Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol

Cancer Biology and Therapy

Volumn 7, Issue 5, 2008, Pages 767-776

  Sikora, Matthew J ^a   Bauer, Joshua A ^a   Verhaegen, Monique ^b   Belbin, Thomas J ^d   Prystowsky, Michael B ^d   Taylor, Joseph C ^a   Brenner, J Chad ^a   Wang, Shaomeng ^c   Soengas, Maria S ^b   Bradford, Carol R ^a   Carey, Thomas E ^a,e  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e Med Sci I   (United States)

Author keywords

( ) gossypol; Apoptosis; Bcl XL; Cisplatin resistance; Head and neck squamous cell carcinoma; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; CISPLATIN; COMPLEMENTARY DNA; GOSSYPOL; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; OXIDIZING AGENT;

AEROBIC METABOLISM; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL CYCLE G1 PHASE; CELL POPULATION; DNA MICROARRAY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SENSITIVITY; HUMAN; HUMAN CELL; IN VIVO STUDY; MICROARRAY ANALYSIS; UPREGULATION; BIOLOGICAL MODEL; CELL LINE; CELL SURVIVAL; DRUG POTENTIATION; GENE EXPRESSION REGULATION; METABOLISM; NEOPLASM; TUMOR CELL LINE;

ACETYLCYSTEINE; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SYNERGISM; GENE EXPRESSION REGULATION, NEOPLASTIC; GOSSYPOL; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDANTS; REACTIVE OXYGEN SPECIES;

EID: 56149114534     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.7.5.5767     Document Type: Article

References (47)

1. Chao DT, Korsmeyer SJ. BCL-2 family: regulators of cell death. Annual review of immunology 1998; 16:395-419.
2. L and Bcl-2 repress a common pathway of cell death. The Journal of experimental medicine 1995; 182:821-8.
3. Korsmeyer SJ. Programmed cell death: Bcl-2. Important advances in oncology 1993; 19-28.
4. Korsmeyer SJ. BCL-2 gene family and the regulation of programmed cell death. Cancer research 1999; 59:1693-700.
5. Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: a link between cancer genetics and chemotherapy. Cell 2002; 108:153-64.
6. Trask DK, Wolf GT, Bradford CR, Fisher SG, Devaney K, Johnson M, Singleton T, Wicha M. Expression of Bcl-2 family proteins in advanced laryngeal squamous cell carcinoma: correlation with response to chemotherapy and organ preservation. The Laryngoscope 2002; 112:638-44.
7. Bradford CR. Predictive factors in head and neck cancer. Hematology/oncology clinics of North America 1999; 13:777-85.
8. Bushunow P, Reidenberg MM, Wasenko J, Winfield J, Lorenzo B, Lemke S, Himpler B, Corona R, Coyle T. Gossypol treatment of recurrent adult malignant gliomas. Journal of neuro-oncology 1999; 43:79-86.
9. Flack MR, Pyle RG, Mullen NM, Lorenzo B, Wu YW, Knazek RA, Nisula BC, Reidenberg MM. Oral gossypol in the treatment of metastatic adrenal cancer. The Journal of clinical endocrinology and metabolism 1993; 76:1019-24.
10. Stein RC, Joseph AE, Matlin SA, Cunningham DC, Ford HT, Coombes RC. A preliminary clinical study of gossypol in advanced human cancer. Cancer chemotherapy and pharmacology 1992; 30:480-2.
11. Van Poznak C, Seidman AD, Reidenberg MM, Moasser MM, Sklarin N, Van Zee K, Borgen P, Gollub M, Bacotti D, Yao TJ, Bloch R, Ligueros M, Sonenberg M, Norton L, Hudis C. Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial. Breast cancer research and treatment 2001; 66:239-48.
12. Zhang M, Liu H, Guo R, Ling Y, Wu X, Li B, Roller PP, Wang S, Yang D. Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochemical pharmacology 2003; 66:93-103.
13. L. Molecular cancer therapeutics 2005; 4:1096-104.
14. Oliver CL, Bauer JA, Wolter KG, Ubell ML, Narayan A, O'Connell KM, Fisher SG, Wang S, Wu X, Ji M, Carey TE, Bradford CR. In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res 2004; 10:7757-63.
15. Wolter KG, Wang SJ, Henson BS, Wang S, Griffith KA, Kumar B, Chen J, Carey TE, Bradford CR, D'Silva NJ. (-)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo. Neoplasia (New York, NY) 2006; 8:163-72.
16. Bauer JA, Kumar B, Cordell KG, Prince ME, Tran HH, Wolf GT, Chepeha DB, Teknos TN, Wang S, Eisbruch A, Tsien CI, Urba SG, Worden FP, Lee J, Griffith KA, Taylor JM, D'Silva N, Wang SJ, Wolter KG, Henson B, Fisher SG, Carey TE, Bradford CR. Targeting apoptosis to overcome cisplatin resistance: a translational study in head and neck cancer. Int J Radiat Oncol Biol Phys 2007; 69:106-8.
17. Carey TE, Kimmel KA, Schwartz DR, Richter DE, Baker SR, Krause CJ. Antibodies to human squamous cell carcinoma. Otolaryngol Head Neck Surg 1983; 91:482-91.
18. Krause CJ, Carey TE, Ott RW, Hurbis C, McClatchey KD, Regezi JA. Human squamous cell carcinoma. Establishment and characterization of new permanent cell lines. Arch Otolaryngol 1981; 107:703-10.
19. Nakata B, Albright KD, Barton RM, Howell SB, Los G. Synergistic interaction between cisplatin and tamoxifen delays the emergence of cisplatin resistance in head and neck cancer cell lines. Cancer chemotherapy and pharmacology 1995; 35:511-8.
20. Park NH, Min BM, Li SL, Huang MZ, Cherick HM, Doniger J. Immortalization of normal human oral keratinocytes with type 16 human papillomavirus. Carcinogenesis 1991; 12:1627-31.
21. Belbin TJ, Singh B, Smith RV, Socci ND, Wreesmann VB, Sanchez Carbayo M, Masterson J, Patel S, Cordon Cardo C, Prystowsky MB, Childs G. Molecular profiling of tumor progression in head and neck cancer. Archives of otolaryngology - head & neck surgery 2005; 131:10-8.
22. Sablina AA, Budanov AV, Ilyinskaya GV, Agapova LS, Kravchenko JE, Chumakov PM. The antioxidant function of the p53 tumor suppressor. Nature medicine 2005; 11:1306-13.
23. Sener G, Sehirli AO, Ayanoglu-Dulger G. Protective effects of melatonin, vitamin E and N-acetylcysteine against acetaminophen toxicity in mice: a comparative study. Journal of pineal research 2003; 35:61-8.
24. Tsai CL, Chang WT, Weng TI, Fang CC, Walson PD. A patient-tailored N-acetylcysteine protocol for acute acetaminophen intoxication. Clinical therapeutics 2005; 27:336-41.
25. Urba S, Wolf G, Eisbruch A, Worden F, Lee J, Bradford C, Teknos T, Chepeha D, Prince M, Hogikyan N, Taylor J. Single-cycle induction chemotherapy selects patients with advanced laryngeal cancer for combined chemoradiation: a new treatment paradigm. J Clin Oncol 2006; 24:593-8.
26. Hou DX, Uto T, Tong X, Takeshita T, Tanigawa S, Imamura I, Ose T, Fujii M. Involvement of reactive oxygen species-independent mitochondrial pathway in gossypol-induced apoptosis. Archives of biochemistry and biophysics 2004; 428:179-87.
27. Jan CR, Lin MC, Chou KJ, Huang JK. Novel effects of gossypol, a chemical contraceptive in man: mobilization of internal Ca(2+) and activation of external Ca(2+) entry in intact cells. Biochimica et biophysica acta 2000; 1496:270-6.
28. Jarvis WD, Turner AJ, Povirk LF, Traylor RS, Grant S. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer research 1994; 54:1707-14.
29. Ligueros M, Jeoung D, Tang B, Hochhauser D, Reidenberg MM, Sonenberg M. Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells. British journal of cancer 1997; 76:21-8.
30. Shidaifat F, Canatan H, Kulp SK, Sugimoto Y, Chang WY, Zhang Y, Brueggemeier RW, Somers WJ, Lin YC. Inhibition of human prostate cancer cells growth by gossypol is associated with stimulation of transforming growth factor-beta. Cancer letters 1996; 107:37-44.
31. 1 phase of the cell cycle. Anticancer research 1997; 17:1003-9.
32. Abou-Donia MB. Physiological effects and metabolism of gossypol. Residue reviews 1976; 61:125-60.
33. de Peyster A, Quintanilha A, Packer L, Smith MT. Oxygen radical formation induced by gossypol in rat liver microsomes and human sperm. Biochemical and biophysical research communications 1984; 118:573-9.
34. Kovacic P. Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer. Current medicinal chemistry 2003; 10:2711-8.
35. Yu YW. Probing into the mechanism of action, metabolism and toxicity of gossypol by studying its (+)- and (-)-stereoisomers. Journal of ethnopharmacology 1987; 20:65-78.
36. Haas RH, Shirley DA. The Oxidation of Gossypol II. Formation of Gossypolone with Ferric Chloride. Journal of organic chemistry 1965; 30:4111-3.
37. Armstrong JL, Veal GJ, Redfern CP, Lovat PE. Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours. Apoptosis 2007.
38. Punj V, Chakrabarty AM. Redox proteins in mammalian cell death: an evolutionarily conserved function in mitochondria and prokaryotes. Cellular microbiology 2003; 5:225-31.
39. Webster KA, Graham RM, Thompson JW, Spiga MG, Frazier DP, Wilson A, Bishopric NH. Redox stress and the contributions of BH3-only proteins to infarction. Antioxidants & redox signaling 2006; 8:1667-76.
40. Fei P, Wang W, Kim SH, Wang S, Burns TF, Sax JK, Buzzai M, Dicker DT, McKenna WG, Bernhard EJ, El-Deiry WS. Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth. Cancer cell 2004; 6:597-609.
41. Guo K, Searfoss G, Krolikowski D, Pagnoni M, Franks C, Clark K, Yu KT, Jaye M, Ivashchenko Y. Hypoxia induces the expression of the pro-apoptotic gene BNIP3. Cell death and differentiation 2001; 8:367-76.
42. Manka D, Spicer Z, Millhorn DE. Bcl-2/adenovirus E1B 19 kDa interacting protein-3 knockdown enables growth of breast cancer metastases in the lung, liver, and bone. Cancer research 2005; 65:11689-93.
43. L. Nature 1995; 374:811-3.
44. L. FEMS yeast research 2004; 5:149-56.
45. Perry HE, Shannon MW. Efficacy of oral versus intravenous N-acetylcysteine in acetaminophen overdose: results of an open-label, clinical trial. The Journal of pediatrics 1998; 132:149-52.
46. Tucker JR. Late-presenting acute acetaminophen toxicity and the role of N-acetylcysteine. Pediatric emergency care 1998; 14:424-6.
47. Tomko RJ Jr., Bansal P, Lazo JS. Airing out an antioxidant role for the tumor suppressor p53. Molecular interventions 2006; 6:23-5.