Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes

Hepatology

Volumn 37, Issue 6, 2003, Pages 1425-1434

  Matsumaru, Katsuhiko ^b   Ji, Cheng ^b   Kaplowitz, Neil ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; GLUTATHIONE DISULFIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALEIC ACID DERIVATIVE; NITRIC OXIDE SYNTHASE; PARACETAMOL; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; GLUTATHIONE METABOLISM; LIVER CELL; MOUSE; NECROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SENSITIZATION; TRANSACTIVATION;

EID: 0038241619     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2003.50230     Document Type: Article

References (38)

1. Fernandez-Checa J, Kaplowitz N, Garcia-Ruiz C, Colell A. Mitochondrial glutathione: importance and transport. Semin Liver Dis 1998;18:389-401.
2. Colell A, Garcia-Ruiz C, Miranda M, Ardite E, Mari M, Morales A, Corrales F, et al. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 1998;115:1541-1551.
3. Koteish A, Yang S, Lin H, Huang X, Diehl AM. Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation. J Biol Chem 2002;277:13037-13044.
4. Nagai H, Matsumaru K, Feng G, Kaplowitz N. Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor α-induced apoptosis in cultured mouse hepatocytes. HEPATOLOGY 2002;36:55-64.
5. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW, Brenner DA. NF-κB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 1998;101:802-811.
6. Kaplowitz N. Biochemical and cellular mechanisms of toxic liver injury. Semin Liver Dis 2002;22:137-144.
7. Feng G, Kaplowitz N. Mechanism of staurosporine-induced apoptosis in murine hepatocytes. Am J Physiol 2002;282:G825-G834.
8. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: application to mammalian blood and other tissues. Anal Biochem 1969;27:502-522.
9. Fernandez-Checa JC, Ookhtens M, Kaplowitz N. Effect of chronic ethanol feeding on rat hepatocyte glutathione: compartmentation, efflux and response to incubation with ethanol. J Clin Invest 1987;80:57-62.
10. Asensi M, Sastre J, Pallardo FV, Garcia de la Asuncion J, Estrela JM, Vina J. A high-performance liquid chromatography method for measurement of oxidized glutathione in biological samples. Anal Biochem 1994;217:323-328.
11. Meredith MJ, Reed DJ. Status of the mitochondrial pool of glutathione in the isolated hepatocyte. J Biol Chem 1982;257:3747-3753.
12. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ, Brenner DA. NF-κB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-α- and Fas-mediated apoptosis. Gastroenterology 2001;120:1251-1262.
13. Sen CK, Packer L. Antioxidant and redox regulation of gene transcription. FASEB J 1996;10:709-720.
14. Arrigo A-P. Gene expression and the thiol redox state. Free Rad Biol Med 1999;27:936-944.
15. Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC, et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A 2001;98;13681-13686.
16. Kim YM, Talanian RV, Billiar TR. Nitric oxide inhibits apoptosis by preventing increase in caspase-3-like activity via two distinct mechanisms. J Biol Chem 1997;272:31138-31148.
17. Li J, Bombeck CA, Yang S, Kim YM, Billiar TR. Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes. J Biol Chem 1999;274:17325-17333.
18. Gardner CR, Heck DE, Yang CS, Thomas PE, Zhang XJ, DeGeorge GL, Laskin JD, et al. Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat. HEPATOLOGY 1998;26:748-754.
19. Hentze H, Schmitz I, Latta M, Krueger A, Krammer PH, Wendel A. Glutathione dependence of caspase-8 activation at the death-inducing signaling complex. J Biol Chem 2002;277:5588-5595.
20. Smith CV, Jones DP, Guenther TM, Lash LH, Lauterburg BH. Compartmentation of glutathione: implications for the study of toxicity and disease. Toxicol Appl Pharmacol 1996;140:1-12.
21. Schafer FQ, Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Rad Biol Med 2001;30:1191-1212.
22. Kaplowitz N. Hepatotoxicity: the road to death and the role of glutathione. In: Arroyo V, Bosch J, Bruix J, Gines P, Navasa M, Rodes J, eds. Therapy in Hepatology. Barcelona, Spain: Ars Medica 2001;407-410.
23. Ginn-Pease ME, Whisler RL. Optimal NF-κB mediated transcriptional responses in Jurkat T cells exposed to oxidative stress are dependent on intracellular glutathione and costimulatory signals. Biochem Biophys Res Commun 1996;226:695-702.
24. Matthews JR, Wakasugi N, Virelizier J-L, Yodoi J, Hay RT. Thioredoxin regulates the DNA binding activity of NF-κB by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res 1992;20:3821-3830.
25. Hatano E, Brenner DA. Akt protects mouse hepatocytes from TNF-α- and Fas- mediated apoptosis through NF-κB activation. Am J Physiol 2002;282:G1357-G1368.
26. Zhong H, May MJ, Jimi E, Ghosh S. The phosphorylation status of nuclear NF-κB determines its association with CBP/p300 or HDAC-1. Mol Cell 2002;9:625-636.
27. Liu H, Lo CR, Czaja MJ. NF-κB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun. HEPATOLOGY 2002;35:772-778.
28. Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, et al. Mammalian thioredoxin is a direct inhibition of apoptosis signal-regulating kinase (ASK) 1. EMBO J 1998;17:2596-2606.
29. Adler V, Yin Z, Fuchs SY, Banezra M, Rosario L, Tew KD, Pincus MR, et al. Regulation of JNK signaling by GSTp. EMBO J 1999;18:1321-1334.
30. Henderson CJ, Wolf CR, Kitteringham N, Powell H, Otto D, Park BK. Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi. PNAS 2000;97:12741-12745.
31. De Smaela E, Zazzeroni F, Papa S, Nguyen DU, Jin R, Jones J, Cong R, et al. Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signaling. Nature 2001;414:308-312.
32. Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A. Inhibition of JNK activation through NF-κB target genes. Nature 2001;414:313-317.
33. Knight TR, Jaeschke H. Acetaminophen-induced inhibition of Fas receptor-mediated liver cell apoptosis: mitochondrial dysfunction versus glutathione depletion. Toxicol Appl Pharmacol 2002;181:133-141.
34. Jones JJ, Fan J, Nathens AB, Kapus A, Shekhman M, Marshall JC, Parodo J, et al. Redox manipulation using the thiol-oxidizing agent diethylmaleate prevents hepatocellular necrosis and apoptosis in a rodent endotoxemia model. HEPATOLOGY 1999;30:714-724.
35. Hentze H, Gantner F, Kolb SA, Wendel A. Depletion of hepatic glutathione prevents death receptor-dependent apoptotic and necrotic liver injury in mice. Am J Pathol 2000;156:2045-2056.
36. Xu Y, Jones BE, Neufeld DS, Czaja MJ. Glutathione modulates rat and mouse hepatocyte sensitivity to tumor necrosis factor α toxicity. Gastroenterology 1998;115:1229-1237.
37. Haouzi D, Lekehal M, Tinel M, Vadrot N, Caussanel L, Letteron P, Moreau A, et al. Prolonged, but not acute, glutathione depletion promotes Fas-mediated mitochondrial permeability transition and apoptosis in mice. HEPATOLOGY 2001;33:1181-1188.
38. Filomeni G, Rotilio G, Ciriolo MR. Cell signaling and the glutathione redox system. Biochem Pharmacol 2002;64:1057-1064.