Conformational diversity and ligand tunnels of mammalian cytochrome P450s

Biotechnology and Applied Biochemistry

Volumn 60, Issue 1, 2013, Pages 134-145

  Yu, Xiaofeng ^a   Cojocaru, Vlad ^b   Wade, Rebecca C ^a,c  

^a HEIDELBERG INSTITUTE FOR THEORETICAL STUDIES   (Germany)

^b MAX PLANCK INSTITUTE FOR MOLECULAR BIOMEDICINE   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

crystal structure; cytochrome P 450; enzyme access tunnel; molecular dynamics simulation; protein conformation; protein dynamics

Indexed keywords

ACTIVE SITE; AQUEOUS ENVIRONMENT; CONFORMATIONAL CHANGE; CYTOCHROME P450; DIFFERENT SUBSTRATES; DRUG METABOLISMS; FLEXIBLE PARTS; LIGAND PROPERTIES; MEMBRANE-BOUND ENZYMES; MOLECULAR DYNAMICS SIMULATIONS; PROTEIN CONFORMATION; PROTEIN DYNAMICS; STEROID BIOSYNTHESIS;

BIOCHEMISTRY; CONFORMATIONS; CRYSTAL STRUCTURE; DYNAMICS; ENZYMES; FLEXIBLE STRUCTURES; LIPID BILAYERS; MAMMALS; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PROTEINS;

LIGANDS;

AROMATASE; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); COUMARIN; CYTOCHROME P450; CYTOCHROME P450 17A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 21A1; CYTOCHROME P450 24A1; CYTOCHROME P450 2A13; CYTOCHROME P450 2A6; CYTOCHROME P450 2B4; CYTOCHROME P450 2B6; CYTOCHROME P450 2C5; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 2R1; CYTOCHROME P450 3A4; CYTOCHROME P450 46A1; CYTOCHROME P450 8A1; FLURBIPROFEN; KETOCONAZOLE; METYRAPONE; PROGESTERONE; TEMAZEPAM; TESTOSTERONE; UNCLASSIFIED DRUG; WARFARIN;

CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; HUMAN; LIPID BILAYER; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN SECONDARY STRUCTURE; REVIEW; SIMULATION;

ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 84874043883     PISSN: 08854513     EISSN: 14708744     Source Type: Journal    
DOI: 10.1002/bab.1074     Document Type: Review

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