Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants

Archives of Biochemistry and Biophysics

Volumn 464, Issue 2, 2007, Pages 197-206

  Sansen, Stefaan ^a   Hsu, Mei Hui ^a   Stout, C David ^a   Johnson, Eric F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Benzyloxyindole; CYP2A6; Cytochrome P450; Enzyme specificity; Indigo; Indirubin; Monooxygenase; P450 2A6; Protein structure; X ray structure

Indexed keywords

ASPARAGINE; CYTOCHROME P450 2A6; CYTOCHROME P450 ISOENZYME; HYDROGEN; INDOLE; MUTANT PROTEIN; PIGMENT; WATER;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME METABOLISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN FAMILY;

AMINO ACID SUBSTITUTION; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; COMPUTER SIMULATION; ENZYME ACTIVATION; HUMANS; MIXED FUNCTION OXYGENASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 34547683239     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2007.04.028     Document Type: Article

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