Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine

Apoptosis

Volumn 12, Issue 11, 2007, Pages 2115-2133

  Malik, Fayaz ^a   Kumar, Ajay ^a   Bhushan, Shashi ^a   Khan, Sheema ^a   Bhatia, Aruna ^b   Suri, Krishan Avtar ^a   Qazi, Ghulam Nabi ^a   Singh, Jaswant ^a  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^b PUNJABI UNIVERSITY   (India)

Author keywords

AIF; Apoptosis; Caspases; NAC; NF B; ROS; Withaferin A

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN BAX; PROTEIN BID; REACTIVE OXYGEN METABOLITE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR RECEPTOR 1; WITHAFERIN A;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HL 60; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; FEMALE; HELA CELL; HUMAN; HUMAN CELL; MALE; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSTATE CARCINOMA; T CELL LYMPHOMA;

ACETYLCYSTEINE; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; ERGOSTEROL; HELA CELLS; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; WITHANIA;

WITHANIA SOMNIFERA;

EID: 34848858255     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-007-0129-x     Document Type: Article

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