Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19 Arf senescence pathways

Genes and Development

Volumn 19, Issue 12, 2005, Pages 1432-1437

  Molofsky, Anna V ^a   He, Shenghui ^a   Bydon, Mohammad ^a   Morrison, Sean J ^a   Pardal, Ricardo ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Bmi 1; Neural crest; p16Ink4a; p19Arf; Self renewal; Stem cell

Indexed keywords

PROTEIN; PROTEIN BMI 1; PROTEIN P16INK4A; PROTEIN P19; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BMI 1 GENE; BRAIN DEVELOPMENT; CELL PROLIFERATION; CELL RENEWAL; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; FOREBRAIN; GENE; GENE DELETION; GROWTH; INTESTINE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NERVOUS TISSUE; NEURAL STEM CELL; NONHUMAN; PERINATAL PERIOD; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN FUNCTION; SENESCENCE; STEM CELL; SURVIVAL;

ANIMALS; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CEREBELLUM; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENES, P16; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPOTENT STEM CELLS; NEURONS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; TUMOR SUPPRESSOR PROTEIN P14ARF;

EID: 22344449361     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1299505     Document Type: Article

References (27)

1. Bixby, S., Kruger, G.M., Mosher, J.T., Joseph, N.M., and Morrison, S.J. 2002. Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity. Neuron 35: 643-656.
2. Bruggeman, S.W.M., Valk-Lingbeek, M.E., van der Stoop, P.P.M., Jacobs, J.J.L., Kieboom, K., Tanger, E., Hulsman, D., Leung, C., Arsenijevic, Y., Marino, S., and van Lohuizen, M. 2005. Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes & Dev. (this issue).
3. Dimri, G.P., Martinez, J.L., Jacobs, J.J., Keblusek, P., Itahana, K., van Lohuizen, M., Campisi, J., Wazer, D.E., and Band, V. 2002. The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res. 62: 4736-4745.
4. Harrison, D.E. 1979. Proliferative capacity of erythropoietic stem cell lines and aging: An overview. Mech. Ageing Dev. 9: 409-426.
5. Itahana, K., Zou, Y., Itahana, Y., Martinez, J.-L., Beausejour, C., Jacobs, J.J.L., van Lohuizen, M., Band, V., Campisi, J., and Dimri, G.P. 2003. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol. Cell. Biol. 23: 389-401.
6. Jacobs, J.J.L., Kieboom, K., Marino, S., DePinho, R.A., and van Lohuizen, M. 1999a. The oncogene and polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397: 164-168.
7. Jacobs, J.J.L., Scheijen, B., Voncken, J.-W., Kieboom, K., Berns, A., and van Lohuizen, M. 1999b. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes & Dev. 13: 2678-2690.
8. Kamijo, T., Zindy, F., Roussel, M.F., Quelle, D.E., Downing, J.R., Ashmun, R.A., Grosveld, G., and Sherr, C.J. 1997. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91: 649-659.
9. Kippin, T.E., Martens, D.J., and van der Kooy, D. 2005. p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes & Dev. 19: 756-767.
10. Kruger, G.M., Mosher, J.T., Bixby, S., Joseph, N., Iwashita, T., and Morrison, S.J. 2002. Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness. Neuron 35: 657-669.
11. Lessard, J. and Sauvageau, G. 2003. Bmi-1 determines the proliferative capacity of normal and leukemic stem cells. Nature 423: 255-260.
12. Lessard, J., Baban, S., and Sauvageau, G. 1998. Stage-specific expression of Polycomb Group genes in human bone marrow cells. Blood 91: 1216-1224.
13. Leung, C., Lingbeek, M., Shakhova, O., Liu, J., Tanger, E., Saremaslani, P., van Lohuizen, M., and Marino, S. 2004. Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature 428: 337-341.
14. Lowe, S.W. and Sherr, C.J. 2003. Tumor suppression by Ink4a-Arf: Progress and puzzles. Curr. Opin. Genet. Dev. 13: 77-83.
15. Maslov, A.Y., Barone, T.A., Plunkett, R.J., and Pruitt, S.C. 2004. Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice. J. Neurosci. 24: 1726-1733.
16. Molofsky, A.V., Pardal, R., Iwashita, T., Park, I.K., Clarke, M.F., and Morrison, S.J. 2003. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425: 962-967.
17. Molofsky, A.V., Pardal, R., and Morrison, S.J. 2004. Diverse mechanisms regulate stem cell self-renewal. Curr. Opin. Cell Biol. 16: 700-707.
18. Morrison, S.J., Wandycz, A.M., Akashi, K., Globerson, A., and Weissman, I.L. 1996. The aging of hematopoietic stem cells. Nat. Med. 2: 1011-1016.
19. Morrison, S.J., Shah, N.M., and Anderson, D.J. 1997. Regulatory mechanisms in stem cell biology. Cell 88: 287-298.
20. Park, I.-K., Qian, D., Kiel, M., Becker, M., Pihalja, M., Weissman, I.L., Morrison, S.J., and Clarke, M. 2003. Bmi-1 is required for the maintenance of adult self-renewing hematopoietic stem cells. Nature 423: 302-305.
21. Qiu, J., Takagi, Y., Harada, J., Rodrigues, N., Moskowitz, M.A., Scadden, D.T., and Cheng, T. 2004. Regenerative response in ischemic brain restricted by p21cip1/waf1. J. Exp. Med. 199: 937-945.
22. Serrano, M., Lee, H., Chin, L., Cordon-Cardo, C., Beach, D., and DePinho, R.A. 1996. Role of the INK4a locus in tumor suppression and cell mortality. Cell 85: 27-37.
23. Sharpless, N.E., Bardeesy, N., Lee, K.-H., Carrasco, D., Castrillon, D.H., Aguirre, A.J., Wu, E.A., Horner, J.W., and DePinho, R.A. 2001. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 413: 86-91.
24. Sherr, C.J. 2001. The INK4a/ARF network in tumour suppression. Nat. Rev. Mol. Cell Biol. 2: 731-737.
25. Stemple, D.L. and Anderson, D.J. 1992. Isolation of a stem cell for neurons and glia from the mammalian neural crest. Cell 71: 973-985.
26. Valk-Lingbeek, M.E., Bruggeman, S.W., and van Lohuizen, M. 2004. Stem cells and cancer: The polycomb connection. Cell 118: 409-418.
27. van der Lugt, N.M.T., Domen, J., Linders, K., van Roon, M., Robanus-Maandag, E., te Riele, H., van der Valk, M., Deschamps, J., Sofroniew, M., van Lohuizen, M., et al. 1994. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes & Dev. 8: 757-769.