of hepatitis B virus (HBV) strains recovered from chimpanzees infected in the wild: implications for an origin of HBV Virology 267 1 2000 58 64
105. Tennant B.C., and Mrosovsky N. Hepatocellular carcinoma in Richardson's ground squirrels (Spermophilus richardsonii): evidence for association with hepatitis B-like virus infection Hepatology 13 6 1991 1215 1221
106. Tennant B.C., and Baldwin B.H. Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection Hepatology 28 1 1998 179 191
107. 5 Tennant B.C., and Toshkov I.A. Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection Gastroenterology 127 Suppl 1 2004 S283 S293
108. Testut P., and Renard C.A. A new hepadnavirus endemic in arctic ground squirrels in Alaska J Virol 70 7 1996 4210 4219
109. Ueda H., and Ullrich S.J. Functional inactivation but not structural mutation of p53 causes liver cancer Nat Genet 9 1 1995 41 47
110. Urban S. Binding of duck carboxypeptidase D to duck hepatitis B virus Methods Mol Med 95 2004 199 212
111. von Weizsacker F., and Kock J. The tupaia model for the study of hepatitis B virus: direct infection and HBV genome transduction of primary tupaia hepatocytes Methods Mol Med 96 2004 153 161
112. Walter E., and Keist R. Hepatitis B virus infection of tupaia hepatocytes in vitro and in vivo Hepatology 24 1 1996 1 5
113. Warren K.S., and Heeney J.L. A new group of hepadnaviruses naturally infecting orangutans (Pongo pygmaeus) J Virol 73 9 1999 7860 7865
114. Will H., and Cattaneo R. Cloned HBV DNA causes hepatitis in chimpanzees Nature 299 5885 1982 740 742
115. Wu C.H., and Ouyang E.C. Human hepatocytes transplanted into genetically immunocompetent rats are susceptible to infection by hepatitis B virus in situ J Viral Hepat 8 2 2001 111 119
116. Yan R.Q., and Su J.J. Human hepatitis B virus and hepatocellular carcinoma. I. Experimental infection of tree shrews with hepatitis B virus J Cancer Res Clin Oncol 122 5 1996 283 288
117. Yan R.Q., and Su J.J. Human hepatitis B virus and hepatocellular carcinoma. II. Experimental induction of hepatocellular carcinoma in tree shrews exposed to hepatitis B virus and aflatoxin B1 J Cancer Res Clin Oncol 122 5 1996 289 295
118. Yang P.L., and Althage A. Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection Proc Natl Acad Sci USA 99 2002 13825 13830
119. Zhang Z., and Protzer U. Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner J Virol 78 9 2004 4566 4572
120. Zoulim F., and Saputelli J. Woodchuck hepatitis virus X protein is required for viral infection in vivo J Virol 68 3 1994 2026 2030