Inhibition of 7,12-dimethylbenzanthracene-induced skin tumors by a nutrient mixture

Medical Oncology

Volumn 25, Issue 3, 2008, Pages 333-340

  Roomi, M W ^a   Roomi, N W ^a   Kalinovsky, T ^a   Ivanov, V ^a   Rath, M ^a   Niedzwiecki, A ^a  

^a Dr Rath Research Institute   (United States)

Author keywords

DMBA; Nutrients; Papillomas; SENCAR mice; Skin cancer; Squamous cell carcinoma

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ACETONE; ACETYLCYSTEINE; AMINO ACID; ARGININE; ASCORBIC ACID; CARCINOGEN; COPPER; GREEN TEA EXTRACT AR25; LYSINE; MANGANESE; PLANT EXTRACT; PROLINE; SELENIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CANCER INCIDENCE; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; DIET THERAPY; FEMALE; HISTOPATHOLOGY; MOUSE; NONHUMAN; NUTRIENT MIXTURE; NUTRIENT SOLUTION; PAPILLOMA; PRIORITY JOURNAL; SENSITIVE TO CARCINOGENESIS MOUSE; SKIN TUMOR; ANIMAL; CHEMICALLY INDUCED DISORDER; DIET; KERATOACANTHOMA; PATHOLOGY; SKIN; TEA;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ACETYLCYSTEINE; AMINO ACIDS; ANIMALS; ARGININE; ASCORBIC ACID; CAMELLIA SINENSIS; CARCINOGENS; COPPER; DIET; FEMALE; KERATOACANTHOMA; LYSINE; MANGANESE; MICE; MICE, INBRED SENCAR; PAPILLOMA; PLANT EXTRACTS; PROLINE; SELENIUM; SKIN; SKIN NEOPLASMS;

EID: 58149240640     PISSN: 13570560     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12032-008-9041-7     Document Type: Article

References (31)

1. National Cancer Institute. Skin Cancer. (2007) http://www.cancer.gov/ cancertopics/types/skin. Accessed 30 July 2007.
2. P. Boukamp 2005 Non-melanoma skin cancer: what drives tumor development and progression? Carcinogenesis 26 10 1657 67
3. TJ Slaga J O'Connell J Rotstein G Patskan R Morris M Aldaz C. Conti 1987 Critical genetic determinants and molecular events in multistage skin carcinogenesis Symp Fundam Cancer Res 39 31 4
4. TJ Slaga SM Fischer CE Weeks AJP Klein-Szanto J. Reiners 2004 Studies on the mechanisms involved in multistage carcinogenesis in mouse skin J Cell Biochem 18 1 99 119
5. J. DiGiovanni 1992 Multistage carcinogenesis in mouse skin Pharmacol Ther 47 63 128
6. AJP Klein-Szanto TJ. Slaga 1982 Effects of peroxides on rodent skin: epidermal hyperplasia and tumor promotion J Invest Dermatol 79 30 4
7. M Rath L. Pauling 1992 Plasmin-induced proteolysis and the role of apoprotein(a), lysine and synthetic analogs Orthomol Med 7 17 23
8. MW Roomi V Ivanov T Kalinovsky A Niedzwiecki M. Rath 2006 In vitro and in vivo antitumor effect of ascorbic acid, lysine, proline, and green tea extract on human melanoma cell line A2058 In Vivo 20 1 25 32
9. MW Roomi V Ivanov T Kalinovsky A Niedzwiecki M. Rath 2006 Inhibition of pulmonary metastasis of melanoma B16FO cells in C57BL/6 mice by a nutrient mixture consisting of ascorbic acid, lysine, proline, arginine, and green tea extract Exp Lung Res 32 10 517 30
10. M Hanausek P Ganesh Z Walaszek CJ Amtzen TJ Slaga JU. Gautterman 2001 Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model PNAS 98 20 11551 6
11. M Quintanilla K Brown M Ramsden A. Balmain 1986 Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis Nature 322 78 80
12. RA. Floyd 1990 Role of oxygen free radicals in carcinogenesis and brain ischemia FASEB J 4 2587 97
13. DC. Malins 1993 Identification of hydroxyl radical-induced lesion in DNA bases structure: Biomarkers with a putative link to cancer development J Toxicol Environ Health 40 247 61
14. BN Ames MK Shipenaga TM. Hagan 1993 Oxidants, antioxidants, and the degenerative diseases of aging PNAS 90 7915 22
15. TJ. Slaga 1995 Inhibition of skin tumor initiation, promotion, and progression by antioxidants and related compounds Crit Rev Food Sci Nutr 35 1-2 51 7
16. C Hu DD. Kitts 2001 Evaluation of antioxidant activity of epigallocatechin gallate in biphasic model systems in vitro Mol Cell Biochem 218 1-2 147 55
17. FF Chu RS Esworthy JH. Doroshow 2004 Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer Free Radic Biol Med 36 12 1481 95
18. V Ivanov S Ivanova MW Roomi T Kalinovsky A Niedzwiecki M. Rath 2007 Naturally-produced extracellular matrix inhibits growth rate and invasiveness of human osteosarcoma cancer cells Med Oncol 24 2 209 17
19. J D'Armiento T DiColandrea SS Dalal Y Okada MT Huang AH Conney K. Chada 1995 Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis Mol Cell Biol 15 10 5732 9
20. Z Sun YH Chen P Wang J. Zhang V Gurewich P Zhang JN. Liu 2002 The blockage of high-affinity lysine binding sites of plasminogen by EACA significantly inhibits prourokinase-induced plasminogen activation Biochem Biophys Acta 1596 182 92
21. S Valcic BN Timmermann DS Alberts GA Wachter M Krutzsch J Wymer JM. Guillen 1996 Inhibitory effect of six green tea catechins and caffeine on the growth of four selected human tumor cell lines Anticancer Drugs 7 461 8
22. H Mukhtar N. Ahmed 2000 Tea polyphenols: prevention of cancer and optimizing health AM J Clin Nutr 71 1698s 702s
23. GY Yang J Liao K Kim EJ Yurtow CS. Yang 1998 Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols Carcinogenesis 19 611 6
24. S Taniguchi H Fujiki H Kobayashi H Go K Miyado H Sadano R. Shimikawa 1992 Effect of (-) epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines Cancer Lett 65 51 4
25. Hare Y. Green tea: health benefits and applications. Basel, NY: Marcel Dekker; 2001.
26. S Kawakami Y Kageyama KK Fujii H. Oshima 2001 Inhibitory effects of N-acetyl cysteine on invasion and MMP 9 production of T24 human bladder cancer cells Anticancer Res 21 213 9
27. M Morini T Cai MG Aluigi DM Noonan L Masiello S De Floro F D'Agostinin A Albini G. Fassima 1999 The role of the thiol N-acetyl cysteine in the prevention of tumor invasion and angiogenesis Int J Biol Markers 14 268 71
28. SO Yoon MM Kim AS. Chung 2001 Inhibitory effects of selenite on invasion of HT 1080 tumor cells J Biol Chem 276 20085 92
29. C Maramag M Menon KC Balaji PG Reddy S. Laxmanan 1997 Effect of vitamin C on prostate cancer cells in vitro: effect on cell number, viability and DNA synthesis Prostate 32 188 95
30. JP Cooke VJ. Dzau 1997 Nitric oxide synthase: Role in the genesis of vascular disease Annu Rev Med 48 489 509
31. MW Roomi V Ivanov SP Netke A Niedzwiecki M. Rath 2003 Serum markers of the liver, heart, and kidney and lipid profile and histopathology in ODS rats treated with nutrient synergy J AM Coll Nutr 22 477 Abstract 86