Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: Ligand-induced structural response through α-helical repositioning

Biochemistry

Volumn 48, Issue 22, 2009, Pages 4762-4771

  Gay, Sean C ^a   Sun, Ling ^b   Maekawa, Keiko ^a,d   Halpert, James R ^a   Stout, C David ^c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1H-IMIDAZOLE; ACTIVE SITE; CYTOCHROME P450; DIRECT RESPONSE; PHENYL RINGS; PIVOT POINT; PLASTIC REGIONS; SECONDARY STRUCTURES; SHAPE AND SIZE; STRUCTURAL MOVEMENTS; STRUCTURAL RESPONSE; TIGHT BINDING; TYPE II;

ENZYME ACTIVITY; X RAY CRYSTALLOGRAPHY;

LIGANDS;

1 (4 CHLOROPHENYL)IMIDAZOLE; 1 BIPHENYL 4 METHYL 1H IMIDAZOLE; 4 (4 CHLOROPHENYL)IMIDAZOLE; BIFONAZOLE; BIPHENYL DERIVATIVE; CYTOCHROME P450 2B4; IMIDAZOLE; IMIDAZOLE DERIVATIVE; LIGAND; PHENYL GROUP; PHENYLALANINE; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; MOLECULAR SIZE; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ARYL HYDROCARBON HYDROXYLASES; BIPHENYL COMPOUNDS; CATALYTIC DOMAIN; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI PROTEINS; IMIDAZOLES; LIGANDS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY;

EID: 66649125786     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9003765     Document Type: Article

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