Carbonyl modified proteins in cellular regulation, aging, and disease

Free Radical Biology and Medicine

Volumn 32, Issue 9, 2002, Pages 790-796

  Levine, Rodney L ^a,b  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Aging; Carbonyl; Carbonylated proteins; Free radical; Protein oxidation

Indexed keywords

CARBONYL DERIVATIVE; FREE RADICAL; REACTIVE OXYGEN METABOLITE;

AGING; CELL FUNCTION; EUKARYOTE; HUMAN; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN MODIFICATION; REGULATORY MECHANISM; REVIEW;

EUKARYOTA; MAMMALIA;

EID: 0036569401     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)00765-7     Document Type: Article

References (55)

1. Aging: A theory based on free radical and radiation chemistry
2. Control of enzyme levels in animal tissues
3. The story of glutamine synthetase regulation
4. Regulation of glutamine synthetase degradation in
5. Turnover of bacterial glutamine synthetase: Oxidative inactivation precedes proteolysis
6. Purification of a protease from Escherichia coli with specificity for oxidized glutamine synthetase
7. Metal-catalyzed oxidation of Escherichia coli glutamine synthetase: Correlation of structural and functional changes
8. Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences
9. Oxidative modification of glutamine synthetase. I. Inactivation is due to loss of one histidine residue
10. Protein oxidation
11. Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low density lipoprotein isolated from human atherosclerotic plaques
12. Determination of carbonyl content in oxidatively modified proteins
13. Determination of protein carbonyl groups by immunoblotting
14. Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells
15. Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine
16. Protein carbonyl measurement by a sensitive ELISA method
17. Differential susceptibility of plasma proteins to oxidative modification. Examination by Western blot immunoassay
18. Immunochemical detection of oxidized proteins
19. A double stain for total and oxidized proteins from two-dimensional fingerprints
20. Determination of carbonyl groups in oxidized proteins
21. Identification of protein carbonyls after two-dimensional electrophoresis
22. Adaptation of protein carbonyl detection to the requirements of proteome analysis demonstrated for hypoxia/reoxygenation in isolated rat liver mitochondria
23. Determination of carbonyl groups in oxidized proteins
24. Oxidative damage to proteins: Spectrophotometric method for carbonyl assay
25. Protein oxidation and aging. I. Difficulties in measuring reactive protein carbonyls in tissues using 2,4-dinitrophenylhydrazine
26. Effect of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone on protein oxidation and life span
27. An overview of oxidative stress
28. Editorial
29. Oxidative stress, caloric restriction, and aging
30. Protein oxidation in response to increased transcriptional or translational errors
31. Bacterial senescence: Protein oxidation in non-proliferating cells is dictated by the accuracy of the ribosomes
32. Protein carbonyl groups' content as a useful clinical marker of antioxidant barrier impairment in plasma of children with juvenile chronic arthritis
33. Oxidation of proteins in neonatal lungs
34. Early protein oxidation in the neonatal lung is related to development of chronic lung disease
35. Elevated protein carbonyls and lipid peroxidation products correlating with myeloperoxidase in tracheal aspirates from premature infants
36. 2macroglobulin tetramers into dysfunctional dimers
37. Plasma protein carbonyls in nonpregnant, healthy pregnant and preeclamptic women
38. Regulating the fate of mRNA: The control of cellular iron metabolism
39. Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome
40. Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2
41. Enhanced degradation of oxidized glutamine synthetase in vitro and after microinjection into hepatoma cells
42. Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins
43. Molecular mechanism of oxidative modification of iron regulatory protein 2
44. Aminomalonic acid: Identification in Escherichia coli and atherosclerotic plaque
45. Elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
46. 2 sensing
47. 2-regulated prolyl hydroxylation
48. Signal transduction. How do cells sense oxygen?
49. Age-related changes in oxidized proteins
50. Role of site-specific, metal-catalyzed oxidation in lens-aging and cataract: A hypothesis
51. Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1)a and short (mev-1) life spans
52. Protein oxidation and proteolysis during aging and oxidative stress
53. Protein oxidative damage is associated with life expectancy of houseflies