Degradation of vincristine by myeloperoxidase and hypochlorous acid in children with acute lymphoblastic leukemia

Leukemia Research

Volumn 27, Issue 12, 2003, Pages 1109-1113

  Özgen, Ünsal ^a   Türköz, Yusuf ^a   Stout, Mark ^b   Özuǧurlu, Fikret ^a   Pelik, Fatma ^a   Bulut, Yunus ^a   Aslan, Mehmet ^a   Ravindranath, Yaddanapudi ^b   Savaşan, Süreyya ^b  

^a INONU UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

Hypochlorous acid; Leukemia; Myeloperoxidase; Vincristine metabolism

Indexed keywords

ANTINEOPLASTIC AGENT; HYPOCHLOROUS ACID; MERCAPTOPURINE; MYELOPEROXIDASE; PARACETAMOL; TAURINE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BLOOD LEVEL; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DEGRADATION; ENZYMATIC DEGRADATION; ENZYME ASSAY; ENZYME BLOOD LEVEL; HUMAN; LYMPHOMA; PEDIATRICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SOLID TUMOR;

EID: 0041663665     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(03)00098-5     Document Type: Article

References (23)

1. Henderson ES. Acute lymphoblastic leukemia. In: Gunz FW, Henderson ES, editors. William Domashek and Frederick Gunz's leukemia. New York, NY: Grune & Stratton; 1983. p. 575-625.
2. Preisler HD. Acute myelocytic leukemia. In: Gunz FW, Henderson ES, editors. William Domashek and Frederick Gunz's leukemia, New York, NY: Grune & Stratton; 1983. p. 627-61.
3. Schlaifer D., Cooper M.R., Attal M., Sorter A.O., Trepel J.B., Laurent G.et al. Myeloperoxidase: an enzyme involved in intrinsic vincristine resistance in human myeloblastic leukemia. Blood. 81:1993;482-489.
4. Schlaifer D., Duchayne E., Demur C., Alvinerie P., Muller C., Attal M.et al. Vincristine degradation by serum from leukemic patients: role of myeloperoxidase. Leuk. Lymphoma. 20(5-6):1996;441-446.
5. Folkes L.K., Candeias L.P., Wardman P. Kinetics and mechanisms of hypochlorous acid reactions. Arch. Biochem. Biophys. 323:1995;120-126.
6. Ozgen U., Savasan S., Stout M., Buck S., Ravindranath Y. Further elucidation of mechanism of resistance to vincristine in myeloid cells: role of hypochlorous acid in degradation of vincristine by myeloperoxidase. Leukemia. 14(1):2000;47-51.
7. Aune T.M., Thomas E.L. Accumulation of hypothiocyanite ion during peroxidase-catalyzed oxidation of thiocyanate ion. Eur. J. Biochem. 80(1):1977;209-214.
8. Ching T.L., de Jong J., Bast A. A method for screening hypochlorous acid scavengers by inhibition of the oxidation of 5-thio-2-nitrobenzoic acid: application to anti-asthmatic drugs. Anal. Biochem. 218(2):1994;377-381.
9. Lerner R.I. The fungicida mechanisms of human monocytes. I. Evidence for myeloperoxidase-linked and myeloperoxidase-independent candidicial mechanisms. J. Clin. Invest. 55:1975;338-346.
10. Malmquist J. Serum myeloperoxidase in leukemia and polycythaemia vera. Scand. J. Haematol. 9:1972;311-317.
11. Schlaifer D., Meyer K., Muller C., Attal M., Smith M.T., Tamaki S.et al. Antisense inhibition of myeloperoxidase increases the sensitivity of the HL-60 cell line to vincristine. Leukemia. 8(2):1994;289-291.
12. Crom W.R., de Graaf S.S., Synold T., Uges D.R., Bloemhof H., Rivera G.et al. Pharmacokinetics of vincristine in children and adolescents with acute lymphocytic leukemia. J. Pediatr. 125(4):1994;642-649.
13. Olsson I., Olofsson T., Ohlsson K., Gustavsson A. Serum and myeloperoxidase, elastase and lactoferrin content in acute myeloid leukemia. Scand. J. Haematol. 22:1979;394-406.
14. Hansen N.E., Malmquist J., Thorell J. Plasma myeloperoxidase and lactoferrin measured by radioimmunoassay: relation to neutrophil kinetics. Acta Med. Scand. 198:1975;437-443.
15. Pichard L., Fabre I., Daujat M., Domergue J., Joyeux H., Maurel P. Effect of corticosteroids on the expression of cytochromes P450 and on cyclosporin A oxidase activity in primary cultures of human hepatocytes. Mol. Pharmacol. 41(6):1992;1047-1055.
16. Groninger E., Meeuwsen-de Boar T., Koopmans P., Uges D., Sluiter W., Veerman A.et al. Pharmacokinetics of vincristine monotherapy in childhood acute lymphoblastic leukemia. Pediatr. Res. 52:2002;113-118.
17. De Graaf S.S., Bloemhof H., Vendrig D.E., Uges D.R. Vincristine disposition in children with acute lymphoblastic leukemia. Med. Pediatr. Oncol. 24(4):1995;235-240.
18. van Zyl J.M., Basson K., van der Walt B.J. The inhibitory effect of acetaminophen on the myeloperoxidase-induced antimicrobial system of the polymorphonuclear leukocyte. Biochem. Pharmacol. 38:1989;161-165.
19. Cabrera-Abreu J.C., Green A. Gamma-glutamyltransferase: value of its measurement in pediatrics. Ann. Clin. Biochem. 39:2002;22-25.
20. Aruoma O.I., Halliwell B., Hoey B.M., Butler J. The antioxidant action of taurine, hypotaurine and their metabolic precursors. Biochem. J. 256:1988;251-255.
21. Mehta T.R., Dawson R. Taurine is a weak scavenger of peroxynitrite and does not attenuate sodium nitroprusside toxicity to cells in culture. Amino Acids. 20:2001;419-433.
22. Green T.R., Fellman J.H., Eicher A.L., Pratt K.L. Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils. Biochim. Biophys. Acta. 1073:1991;91-97.
23. Gidding C.E., Meeuwsen-de Boer G.J., Koopmans P., Uges D.R., Kamps W.A., Graaf S.S. Vincristine pharmacokinetics after repetitive dosing in children. Cancer Chemother. Pharmacol. 44:1999;203-209.