A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis

Human Molecular Genetics

Volumn 18, Issue 9, 2009, Pages 1578-1589

  Park, Jeong Soon ^a   Sharma, Lokendra Kumar ^a   Li, Hongzhi ^b   Xiang, Ruihua ^a   Holstein, Deborah ^a   Wu, Jun ^a   Lechleiter, James ^a   Naylor, Susan L ^a   Deng, Janice J ^a   Lu, Jianxin ^b   Bai, Yidong ^a,b  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; LACTIC ACID; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CONTROLLED STUDY; FRAMESHIFT MUTATION; GENE MUTATION; HETEROPLASMY; HUMAN; HUMAN CELL; MITOCHONDRIAL DNA DISORDER; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; NONSENSE MUTATION; OSTEOSARCOMA; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN FUNCTION; TUMOR GROWTH;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX I; HUMANS; MALE; MICE; MICE, NUDE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUTATION; NADH DEHYDROGENASE; NEOPLASMS; REACTIVE OXYGEN SPECIES;

MUS MUSCULUS;

EID: 64549098628     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddp069     Document Type: Article

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