The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress

Journal of Biological Chemistry

Volumn 284, Issue 20, 2009, Pages 13291-13295

  Nguyen, Truyen ^a   Nioi, Paul ^a   Pickett, Cecil B ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT CAPACITY; ANTIOXIDANT RESPONSE ELEMENTS; CYTOSOLIC PROTEINS; MOLECULAR LEVELS; NEUROPROTECTION; REGULATORY MECHANISM; SIGNALING PATHWAYS;

OXIDANTS;

SIGNALING;

FUMARIC ACID DIMETHYL ESTER; KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; CYTOSKELETON PROTEIN; KEAP1 PROTEIN, HUMAN; KEAP1 PROTEIN, MOUSE; NFE2L2 PROTEIN, HUMAN; NFE2L2 PROTEIN, MOUSE; REACTIVE OXYGEN METABOLITE; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANTIOXIDANT RESPONSIVE ELEMENT; CELLULAR IMMUNITY; CELLULAR STRESS RESPONSE; CELLULAR STRESS SIGNAL; DEGENERATIVE DISEASE; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; MULTIPLE SCLEROSIS; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; BIOSYNTHESIS; DNA RESPONSIVE ELEMENT; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY; REVIEW; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIOXIDANTS; CELL LINE, TUMOR; CYTOSKELETAL PROTEINS; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 67649402187     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.R900010200     Document Type: Short Survey

References (52)

1. Rushmore, T. H., and Pickett, C. B. (1990) J. Biol. Chem. 265, 14648-14653
2. Friling, R. S., Bensimon, A., Tichauer, Y., and Daniel, V. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 6258-6262
3. Favreau, L. V., and Pickett, C. B. (1991) J. Biol. Chem. 266, 4556-4561
4. Li, Y., and Jaiswal, A. K. (1992) J. Biol. Chem. 267, 15097-15104
5. Rushmore, T. H., Morton, M. R., and Pickett, C. B. (1991) J. Biol. Chem. 266, 11632-11639
6. Rushmore, T. H., King, R. G., Paulson, K. E., and Pickett, C. B. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 3826-3830
7. Moi, P., Chan, K., Asunis, I., Cao, A., and Kan, Y. W. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 9926-9930
8. Venugopal, R., and Jaiswal, A. K. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14960-14965
9. Nguyen, T., Sherratt, P. J., and Pickett, C. B. (2003) Annu. Rev. Pharmacol. Toxicol. 43, 233-260
10. Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., Yamamoto, M., and Nabeshima, Y. I. (1997) Biochem. Biophys. Res. Commun. 236, 313-322
11. McMahon, M., Itoh, K., Yamamoto, M., Chanas, S. A., Henderson, C. J., McLellan, L. I., Wolf, C. R., Cavin, C., and Hayes, J. D. (2001) Cancer Res. 61, 3299-3307
12. Nguyen, T., Sherratt, P. J., Nioi, P., Yang, C. S., and Pickett, C. B. (2005) J. Biol. Chem. 280, 32485-32492
13. Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., and Yamamoto, M. (1999) Genes Dev. 13, 76-86
14. Nguyen, T., Sherratt, P. J., Huang, H.-C., Yang, C. S., and Pickett, C. B. (2003) J. Biol. Chem. 278, 4536-4541
15. Stewart, D., Killeen, E., Naquin, R., Alam, S., and Alam, J. (2003) J. Biol. Chem. 278, 2396-2402
16. McMahon, M., Itoh, K., Yamamoto, M., and Hayes, J. D. (2003) J. Biol. Chem. 278, 21592-21600
17. Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., O'Connor, T., and Yamamoto, M. (2003) Genes Cells 8, 379-391
18. Zhang, D. D., and Hannink, M. (2003) Mol. Cell. Biol. 23, 8137-8151
19. Kobayashi, A., Kang, M. I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., and Yamamoto, M. (2004) Mol. Cell. Biol. 24, 7130-7139
20. Cullinan, S. B., Gordan, J. D., Jin, J., Harper, J. W., and Diehl, J. A. (2004) Mol. Cell. Biol. 24, 8477-8486
21. Zhang, D. D., Lo, S.-C., Cross, J. V., Templeton, D. J., and Hannink, M. (2004) Mol. Cell. Biol. 24, 10941-10953
22. Furukawa, M., and Xiong, Y. (2005) Mol. Cell. Biol. 25, 162-171
23. Wakabayashi, N., Itoh, K., Wakabayashi, J., Motohashi, H., Noda, S., Takahashi, S., Imakado, S., Kotsuji, T., Otsuka, F., Roop, D. R., Harada, T., Engel, J. D., and Yamamoto, M. (2003) Nat. Genet. 35, 238-245
24. Devling, T. W., Lindsay, C. D., McLellan, L. I., McMahon, M., and Hayes, J. D. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 7280-7285
25. Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., and Talalay, P. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 11908-11913
26. Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M. I., Kobayashi, A., Yamamoto, M., Kensler, T. W., and Talalay, P. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 2040-2045
27. Huang, H.-C., Nguyen, T., and Pickett, C. B. (2002) J. Biol. Chem. 277, 42769-42774
28. Bloom, D. A., and Jaiswal, A. K. (2003) J. Biol. Chem. 278, 44675-44682
29. Cullinan, S. B., Zhang, D., Hannink, M., Arvisais, E., Kaufman, R. J., and Diehl, J. A. (2003) Mol. Cell. Biol. 23, 7198-7209
30. Karapetian, R. N., Evstafieva, A. G., Abaeva, I. S., Chichkova, N. V., Filonov, G. S., Rubtsov, Y. P., Sukhacheva, E. A., Melnikov, S. V., Schneider, U., Wanker, E. E., and Vartapetian, A. B. (2005) Mol. Cell. Biol. 25, 1089-1099
31. Velichkova, M., and Hasson, T. (2005) Mol. Cell. Biol. 25, 4501-4513
32. Sun, Z., Zhang, S., Chan, J. Y., and Zhang, D. D. (2007) Mol. Cell. Biol. 27, 6334-6349
33. Watai, Y., Kobayashi, A., Nagase, H., Mizukami, M., McEvoy, J., Singer, J. D., Itoh, K., and Yamamoto, M. (2007) Genes Cells 12, 1163-1178
34. Zhang, D. D., Lo, S.-C., Sun, Z., Habib, G. M., Lieberman, M. W., and Hannink, M. (2005) J. Biol. Chem. 280, 30091-30099
35. Hong, F., Sekhar, K. R., Freeman, M. L., and Liebler, D. C. (2005) J. Biol. Chem. 280, 31768-31775
36. Kobayashi, A., Kang, M. I., Watai, Y., Tong, K. I., Shibata, T., Uchida, K., and Yamamoto, M. (2006) Mol. Cell. Biol. 26, 221-229
37. Muratani, M., and Tansey, W. P. (2003) Nat. Rev. Mol. Cell Biol. 4, 1-10
38. Katoh, Y., Itoh, K., Yoshida, E., Miyagishi, M., Fukamizu, A., and Yamamoto, M. (2001) Genes Cells 6, 857-868
39. Shen, G., Hebbar, V., Nair, S., Xu, C., Li, W., Lin, W., Keum, Y. S., Han, J., Gallo, M. A., and Kong, A. N. (2004) J. Biol. Chem. 279, 23052-23060
40. Eggler, A. L., Liu, G., Pezzuto, J. M., van Breemen, R. B., and Mesecar, A. D. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 10070-10075
41. Numazawa, S., Ishikawa, M., Yoshida, A., Tanaka, S., and Yoshida, T. (2003) Am. J. Physiol. 285, C334-C342
42. Kang, K. W., Cho, M. K., Lee, C. H., and Kim, S. G. (2001) Mol. Pharmacol. 59, 1147-1156
43. Lee, J.-M., Hanson, J. M., Chu, W. A., and Johnson, J. A. (2001) J. Biol. Chem. 276, 20011-20016
44. Nakaso, K., Yano, H., Fukuhara, Y., Takeshima, T., Wada-Isoe, K., and Nakashima, K. (2003) FEBS Lett. 546, 181-184
45. Shih, A. Y., Johhnson, D. A., Wong, G., Kraft, A. D., Jiang, L., Erb, H., Johnson, J. A., and Murphy, T. H. (2003) J. Neurosci. 23, 3394-3406
46. Kraft, A. D., Johnson, D. A., and Johnson, J. A. (2004) J. Neurosci. 24, 1101-1112
47. Hubbs, A. F., Benkovic, S. A., Miller, D. B., O'Callaghan, J. P., Battelli, L., Schwegler-Berry, D., and Ma, Q. (2007) Am. J. Pathol. 170, 2068-2076
48. Johnson, D. A., Resch, J. M., Fabry, Z., and Johnson, J. A. (2007) SfN Neuroscience Meeting Planner, Program No. 901.26, Society for Neuroscience, San Diego, CA
49. Gröger, M., Holnthoner, W., Wolff, K., Wiegrebe, W., Jirovsky, D., and Petzelbauer, P. J. Investig. Dermatol. 117, 1363-1368
50. Wierinckx, A., Breve, J., Mercier, D., Schultzberg, M., Drukarch, B., and Van Dam, A.-M. (2005) J. Neuroimmunol. 166, 132-143
51. Schilling, S., Goelz, S., Linker, R., and Luehder, R. (2006) Clin. Exp. Immunol. 145, 101-107
52. Schmierer, K., Yousry, T. A., Yang, M., Eraksoy, M., Meluzinova, E., Rektor, I., Dawson, K. T., Sandrock, A. W., and O'Neill, G. N. (2008) Lancet 372, 1463-1472