Antioxidant effects of methionine, α-lipoic acid, N-acetylcysteine and homocysteine on lead-induced oxidative stress to erythrocytes in rats

Experimental and Toxicologic Pathology

Volumn 60, Issue 4-5, 2008, Pages 289-294

  Caylak, Emrah ^a   Aytekin, Metin ^b   Halifeoglu, Ihsan ^a  

^a FIRAT UNIVERSITY   (Turkey)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Homocysteine; Lead; Lipoic acid; Methionine; N Acetylcysteine; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; GLUTATHIONE PEROXIDASE; HEMOGLOBIN; LEAD; MALONALDEHYDE; METHIONINE; RETINOL; SULFUR; SUPEROXIDE DISMUTASE; THIOCTIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; ENZYME ACTIVITY; ERYTHROCYTE; HEMOLYSATE; MALE; NONHUMAN; OXIDATIVE STRESS; RAT;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ERYTHROCYTES; GLUTATHIONE PEROXIDASE; HEMOGLOBINS; HOMOCYSTINE; LEAD; MALE; MALONDIALDEHYDE; METHIONINE; OXIDATIVE STRESS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOCTIC ACID; VITAMIN A; VITAMIN E;

ANIMALIA; RATTUS;

EID: 46649091905     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2007.11.004     Document Type: Article

References (34)

1. Aruoma O.I., Halliwell B., Hoey B.M., and Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 6 (1989) 593-597
2. Attri J., Dhawan V., Mahmood S., Pandhi P., Parwana H.K., and Nath R. Effect of vitamin C supplementation on oxidative DNA damage in an experimental model of lead-induced hypertension. Ann Nutr Metab 47 (2003) 294-301
3. Bernard A., and Lauwerys R. Metal-induced alterations of delta-aminolevulinic acid dehydratase. Ann NY Acad Sci 514 (1987) 41-47
4. Ercal N., Treeratphan P., Lutz P., Hammond T.C., and Matthews R.H. N-actylcysteine protects Chinese hamster ovary (CHO) cells from lead-induced oxidative stress. Toxicology 108 (1996) 57-64
5. Fujita H., and Ishihara N. Evidence of the induction of de novo synthesis of delta-aminolaevulinate dehydratase by lead. Br J Ind Med 45 (1988) 710-712
6. Fujita H., Orii Y., and Sano S. Evidence of increased synthesis of delta-aminolevulinic acid dehydratase in experimental lead-poisoned rats. Biochim Biophys Acta 678 (1981) 39-50
7. Fujita H., Sato K., and Sano S. Increase in the amount of erythrocyte delta-aminolevulinic acid dehydratase in workers with moderate lead exposure. Int Arch Occup Environ Health 50 (1982) 287-297
8. Fujita H., Nishitani C., and Ogawa K. Lead, chemical porphyria, and heme as a biological mediator. Tohoku J Exp Med 196 (2002) 53-64
9. Goyer R.A., and Rhyne B.C. Pathological effects of lead. Int Rev Exp Pathol 12 (1973) 1-77
10. Gurer H., Ozgunes H., Neal R., Spitz D.R., and Ercal N. Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats. Toxicology 128 (1998) 181-189
11. Hermes-Lima M., Pereira B., and Bechara E.J. Are free radicals involved in lead poisoning?. Xenobiotica 21 (1991) 1085-1090
12. Leggett R.W. An age-specific kinetic model of lead metabolism in humans. Environ Health Perspect 101 (1993) 598-616
13. Leong W.I., Bowlus C.L., Tallkvist J., and Lonnerdal B. DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption. Am J Physiol Gastrointest Liver Physiol 285 (2003) G1153-G1161
14. Machartova V., Racek J., Kohout J., Senft V., and Trefil L. [Effect of antioxidant therapy on indicators of free radical activity in workers at risk of lead exposure]. Vnitr Lek 46 (2000) 444-446
15. Othman A.I., and El Missiry M.A. Role of selenium against lead toxicity in male rats. J Biochem Mol Toxicol 12 (1998) 345-349
16. Packer L., Witt E.H., and Tritschler H.J. Alpha-lipoic acid as a biological antioxidant. Free Radic Biol Med 19 (1995) 227-250
17. Paglia D.E., and Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70 (1967) 158-169
18. Patel M.S., and Roche T.E. Molecular biology and biochemistry of pyruvate dehydrogenase complexes. FASEB J 4 (1990) 3224-3233
19. Patra R.C., Swarup D., and Dwivedi S.K. Antioxidant effects of alpha tocopherol, ascorbic acid and l-methionine on lead induced oxidative stress to the liver, kidney and brain in rats. Toxicology 162 (2001) 81-88
20. Reed D.J. Glutathione: toxicological implications. Annu Rev Pharmacol Toxicol 30 (1990) 603-631
21. Reed D.J., and Orrenius S. The role of methionine in glutathione biosynthesis by isolated hepatocytes. Biochem Biophys Res Commun 77 (1977) 1257-1264
22. Refsum H., and Ueland P.M. Recent data are not in conflict with homocysteine as a cardiovascular risk factor. Curr Opin Lipidol 9 (1998) 533-539
23. Rice-Evans C., and Baysal E. Iron-mediated oxidative stress in erythrocytes. Biochem J 244 (1987) 191-196
24. Sandhir R., Julka D., and Gill K.D. Lipoperoxidative damage on lead exposure in rat brain and its implications on membrane bound enzymes. Pharmacol Toxicol 74 (1994) 66-71
25. Satoh K. Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chim Acta 90 (1978) 37-43
26. Sivaprasad R., Nagaraj M., and Varalakshmi P. Combined efficacies of lipoic acid and 2,3-dimercaptosuccinic acid against lead-induced lipid peroxidation in rat liver. J Nutr Biochem 15 (2004) 18-23
27. Solliway B.M., Schaffer A., Pratt H., and Yannai S. Effects of exposure to lead on selected biochemical and haematological variables. Pharmacol Toxicol 78 (1996) 18-22
28. Soltaninejad K., Kebriaeezadeh A., Minaiee B., Ostad S.N., Hosseini R., Azizi E., et al. Biochemical and ultrastructural evidences for toxicity of lead through free radicals in rat brain. Hum Exp Toxicol 22 (2003) 417-423
29. Sugawara E., Nakamura K., Miyake T., Fukumura A., and Seki Y. Lipid peroxidation and concentration of glutathione in erythrocytes from workers exposed to lead. Br J Ind Med 48 (1991) 239-242
30. Vallee B.L., and Ulmer D.D. Biochemical effects of mercury, cadmium, and lead. Annu Rev Biochem 41 (1972) 91-128
31. Waldron H.A. The anaemia of lead poisoning: a review. Br J Ind Med 23 (1966) 83-100
32. Warren M.J., Cooper J.B., Wood S.P., and Shoolingin-Jordan P.M. Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase. Trends Biochem Sci 23 (1998) 217-221
33. Yagi K. Assay for blood plasma or serum. Methods Enzymol 105 (1984) 328-331
34. Zappacosta B., Mordente A., Persichilli S., Giardina B., and De Sole P. Effect of homocysteine on polymorphonuclear leukocyte activity and luminol-dependent chemiluminescence. Luminescence 15 (2000) 257-260