How do substrates enter and products exit the buried active site of cytochrome P450cam? 1. Random expulsion molecular dynamics investigation of ligand access channels and mechanisms

Journal of Molecular Biology

Volumn 303, Issue 5, 2000, Pages 797-811

  Lüdemann, Susanna K ^a   Lounnas, Valère ^a   Wade, Rebecca C ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Buried active site; Cytochrome P450; Enzyme substrate binding; Molecular dynamics simulation; Protein dynamics

Indexed keywords

CAMPHOR 5 MONOOXYGENASE; CYTOCHROME P450BM 3; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; LIGAND BINDING; MOLECULAR DYNAMICS; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; SIMULATION;

EID: 0034634393     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4154     Document Type: Article

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