Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells

Nature

Volumn 444, Issue 7120, 2006, Pages 761-765

  Piccirillo, S G M ^a   Reynolds, B A ^b   Zanetti, N ^a   Lamorte, G ^a   Binda, E ^c   Broggi, G ^d   Brem, H ^e   Olivi, A ^e   Dimeco, F ^d,e   Vescovi, A L ^a,c  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c Stem Cell Research Institute   (Italy)

^d DEPARTMENT OF NEUROSURGERY   (Italy)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTOR; CD133 ANTIGEN; SMAD PROTEIN;

BONE; BRAIN; CANCER; MORPHOGENESIS; PROTEIN; TUMOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TUMOR; CANCER GROWTH; CANCER INHIBITION; CANCER STEM CELL; CARCINOGENESIS; CELL POPULATION; CELL PROLIFERATION; CELL SIZE; CELL VIABILITY; CLONOGENESIS; CONTROLLED STUDY; GLIOBLASTOMA; HUMAN; HUMAN CELL; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 33845610993     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05349     Document Type: Article

References (30)

1. Vescovi, A. L., Galli, R. & Reynolds, B. A. Brain tumour stem cells. Nature Rev. Cancer 6, 425-436 (2006).
2. Lim, D. A. et al. Noggin antagonizes BMP signaling to create a niche for adult neurogenesis. Neuron 28, 713-726 (2000).
3. Panchision, D. M. & McKay, R. D. The control of neural stem cells by morphogenic signals. Curr. Opin. Genet. Dev. 12, 478-487 (2002).
4. Lapidot, T. et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367, 645-648 (1994).
5. Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J. & Clarke, M. F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA 100, 3983-3988 (2003).
6. Ignatova, T. N. et al. Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 39, 193-206 (2002).
7. Hemmati, H. D. et al. Cancerous stem cells can arise from pediatric brain tumors. Proc. Natl Acad. Sci. USA 100, 15178-15183 (2003).
8. Galli, R. et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. 64, 7011-7021 (2004).
9. Singh, S. K. et al. Identification of human brain tumour initiating cells. Nature 432, 396-401 (2004).
10. Taylor, M. D. et al. Radial glia cells are candidate stem cells of ependymoma. Cancer Cell 8, 323-335 (2005).
11. Sell, S. Stem cell origin of cancer and differentiation therapy. Crit. Rev. Oncol. Hematol. 51, 1-28 (2004).
12. Reya, T., Morrison, S. J., Clarke, M. F. & Weissman, I. L. Stem cells, cancer, and cancer stem cells. Nature 414, 105-111 (2001).
13. Potten, C. S. & Loeffler, M. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 110, 1001-1020 (1990).
14. Weiss, S. et al. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J. Neurosci. 16, 7599-7609 (1996).
15. Shah, N. M., Groves, A. K. & Anderson, D. J. Alternative neural crest cell fates are instructively promoted by TGFb superfamily members. Cell 85, 331-343 (1996).
16. Furuta, Y., Piston, D. W. & Hogan, B. L. Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development 124, 2203-2212 (1997).
17. Li, W., Cogswell, C. A. & LoTurco, J. J. Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J. Neurosci. 18, 8853-8862 (1998).
18. Iantosca, M., McPherson, C., Ho, S.&Maxwell, G. Bone morphogenetic proteins-2 and -4 attenuate apoptosis in a cerebellar primitive neuroectodermal tumor cell line. J. Neurosci. Res. 56, 248-258 (1999).
19. Chen, D., Zhao, M. & Mundy, G. R. Bone morphogenetic proteins. Growth Factors 22, 233-241 (2004).
20. Hallahan, A. R. et al. BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Nature Med. 9, 1033-1038 (2003).
21. Kjellman, C. et al. Expression of TGF-b isoforms, TGF-b receptors, and SMAD molecules at different stages of human glioma. Int. J. Cancer 89, 251-258 (2000).
22. Canalis, E., Economides, A. & Gazzerro, E. Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr. Rev. 2, 218-235 (2003).
23. Golestaneh, N. & Mishra, B. TGF-β, neuronal stem cells and glioblastoma. Oncogene 24, 5722-5730 (2005).
24. Reynolds, B. A. & Weiss, S. Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. Dev. Biol. 175, 1-13 (1996).
25. Reynolds, B. A. & Rietze, R. L. Neural stem cells and neurospheres-re-evaluating the relationship. Nature Methods 2, 333-336 (2005).
26. Barker, F. G. II. et al. Survival and functional status after resection of recurrent glioblastoma multiforme. Neurosurgery 42, 709-720; discussion 720-3 (1998).
27. Dean, M., Fojo, T. & Bates, S. Tumour stem cells and drug resistance. Nature Rev. Cancer 5, 275-284 (2005).
28. Pardal, R., Clarke, M. F. & Morrison, S. J. Applying the principles of stem-cell biology to cancer. Nature Rev. Cancer 3, 895-902 (2003).
29. Rajan, P., Panchision, D. M., Newell, L. F. & McKay, R. D. BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells. J. Cell Biol. 161, 911-921 (2003).
30. Vescovi, A. L. et al. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation. Exp. Neurol. 156, 71-83 (1999).