Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1

Journal of Biological Chemistry

Volumn 286, Issue 7, 2011, Pages 5607-5613

  Mast, Natalia ^a   Annalora, Andrew J ^b   Lodowski, David T ^a   Palczewski, Krzysztof ^a   Stout, C David ^b   Pikuleva, Irina A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CATALYTIC EFFICIENCIES; CHOLESTEROL SIDE CHAIN CLEAVAGES; CURVED TUBE; HEME GROUP; HYDROXYL GROUPS; MITOCHONDRIAL CYTOCHROME; MONOOXYGENATION; ORDERED WATER; PREGNENOLONE; PROTEIN SURFACE; REDOX PARTNER INTERACTIONS; SIDE CHAINS; SOLUTION STUDY; STEROID HORMONE; STRUCTURAL BASIS; STRUCTURAL MOTIFS; SUBSTRATE SPECIFICITY; TORSIONAL MOTION; TRANSLATIONAL FREEDOM; WATER MOLECULE;

CATALYSIS; CHOLESTEROL; CRYSTAL STRUCTURE; ENZYMES; HORMONES; MITOCHONDRIA; MOLECULES; PORPHYRINS; VEHICULAR TUNNELS;

REACTION INTERMEDIATES;

CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME BINDING; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PURIFICATION; SEQUENCE ANALYSIS;

AMINO ACID MOTIFS; ANIMALS; CATALYSIS; CATALYTIC DOMAIN; CATTLE; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CRYSTALLOGRAPHY, X-RAY; HYDROXYCHOLESTEROLS; MITOCHONDRIAL PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953148368     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.188433     Document Type: Article

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