Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme

FEBS Journal

Volumn 279, Issue 9, 2012, Pages 1607-1620

  Wilderman, P Ross ^a   Gay, Sean C ^a   Jang, Hyun Hee ^a   Zhang, Qinghai ^b   Stout, C David ^b   Halpert, James R ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

CYP2B; cytochrome P450; polymorphism; site directed mutagenesis

Indexed keywords

4 (4 CHLOROPHENYL)IMIDAZOLE; 7 ETHOXY 4 (TRIFLUOMETHYL)COUMARIN; 7 METHOXY 4 (TRIFLUOMETHYL)COUMARIN; BENZYLOXYRESORUFIN; BIFONAZOLE; COUMARIN DERIVATIVE; CYTOCHROME P450 2B4; IMIDAZOLE DERIVATIVE; RESORUFIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; MOLECULAR DYNAMICS; MUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LIGAND INTERACTION; SITE DIRECTED MUTAGENESIS; WILD TYPE;

ARYL HYDROCARBON HYDROXYLASES; COUMARINS; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; IMIDAZOLES; LIGANDS; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED;

ESCHERICHIA COLI;

EID: 84857922306     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08411.x     Document Type: Article

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