Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and x-ray crystallography

Journal of Biological Chemistry

Volumn 285, Issue 49, 2010, Pages 38602-38611

  Wilderman, P Ross ^a   Shah, Manish B ^a   Liu, Tong ^b   Li, Sheng ^b   Hsu, Simon ^b   Roberts, Arthur G ^a   Goodlett, David R ^c   Zhang, Qinghai ^d   Woods Jr , Virgil L ^b   Stout, C David ^d   Halpert, James R ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1H-IMIDAZOLE; CONFORMATIONAL CHANGE; CYTOCHROME P450; HYDROGEN-DEUTERIUM EXCHANGE; LIGAND-FREE; LIGAND-FREE STRUCTURES; MOLECULAR DYNAMICS SIMULATIONS; NEW HIGH; STRUCTURAL BEHAVIORS;

CONFORMATIONS; DEUTERIUM; HYDROGEN; LIGANDS; MASS SPECTROMETRY; MOLECULAR DYNAMICS; PLASTICITY; PROBES; REACTION KINETICS; X RAY CRYSTALLOGRAPHY;

CRYSTAL STRUCTURE;

1 BIPHENYL 4 METHYL 1H IMIDAZOLE; 4 (4 CHLOROPHENYL)IMIDAZOLE; CYTOCHROME P450 2B4; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE MASS SPECTROMETRY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME STRUCTURE; LIGAND BINDING; MASS SPECTROMETRY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY;

EID: 78649672754     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.180646     Document Type: Article

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