Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells

Cancer Letters

Volumn 208, Issue 2, 2004, Pages 143-153

  Zhang, Siyuan ^a   Ong, Choon Nam ^a   Shen, Han Ming ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

AO, acridine orange; Apoptosis; BSO, buthionine sulfoximine; Calcium; EB, ethidium bromide; Glutathione; GSH, reduced glutathione; GSSG, oxidized glutathione; NAC, N acetylcysteine; Parthenolide; PN, parthenolide; Reactive oxygen species; Thiol

Indexed keywords

ACETYLCYSTEINE; CALCIUM; GLUCOSE REGULATED PROTEIN 78; GLUTATHIONE; PARTHENOLIDE; REACTIVE OXYGEN METABOLITE; THIOL DERIVATIVE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL PROTECTION; COLORECTAL CANCER; CONTROLLED STUDY; CYTOSOL; DOSE RESPONSE; DOSE TIME EFFECT RELATION; ENDOPLASMIC RETICULUM; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS;

ACETYLCYSTEINE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; BUTHIONINE SULFOXIMINE; CALCIUM; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SESQUITERPENES; SULFHYDRYL COMPOUNDS;

TANACETUM PARTHENIUM;

EID: 2442538125     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2003.11.028     Document Type: Article

References (35)

1. Hehner S.P., Hofmann T.G., Droge W., Schmitz M.L. The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex. J. Immunol. 163:1999;5617-5623
2. Sobota R., Szwed M., Kasza A., Bugno M., Kordula T. Parthenolide inhibits activation of signal transducers and activators of transcription (STATs) induced by cytokines of the IL-6 family. Biochem. Biophys. Res. Commun. 267:2000;329-333
3. Hoffmann J.J., Torrance S.J., Widehopf R.M., Cole J.R. Cytotoxic agents from Michelia champaca and Talauma ovata: parthenolide and costunolide. J. Pharm. Sci. 66:1977;883-884
4. Hall I.H., Williams W.L. Jr., Grippo A.A., Lee K.H., Holbrook D.J., Chaney S.G. Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia cells in culture by sesquiterpene lactones. Anticancer Res. 8:1988;33-42
5. Ross J.J., Arnason J.T., Birnboim H.C. Low concentrations of the feverfew component parthenolide inhibit in vitro growth of tumor lines in a cytostatic fashion. Planta Med. 65:1999;126-129
6. Patel N.M., Nozaki S., Shortle N.H., Bhat-Nakshatri P., Newton T.R., Rice S., et al. Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide. Oncogene. 19:2000;4159-4169
7. Wen J., You K.R., Lee S.Y., Song C.H., Kim D.G. Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide. J. Biol. Chem. 277:2002;38954-38964
8. Buttke T.M., Sandstrom P.A. Oxidative stress as a mediator of apoptosis. Immunol. Today. 15:1994;7-10
9. Davis W., Ronai Z., Tew K.D. Cellular thiols and reactive oxygen species in drug-induced apoptosis. J. Pharmacol. Exp. Ther. 296:2001;1-6
10. Hampton M.B., Orrenius S. Redox regulation of apoptotic cell death. Biofactors. 8:1998;1-5
11. Ghibelli L., Coppola S., Rotilio G., Lafavia E., Maresca V., Ciriolo M.R. Non-oxidative loss of glutathione in apoptosis via GSH extrusion. Biochem. Biophys. Res. Commun. 216:1995;313-320
12. Voehringer D.W., McConkey D.J., McDonnell T.J., Brisbay S., Meyn R.E. Bcl-2 expression causes redistribution of glutathione to the nucleus. Proc. Natl. Acad. Sci. USA. 95:1998;2956-2960
13. Sandau K.B., Brune B. Up-regulation of Bcl-2 by redox signals in glomerular mesangial cells. Cell Death Differ. 7:2000;118-125
14. Schmidt T.J., Lyss G., Pahl H.L., Merfort I. Helenanolide type sesquiterpene lactones. Part 5. The role of glutathione addition under physiological conditions. Bioorg. Med. Chem. 7:1999;2849-2855
15. Yang C.F., Shen H.M., Ong C.N. Intracellular thiol depletion causes mitochondrial permeability transition in ebselen-induced apoptosis. Arch. Biochem. Biophys. 380:2000;319-330
16. Yang C.F., Shen H.M., Ong C.N. Ebselen induces apoptosis in HepG(2) cells through rapid depletion of intracellular thiols. Arch. Biochem. Biophys. 374:2000;142-152
17. Ghibelli L., Fanelli C., Rotilio G., Lafavia E., Coppola S., Colussi C., et al. Rescue of cells from apoptosis by inhibition of active GSH extrusion. Fed. Am. Soc. Exp. Biol. J. 12:1998;479-486
18. Slater A., Stefan C., Nobel I., Dobbelsteen D.J., Orrenius S. Intrcellular redox changes during apoptosis. Cell Death Differ. 3:1996;57-62
19. Kramer R.A., Soble M., Howes A.E., Montoya V.P. The effect of glutathione (GSH) depletion in vivo by buthionine sulfoximine (BSO) on the radiosensitization of SR 2508. Int. J. Radiat. Oncol. Biol. Phys. 16:1989;1325-1329
20. Schmidt T.J. Helenanolide-type sesquiterpene lactones. III. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomolecules. Bioorg. Med. Chem. 5:1997;645-653
21. Schmidt T.J. Toxic activities of sesquiterpene lactones: structural and biochemical aspects. Curr. Org. Chem. 3:1999;577-608
22. Aruoma O.I., Halliwell B., Hoey B.M., Bulter J. The antioxidant action of N-acetylcysteine on superoxide anion generation in human polymorphonuclear leukocytes. Free Radic. Biol. Med. 6:1989;593-597
23. Cotgreave I.A., Gerdes R.G. Recent trends in glutathione biochemistry-glutathione-protein interactions: a molecular link between oxidative stress and cell proliferation? Biochem. Biophys. Res. Commun. 242:1998;1-9
24. Bhanoori M., Yellaturu C.R., Ghosh S.K., Hassid A., Jennings L.K., Rao G.N. Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1). Oncogene. 22:2003;117-130
25. Garcia-Pineres A.J., Castro V., Mora G., Schmidt T.J., Strunck E., Pahl H.L., Merfort I. Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones. J. Biol. Chem. 276:2001;39713-39720
26. Costantini P., Belzacq A.S., Vieira H.L., Larochette N., de Pablo M.A., Zamzami N., et al. Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis. Oncogene. 19:2000;307-314
27. Dirsch V.M., Stuppner H., Vollmar A.M. Helenalin triggers a CD95 death receptor-independent apoptosis that is not affected by overexpression of Bcl-X-L or Bcl-2. Cancer Res. 61:2001;5817-5823
28. Lee M.G., Lee K.T., Chi S.G., Park J.H. Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release. Biol. Pharm. Bull. 24:2001;303-306
29. McStay G.P., Clarke S.J., Halestrap A.P. Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore. Biochem. J. 367:2002;541-548
30. Nicotera P., Orrenius S. The role of calcium in apoptosis. Cell Calcium. 23:1998;173-180
31. Takemura H., Thastrup O., Putney J.W. Jr. Calcium efflux across the plasma membrane of rat parotid acinar cells is unaffected by receptor activation or by the microsomal calcium ATPase inhibitor, thapsigargin. Cell Calcium. 11:1990;11-17
32. Furuya Y., Lundmo P., Short A.D., Gill D.L., Isaacs J.T. The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin. Cancer Res. 54:1994;6167-6175
33. 2+ signaling caused by the antitumor agent helenalin and its analogs. Cancer Chemotherapy and Pharmacology. 34:1994;344-350
34. Lee A.S. The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem. Sci. 26:2001;504-510
35. Rao R.V., Peel A., Logvinova A., del Rio G., Hermel E., Yokota T., et al. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. Fed. Eur. Biochem. Soc. Lett. 514:2002;122-128