Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses

Gastroenterology

Volumn 127, Issue 4, 2004, Pages 1189-1197

  Takehara, Tetsuo ^a   Tatsumi, Tomohide ^a   Suzuki, Takahiro ^a   Rucker III, Edmund B ^b   Hennighausen, Lothar ^c   Jinushi, Masahisa ^a   Miyagi, Takuya ^a   Kanazawa, Yoshiyuki ^a   Hayashi, Norio ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF MISSOURI   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL XL; TRANSFORMING GROWTH FACTOR BETA;

ALLELE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ISOLATION; FEMALE; LIVER FIBROSIS; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 5144232785     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2004.07.019     Document Type: Article

References (32)

1. P.R. Bar Apoptosis--the cell's silent exit Life Sci 59 1996 369 378
2. P.R. Galle, W.J. Hofmann, H. Walczak, H. Schaller, G. Otto, W. Stremmel, P.H. Krammer, L. Runkel Involvement of the CD95 (Apo-1/Fas) receptor and ligand in liver damage J Exp Med 182 1995 1223 1230
3. A.E. Feldstein, A. Canbay, P. Angulo, M. Taniai, L.J. Burgart, K.D. Lindor, G.J. Gores Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis Gastroenterology 125 2003 437 443
4. B.D. Uhal, I. Joshi, W.F. Hughes, C. Ramos, A. Pardo, M. Selman Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung Am J Physiol 275 1998 L1192 L1199
5. T. Takehara, X. Liu, J. Fujimoto, S.L. Friedman, H. Takahashi Expression and role of Bcl-xL in human hepatocellular carcinomas Hepatology 34 2001 55 61
6. S.P. Tzung, N. Fausto, D.M. Hockenbery Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene Am J Pathol 150 1997 1985 1995
7. K. Kovalovich, W. Li, R. DeAngelis, L.E. Greenbaum, G. Ciliberto, R. Taub Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2 and Bcl-xL J Biol Chem 276 2001 26605 26613
8. N. Motoyama, F. Wang, K.A. Roth, H. Sawa, K. Nakayama, K. Nakayama, I. Negishi, S. Senju, Q. Zhang, S. Fujii, D.Y. Loh Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice Science 267 1995 1506 1510
9. E.B. Rucker III, P. Dierisseau, K.U. Wagner, L. Garrett, A. Wynshaw-Boris, J.A. Flaws, L. Hennighausen Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis Mol Endocrinol 14 2000 1038 1052
10. C. Postic, M. Shiota, K.D. Niswender, T.L. Jetton, Y. Chen, J.M. Moates, K.D. Shelton, J. Lindner, A.D. Cherrington, M.A. Magnuson Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase J Biol Chem 274 1999 305 315
11. E. Song, S.K. Lee, J. Wang, N. Ince, N. Ouyang, J. Min, J. Chen, P. Shankar, J. Lieberman RNA interference targeting Fas protects mice from fulminant hepatitis Nat Med 9 2003 347 351
12. Y. Kanegae, G. Lee, Y. Sato, M. Tanaka, M. Nakai, T. Sakaki, S. Sugano, I. Saito Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase Nucleic Acids Res 23 1995 3816 3821
13. T. Takehara, H. Takahashi Suppression of Bcl-xL deamidation in human hepatocellular carcinomas Cancer Res 63 2003 3054 3057
14. M.A. Morsy, E.L. Alford, A. Bett, F.L. Graham, C.T. Caskey Efficient adenoviral-mediated ornithine transcarbamylase expression in deficient mouse and human hepatocytes J Clin Invest 92 1993 1580 1586
15. S.L. Friedman Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury J Biol Chem 275 2000 2247 2250
16. N. Sanderson, V. Factor, P. Nagy, J. Kopp, P. Kondaiah, L. Wakefield, A.B. Roberts, M.B. Sporn, S.S. Thorgeirsson Hepatic expression of mature transforming growth factor β1 in transgenic mice results in multiple tissue lesions Proc Natl Acad Sci U S A 92 1995 2572 2576
17. S. Kanzler, A.W. Lohse, A. Keil, J. Henninger, H.P. Dienes, P. Schirmacher, S. Rose-John, K.H. zum Buschenfelde, M. Blessing TGF-β1 in liver fibrosis an inducible transgenic mouse model to study liver fibrogenesis Am J Physiol 276 1999 G1059 G1068
18. B.L. McVicker, D.J. Tuma, J.A. Kubik, A.M. Hindemith, C.R. Baldwin, C.A. Casey The effect of ethanol on asialoglycoprotein receptor-mediated phagocytosis of apoptotic cells by rat hepatocytes Hepatology 36 2002 1478 1487
19. L. Gibson, S.P. Holmgreen, D.C. Huang, O. Bernard, N.G. Copeland, N.A. Jenkins, G.R. Sutherland, E. Baker, J.M. Adams, S. Cory bcl-w, a novel member of the bcl-2 family, promotes cell survival Oncogene 13 1996 665 675
20. J.R. Chao, J.M. Wang, S.F. Lee, H.W. Peng, Y.H. Lin, C.H. Chou, J.C. Li, H.M. Huang, C.K. Chou, M.L. Kuo, J.J. Yen, H.F. Yang-Yen mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response Mol Cell Biol 18 1998 4883 4898
21. S. Cory, D.C. Huang, J.M. Adams The Bcl-2 family roles in cell survival and oncogenesis Oncogene 22 2003 8590 8607
22. N. Hagimoto, K. Kuwano, H. Miyazaki, R. Kunitake, M. Fujita, M. Kawasaki, Y. Kaneko, N. Hara Induction of apoptosis and pulmonary fibrosis in mice in response to ligation of Fas antigen Am J Respir Cell Mol Biol 17 1997 272 278
23. K. Kuwano, N. Hagimoto, M. Kawasaki, T. Yatomi, N. Nakamura, S. Nagata, T. Suda, R. Kunitake, T. Maeyama, H. Miyazaki, N. Hara Essential role of the Fas-Fas ligand pathway in the development of pulmonary fibrosis J Clin Invest 104 1999 13 19
24. A. Canbay, H. Higuchi, S.F. Bronk, M. Taniai, T.J. Sebo, G.J. Gores Fas enhances fibrogenesis in the bile duct ligated mouse a link between apoptosis and fibrosis Gastroenterology 123 2002 1323 1330
25. H.A. Chapman A Fas pathway to pulmonary fibrosis J Clin Invest 104 1999 1 2
26. A. Janin, C. Deschaumes, M. Daneshpouy, J. Estaquier, J. Micic-Polianski, P. Rajagopalan-Levasseur, K. Akarid, N. Mounier, E. Gluckman, G. Socie, J.C. Ameisen CD95 engagement induces disseminated endothelial cell apoptosis in vivo immunopathologic implications Blood 99 2002 2940 2947
27. Z. Shi, A.E. Wakil, D.C. Rockey Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses Proc Natl Acad Sci U S A 94 1997 10663 10668
28. P.L. Cohen, R.A. Eisenberg Lpr and gld single gene models of systemic autoimmunity and lymphoproliferative disease Annu Rev Immunol 9 1991 243 269
29. V.A. Fadok, D.L. Bratton, A. Konowal, P.W. Freed, J.W. Westcott, P.M. Henson Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF J Clin Invest 101 1998 890 898
30. M.L.N. Huynh, V.A. Fadok, P.M. Henson Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and resolution of inflammation J Clin Invest 109 2002 41 50
31. A. Canbay, P. Taimr, N. Torok, H. Higuchi, S. Friedman, G.J. Gores Apoptotic body engulfment by a human stellate cell line is profibrogenic Lab Invest 83 2003 655 663
32. S. Natori, C. Rust, L.M. Stadheim, A. Srinivasan, L.J. Burgart, G.J. Gores Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis J Hepatol 34 2001 248 253