Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 Å resolution: Evidence for an induced fit model of substrate binding

Biochemistry

Volumn 42, Issue 31, 2003, Pages 9335-9345

  Wester, Michael R ^a   Johnson, Eric F ^a   Marques Soares, Cristina ^b   Dijols, Sylvie ^b   Dansette, Patrick M ^b   Mansuy, Daniel ^b   Stout, C David ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CONFORMATIONS; CYTOLOGY; DRUG PRODUCTS; ENZYMES; HYDROGEN BONDS; HYDROXYLATION; X RAY CRYSTALLOGRAPHY;

CYTOCHROMES;

BIOCHEMISTRY;

4 METHYL N METHYL N (2 PHENYL 2H PYRAZOL 3 YL)BENZENESULFONAMIDE; BENZENESULFONAMIDE DERIVATIVE; CYTOCHROME P450 2C; CYTOCHROME P450 2C5; DICLOFENAC; IRON; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DRUG BINDING; DRUG METABOLISM; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDRATION; HYDROGEN BOND; HYDROXYLATION; MOLECULAR RECOGNITION; NONHUMAN; PH; PRIORITY JOURNAL; PROTON TRANSPORT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARBOXYLIC ACIDS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; DICLOFENAC; HEME; IRON; MICROSOMES; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; RABBITS; STEROID 21-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; WATER;

MAMMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0042573727     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034556l     Document Type: Article

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