Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4

Biochemistry

Volumn 46, Issue 41, 2007, Pages 11559-11567

  Zhao, Yonghong ^a,c   Sun, Ling ^a   Muralidhara, B K ^a,d   Kumar, Santosh ^a   White, Mark A ^a   Stout, C David ^b   Halpert, James R ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c CENTOCOR INC   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC SIDE CHAIN; ISOTHERMAL TITRATION CALORIMETRY; RESIDUE ORIENTATIONS; THERMODYNAMIC SIGNATURES;

BINDING SITES; CRYSTAL STRUCTURE; ENTHALPY; ENTROPY; HYDROGEN BONDS; LIGANDS; THERMODYNAMICS; TITRATION;

PROTEINS;

1 (4 CHLOROPHENYL)IMIDAZOLE; 4 (4 CHLOROPHENYL)IMIDAZOLE; ALANINE; CYTOCHROME P450 2B4; GLUTAMIC ACID; IMIDAZOLE DERIVATIVE; PHENYLALANINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENTHALPY; ENTROPY; ENZYME ACTIVE SITE; ENZYME BINDING; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; PRIORITY JOURNAL; THERMODYNAMICS;

AMINO ACIDS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; DNA PRIMERS; IMIDAZOLES; KINETICS; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; THERMODYNAMICS;

EID: 34548423359     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7011614     Document Type: Article

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