Fructose at the center of necroinflammation and fibrosis in nonalcoholic steatohepatitis

Hepatology

Volumn 53, Issue 1, 2011, Pages 372-373

  Alisi, Anna ^a   Manco, Melania ^a   Pezzullo, Marco ^a   Nobili, Valerio ^a  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; CYTOKINE; FRUCTOSE; LIPID; SUPEROXIDE;

COENZYME; DISEASE ASSOCIATION; EATING HABIT; FIBROGENESIS; FOOD INTAKE; HEPATITIS; INFLAMMATORY CELL; INSULIN SENSITIVITY; LETTER; LIPID DIET; LIVER FIBROSIS; LIVER NECROSIS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALS; DIETARY CARBOHYDRATES; DIETARY FATS; FATTY LIVER; FRUCTOSE; LIVER CIRRHOSIS; MODELS, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; TRANS FATTY ACIDS;

EID: 78751541079     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.23873     Document Type: Letter

References (5)

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2. Malaguarnera M, Di Rosa M, Nicoletti F, Malaguarnera L. Molecular mechanisms involved in NAFLD progression. J Mol Med 2009; 87: 679-695.
3. Tetri LH, Basaranoglu M, Brunt EM, Yerian LM, Neuschwander-Tetri BA. Severe NAFLD with hepatic necroinflammatory changes in mice fed trans-fats and a high fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol 2008; 295: G987-G995.
4. Larter CZ, Yeh MM. Animal models of NASH: getting both pathology and metabolic context right. J Gastroenterol Hepatol 2007; 23: 1635-1648.
5. Abdelmalek MF, Suzuki A, Guy C, Unalp-Arida A, Colvin R, Johnson RJ, et al. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. HEPATOLOGY 2010; 51: 1961-1971.