Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: Insight into partial enzymatic activity

Biochemistry

Volumn 50, Issue 22, 2011, Pages 4903-4911

  Gay, Sean C ^a   Zhang, Haoming ^b   Wilderman, P Ross ^a   Roberts, Arthur G ^a   Liu, Tong ^c   Li, Sheng ^c   Lin, Hsia Lien ^b   Zhang, Qinghai ^d   Woods, Virgil L ^c   Stout, C David ^d   Hollenberg, Paul F ^b   Halpert, James R ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE RESIDUES; COMPUTATIONAL ANALYSIS; COVALENTLY BOUND; CYTOCHROME P450; ENZYMATIC ACTIVITIES; IN-SILICO; PLASTIC REGIONS; RESIDUAL ACTIVITY;

CONFORMATIONS; DIMERS; EXPERIMENTS; MAMMALS; PORPHYRINS; STRUCTURAL ANALYSIS;

ENZYME ACTIVITY;

CYTOCHROME B5; CYTOCHROME P450 2B4; HEME; PHENYLACETYLENE; SULFITE REDUCTASE (NADPH); TERT BUTYLPHENYLACETYLENE; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; ENZYME ACTIVITY; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE;

ACETYLENE; AMINO ACID SEQUENCE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM EXCHANGE MEASUREMENT; DIMERIZATION; MODELS, MOLECULAR; PROTEIN CONFORMATION; RABBITS;

MAMMALIA; ORYCTOLAGUS CUNICULUS;

EID: 79958024314     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200482g     Document Type: Article

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