Synthetic inhibitors of cytochrome P-450 2A6: Inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization

Journal of Medicinal Chemistry

Volumn 49, Issue 24, 2006, Pages 6987-7001

  Yano, Jason K ^b   Denton, Travis T ^a   Cerny, Matthew A ^a   Zhang, Xiaodong ^a   Johnson, Eric F ^b   Cashman, John R ^a  

^a HUMAN BIOMOLECULAR RESEARCH INSTITUTE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4 DIPYRIDYL DISULFIDE; ACETYLENE; CYTOCHROME P450 2A6; CYTOCHROME P450 2A6 INHIBITOR; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; FURAN; HEME; IMIDAZOLE; ISOXAZOLE; NICOTINE; PYRAZOLE; PYRIDINE DERIVATIVE; THIAZOLE; THIOPHENE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CRYSTALLIZATION; DRUG MECHANISM; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; INHIBITION KINETICS; LIVER METABOLISM; LIVER MICROSOME; MOUSE; NONHUMAN; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

ACETYLENE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FURANS; HUMANS; IMIDAZOLES; ISOXAZOLES; MICE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NICOTINE; PYRAZOLES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THIOPHENES; TIME FACTORS;

EID: 33845358503     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060519r     Document Type: Article

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