Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel

Biochemistry

Volumn 49, Issue 40, 2010, Pages 8709-8720

  Gay, Sean C ^a   Roberts, Arthur G ^a   Maekawa, Keiko ^b   Talakad, Jyothi C ^a   Hong, Wen Xu ^c   Zhang, Qinghai ^c   Stout, C David ^c   Halpert, James R ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BINDING POCKETS; CLOPIDOGREL; CLOSED STRUCTURES; CONFORMATIONAL CHANGE; CYTOCHROME P450; ELECTRON DENSITIES; ELECTRON DENSITY MAPS; ENZYME CONFORMATIONS; FREEDOM OF MOVEMENT; LIGAND DOCKING; METABOLIC DATA; NMR RELAXATION; PROTEIN CONFORMATION; SIDE CHAINS; SINGLE ORIENTATIONS; SMALL MOLECULE INHIBITOR; STEREOCENTERS; X RAY CRYSTAL STRUCTURES;

CARRIER CONCENTRATION; ELECTRON DENSITY MEASUREMENT; ENZYMES; LIGANDS; MAMMALS; MOLECULES; PLANTS (BOTANY); PORPHYRINS; PYRIDINE;

CONFORMATIONS;

1 (4 CHLOROPHENYL)IMIDAZOLE; 4 (4 CHLOROPHENYL)IMIDAZOLE; CLOPIDOGREL; CYTOCHROME P450 2B4; CYTOCHROME P450 INHIBITOR; HEME; IMIDAZOLE DERIVATIVE; TICLOPIDINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; ENZYME INHIBITION; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLATELET AGGREGATION INHIBITORS; PROTEIN BINDING; RABBITS; TICLOPIDINE;

MAMMALIA; ORYCTOLAGUS CUNICULUS;

EID: 77957690235     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100914z     Document Type: Article

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