Sulphur-containing non enzymatic antioxidants: Therapeutic tools against cancer

Frontiers in Bioscience - Scholar

Volumn 4 S, Issue 2, 2012, Pages 722-748

  Mates, Jose M ^a   Segura, Juan A ^a   Alonso, Francisco J ^a   Marquez, Javier ^a  

^a UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

Cysteine; Glutathione; Homocysteine; Lipoic acid; Methionine; Review; ROS; Taurine

Indexed keywords

ACETYLCYSTEINE; ANTIMYCIN A1; ANTINEOPLASTIC AGENT; ANTIOXIDANT; BEVACIZUMAB; CISPLATIN; COLECALCIFEROL DERIVATIVE; CYCLOPHOSPHAMIDE; CYSTEINE; CYTARABINE; DEHYDROASCORBIC ACID; ETOPOSIDE; FLUOROURACIL; FOLINIC ACID; GLUTAMIC ACID; GLUTATHIONE; GOSSYPOL; HOMOCYSTEINE; HOMOCYSTEINE THIOLACTONE; METHIONINE; MITOXANTRONE; OXALIPLATIN; PACLITAXEL; S ADENOSYLMETHIONINE; SEOCALCITOL; TAURINE; THIOCTIC ACID; THYMOQUINONE; UNINDEXED DRUG; WITHAFERIN A; SULFUR DERIVATIVE;

AMINO ACID METABOLISM; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW SUPPRESSION; CANCER CELL CULTURE; CANCER RESISTANCE; CANCER RISK; CANCER THERAPY; CELL CYCLE ARREST; CELL DAMAGE; CELL DEATH; CELL PROLIFERATION; CELL PROTECTION; CHEMOPROPHYLAXIS; COLORECTAL CARCINOMA; DETOXIFICATION; DIET SUPPLEMENTATION; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG METABOLISM; DRUG SAFETY; GLUTATHIONE METABOLISM; HEAD AND NECK CANCER; HUMAN; NEPHROTOXICITY; NONHUMAN; OTOTOXICITY; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; PROTEIN DEPLETION; PROTEIN METHYLATION; REGENERATION; TUMOR GROWTH; UPREGULATION; ANIMAL; CELL TRANSFORMATION; DRUG EFFECT; METABOLISM; NEOPLASM; OXIDATION REDUCTION REACTION; PATHOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL TRANSFORMATION, NEOPLASTIC; GLUTATHIONE; HUMANS; NEOPLASMS; OXIDATION-REDUCTION; OXIDATIVE STRESS; SULFUR COMPOUNDS;

EID: 84869411749     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: 10.2741/s296     Document Type: Article

References (167)

1. J. Lora, F. J. Alonso, J. A. Segura, C. Lobo, J. Márquez and J. M. Matés: Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells. Eur J Biochem 271, 4298-4306 (2004) (Pubitemid 39506759)
2. J. M. Matés: Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 153, 83-104 (2000)
3. J. M. Matés, C. Pérez-Gómez, I. Núñez de Castro, M. Asenjo and J. Márquez: Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death. Int J Biochem Cell Biol 34, 439-458 (2002) (Pubitemid 34242758)
4. R. Masella, R. Di Benedetto, R. Varì, C. Filesi and C. Giovannini: Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J Nutr Biochem 16, 577-586 (2005) (Pubitemid 41338369)
5. A. Gosslau and L. Rensing: Oxidative stress, agedependent (correction of age-related) cell damage and antioxidative mechanisms. Z Gerontol Geriatr 35, 139-150 (2002) (Pubitemid 34493087)
6. S. Parcell: Sulfur in human nutrition and applications in medicine. Altern Med Rev 7, 22-44 (2002) (Pubitemid 34203978)
7. S. Kawanishi, S. Oikawa and M. Murata: Evaluation for safety of antioxidant chemopreventive agents. Antioxid Redox Signal 7, 1728-1739 (2005) (Pubitemid 41768004)
8. C. Gerhäuser, K. Klimo, E. Heiss, I. Neumann, A. Gamal-Eldeen, J. Knauft, G. Y. Liu, S. Sitthimonchai and N. Frank: Mechanism-based in vitro screening of potential cancer chemopreventive agents. Mutat Res 523-524, 163-172 (2003) (Pubitemid 36293243)
9. J. M. Matés, J. A. Segura, F. J. Alonso and J. Márquez: Natural antioxidants, therapeutic prospects for cancer and neurological diseases. Mini Rev Med Chem 9, 1202-1214 (2009)
10. V. Calabrese, C. Cornelius, C. Mancuso, R. Lentile, A. M. Stella and D. A. Butterfield: Redox homeostasis and cellular stress response in aging and neurodegeneration. Methods Mol Biol 610, 285-308 (2010)
11. A. Kawashima, T. Madarame, H. Koike, Y. Komatsu and J. A. Wise: Four week supplementation with mixed fruit and vegetable juice concentrates increased protective serum antioxidants and folate and decreased plasma homocysteine in Japanese subjects. Asia Pac J Clin Nutr 16, 411-421 (2007) (Pubitemid 47463617)
12. G. Alfthan: Lowering risk factors for heart diseases by dietary approaches. Ukr Biokhim Zh 76, 82-85 (2004) (Pubitemid 39462836)
13. R. F. Grimble: Nutritional antioxidants and the modulation of inflammation: theory and practice. New Horiz 2, 175-185 (1994)
14. C. Bauchart-Thevret, B. Stoll and D. G. Burrin: Intestinal metabolism of sulfur amino acids. Nutr Res Rev 22, 175-187 (2009)
15. T. P. Smith, C. P. Cruz, A. T. Brown, J. F. Eidt, M. M. Moursi: Folate supplementation inhibits intimal hyperplasia induced by a high-homocysteine diet in a rat carotid endarterectomy model. J Vasc Surg 34, 474-481 (2001) (Pubitemid 33661181)
16. E. Caylak, M. Aytekin and I. Halifeoglu: Antioxidant effects of methionine, alpha-lipoic acid, N-acetylcysteine and homocysteine on lead-induced oxidative stress to erythrocytes in rats. Exp Toxicol Pathol 60, 289-294 (2008)
17. S. A. Lee: Gene-diet interaction on cancer risk in epidemiological studies. J Prev Med Public Health 42, 360-370 (2009)
18. L. Packer, E. H. Witt and H. J. Tritschler: Alpha-Lipoic acid as a biological antioxidant. Free Radic Biol Med 19, 227-250 (1995)
19. C. G. Yedjou and P. B. Tchounwou: N-acetyl-Lcysteine affords protection against lead-induced cytotoxicity and oxidative stress in human liver carcinoma (HepG2) cells: Int J Environ Res Public Health 4, 132-137 (2007) (Pubitemid 47026517)
20. C. Perotti, A. Casas and A. M. Del C Batlle: Scavengers protection of cells against ALA-based photodynamic therapy-induced damage. Lasers Med Sci 17, 222-229 (2002) (Pubitemid 35252877)
21. M. Benlloch, A. Ortega, P. Ferrer, R. Segarra, E. Obrador, M. Asensi, J. Carretero and J. M. Estrela: Acceleration of glutathione efflux and inhibition of gamma-glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity. J Biol Chem 280, 6950-6959 (2005) (Pubitemid 40341251)
22. G. J. Kelloff, J. A. Crowell, C. W. Boone, V. E. Steele, R. A. Lubet, P. Greenwald, D. S. Alberts, J. M. Covey, L. A. Doody and G. G. Knapp: Clinical development plan: NAcetyll-cysteine. J Cell Biochem 20, 63-73 (1994)
23. J. O. Rosado, M. Salvador and D. Bonatto: Importance of the trans-sulfuration pathway in cancer prevention and promotion. Mol Cell Biochem 301, 1-12 (2007) (Pubitemid 46895141)
24. S. Kandil, L. Brennan and G. J. McBean: Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase and upregulation of the transsulfuration pathway in C6 glioma cells. Neurochem Int 56, 611-619 (2010)
25. B. Bekaert, M. L. Cooper, F. R. Green, H. McNulty, K. Pentieva, J. M. Scott, A. M. Molloy and M. P. Rayman: Effect of selenium status and supplementation with highselenium yeast on plasma homocysteine and B vitamin concentrations in the UK elderly. Mol Nutr Food Res 52, 1324-1333 (2008)
26. A. Prudova, Z. Bauman, A. Braun, V. Vitvitsky, S. C. Lu and R. Banerjee: S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc Natl Acad Sci U S A 103, 6489-6494 (2006)
27. K. Fink, A. Brink, J. Vienken, A. Heidland and H. Stopper: Homocysteine exerts genotoxic and antioxidative effects in vitro. Toxicol In vitro 21, 1402-1408 (2007) (Pubitemid 350086857)
28. S. E. George, K. Ramalakshmi and L. J. Mohan Rao: A perception on health benefits of coffee. Crit Rev Food Sci Nutr 48, 464-486 (2008) (Pubitemid 351883139)
29. A. Prudova, M. Albin, Z. Bauman, A. Lin, V. Vitvitsky and R. Banerjee: Testosterone regulation of homocysteine metabolism modulates redox status in human prostate cancer cells. Antioxid Redox Signal 9, 1875-1881 (2007) (Pubitemid 47622347)
30. J. Zhang, V. Svehlíková, Y. Bao, A. F. Howie, G. J. Beckett and G. Williamson: Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis 24, 497-503 (2003) (Pubitemid 36432646)
31. C. L. Anderson, S. S. Iyer, T. R. Ziegler and D. P. Jones: Control of extracellular cysteine/cystine redox state by HT-29 cells is independent of cellular glutathione. Am J Physiol Regul Integr Comp Physiol 293, R1069-R1075 (2007) (Pubitemid 47358926)
32. T. Noda, R. Iwakiri, K. Fujimoto, C. A. Rhoads and T. Y. Aw: Exogenous cysteine and cystine promote cell proliferation in CaCo-2 cells. Cell Prolif 35, 117-129 (2002) (Pubitemid 34603858)
33. S. K. Niture, U. S. Rao and K. S. Srivenugopal: Chemopreventative strategies targeting the MGMT repair protein: augmented expression in human lymphocytes and tumor cells by ethanolic and aqueous extracts of several Indian medicinal plants. Int J Oncol 29, 1269-1278 (2006)
34. S. K. Niture, C. S. Velu, Q. R. Smith, G. J. Bhat and K. S. Srivenugopal: Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. Carcinogenesis 28, 378-389 (2007) (Pubitemid 46321854)
35. S. De Flora, A. Izzotti, F. D'Agostini and R. M. Balansky: Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis 22, 999-1013 (2001) (Pubitemid 32633597)
36. I. H. Lambert: Activation and inactivation of the volumesensitive taurine leak pathway in NIH3T3 fibroblasts and Ehrlich Lettre ascites cells. Am J Physiol Cell Physiol 293, C390-400 (2007) (Pubitemid 47105013)
37. Q. Zhang, F. Tsukahara and Y. Maru: N-acetyl-cysteine enhances growth in BCR-ABL-transformed cells. Cancer Sci 96, 240-244 (2005) (Pubitemid 40767062)
38. R. Garcia-Roman, D. Salazar-Gonzalez, S. Rosas, J. Arellanes-Robledo, O. Beltran-Ramirez, S. Fattel-Fazenda and S. Villa-Treviño: The differential NF-kB modulation by Sadenosyl-L-methionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis. Free Radic Res 42, 331-343 (2008)
39. M. W. Roomi, N. W. Roomi, T. Kalinovsky, M. Rath and A. Niedzwiecki: Chemopreventive effect of a novel nutrient mixture on lung tumorigenesis induced by urethane in male A/J mice. Tumori 95, 508-513 (2008)
40. M. W. Roomi, N. W. Roomi, T. Kalinovsky, V. Ivanov and A. Niedzwiecki: Inhibition of 7, 12-dimethylbenzanthracene-induced skin tumors by a nutrient mixture. Med Oncol 25, 333-340 (2008)
41. H. Babich, N. J. Ackerman, F. Burekhovich, H. L. Zuckerbraun and A. G. Schuck: Gingko biloba leaf extract induces oxidative stress in carcinoma HSC-2 cells. Toxicol In vitro 23, 992-999 (2009)
42. F. Malik, A. Kumar, S. Bhushan, S. Khan, A. Bhatia, K. A. Suri, G. N. Qazi and J. Singh: Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine. Apoptosis 12, 2115-2133 (2007) (Pubitemid 47498235)
43. X. Huang, A. Kurose, T. Tanaka, F. Traganos, W. Dai and Z. Darzynkiewicz: Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-Lcysteine. Cancer Biol Ther 5, 959-649 (2006)
44. T. Tanaka, H. D. Halicka, F. Traganos, K. Seiter and Z. Darzynkiewicz: Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase. Cell Cycle 6, 371-376 (2007)
45. F. Song, Z. F. Zhang, L. Liu, T. Yang, J. Jiang and P. Li: Small interfering RNA-mediated silencing of heat shock protein 27 (HSP27) increases chemosensitivity to paclitaxel by increasing production of reactive oxygen species in human ovarian cancer cells (HO8910). J Int Med Res 37, 1375-1388 (2009)
46. M. J. Sikora, J. A. Bauer, M. Verhaegen, T. J. Belbin, M. B. Prystowsky, J. C. Taylor, J. C. Brenner, S. Wang, M. S. Soengas, C. R. Bradford and T. E. Carey: Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol. Cancer Biol Ther 7, 767-776 (2008)
47. M. Jiang, Q. Wei, N. Pabla, G. Dong, C. Y. Wang, T. Yang, S. B. Smith and Z. Dong: Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity. Biochem Pharmacol 73, 1499-1510 (2007) (Pubitemid 46452592)
48. S. Senturker, R. Tschirret-Guth, J. Morrow, R. Levine and E. Shacter: Induction of apoptosis by chemotherapeutic drugs without generation of reactive oxygen species. Arch Biochem Biophys 397, 262-272 (2002) (Pubitemid 34852290)
49. P. Bondza-Kibangou, C. Millot, V. El Khoury and J. M. Millot: Antioxidants and doxorubicin supplementation to modulate CD14 expression and oxidative stress induced by vitamin D3 and seocalcitol in HL60 cells. Oncol Rep 18, 1513-1519 (2007)
50. A. Nyska, A. Suttie, S. Bakshi, L. Lomnitski, S. Grossman, M. Bergman, V. Ben-Shaul, P. Crocket, J. K. Haseman, G. Moser, T. L. Goldsworthy and R. R. Maronpot: Slowing tumorigenic progression in TRAMP mice and prostatic carcinoma cell lines using natural anti-oxidant from spinach, NAO-a comparative study of three anti-oxidants. Toxicol Pathol 31, 39-51 (2003) (Pubitemid 36169420)
51. S. Kanno, A. Shouji, R. Hirata, K. Asou and M. Ishikawa: Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells. Life Sci 75, 353-365 (2004) (Pubitemid 38591646)
52. L. A. Harker, J. M. Harlan and R. Ross: Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons. Circ Res 53, 731-739 (1983) (Pubitemid 14219935)
53. J. C. Tsai, M. A. Perrella, M. Yoshizumi, C. M. Hsieh, E. Haber, R. Schlegel and M. E. Lee: Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci U S A 91, 6369-6373 (1994) (Pubitemid 24200662)
54. R. A. Cavallaro, A. Fuso, V. Nicolia and S. Scarpa: SAdenosylmethionine Prevents Oxidative Stress and Modulates Glutathione Metabolism in TgCRND8 Mice Fed with B Vitamin Deficient Diet. J Alzheimers Dis 20, 997-1002 (2010)
55. M. Fenech: Micronucleus frequency in human lymphocytes is related to plasma vitamin B12 and homocysteine. Mutat Res 428, 299-304 (1999) (Pubitemid 29389701)
56. A. S. Sethi, D. M. Lees, J. A. Douthwaite, A. B. Dawnay and R. Corder: Homocysteine-induced endothelin-1 release is dependent on hyperglycaemia and reactive oxygen species production in bovine aortic endothelial cells. J Vasc Res 43, 175-183 (2006) (Pubitemid 43247999)
57. S. M. Lynch, A. L. Campione and M. K. Moore: Plasma thiols inhibit hemin-dependent oxidation of human low-density lipoprotein. Biochim Biophys Acta 1485, 11-22 (2000) (Pubitemid 30259191)
58. I. Kato, A. M. Dnistrian, M. Schwartz, P. Toniolo, K. Koenig, R. E. Shore, A. Akhmedkhanov, A. Zeleniuch-Jacquotte and E. Riboli: Serum folate, homocysteine and colorectal cancer risk in women: a nested case-control study. Br J Cancer 79, 1917-1922 (1999) (Pubitemid 29132325)
59. J. Hultdin, B. Van Guelpen, A. Bergh, G. Hallmans and P. Stattin: Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study. Int J Cancer 113, 819-824 (2005) (Pubitemid 40101265)
60. A. J. McEligot, C. L. Rock, E. A. Gilpin and J. P. Pierce: Responsiveness of homocysteine concentrations to food and supplemental folate intakes in smokers and neversmokers enrolled in a diet intervention trial. Nicotine Tob Res 8, 57-66 (2006)
61. B. Melichar, H. Kalábová, L. Krcmová, M. Kasparová, E. Malírová, K. Melicharová, M. Pecka, R. Hyspler and D. Solichová: Serum homocysteine, cholesterol, retinol, alphatocopherol, glycosylated hemoglobin and inflammatory response during therapy with bevacizumab, oxaliplatin, 5-fluorouracil and leucovorin. Anticancer Res 29, 4813-2048 (2009)
62. S. Bergmann, V. Shatrov, F. Ratter, S. Schiemann, K. Schulze-Osthoff and V. Lehmann: Adenosine and homocysteine together enhance TNF-mediated cytotoxicity but do not alter activation of nuclear factor-kappa B in L929 cells. J Immunol 153, 1736-1743 (1994) (Pubitemid 24251118)
63. V. A. Shatrov, M. Ameyar, Z. Cai, A. Bettaieb and S. Chouaib: Methyltransferase inhibitor S-adenosyl-Lhomocysteine sensitizes human breast carcinoma MCF7 cells and related TNF-resistant derivatives to TNFmediated cytotoxicity via the ceramide-independent pathway. Eur Cytokine Netw 10, 247-252 (1999) (Pubitemid 29332781)
64. A. Fuso, R. A. Cavallaro, A. Zampelli, F. D'Anselmi, P. Piscopo, A. Confaloni and S. Scarpa: gamma-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells. J Alzheimers Dis 11, 275-290 (2007) (Pubitemid 47094027)
65. J. I. Toohey: Dehydroascorbic acid as an anti-cancer agent. Cancer Lett 263, 164-169 (2008)
66. J. I. Toohey: Homocysteine toxicity in connective tissue: theories, old and new. Connect Tissue Res 49, 57-61 (2008)
67. M. Valko, M. Izakovic, M. Mazur, C. J. Rhodes and J. Telser: Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 266, 37-56 (2004) (Pubitemid 39562306)
68. J. H. Jackson: Potential molecular mechanisms of oxidantinduced carcinogenesis. Environ Health Perspect 102, 155-158 (1994)
69. J. M. Matés, C. Pérez-Gómez and I. Núñez de Castro: Antioxidant enzymes and human diseases. Clin Biochem 32, 595-603 (1999)
70. T. Lin and M. S. Yang: Benzo (a) pyrene-induced elevation of GSH level protects against oxidative stress and enhances xenobiotic detoxification in human HepG2 cells. Toxicology 235, 1-10 (2007) (Pubitemid 46669765)
71. D. P. Jones: Redox potential of GSH/GSSG couple: assay and biological significance. Methods Enzymol 348, 93-112 (2002) (Pubitemid 41103102)
72. J. M. Matés, J. A. Segura, F. J. Alonso and J. Márquez: Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis. Arch Toxicol 82, 273-299 (2008)
73. J. M. Estrela, A. Ortega and E. Obrador: Glutathione in cancer biology and therapy. Crit Rev Clin Lab Sci 43, 143-181 (2006) (Pubitemid 43860449)
74. J. M. Matés, J. A. Segura, F. J. Alonso and J. Márquez: Pathways from glutamine to apoptosis. Front Biosci 11, 3164-3180 (2006) (Pubitemid 43804592)
75. V. M. Lakshmi, F. F. Hsu and T. V. Zenser: Nitrosation and nitration of 2-amino-3-methylimidazo (4, 5-f) quinoline by reactive nitrogen oxygen species. Chem Res Toxicol 15, 1059-1068 (2002) (Pubitemid 34977272)
76. K. Matsumaru, C. Ji and N. Kaplowitz: Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. Hepatology 37, 1425-1434 (2003) (Pubitemid 36667323)
77. C. Domenicotti, B. Marengo, D. Verzola, G. Garibotto, N. Traverso, S. Patriarca, G. Maloberti, D. Cottalasso, G. Poli, M. Passalacqua, E. Melloni, M. A. Pronzato and U. M. Marinari: Role of PKC-delta activity in glutathione-depleted neuroblastoma cells. Free Radic Biol Med 35, 504-516 (2003) (Pubitemid 37289160)
78. B. Marengo, C. De Ciucis, D. Verzola, V. Pistoia, L. Raffaghello, S. Patriarca, E. Balbis, N. Traverso, D. Cottalasso, M. A. Pronzato, U. M. Marinari and C. Domenicotti: Mechanisms of BSO (L-buthionine-S, Rsulfoximine) - induced cytotoxic effects in neuroblastoma. Free Radic Biol Med 44, 474-482 (2008)
79. S. M. Zhang, W. C. Willett, J. Selhub, J. E. Manson, G. A. Colditz and S. E. Hankinson: A prospective study of plasma total cysteine and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 12, 1188-1193 (2003) (Pubitemid 37499442)
80. F. Holguin, I. Moss, L. A. Brown and D. M. Guidot: Chronic ethanol ingestion impairs alveolar type II cell glutathione homeostasis and function and predisposes to endotoxin-mediated acute edematous lung injury in rats. J Clin Invest 101, 761-768 (1998) (Pubitemid 28096072)
81. R. H. Engel and A. M. Evens: Oxidative stress and apoptosis: a new treatment paradigm in cancer. Front Biosci 11, 300-312 (2006) (Pubitemid 43253493)
82. S. Zhang, C. N. Ong and H. M. Shen: Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells. Cancer Lett 208, 143-153 (2004) (Pubitemid 38624155)
83. F. J. Alonso, J. A. Segura, J. Lora, C. Lobo, B. Fernández-Molina, J. Márquez and J. M. Matés: Sensitisation of Ehrlich ascitic tumour cells to methotrexate by inhibiting glutaminase. Anticancer Res 25, 3315-3320 (2005) (Pubitemid 41105206)
84. J. M. Matés, J. A. Segura, J. A. Campos-Sandoval, C. Lobo, L. Alonso, F. J. Alonso and J. Márquez: Glutamine homeostasis and mitochondrial dynamics. Int J Biochem Cell Biol 41, 2051-2061 (2009)
85. S. Suzuki, T. Tanaka, M. V. Poyurovsky, H. Nagano, T. Mayama, S. Ohkubo, M. Lokshin, H. Hosokawa, T. Nakayama, Y. Suzuki, S. Sugano, E. Sato, T. Nagao, K. Yokote, I. Tatsuno and C. Prives: Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci U S A 107, 7461-7466 (2010)
86. W. Hu, C. Zhang, R. Wu, Y. Sun, A. Levine and Z. Feng: Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A 107, 7455-7460 (2010)
87. W. G. Kaelin Jr. and C. B. Thompson: Cancer: Clues from cell metabolism. Nature 465, 562-564 (2010)
88. J. Márquez, M. Tosina, V. de la Rosa, J. A. Segura, F. J. Alonso, J. M. Matés and J. A. Campos-Sandoval: New insights into brain glutaminases: beyond their role on glutamatergic transmission. Neurochem Int 55, 64-70. (2009)
89. E. P. Seidlitz, M. K. Sharma and G. Singh: A by-product of glutathione production in cancer cells may cause disruption in bone metabolic processes. Can J Physiol Pharmacol 88, 197-203 (2010)
90. G. C. Das, A. Bacsi, M. Shrivastav, T. K. Hazra and I. Boldogh: Enhanced gamma-glutamylcysteine synthetase activity decreases drug-induced oxidative stress levels and cytotoxicity. Mol Carcinog 45, 635-647 (2006) (Pubitemid 44406634)
91. J. K. Kwee, D. G. Luque, A. C. Ferreira, F. C. Vasconcelos, K. L. Silva, C. E. Klumb and R. C. Maia: Modulation of reactive oxygen species by antioxidants in chronic myeloid leukemia cells enhances imatinib sensitivity through survivin downregulation. Anticancer Drugs 19, 975-981 (2008)
92. H. Goto, H. Takahashi, H. Fujii, K. Ikuta and S. Yokota: N-(4-Hydroxyphenyl) retinamide (4-HPR) induces leukemia cell death via generation of reactive oxygen species. Int J Hematol 78, 219-225 (2003) (Pubitemid 37288508)
93. M. C. Morales, G. Pérez-Yarza, N. Nieto-Rementeria, M. D. Boyano, M. Jangi, R. Atencia and A. Asumendi: Intracellular glutathione levels determine cell sensitivity to apoptosis induced by the antineoplasic agent N-(4-hydroxyphenyl) retinamide. Anticancer Res 25, 1945-1951 (2005) (Pubitemid 40904589)
94. B. Ozpolat, U. Akar, M. Steiner, I. Zorrilla-Calancha, M. Tirado-Gómez, N. Colburn, M. Danilenko, S. Kornblau and G. L. Berestein: Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells. Mol Cancer Res 5, 95-108 (2007)
95. C. Porta, M. Moroni, P. Guallini, C. Torri and F. Marzatico: Antioxidant enzymatic system and free radicals pathway in two different human cancer cell lines. Anticancer Res 16, 2741-2747 (1996) (Pubitemid 26388247)
96. Y. H. Han and W. H. Park: The effects of N-acetyl cysteine, buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1, 2, 4-triazole on antimycin A-treated Calu-6 lung cells in relation to cell growth, reactive oxygen species and glutathione. Oncol Rep 22, 385-391 (2009)
97. M. Udler, A. T. Maia, A. Cebrian, C. Brown, D. Greenberg, M. Shah, C. Caldas, A. Dunning, D. Easton, B. Ponder and P. Pharoah: Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer. J Clin Oncol 25, 3015-3023 (2007) (Pubitemid 47218047)
98. C. H. Dung, S. C. Wu and G. C. Yen: Genotoxicity and oxidative stress of the mutagenic compounds formed in fumes of heated soybean oil, sunflower oil and lard. Toxicol In vitro 20, 439-447 (2006)
99. *-) generator induces apoptosis via the depletion of intracellular GSH contents in Calu-6 cells. Lung Cancer 63, 201-209 (2009)
100. S. Parvez, H. Tabassum, B. D. Banerjee and S. Raisuddin: Taurine prevents tamoxifen-induced mitochondrial oxidative damage in mice. Basic Clin Pharmacol Toxicol 102, 382-387 (2008) (Pubitemid 351393108)
101. M. M. Cortes-Wanstreet, E. Giedzinski, C. L. Limoli and U. Luderer: Overexpression of glutamate-cysteine ligase protects human COV434 granulosa tumour cells against oxidative and gamma-radiation-induced cell death. Mutagenesis 24, 211-224 (2009)
102. D. F. Calvisi, M. M. Simile, S. Ladu, R. Pellegrino, V. De Murtas, F. Pinna, M. L. Tomasi, M. Frau, P. Virdis, M. R. De Miglio, M. R. Muroni, R. M. Pascale and F. Feo: Altered methionine metabolism and global DNA methylation in liver cancer: relationship with genomic instability and prognosis. Int J Cancer 121, 2410-2420 (2007) (Pubitemid 350022410)
103. R. M. Pascale, M. M. Simile and F. Feo: Genomic abnormalities in hepatocarcinogenesis. Implications for a chemopreventive strategy. Anticancer Res 13, 1341-1356 (1993) (Pubitemid 23334759)
104. R. M. Pascale, R. M., M. M. Simile, M. R. De Miglio and F. Feo: Chemoprevention of hepatocarcinogenesis: Sadenosyl-L-methionine. Alcohol 27, 193-198 (2002)
105. Y. M. Fu, H. Zhang, M. Ding, Y. Q. Li, X. Fu, Z. X. Yu and G. G. Meadows: Selective amino acid restriction targets mitochondria to induce apoptosis of androgenindependent prostate cancer cells. J Cell Physiol 209, 522-534 (2006) (Pubitemid 44484643)
106. D. Gao, C. Wei, L. Chen, J. Huang, S. Yang and A. M. Diehl: Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease. Am J Physiol Gastrointest Liver Physiol 287, G1070-G1077 (2004) (Pubitemid 39423700)
107. N. P. Núñez, H. Liu and G. G. Meadows: PPARgamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells. Cancer Lett 236, 133-141 (2006) (Pubitemid 44419327)
108. G. C. Farrell, C. Z. Larter, J. Y. Hou, R. H. Zhang, M. M. Yeh, J. Williams, A. dela Pena, R. Francisco, S. R. Osvath, J. Brooling, N. Teoh and L. M. Sedger: Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression. J Gastroenterol Hepatol 24, 443-452 (2009)
109. G. Kune and L. Watson: Colorectal cancer protective effects and the dietary micronutrients folate, methionine, vitamins B6, B12, C, E, selenium, and lycopene. Nutr Cancer 56, 11-21 (2006) (Pubitemid 46173410)
110. K. Zhu, S. Hunter, K. Payne-Wilks, C. Sutcliffe, C. Bentley, C. L. Roland and S. M. Williams: Potential differences in breast cancer risk factors based on CYP1A1 MspI and African-American-specific genotypes. Ethn Dis 16, 207-215 (2006) (Pubitemid 46959269)
111. P. Giordano, G. Lorito, A. Ciorba, A. Martini and S. Hatzopoulos: Protection against cisplatin ototoxicity in a Sprague-Dawley rat animal model. Acta Otorhinolaryngol Ital 26, 198-207 (2006)
112. D. Reser, J. Arezzo, D. Dewan, D. Frenz, L. Goldbloom, L. Herbst, R. Kopke, J. Arezzo and T. Van De Water: L-and D-Methionine provide equivalent long term protection against CDDP-induced ototoxicity in vivo, with partial in vitro and in vivo retention of antineoplastic activity. Neurotoxicology 20, 731-748 (1999)
113. A. Ayhanci, S. Yaman, S. Appak and S. Gunes: Hematoprotective effect of seleno-L-methionine on cyclophosphamide toxicity in rats. Drug Chem Toxicol 32, 424-428 (2009)
114. E. Giovannucci, M. J. Stampfer, G. A. Colditz, E. B. Rimm, D. Trichopoulos, B. A, Rosner, F. E. Speizer and W. C. Willett: Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 85, 875-884 (1993) (Pubitemid 23157127)
115. A. Forte, R. De Sanctis, G. Leonetti, S. Manfredelli, V. Urbano and M. Bezzi: Dietary chemoprevention of colorectal cancer. Ann Ital Chir 79, 261-267 (2008)
116. I. H. McKillop and L. W. Schrum: Alcohol and liver cancer. Alcohol 35, 195-203 (2005) (Pubitemid 41079923)
117. I. H. McKillop and L. W. Schrum: Role of alcohol in liver carcinogenesis: Semin Liver Dis 29, 222-232 (2009)
118. T. W. Li, Q. Zhang, P. Oh, M. Xia, H. Chen, S. Bemanian, N. Lastra, M. Circ, M. P. Moyer, J. M. Mato, T. Y. Aw and S. C. Lu: S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells. Mol Pharmacol 76, 192-200 (2009)
119. A. L. Subhi, B. Tang, B. R. Balsara, D. A. Altomare, J. R. Testa, H. S. Cooper, J. P. Hoffman, N. J. Meropol and W. D. Kruger: Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer. Clin Cancer Res 10, 7290-7296 (2004) (Pubitemid 39487717)
120. H. Yang, M. R. Sadda, M. Li, Y. Zeng, L. Chen, W. Bae, X. Ou, M. T. Runnegar, J. M. Mato and S. C. Lu: Sadenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-x (S). Hepatology 40, 221-231 (2004) (Pubitemid 38868941)
121. J. Yu and A. K. Kim: Effect of taurine on antioxidant enzyme system in B16F10 melanoma cells. Adv Exp Med Biol 643, 491-499 (2009)
122. F. Klamt and E. Shacter: Taurine chloramine, an oxidant derived from neutrophils, induces apoptosis in human B lymphoma cells through mitochondrial damage. J Biol Chem 280, 21346-21352 (2005) (Pubitemid 40805697)
123. C. Kim and Y. N. Cha: Production of reactive oxygen and nitrogen species in phagocytes is regulated by taurine chloramine. Adv Exp Med Biol 643, 463-472 (2009)
124. S. Heigold and G. Bauer: RAW 264.7 macrophages induce apoptosis selectively in transformed fibroblasts: intercellular signaling based on reactive oxygen and nitrogen species. J Leukoc Biol 72, 554-563 (2002)
125. H. Suzuki, K. Seto, M. Mori, M. Suzuki, S. Miura and H. Ishii: Monochloramine induced DNA fragmentation in gastric cell line MKN45. Am J Physiol 275, G712-G716 (1998)
126. M. B. Grisham, M. M. Jefferson, D. F. Melton and E. L. Thomas: Chlorination of endogenous amines by isolated neutrophils. Ammonia-dependent bactericidal, cytotoxic, and cytolytic activities of the chloramines. J Biol Chem 259, 10404-10413 (1984) (Pubitemid 14065348)
127. A. M. Cantin, G. Bilodeau, C. Ouellet, J. Liao and J. W. Hanrahan: Oxidant stress suppresses CFTR expression. Am J Physiol Cell Physiol 290, C262-C270 (2006)
128. F. Klamt, S. Zdanov, R. L. Levine, A. Pariser, Y. Zhang, B. Zhang, L. R. Yu, T. D. Veenstra and E. Shacter: Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin. Nat Cell Biol 11, 1241-1246 (2009)
129. D. S. Lakshmi and C. V. Anuradha: Mitochondrial damage, cytotoxicity and apoptosis in iron-potentiated alcoholic liver fibrosis: amelioration by taurine. Amino Acids 38, 869-879 (2010)
130. K. R. Villumsen, L. Duelund and I. H. Lambert: Acute cholesterol depletion leads to net loss of the organic osmolyte taurine in Ehrlich Lettré tumor cells. Amino Acids 39, 1521-1536 (2010)
131. I. Engelmann, S. Dormann, M. Saran and G. Bauer G: Transformed target cell-derived superoxide anions drive apoptosis induction by myeloperoxidase. Redox Rep 5, 207-214 (2000)
132. H. Iishi, M. Tatsuta, M. Baba, T. Mikuni, R. Yamamoto, K. Iseki, H. Yano, H. Uehara and A. Nakaizumi: Enhancement by monochloramine of the development of gastric cancers in rats: a possible mechanism of Helicobacter pylori-associated gastric carcinogenesis. J Gastroenterol 32, 435-441 (1997) (Pubitemid 27367971)
133. A. Horikoshi, K. Takei, N. Iriyama, K. Uenogawa, H. Ishizuka, H. Shiraiwa, Y. Hosokawa, S. Sawada and T. Kitoh: Effect of L-asparaginase combined with vincristine and prednisolone on acute myeloblastic leukemia (M0) associated with non-Hodgkin lymphoma. Acta Haematol 122, 54-57 (2009)
134. U. Ozgen, S. Savasan, M. Stout, S. Buck and Y. Ravindranath: Further elucidation of mechanism of resistance to vincristine in myeloid cells: role of hypochlorous acid in degradation of vincristine by myeloperoxidase. Leucemia 14, 47-51 (2000) (Pubitemid 30068372)
135. U. Ozgen, Y. Turkoz, M. Stout, F. Ozugurlu, F. Pelik, Y. Bulut, M. Aslan, Y. Ravindranath and S. Sava°an: Degradation of vincristine by myeloperoxidase and hypochlorous acid in children with acute lymphoblastic leukemia. Leuk Res 27, 1109-1113 (2003) (Pubitemid 36966082)
136. X. R. Jiang, M. Yang, C. J. Morris, A. C. Newland, D. P. Naughton, D. R. Blake, Z. Zhang and M. C. Grootveld: High field proton NMR investigations of the metabolic profiles of multidrug-sensitive and -resistant leukaemic cell lines: evidence for diminished taurine levels in multidrugresistant cells. Free Radic Res Commun 19, 355-369 (1993)
137. Y. Hua, M. R. Kandadi, M. Zhu, J. Ren and N. Sreejayan: Tauroursodeoxycholic acid attenuates lipid accumulation in endoplasmic reticulum-stressed macrophages. J Cardiovasc Pharmacol 55, 49-55 (2010)
138. J. Hong, J. Behar, J. Wands, M. Resnick, L. J. Wang, R. A. Delellis, D. Lambeth and W. Cao: Bile acid reflux contributes to development of esophageal adenocarcinoma via activation of phosphatidylinositol-specific phospholipase Cgamma2 and NADPH oxidase NOX5-S. Cancer Res 70, 1247-1255 (2010)
139. S. Lechner, U. Muller-Ladner, K. Schlottmann, B. Jung, M. McClelland, J. Ruschoff, J. Welsh, J. Schölmerich and F. Kullmann: Bile acids mimic oxidative stress induced upregulation of thioredoxin reductase in colon cancer cell lines. Carcinogenesis 23, 1281-1288 (2002)
140. A. Maczurek, K. Hager, M. Kenklies, M. Sharman, R. Martins, J. Engel, D. A. Carlson and G. Munch: Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Adv Drug Deliv Rev 60, 1463-1470 (2008)
141. R. K. Monroe and S. W. Halvorsen: Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption. Neurotoxicology 30, 589-598 (2009)
142. Y. J. Wang, M. C. Yang, and M. H. Pan: Dihydrolipoic acid inhibits tetrachlorohydroquinone-induced tumor promotion through prevention of oxidative damage. Food Chem Toxicol 46, 3739-3748 (2008)
143. M. Yamasaki, A. Kawabe, K. Nishimoto, H. Madhyastha, Y. Sakakibara, M. Suiko, T. Okamoto, T. Suda, K. Uehira and K. Nishiyama: Dihydro-alpha-lipoic acid has more potent cytotoxicity than alpha-lipoic acid. In vitro Cell Dev Biol Anim 45, 275-280 (2009)
144. D. Dymkowska and L. Wojtczak: Arachidonic acidinduced apoptosis in rat hepatoma AS-30D cells is mediated by reactive oxygen species. Acta Biochim Pol 56, 711-715 (2009)
145. D. Mukherjea, S. Jajoo, C. Whitworth, J. R. Bunch, J. G. Turner, L. P. Rybak and V. Ramkumar: Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat. J Neurosci 28, 13056-13065 (2008)
146. G. Simbula, A. Columbano, G. M. Ledda-Columbano, L. Sanna, M. Deidda, A. Diana and M. Pibiri: Increased ROS generation and p53 activation in alpha-lipoic acidinduced apoptosis of hepatoma cells. Apoptosis 12, 113-123 (2007) (Pubitemid 46009508)
147. X. Wang, X. Zhang, Y. Cheng, C. Li, W. Zhang, L. Liu and Z. Ding: Alpha-lipoic acid prevents bupivacaineinduced neuron injury in vitro through a PI3K/Aktdependent mechanism. Neurotoxicology 31, 101-112 (2010)
148. D. Y. Shi, H. L. Liu, J. S. Stern, P. Z. Yu, P. Z. and S. L. Liu: Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway. FEBS Lett 582, 1667-1671 (2008)
149. J. Moungjaroen, U. Nimmannit, P. S. Callery, L. Wang, N. Azad, V. Lipipun, P. Chanvorachote and Y. Rojanasakul: Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation. J Pharmacol Exp Ther 319, 1062-1069 (2006)
150. G. E. Weitsman, A. Ravid, U. A. Liberman and R. Koren: Vitamin D enhances caspase-dependent and - independent TNFalpha-induced breast cancer cell death: The role of reactive oxygen species and mitochondria. Int J Cancer 106, 178-186 (2003) (Pubitemid 36835169)
151. *-generation. Apoptosis 10, 359-368 (2005) (Pubitemid 40603489)
152. G. D. Davis, J. G. Masilamoni, V. Arul, M. S. Kumar, U. Baraneedharan, S. F. Paul, I. V. Sakthivelu, E. P. Jesudason and R. Jayakumar: Radioprotective effect of DLalphalipoic acid on mice skin fibroblasts. Cell Biol Toxicol 25, 331-340 (2009)
153. K. B. Kumar, and R. Kuttan: Protective effect of an extract of Phyllanthus amarus against radiation-induced damage in mice. J Radiat Res 45, 133-139 (2004) (Pubitemid 38698660)
154. L. Li, K. K. Steinauer, A. J. Dirks, B. Husbeck, I. Gibbs and S. J. Knox: Radiation-induced cyclooxygenase 2 up-regulation is dependent on redox status in prostate cancer cells. Radiat Res 160, 617-621 (2003) (Pubitemid 37521703)
155. G. Mantovani, A. Macciò, C. Madeddu, G. Gramignano, M. R. Lusso, R. Serpe, E. Massa, G. Astara and L. Deiana: A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. Cancer Epidemiol Biomarkers Prev 15, 1030-1034 (2006) (Pubitemid 43823535)
156. G. Mantovani, A. Macciò, C. Madeddu, L. Mura, G. Gramignano, M. R. Lusso, E. Massa, M. Mocci and R. Serpe: Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress. J Mol Med 81, 664-673 (2003) (Pubitemid 37357681)
157. G. Mantovani, A. Macciò, C. Madeddu, L. Mura, G. Gramignano, M. R. Lusso, V. Murgia, P. Camboni, L. Ferreli, M. Mocci and E. Massa: The impact of different antioxidant agents alone or in combination on reactive oxygen species, antioxidant enzymes and cytokines in a series of advanced cancer patients at different sites: correlation with disease progression. Free Radic Res 37, 213-223 (2003) (Pubitemid 36124348)
158. N. El-Najjar, M. Chatila, H. Moukadem, H. Vuorela, M. Ocker, M. Gandesiri, R. Schneider-Stock and H. Gali-Muhtasib: Reactive oxygen species mediate thymoquinoneinduced apoptosis and activate ERK and JNK signaling. Apoptosis 15, 183-195 (2010)
159. J. A. Powell-Coffman and C. R. Coffman: Apoptosis: Lack of oxygen aids cell survival. Nature 465, 554-555 (2010)
160. J. M. Lü, P. H. Lin, Q. Yao and C. Chen: Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. J Cell Mol Med 14, 840-860 (2010)
161. V. M. Lakshmi, F. F. Hsu and T. V. Zenser: Transformation and activation of benzidine by oxidants of the inflammatory response. Chem Res Toxicol 16, 367-374 (2003) (Pubitemid 36373701)
162. C. E. Klein, B. Roberts, J. Holcenberg and L. M. Glode: Cystathionine metabolism in neuroblastoma. Cancer 62, 291-298 (1988)
163. C. F. Geiser and V. E. Shih: Cystathioninuria and its origin in children with hepatoblastoma. J Pediatr 96, 72-75 (1980) (Pubitemid 10160174)
164. L. M. Glode, H. L. Greene and I. Bikel: gamma-Cystathionase in normal and leukemic cells. Cancer Treat Rep 63, 1081-1088 (1979)
165. I. Kwiecien, M. Sokolowska and L. Wlodek: Nephroprotective effect of cystathionine is due to its diverse action on the kidney and Ehrlich ascites tumor cells. Pharmacol Rep 59, 553-564 (2007)
166. M. Iciek, J. Marcinek, U. Mleczko and L. Wlodek: Selective effects of diallyl disulfide, a sulfane sulfur precursor, in the liver and Ehrlich ascites tumor cells. Eur J Pharmacol 569, 1-7 (2007) (Pubitemid 47175873)
167. D. Mikeladze, E. Zhuravliova and T. Barbakadze: Ras proteins, nitrosylation and homocysteine metabolism. Georgian Med News 162, 30-33 (2008)