Structural characterization of the complex between α-naphthoflavone and human cytochrome P450 1B1

Journal of Biological Chemistry

Volumn 286, Issue 7, 2011, Pages 5736-5743

  Wang, An ^a   Savas, Uzen ^a   Stout, C David ^a   Johnson, Eric F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMINO ACID RESIDUES; AMINO ACID SEQUENCE; ATOMIC STRUCTURE; HUMAN CYTOCHROME; HYDROGEN BONDING INTERACTIONS; STRUCTURAL CHARACTERIZATION; STRUCTURAL FEATURE; SUBSTRATE PROFILE; VERTEBRATE SPECIES;

AMINO ACIDS; CONFORMATIONS; ENZYMES; HYDROGEN BONDS; X RAY CRYSTALLOGRAPHY;

CATALYSTS;

ALPHA NAPHTHOFLAVONE; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1;

AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME STABILITY; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

ARYL HYDROCARBON HYDROXYLASES; BENZOFLAVONES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY;

VERTEBRATA;

EID: 79953126762     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.204420     Document Type: Article

References (31)

1. Nebert, D. W., Dalton, T. P., Okey, A. B., and Gonzalez, F. J. (2004) J. Biol. Chem. 279, 23847-23850
2. Buters, J. T., Sakai, S., Richter, T., Pineau, T., Alexander, D. L., Savas, U., Doehmer, J., Ward, J. M., Jefcoate, C. R., and Gonzalez, F. J. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 1977-1982
3. Vasiliou, V., and Gonzalez, F. J. (2008) Annu. Rev. Pharmacol. Toxicol. 48, 333-358
4. Choudhary, D., Jansson, I., and Schenkman, J. B. (2009) Xenobiotica 39, 606-615
5. Zheng, W., Brake, P. B., Bhattacharyya, K. K., Zhang, L., Zhao, D., and Jefcoate, C. R. (2003) Arch. Biochem. Biophys. 416, 53-67
6. Sissung, T. M., Price, D. K., Sparreboom, A., and Figg, W. D. (2006) Mol. Cancer Res. 4, 135-150
7. Chun, Y. J., and Kim, S. (2003) Med. Res. Rev. 23, 657-668
8. Bruno, R. D., and Njar, V. C. (2007) Bioorg. Med. Chem. 15, 5047-5060
9. Shimada, T., Yamazaki, H., Foroozesh, M., Hopkins, N. E., Alworth, W. L., and Guengerich, F. P. (1998) Chem. Res. Toxicol. 11, 1048-1056
10. Sansen, S., Yano, J. K., Reynald, R. L., Schoch, G. A., Griffin, K. J., Stout, C. D., and Johnson, E. F. (2007) J. Biol. Chem. 282, 14348-14355
11. Wester, M. R., Johnson, E. F., Marques-Soares, C., Dijols, S., Dansette, P. M., Mansuy, D., and Stout, C. D. (2003) Biochemistry 42, 9335-9345
12. Collaborative Computational Project, Number 4 (1994) Acta Crystallogr. D Biol. Crystallogr. 50, 760-763
13. McCoy, A. J., Grosse-Kunstleve, R. W., Storoni, L. C., and Read, R. J. (2005) Acta Crystallogr. D Biol. Crystallogr. 61, 458-464
14. Sali, A., Potterton, L., Yuan, F., van Vlijmen, H., and Karplus, M. (1995) Proteins 23, 318-326
15. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D Biol Crystallogr. 54, 905-921
16. Cosme, J., and Johnson, E. F. (2000) J. Biol. Chem. 275, 2545-2553
17. von Wachenfeldt, C., Richardson, T. H., Cosme, J., and Johnson, E. F. (1997) Arch. Biochem. Biophys. 339, 107-114
18. Williams, P. A., Cosme, J., Sridhar, V., Johnson, E. F., and McRee, D. E. (2000) Mol. Cell 5, 121-131
19. Thomas, J. H. (2007) PLoS Genet. 3, e67
20. Goldstone, H. M., and Stegeman, J. J. (2006) J. Mol. Evol. 62, 708-717
21. Wang, R., Lai, L., and Wang, S. (2002) J. Comput. Aided Mol. Des 16, 11-26
22. Bauer, E., Guo, Z., Ueng, Y. F., Bell, L. C., Zeldin, D., and Guengerich, F. P. (1995) Chem. Res. Toxicol. 8, 136-142
23. Andries, M. J., Lucier, G. W., Goldstein, J., and Thompson, C. L. (1990) Mol. Pharmacol. 37, 990-995
24. Kleywegt, G. J., and Jones, T. A. (1994) Acta Crystallogr. D Biol. Crystallogr. 50, 178-185
25. Porubsky, P. R., Meneely, K. M., and Scott, E. E. (2008) J. Biol. Chem. 283, 33698-33707
26. Schoch, G. A., Yano, J. K., Wester, M. R., Griffin, K. J., Stout, C. D., and Johnson, E. F. (2004) J. Biol. Chem. 279, 9497-9503
27. Tu, Y., Deshmukh, R., Sivaneri, M., and Szklarz, G. D. (2008) Drug Metab. Dispos. 36, 2371-2380
28. Petrek, M., Kosinová, P., Koca, J., and Otyepka, M. (2007) Structure 15, 1357-1363
29. Wester, M. R., Johnson, E. F., Marques-Soares, C., Dansette, P. M., Mansuy, D., and Stout, C. D. (2003) Biochemistry 42, 6370-6379
30. Luch, A., Coffing, S. L., Tang, Y. M., Schneider, A., Soballa, V., Greim, H., Jefcoate, C. R., Seidel, A., Greenlee, W. F., Baird, W. M., and Doehmer, J. (1998) Chem. Res. Toxicol. 11, 686-695
31. Lee, A. J., Cai, M. X., Thomas, P. E., Conney, A. H., and Zhu, B. T. (2003) Endocrinology 144, 3382-3398