α-Lipoic acid prevents bupivacaine-induced neuron injury in vitro through a PI3K/Akt-dependent mechanism

NeuroToxicology

Volumn 31, Issue 1, 2010, Pages 101-112

  Wang, Xiaohui ^a   Zhang, Xiaojin ^a   Cheng, Yunlin ^a   Li, Chuanfu ^b   Zhang, Wenbo ^c   Liu, Li ^a   Ding, Zhengnian ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b East Tennessee State University   (United States)

^c NANJING NORMAL UNIVERSITY   (China)

Author keywords

Lipoic acid; Local anesthetics; Neurotoxicity; PI3K Akt signaling pathway

Indexed keywords

BUPIVACAINE; LIPOCORTIN 5; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; MOUSE; NERVE INJURY; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANESTHETICS, LOCAL; ANIMALS; ANIMALS, NEWBORN; ANNEXIN A5; APOPTOSIS; BUPIVACAINE; CELL LINE, TUMOR; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; HIPPOCAMPUS; L-LACTATE DEHYDROGENASE; MICE; MICE, INBRED C57BL; NEUROBLASTOMA; NEURONS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; TETRAZOLIUM SALTS; THIAZOLES; THIOCTIC ACID; TIME FACTORS; VITAMIN B COMPLEX;

EID: 74249115601     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2009.10.010     Document Type: Article

References (41)

1. Abdul H.M., and Butterfield D.A. Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-l-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. Free Radic Biol Med 42 3 (2007) 371-384
2. Antonio A.M., and Druse M.J. Antioxidants prevent ethanol-associated apoptosis in fetal rhombencephalic neurons. Brain Res 1204 (2008) 16-23
3. Auroy Y., Benhamou D., Bargues L., Ecoffey C., Falissard B., Mercier F.J., et al. Major complications of regional anesthesia in France: The SOS Regional Anesthesia Hotline Service. Anesthesiology 97 5 (2002) 1274-1280
4. Auroy Y., Narchi P., Messiah A., Litt L., Rouvier B., and Samii K. Serious complications related to regional anesthesia: results of a prospective survey in France. Anesthesiology 87 3 (1997) 479-486
5. Bharat S., Cochran B.C., Hsu M., Liu J., Ames B.N., and Andersen J.K. Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapy. Neurotoxicology 23 4-5 (2002) 479-486
6. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 296 5573 (2002) 1655-1657
7. Chung H., Seo S., Moon M., and Park S. Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells. J Endocrinol 198 3 (2008) 511-521
8. Dicter N., Madar Z., and Tirosh O. Alpha-lipoic acid inhibits glycogen synthesis in rat soleus muscle via its oxidative activity and the uncoupling of mitochondria. J Nutr 132 10 (2002) 3001-3006
9. Friederich P., and Schmitz T.P. Lidocaine-induced cell death in a human model of neuronal apoptosis. Eur J Anaesthesiol 19 8 (2002) 564-570
10. Fruman D.A., and Cantley L.C. Phosphoinositide 3-kinase in immunological systems. Semin Immunol 14 (2002) 7-18
11. Groeger G., Mackey A.M., Pettigrew C.A., Bhatt L., and Cotter T.G. Stress-induced activation of NOx contributes to cell survival signalling via production of hydrogen peroxide. J Neurochem 109 5 (2009) 1544-1554
12. Hetz C., Russelakis-Carneiro M., Wälchli S., Carboni S., Vial-Knecht E., Maundrell K., et al. The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity. J Neurosci 25 11 (2005) 2793-2802
13. Hodgson P.S., Neal J.M., Pollock J.E., and Liu S.S. The neurotoxicity of drugs given intrathecally (spinal). Anesth Analg 88 4 (1999) 797-809
14. Huang X., Choi J.K., Park S.R., Ha Y., Park H., Yoon S.H., et al. GM-CSF inhibits apoptosis of neural cells via regulating the expression of apoptosis-related proteins. Neurosci Res 58 1 (2007) 50-57
15. Johnson M.E., Saenz J.A., DaSilva A.D., Uhl C.B., and Gores G.J. Effect of local anesthetic on neuronal cytoplasmic calcium and plasma membrane lysis (necrosis) in a cell culture model. Anesthesiology 97 6 (2002) 1466-1476
16. Kim A.H., Khursigara G., Sun X., Franke T.F., and Chao M.V. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 21 3 (2001) 893-901
17. Kim M., Lee Y.S., Mathews H.L., and Wurster R.D. Induction of apoptotic cell death in a neuroblastoma cell line by dibucaine. Exp Cell Res 231 2 (1997) 235-241
18. Kim Y.H., Kim Y.S., Park C.H., Chung I.Y., Yoo J.M., Kim J.G., et al. Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway. Diabetes 57 8 (2008) 2181-2190
19. Kojima N., Kurosawa N., Nishi T., Hanai N., and Tsuji S. Induction of cholinergic differentiation with neurite sprouting by de novo biosynthesis and expression of GD3 and b-series gangliosides in Neuro2a cells. J Biol Chem 269 48 (1994) 30451-30456
20. Lee H.T., Xu H., Siegel C.D., and Krichevsky I.E. Local anesthetics induce human renal cell apoptosis. Am J Nephrol 23 3 (2003) 129-139
21. Lima R.M., Alvarez L.D., Costa M.F., Costa S.L., Clarêncio J., and El-Bachá R.S. Cytotoxic effects of catechol to neuroblastoma N2a cells. Gen Physiol Biophys 27 4 (2008) 306-314
22. Lirk P., Haller I., Colvin H.P., Lang L., Tomaselli B., Klimaschewski L., et al. In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity. Anesth Analg 106 5 (2008) 1456-1464
23. Liu L., Zhang X.J., Jiang S.R., Ding Z.N., Ding G.X., Huang J., et al. Heat shock protein 27 regulates oxidative stress-induced apoptosis in cardiomyocytes: mechanisms via reactive oxygen species generation and Akt activation. Chin Med J (Engl) 120 24 (2007) 2271-2277
24. Mackey A.M., Sanvicens N., Groeger G., Doonan F., Wallace D., and Cotter T.G. Redox survival signalling in retina-derived 661W cells. Cell Death Differ 15 8 (2008) 1291-1303
25. Nair V.D., and Olanow C.W. Differential modulation of Akt/glycogen synthase kinase-3beta pathway regulates apoptotic and cytoprotective signaling responses. J Biol Chem 283 22 (2008) 15469-15478
26. O'Connor T.P., Cockburn K., Wang W., Tapia L., Currie E., and Bamji S.X. Semaphorin 5B mediates synapse elimination in hippocampal neurons. Neural Dev 4 (2009) 18
27. Onizuka S., Takasaki M., and Syed N.I. Long-term exposure to local but not inhalation anesthetics affects neurite regeneration and synapse formation between identified lymnaea neurons. Anesthesiology 102 2 (2005) 353-363
28. Park C.H., Kim Y.S., Kim Y.H., Choi M.Y., Yoo J.M., Kang S.S., et al. Calcineurin mediates AKT dephosphorylation in the ischemic rat retina. Brain Res 1234 (2008) 148-157
29. Park C.J., Park S.A., Yoon T.G., Lee S.J., Yum K.W., and Kim H.J. Bupivacaine induces apoptosis via ROS in the Schwann cell line. J Dent Res 84 9 (2005) 852-857
30. Perez-Castro R., Patel S., Garavito-Aguilar Z.V., Rosenberg A., Recio-Pinto E., Zhang J., et al. Cytotoxicity of local anesthetics in human neuronal cells. Anesth Analg 108 3 (2009) 997-1007
31. Pollock J.E., Neal J.M., Stephenson C.A., and Wiley C.E. Prospective study of the incidence of transient radicular irritation in patients undergoing spinal anesthesia. Anesthesiology 84 6 (1996) 1361-1367
32. Simbula G., Columbano A., Ledda-Columbano G.M., Sanna L., Deidda M., Diana A., et al. Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells. Apoptosis 12 1 (2007) 113-123
33. Tan Z., Dohi S., Chen J., Banno Y., and Nozawa Y. Involvement of the mitogen-activated protein kinase family in tetracaine-induced PC12 cell death. Anesthesiology 96 5 (2002) 1191-1201
34. Vauzour D., Vafeiadou K., Rice-Evans C., Williams R.J., and Spencer J.P. Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons. J Neurochem 103 4 (2007) 1355-1367
35. Vincent A.M., Stevens M.J., Backus C., McLean L.L., and Feldman E.L. Cell culture modeling to test therapies against hyperglycemia-mediated oxidative stress and injury. Antioxid Redox Signal 7 11-12 (2005) 1494-1506
36. 2). J Physiol 540 Pt 3 (2002) 951-970
37. Werdehausen R., Braun S., Essmann F., Schulze-Osthoff K., Walczak H., Lipfert P., et al. Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling. Anesthesiology 107 1 (2007) 136-143
38. Wu H., Lu D., Jiang H., Xiong Y., Qu C., Li B., et al. Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury. J Neurosurg 109 4 (2008) 691-698
39. You W., Min X., Zhang X., Qian B., Pang S., Ding Z., et al. Cardiac-specific expression of heat shock protein 27 attenuated endotoxin-induced cardiac dysfunction and mortality in mice through a PI3K/Akt-dependent mechanism. Shock 32 1 (2009) 108-117
40. Zhang L., Xing G.Q., Barker J.L., Chang Y., Maric D., Ma W., et al. Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway. Neurosci Lett 312 3 (2001) 125-128
41. Zhang W.J., Wei H., Hagen T., and Frei B. Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. Proc Natl Acad Sci USA 104 10 (2007) 4077-4082