Development of Humanized Mice for the Study of Hepatitis C Virus Infection

Transplantation Proceedings

Volumn 38, Issue 4, 2006, Pages 1181-1184

  Turrini, P ^a   Sasso, R ^a   Germoni, S ^a   Marcucci, I ^a   Celluci, A ^a   Di Marco, A ^a   Marra, E ^a   Paonessa, G ^a   Eutropi, A ^a   Laufer, R ^a   Migliaccio, G ^a   Padron, J ^a  

^a IRBM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN;

ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH; CHIMERA; DEVELOPMENTAL STAGE; GENETIC DISORDER; GENOME; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; IMMUNE DEFICIENCY; LIVER CELL; LIVER DISEASE; MICROSURGERY; MORPHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERUM; STEM CELL; VIREMIA; VIRUS INFECTION; XENOTRANSPLANTATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIVIRAL AGENTS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; HEPATITIS C; HEPATOCYTES; HUMANS; LIVER DISEASES; LIVER NEOPLASMS; MICE; MICE, SCID; MICE, TRANSGENIC; SERUM ALBUMIN; TRANSPLANTATION, HETEROLOGOUS; URINARY PLASMINOGEN ACTIVATOR;

EID: 33744533583     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2006.02.149     Document Type: Article

References (14)

1. Törnell J., and Snaith M. Transgenic systems in drug discovery. from target identification to humanized mice. Drug Discov Today 7 (2002) 461
2. Bolon B. Genetically engineered animals in drug discovery and development:amaturing resource for toxicologic research. Basic & Clinical Pharmacology & Toxicology 95 (2004) 154
3. Labonte P., Morin N., Bowlin T., et al. Basal replication of hepatitis C virus in nude mice harboring human tumor. J Med Virol 66 (2002) 312
4. Rhim J.A., Sandgren E.P., Palmiter R.D., et al. Complete reconstitution of mouse liver with xenogeneic hepatocytes. Proc Natl Acad Sci U S A 92 (1995) 4942
5. Zhang Y., Huang S.Z., Wang S., et al. Development of an HSV-tk transgenic mouse model for study of liver damage. FEBS J 272 (2005) 2207
6. Dieter M.Z., Freshwater S.L., Miller M.L., et al. Pharmacological rescue of the 14CoS/14CoS mouse. hepatocyte apoptosis is likely caused by endogenous oxidative stress. Free Radic Biol Med 35 (2003) 351
7. Grompe M. The pathophysiology and treatment of hereditary tyrosinemia type 1. Semin Liver Dis 21 (2001) 563
8. Brown J.J., Parashar B., Moshage H., et al. A long-term hepatitis B viremia model generated by transplanting nontumorigenic immortalized human hepatocytes in Rag-2-deficient mice. Hepatology 31 (2000) 173
9. Willenbring H., Bailey A.S., Foster M., et al. Myelomonocytic cells are sufficient for therapeutic cell fusion in liver. Nat Med 10 (2004) 744
10. Sharma A.D., Cantz T., Richter R., et al. Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver. Am J Pathol 167 (2005) 555
11. Mercer D.F., Schiller D.E., Elliott J.F., et al. Hepatitis C virus replication in mice with chimeric human livers. Nat Med 7 (2001) 927
12. Meuleman P., Libbrecht L., De Vos R., et al. Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera. Hepatology 41 (2005) 847
13. Tateno C., Yoshizane Y., Saito N., et al. Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am J Pathol 165 (2004) 901
14. Turrini P., Monego G., Gonzalez J., et al. Human hepatocytes in mice receiving pre-immune injections with human cord blood cells. Biochem Biophys Res Commun 326 (2005) 66