Carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP) as an O2{radical dot}- generator induces apoptosis via the depletion of intracellular GSH contents in Calu-6 cells

Lung Cancer

Volumn 63, Issue 2, 2009, Pages 201-209

  Han, Yong Hwan ^a   Kim, Suhn Hee ^a   Kim, Sung Zoo ^a   Park, Woo Hyun ^a  

^a Chonbuk National University   (South Korea)

Author keywords

Calu 6; FCCP; GSH; Mitochondria; ROS; ROS scavenger

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; BUTHIONINE SULFOXIMINE; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; DITHIOTHREITOL; GLUTATHIONE; OXYGEN; SCAVENGER; SUPEROXIDE DISMUTASE; TEMPOL; TIRON;

APOPTOSIS; ARTICLE; CELL DEATH; CELL LEVEL; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; INHIBITION KINETICS; LUNG ADENOCARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEPLETION; PROTEIN SYNTHESIS;

ADENOCARCINOMA; APOPTOSIS; BUTHIONINE SULFOXIMINE; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; CELL LINE, TUMOR; DITHIOTHREITOL; FREE RADICAL SCAVENGERS; GLUTATHIONE; HUMANS; LUNG NEOPLASMS; SUPEROXIDES;

EID: 58149131828     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2008.05.005     Document Type: Article

References (49)

1. Gonzalez C., Sanz-Alfayate G., Agapito M.T., Gomez-Nino A., Rocher A., and Obeso A. Significance of ROS in oxygen sensing in cell systems with sensitivity to physiological hypoxia. Respir Physiol Neurobiol 132 (2002) 17-41
2. Baran C.P., Zeigler M.M., Tridandapani S., and Marsh C.B. The role of ROS and RNS in regulating life and death of blood monocytes. Curr Pharm Des 10 (2004) 855-866
3. Bubici C., Papa S., Pham C.G., Zazzeroni F., and Franzoso G. The NF-kappaB-mediated control of ROS and JNK signaling. Histol Histopathol 21 (2006) 69-80
4. Zorov D.B., Juhaszova M., and Sollott S.J. Mitochondrial ROS-induced ROS release: an update and review. Biochim Biophys Acta 1757 (2006) 509-517
5. Wilcox C.S. Reactive oxygen species: roles in blood pressure and kidney function. Curr Hypertens Rep 4 (2002) 160-166
6. Poot M., Teubert H., Rabinovitch P.S., and Kavanagh T.J. De novo synthesis of glutathione is required for both entry into and progression through the cell cycle. J Cell Physiol 163 (1995) 555-560
7. Schnelldorfer T., Gansauge S., Gansauge F., Schlosser S., Beger H.G., and Nussler A.K. Glutathione depletion causes cell growth inhibition and enhanced apoptosis in pancreatic cancer cells. Cancer 89 (2000) 1440-1447
8. Lauterburg B.H. Analgesics and glutathione. Am J Ther 9 (2002) 225-233
9. Chen T.J., Jeng J.Y., Lin C.W., Wu C.Y., and Chen Y.C. Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells. Toxicology 223 (2006) 113-126
10. Dasmahapatra G., Rahmani M., Dent P., and Grant S. The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism. Blood 107 (2006) 232-240
11. Wallach-Dayan S.B., Izbicki G., Cohen P.Y., Gerstl-Golan R., Fine A., and Breuer R. Bleomycin initiates apoptosis of lung epithelial cells by ROS but not by Fas/FasL pathway. Am J Physiol Lung Cell Mol Physiol 290 (2006) L790-L796
12. Simon H.U., Haj-Yehia A., and Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5 (2000) 415-418
13. Daouphars M., Koufany M., Benani A., Marchal S., Merlin J.L., Netter P., et al. Uncoupling of oxidative phosphorylation and Smac/DIABLO release are not sufficient to account for induction of apoptosis by sulindac sulfide in human colorectal cancer cells. Int J Oncol 26 (2005) 1069-1077
14. Dispersyn G., Nuydens R., Connors R., Borgers M., and Geerts H. Bcl-2 protects against FCCP-induced apoptosis and mitochondrial membrane potential depolarization in PC12 cells. Biochim Biophys Acta 1428 (1999) 357-371
15. Millar T.M., Phan V., and Tibbles L.A. ROS generation in endothelial hypoxia and reoxygenation stimulates MAP kinase signaling and kinase-dependent neutrophil recruitment. Free Radic Biol Med 42 (2007) 1165-1177
16. Leloup C., Magnan C., Benani A., Bonnet E., Alquier T., Offer G., et al. Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing. Diabetes 55 (2006) 2084-2090
17. Petty R.D., Nicolson M.C., Kerr K.M., Collie-Duguid E., and Murray G.I. Gene expression profiling in non-small cell lung cancer: from molecular mechanisms to clinical application. Clin Cancer Res 10 (2004) 3237-3248
18. Guardavaccaro D., Corrente G., Covone F., Micheli L., D'Agnano I., Starace G., et al. Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription. Mol Cell Biol 20 (2000) 1797-1815
19. Han Y.W., Kim S.Z., Kim S.H., and Park W.H. The changes of intracellular H2O2 are an important factor maintaining mitochondria membrane potential of antimycin A-treated As4.1 juxtaglomerular cells. Biochem Pharmacol 73 (2007) 863-872
20. Han Y.H., Kim S.Z., Kim S.H., and Park W.H. Arsenic trioxide inhibits the growth of As4.1 juxtaglomerular cells via cell cycle arrest and caspase-independent apoptosis. Am J Physiol Renal Physiol (2007)
21. Bass D.A., Parce J.W., Dechatelet L.R., Szejda P., Seeds M.C., and Thomas M. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J Immunol 130 (1983) 1910-1917
22. Hedley D.W., and Chow S. Evaluation of methods for measuring cellular glutathione content using flow cytometry. Cytometry 15 (1994) 349-358
23. Fruehauf J.P., and Meyskens Jr. F.L. Reactive oxygen species: a breath of life or death?. Clin Cancer Res 13 (2007) 789-794
24. Meister A., and Anderson M.E. Glutathione. Annu Rev Biochem 52 (1983) 711-760
25. Tikhaze A.K., Lankin V.Z., Zharova E.A., and Kolycheva S.V. Trimetazidine as indirect antioxidant. Bull Exp Biol Med 130 (2000) 951-953
26. Bailey H.H. l-S,R-buthionine sulfoximine: historical development and clinical issues. Chem Biol Interact 111-112 (1998) 239-254
27. Yamada J., Yoshimura S., Yamakawa H., Sawada M., Nakagawa M., Hara S., et al. Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation. Neurosci Res 45 (2003) 1-8
28. Cuzzocrea S., McDonald M.C., Mazzon E., Siriwardena D., Costantino G., Fulia F., et al. Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury. Brain Res 875 (2000) 96-106
29. Greenstock C.L., and Miller R.W. The oxidation of tiron by superoxide anion. Kinetics of the reaction in aqueous solution in chloroplasts. Biochim Biophys Acta 396 (1975) 11-16
30. Stanley W.C., and Marzilli M. Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine. Fundam Clin Pharmacol 17 (2003) 133-145
31. Zafarullah M., Li W.Q., Sylvester J., and Ahmad M. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 60 (2003) 6-20
32. Kulinsky V.I., and Kolesnichenko L.S. Mitochondrial glutathione. Biochemistry (Mosc) 72 (2007) 698-701
33. Ichimura H., Parthasarathi K., Quadri S., Issekutz A.C., and Bhattacharya J. Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries. J Clin Invest 111 (2003) 691-699
34. Forman H.J., Torres M., and Fukuto J. Redox signaling. Mol Cell Biochem 234-235 (2002) 49-62
35. Virag L., Szabo E., Gergely P., and Szabo C. Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention. Toxicol Lett 140-141 (2003) 113-124
36. Blaise G.A., Gauvin D., Gangal M., and Authier S. Nitric oxide, cell signaling and cell death. Toxicology 208 (2005) 177-192
37. Jiang M., Wei Q., Pabla N., Dong G., Wang C.Y., Yang T., et al. Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity. Biochem Pharmacol 73 (2007) 1499-1510
38. Dayani P.N., Bishop M.C., Black K., and Zeltzer P.M. Desferoxamine (DFO)-mediated iron chelation: rationale for a novel approach to therapy for brain cancer. J Neurooncol 67 (2004) 367-377
39. Littlefield L.G., Joiner E.E., Colyer S.P., Sayer A.M., and Frome E.L. Modulation of radiation-induced chromosome aberrations by DMSO, an OH radical scavenger. 1. Dose-response studies in human lymphocytes exposed to 220 kV X-rays. Int J Radiat Biol Relat Stud Phys Chem Med 53 (1988) 875-890
40. Daiber A., Zou M.H., Bachschmid M., and Ullrich V. Ebselen as a peroxynitrite scavenger in vitro and ex vivo. Biochem Pharmacol 59 (2000) 153-160
41. Akaike T., Yoshida M., Miyamoto Y., Sato K., Kohno M., Sasamoto K., et al. Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 32 (1993) 827-832
42. Konarkowska B., Aitken J.F., Kistler J., Zhang S., and Cooper G.J. Thiol reducing compounds prevent human amylin-evoked cytotoxicity. FEBS J 272 (2005) 4949-4959
43. Wang Y.M., Peng S.Q., Zhou Q., Wang M.W., Yan C.H., Yang H.Y., et al. Depletion of intracellular glutathione mediates butenolide-induced cytotoxicity in HepG2 cells. Toxicol Lett 164 (2006) 231-238
44. Park E.S., Kim S.Y., Na J.I., Ryu H.S., Youn S.W., Kim D.S., et al. Glutathione prevented dopamine-induced apoptosis of melanocytes and its signaling. J Dermatol Sci (2007)
45. Estrela J.M., Ortega A., and Obrador E. Glutathione in cancer biology and therapy. Crit Rev Clin Lab Sci 43 (2006) 143-181
46. Higuchi Y. Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis. J Cell Mol Med 8 (2004) 455-464
47. Biroccio A., Benassi B., Fiorentino F., and Zupi G. Glutathione depletion induced by c-Myc downregulation triggers apoptosis on treatment with alkylating agents. Neoplasia 6 (2004) 195-206
48. Honda T., Coppola S., Ghibelli L., Cho S.H., Kagawa S., Spurgers K.B., et al. GSH depletion enhances adenoviral bax-induced apoptosis in lung cancer cells. Cancer Gene Ther 11 (2004) 249-255
49. Wanpen S., Govitrapong P., Shavali S., Sangchot P., and Ebadi M. Salsolinol, a dopamine-derived tetrahydroisoquinoline, induces cell death by causing oxidative stress in dopaminergic SH-SY5Y cells, and the said effect is attenuated by metallothionein. Brain Res 1005 (2004) 67-76