Intracellular glutathione levels determine cell sensitivity to apoptosis induced by the antineoplasic agent N-(4-hydroxyphenyl)retinamide

Anticancer Research

Volumn 25, Issue 3 B, 2005, Pages 1945-1951

  Morales, María Celia ^a   Pérez Yarza, Gorka ^a   Nieto Rementeria, Naiara ^a   Boyano, María Dolores ^a   Jangi, Muhialdin ^a   Atencia, Rafael ^a   Asumendi, Aintzane ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

All trans retinoic acid (ATRA); Apoptosis; BSO; Glutathione; N (4 hydroxyphenyl) retinamide; Reactive oxygen species; Tissue transglutaminase

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; BUTHIONINE SULFOXIMINE; CASPASE; CYTOCHROME C; FENRETINIDE; GLUTATHIONE; GLUTATHIONE INHIBITING AGENT; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; RETINOIC ACID; RETINOID DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL ASSAY; CELL DEATH; CELL LEVEL; CELL SURVIVAL; CONTROLLED STUDY; CYTOFLUOROMETRY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENTIATION; DRUG SENSITIVITY; DRUG SENSITIZATION; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BUTHIONINE SULFOXIMINE; CADAVERINE; CELL LINE, TUMOR; ENZYME INHIBITORS; FENRETINIDE; GLUTATHIONE; HUMANS; JURKAT CELLS; LEUKEMIA, T-CELL; OXIDATIVE STRESS; TRANSGLUTAMINASES; TRETINOIN;

EID: 21344433622     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Oridate N, Suzuki S, Higuchi M, Mitchell MF, Hong WK and Lotan R: Involvement of reactive oxygen species in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells. J Natl Cancer Inst 59: 1191-1198, 1997.
2. Sun S-Y, Li W, Yue P, Lippman SM, Hong WK and Lotan R: Mediation of N-(4-hydroxyphenyl)retinamide-induced apoptosis in human cancer cells by different mechanisms. Cancer Res 59: 2493-2498, 1999.
3. Hail N and Lotan R: Mitochondrial respiration is uniquely associated with the prooxidant and apoptotic effects of N-(4-hydroxyphenyl)retinamide. J Biol Chem 276: 45614-45621, 2001.
4. Wu JM, DiPietrantonio M and Hsieh TC: Mechanism of fenretinide (4-HPR)-induced cell death. Apoptosis 6: 377-388, 2001.
5. Tosetti F, Vene R, Arena G, Morini M, Minghelli S, Noonan DM and Albin A: N-(4-hydroxyphenyl)retinamide inhibits retinoblastoma growth through oxygen species-mediated cell death. Mol Pharmacol 63(3): 565-573, 2003.
6. Danviche N, Hatoum A, Dbaibo G, Kadara H, Nars R, Abou-Lteif G, Bazzi R, Hermine O, de The H and Bazarbachi A: N-(4-hydroxyphenyl)retinamide induces growth arrest and apoptosis in transformed cells. Leukemia 18(3): 607-615, 2004.
7. Kroemer G and Reed JC: Mitochondrial control of cell death. Nat Med 6: 513-519, 2000.
8. Asumendi A, Morales MC, Alvarez A, Arechaga J and Pérez-Yarza G: Implication of mitochondria-derived ROS and cardiolipin peroxidation in N-(4-hydroxyphenyl)retinamide-induced apoptosis. Br J Cancer 86: 1951-1956, 2002.
9. Boya P, Morales MC, González-Polo RA, Andreau K, Goudier I, Perfettini JL, Larochette N, Deniaud A, Bara-Marszak F, Fagard R, Feuillard J, Asumendi A, Raphael M, Pau B, Brenner C and Kroemer G: The chemopreventive agent N-(4-hydroxyphenyl) retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family. Oncogene 22: 6220-6230, 2003.
10. Chandra J, Samali A and Orrenius S: Triggering and modulation of apoptosis by oxidative stress. Free Rad Bio Med 29: 323-333, 2000.
11. Fernández-Checa JC, García-Ruiz C, Colell A, Morales A, Mari M, Miranda M and Ardite E: Oxidative stress: role of mitochondria and protection by glutathione. BioFactors 8: 7-11, 1998.
12. Dringen R: Metabolism and functions of glutathione in brain. Prog Neurobiol 62: 649-671, 2000.
13. Kirkland RA and Franklin JL: Evidence for redox regulation of cytochrome c release during programmed neuronal death: antioxidant effects of protein synthesis and caspase inhibition. J Neuroscience 21: 1949-1963, 2001.
14. Ueda S, Masutani H, Nakamura H, Tanaka T, Ueno M and Yodoi J: Redox control of cell death. Antioxid Redox Signal 4: 405-414, 2002.
15. Jungas T, Motta I, Duffieux F, Fannen P, Sloven V and Ojcius DM: Glutathione levels and Bax activation during apoptosis due to oxidative stress in cells expressing wildtype and mutant cystic fibrosis transmembrane conductance regulator. J Biol Chem 277: 27912-27918, 2002.
16. Wang JJ, Liu TY, Yin PH, Wu CW, Chern YT and Chi CW: Adamantyl maleimide induced changes in adhesion molecules and ROS are involved in apoptosis of human gastric cancer cells. Anticancer Res 20: 3067-3074, 2000.
17. Melino G and Piacentini M: Tissue transglutaminase in cell death: a downstream or a multifunctional upstream effector?. FEBS Lett 430: 59-63, 1998.
18. Piacentini M, Rodolfo C, Farrace MG and Autuori F: "Tissue" transglutaminase in animal development. Int J Dev Biol 44: 655-662, 2000.
19. Han JA and Park SC: Reduction of transglutaminase 2 expression is associated with an induction of drug sensitivity in the PC-14 human lung cancer cell line. J Cancer Res Clin Oncol 125: 89-95, 1999.
20. Chen JSK, Agarwal N and Mehta K: Multidrug-resistant MCF-7 breast cancer cells contain deficient intracellular calcium pools. Breast Cancer Res Treat 71: 237-247, 2002.
21. Isogai M, Chiantore MV, Haque M, Scita G and De Luca LM: Expression of a dominant-negative retinoic acid receptor construct reduces retinoic acid metabolism and retinoic acid-induced inhibition of NIH-3T3 cell growth. Cancer Res 57: 4460-4464, 1997.
22. Zhang J, Lesot M, Guttmann RP and Johnson GVW: Modulation of the in situ activity of tissue transglutaminase by calcium and GTP. J Biol Chem 273: 2288-2295, 1998.
23. Giandomenico V, Andreola F, Rodriguez de la Concepcion ML, Collins SJ and De Luca LM: Retinoic acid and 4-hydroxyphenylretinamide induce growth inhibition and tissue transglutaminase through different signal transduction pathways in mouse fibroblasts (NIH 3T3 cells). Carcinogenesis 20: 1133-1135, 1999.
24. Suzuki S, Higuchi M, Proske RJ, Oridate N, Hong WK and Lotan R: Implication of mitochondria-derived reactive oxygen species, cytochrome c and caspase-3 in N-(4-hydroxyphenyl) retinamide-induced apoptosis in cervical carcinoma cells. Oncogene 18: 6380-6387, 1999.
25. García-Ruiz C, Colell A, Morales A, Kaplowitz N and Fernández-Checa JC: Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor NFκB: studies with isolated mitochondria and rat hepatocytes. Mol Pharmacol 48: 825-834, 1995.
26. Marchetti P, Decaudin D, Macho A, Zamzami N, Hirsch T, Susin SA and Kroemer G: Redox regulation of apoptosis: impact of thiol oxidation status on mitochondrial function. Eur J Immunol 27: 289-296, 1997.
27. Iida M, Doi H, Asamoto S, Sugiyama H, Sakagami H, Kuribayashi N, Takeda M, Okamur Y and Matsumoto K: Effect of glutathione-modulating compounds on platinum compounds-induced cytotoxicity in human glioma cell lines. Anticancer Res 19: 5383-5384, 1999.
28. Chang WE, Yang KD, Chuang H, Jan JT and Shaio MF: Glutamine protects activated human T cells from apoptosis by up-regulating glutathione and Bcl-2 levels. Clin Immun 104: 151-160, 2002.
29. Sanchez A, Álvarez AM, Benito M and Fabregaat I: Cyclohexamide prevents apoptosis, reactive oxygen species production, and glutathione depletion induced by TGF-β in fetal rat hepatocytes in primary culture. Hepatology 26: 935-943, 1997.
30. Anderson CP, Tsai JM, Meek WE, Liu RM, Tang Y, Forman HJ and Reynolds CP: Depletion of glutathione by buthionine sulfoximine is cytotoxic for human neuroblastoma cell lines via apoptosis. Exp Cell Res 246: 183-192, 1999.
31. Friesen C, Fulda S and Debatin KM: Induction of CD95 ligand and apoptosis by doxorubicin is modulated by the redox state in chemosensitive- and drug-resistant tumor cells. Cell Death Differ 6: 471-480, 1999.
32. Gallo JM, Brennan J, Hamiton TC, Habherr T, Laub PB, Ozols RF and O'Dwyer PJ: Time-dependent pharmacodynamic models in cancer chemotherapy: population pharmacodynamic model for glutathione depletion following modulation by buthionine sulfoximine (BSO) in a Phase I trial of melphalan and BSO. Cancer Res 55: 4507-4511, 1995.
33. Mantymaa P, Guttorm T, Siitonen T, Saily M, Savolainen ER, Levonen AL, Kinnula V and Koistinen P: Cellular redox state and its relationship to the inhibition of clonal cell growth and the induction of apoptosis during all-trans retinoic acid exposure in acute myeloblastic leukemia cells. Haematologica 55: 238-245, 2000.
34. Formelli F and Cleris L: Therapeutic effects of the combination of fenretinide and all-trans-retinoic acid and of the two retinoids with cisplatin in a human ovarian carcinoma xenograft and in a cisplatin-resistant sub-line. Eur J Cancer 36: 2411-2419, 2000.
35. Chiantore MV, Giandomenico V and De Luca LM: Carcinoma cell lines resistant for growth inhibition and apoptosis to retinoic acid are responsive to 4-hydroxy-phenyl-retinamide: correlation with tissue transglutaminase. Biochem Biophys Res Commun 254: 636-641, 1999.
36. Antonyak MA, Singh US, Lee DA, Boehm JE, Combs C, Zgola MM, Page RL and Cerione RA: Effects of tissue transglutaminase on retinoic acid-induced cellular differentiation and protection against apoptosis. J Biol Chem 276: 33582-33587, 2001.
37. Boehm JE, Singh US, Combs C, Antonyak MA and Cerione RA: Tissue transglutaminase protects against apoptosis by modifying the tumor suppressor protein p110 Rb. J Biol Chem 277: 20127-20130, 2002.
38. Tucholski J, Lesort M and Johnson GVW: Tissue transglutaminase is essential for neurite outgrowth in human neuroblastoma SH-SY5Y. Neuroscience 102: 481-491, 2001.
39. Nanda N, Iismaa SE, Owens WA, Husain A, Mackay F and Graham RM: Targeted inactivation of Gh / tissue transglutaminase II. J Biol Chem 276: 20673-20678, 2001.