Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat

Journal of Neuroscience

Volumn 28, Issue 49, 2008, Pages 13056-13065

  Mukherjea, Debashree ^a   Jajoo, Sarvesh ^a   Whitworth, Craig ^a   Bunch, Jennifer R ^a   Turner, Jeremy G ^a   Rybak, Leonard P ^a   Ramkumar, Vickram ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cisplatin; Cochlea; Hair cells; NADPH oxidase; Short interfering RNA; Transient receptor potential vanilloid 1 channel

Indexed keywords

CAPSAZEPINE; CISPLATIN; NOX3 ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RUTHENIUM RED; SMALL INTERFERING RNA; THIOCTIC ACID; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ISOENZYME; NOX3 PROTEIN, RAT; REACTIVE OXYGEN METABOLITE; TRPV1 PROTEIN, RAT; VANILLOID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COCHLEA; CONTROLLED STUDY; CORTI ORGAN; HAIR CELL; HEARING LOSS; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPIRAL GANGLION; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; OXIDATIVE STRESS; PERCEPTION DEAFNESS; RNA INTERFERENCE; WISTAR RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; CELLS, CULTURED; CISPLATIN; DISEASE MODELS, ANIMAL; DOWN-REGULATION; HAIR CELLS, AUDITORY; HEARING LOSS, SENSORINEURAL; ISOENZYMES; MALE; NADPH OXIDASE; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; THIOCTIC ACID; TRPV CATION CHANNELS;

EID: 58149395091     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1307-08.2008     Document Type: Article

References (37)

1. Bánfi B, Malgrange B, Knisz J, Steger K, Dubois-Dauphin M, Krause KH (2004) NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem 279:46065-46072.
2. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816-824.
3. Christoph T, Grünweller A, Mika J, Schäfer MK, Wade EJ, Weihe E, Erdmann VA, Frank R, Gillen C, Kurreck J (2006) Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. Biochem Biophys Res Commun 350:238-243.
4. Clerici WJ, Hensley K, DiMartino DL, Butterfield DA (1996) Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hear Res 98:116-124.
5. Diatchuk V, Lotan O, Koshkin V, Wikstroem P, Pick E (1997) Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds. J Biol Chem 272:13292-13301.
6. Dunaway G, Mhaskar Y, Armour G, Whitworth C, Rybak LP (2003) Migration of cochlear lateral wall cells. Hear Res 177:1-11.
7. Ford MS, Nie Z, Whitworth C, Rybak LP, Ramkumar V (1997) Upregulation of adenosine receptors in the cochlea by cisplatin. Hear Res 111:143-152.
8. Gale JE, Marcotti W, Kennedy HJ, Kros CJ, Richardson GP (2001) FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel. J Neurosci 21:7013-7025.
9. Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ (2002) p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 36:57-68.
10. Kamimura T, Whitworth CA, Rybak LP (1999) Effect of 4-methylthiobenzoic acid on cisplatin-induced ototoxicity in the rat. Hear Res 131:117-127.
11. Kopke RD, Liu W, Gabaizadeh R, Jacono A, Feghali J, Spray D, Garcia P, Steinman H, Malgrange B, Ruben RJ, Rybak L, Van de Water TR (1997) Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells. Am J Otol 18:559-571.
12. Korver KD, Rybak LP, Whitworth C, Campbell KM (2002) Round window application of D-methionine provides complete cisplatin otoprotection. Otolaryngol Head Neck Surg 126:683-689.
13. Linden J (1994) Purinergic systems. In: Basic neurochemistry (Siegel G, Agranoff B, Albers R, Molinoff P, eds), pp 401-416. New York: Raven.
14. Meyers JR, MacDonald RB, Duggan A, Lenzi D, Standaert DG, Corwin JT, Corey DP (2003) Lighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels. J Neurosci 23:4054-4065.
15. Moriyama T, Iida T, Kobayashi K, Higashi T, Fukuoka T, Tsumura H, Leon C, Suzuki N, Inoue K, Gachet C, Noguchi K, TominagaM (2003) Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity. J Neurosci 23:6058-6062.
16. Mukherjea D, Whitworth CA, Nandish S, Dunaway GA, Rybak LP, Ramkumar V (2006) Expression of the kidney injury molecule 1 in the rat cochlea and induction by cisplatin. Neuroscience 139:733-740.
17. O'Donnell BV, Tew DG, Jones OT, England PJ (1993) Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase. Biochem J 290:41-49.
18. Puntambekar P, Mukherjea D, Jajoo S, Ramkumar V (2005) Essential role of Rac1/NADPH oxidase in nerve growth factor induction of TRPV1 expression. J Neurochem 95:1689-1703.
19. Rivolta MN, Grix N, Lawlor P, Ashmore JF, Jagger DJ, Holley MC (1998) Auditory hair cell precursors immortalized from the mammalian inner ear. Proc Biol Sci 265:1595-1603.
20. Rivolta MN, Halsall A, Johnson CM, Tones MA, Holley MC (2002) Transcript profiling of functionally related groups of genes during conditional differentiation of a mammalian cochlear hair cell line. Genome Res 12:1091-1099.
21. Ruan T, Lin YS, Lin KS, Kou YR (2005) Sensory transduction of pulmonary reactive oxygen species by capsaicin-sensitive vagal lung afferent fibres in rats. J Physiol 565:563-578.
22. Rybak LP, Kelly T (2003) Ototoxicity: bioprotective mechanisms. Curr Opin Otolaryngol Head Neck Surg 11:328-333.
23. Rybak LP, Ramkumar V (2007) Ototoxicity. Kidney Int 72:931-935.
24. Rybak LP, Whitworth CA, Mukherjea D, Ramkumar V (2007) Mechanisms of cisplatin-induced ototoxicity and prevention. Hear Res 226:157-167.
25. Schultz HD, Ustinova EE (1998) Capsaicin receptors mediate free radical-induced activation of cardiac afferent endings. Cardiovasc Res 38:348-355.
26. Soong R, Beyser K, Basten O, Kalbe A, Rueschoff J, Tabiti K (2001) Quantitative reverse transcription-polymerase chain reaction detection of cytokeratin 20 in noncolorectal lymph nodes. Clin Cancer Res 7:3423-3429.
27. Southall MD, Li T, Gharibova LS, Pei Y, Nicol GD, Travers JB (2003) Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes. J Pharmacol Exp Ther 304:217-222.
28. Suzukawa K, Miura K, Mitsushita J, Resau J, Hirose K, Crystal R, Kamata T (2000) Nerve growth factor-induced neuronal differentiation requires generation of Rac1-regulated reactive oxygen species. J Biol Chem 275:13175-13178.
29. Tanaka F, Whitworth CA, Rybak LP (2003) Influence of pH on the ototoxicity of cisplatin: a round window application study. Hear Res 177:21-31.
30. van den Berg JH, Beijnen JH, Balm AJ, Schellens JH (2006) Future opportunities in preventing cisplatin induced ototoxicity. Cancer Treat Rev 32:390-397.
31. Watanabe K, Hess A, Michel O, Yagi T (2000) Nitric oxide synthase inhibitor reduces the apoptotic change in the cisplatin-treated cochlea of guinea pigs. Anticancer Drugs 11:731-735.
32. Watanabe K, Inai S, Jinnouchi K, Bada S, Hess A, Michel O, Yagi T (2002) Nuclear-factor kappa B NF-κB-inducible nitric oxide synthase (iNOS/ NOS II) pathway damages the stria vascularis in cisplatin-treated mice. Anticancer Res 22:4081-4085.
33. Whitworth CA, Ramkumar V, Jones B, Tsukasaki N, Rybak LP (2004) Protection against cisplatin ototoxicity by adenosine agonists. Biochem Pharmacol 67:1801-1807.
34. Xue Q, Jong B, Chen T, SchumacherMA (2007) Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor. J Neurochem 101:212-222.
35. Yoshida T, Inoue R, Morii T, Takahashi N, Yamamoto S, Hara Y, Tominaga M, Shimizu S, Sato Y, Mori Y (2006) Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol 2:596-607.
36. Zheng J, Dai C, Steyger PS, Kim Y, Vass Z, Ren T, Nuttall AL (2003) Vanilloid receptors in hearing: altered cochlear sensitivity by vanilloids and expression of TRPV1 in the organ of corti. J Neurophysiol 90:444-455.
37. Zimmermann TS, Lee AC, Akinc A, Bramlage B, Bumcrot D, Fedoruk MN, Harborth J, Heyes JA, Jeffs LB, John M, Judge AD, Lam K, McClintock K, Nechev LV, Palmer LR, Racie T, Röhl I, Seiffert S, Shanmugam S, Sood V, et al (2006) RNAi-mediated gene silencing in non-human primates. Nature 441:111-114.