메뉴 건너뛰기




Volumn 580, Issue 12, 2006, Pages 2811-2820

The logic of TGFβ signaling

Author keywords

Cancer; Cell cycle; Cyclin dependent kinase; Cytostasis; Metastasis; Receptor serine threonine kinase; Smad transcription factor; TGF ; Tumor suppressor

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; CYTOKINE; MEMBRANE RECEPTOR; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; SMAD PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXO; TRANSFORMING GROWTH FACTOR BETA;

EID: 33646562542     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.04.033     Document Type: Short Survey
Times cited : (674)

References (108)
  • 1
    • 0000116653 scopus 로고
    • The transforming growth factor-betas
    • Roberts A.B. (Ed), Springer-Verlag, Heidelberg
    • Roberts A.B., and Sporn M.B. The transforming growth factor-betas. In: Roberts A.B. (Ed). Peptide Growth Factors and Their Receptors (1990), Springer-Verlag, Heidelberg 419-472
    • (1990) Peptide Growth Factors and Their Receptors , pp. 419-472
    • Roberts, A.B.1    Sporn, M.B.2
  • 2
    • 0025222517 scopus 로고
    • The transforming growth factor-beta family
    • Massague J. The transforming growth factor-beta family. Annu. Rev. Cell Biol. 6 (1990) 597-641
    • (1990) Annu. Rev. Cell Biol. , vol.6 , pp. 597-641
    • Massague, J.1
  • 3
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • Massague J. TGF-beta signal transduction. Annu. Rev. Biochem. 67 (1998) 753-791
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 753-791
    • Massague, J.1
  • 4
    • 0023652332 scopus 로고
    • The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors
    • Cheifetz S., Weatherbee J.A., Tsang M.L., Anderson J.K., Mole J.E., Lucas R., and Massague J. The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors. Cell 48 3 (1987) 409-415
    • (1987) Cell , vol.48 , Issue.3 , pp. 409-415
    • Cheifetz, S.1    Weatherbee, J.A.2    Tsang, M.L.3    Anderson, J.K.4    Mole, J.E.5    Lucas, R.6    Massague, J.7
  • 6
    • 0025326725 scopus 로고
    • Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation
    • Laiho M., DeCaprio J.A., Ludlow J.W., Livingston D.M., and Massague J. Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell 62 1 (1990) 175-185
    • (1990) Cell , vol.62 , Issue.1 , pp. 175-185
    • Laiho, M.1    DeCaprio, J.A.2    Ludlow, J.W.3    Livingston, D.M.4    Massague, J.5
  • 7
    • 0027257850 scopus 로고
    • Molecular characterization of rat transforming growth factor-beta type II receptor
    • Tsuchida K., Lewis K.A., Mathews L.S., and Vale W.W. Molecular characterization of rat transforming growth factor-beta type II receptor. Biochem. Biophys. Res. Commun. 191 3 (1993) 790-795
    • (1993) Biochem. Biophys. Res. Commun. , vol.191 , Issue.3 , pp. 790-795
    • Tsuchida, K.1    Lewis, K.A.2    Mathews, L.S.3    Vale, W.W.4
  • 8
    • 0028954487 scopus 로고
    • Molecular characterization of a type I serine-threonine kinase receptor for TGF-beta and activin in the rat pituitary tumor cell line GH3
    • Takumi T., Moustakas A., Lin H.Y., and Lodish H.F. Molecular characterization of a type I serine-threonine kinase receptor for TGF-beta and activin in the rat pituitary tumor cell line GH3. Exp. Cell. Res. 216 1 (1995) 208-214
    • (1995) Exp. Cell. Res. , vol.216 , Issue.1 , pp. 208-214
    • Takumi, T.1    Moustakas, A.2    Lin, H.Y.3    Lodish, H.F.4
  • 9
    • 0026527384 scopus 로고
    • Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors
    • Attisano L., Wrana J.L., Cheifetz S., and Massague J. Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors. Cell 68 1 (1992) 97-108
    • (1992) Cell , vol.68 , Issue.1 , pp. 97-108
    • Attisano, L.1    Wrana, J.L.2    Cheifetz, S.3    Massague, J.4
  • 10
    • 0028170226 scopus 로고
    • Mechanism of activation of the TGF-beta receptor
    • Wrana J.L., Attisano L., Wieser R., Ventura F., and Massague J. Mechanism of activation of the TGF-beta receptor. Nature 370 6488 (1994) 341-347
    • (1994) Nature , vol.370 , Issue.6488 , pp. 341-347
    • Wrana, J.L.1    Attisano, L.2    Wieser, R.3    Ventura, F.4    Massague, J.5
  • 11
    • 0033524943 scopus 로고    scopus 로고
    • Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12
    • Huse M., Chen Y.G., Massague J., and Kuriyan J. Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell 96 3 (1999) 425-436
    • (1999) Cell , vol.96 , Issue.3 , pp. 425-436
    • Huse, M.1    Chen, Y.G.2    Massague, J.3    Kuriyan, J.4
  • 12
    • 0034796457 scopus 로고    scopus 로고
    • The TGF beta receptor activation process: an inhibitor- to substrate-binding switch
    • Huse M., Muir T.W., Xu L., Chen Y.G., Kuriyan J., and Massague J. The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Mol. Cell 8 3 (2001) 671-682
    • (2001) Mol. Cell , vol.8 , Issue.3 , pp. 671-682
    • Huse, M.1    Muir, T.W.2    Xu, L.3    Chen, Y.G.4    Kuriyan, J.5    Massague, J.6
  • 13
    • 20444430827 scopus 로고    scopus 로고
    • Nuclear targeting of transforming growth factor-beta-activated Smad complexes
    • Chen H.B., Rud J.G., Lin K., and Xu L. Nuclear targeting of transforming growth factor-beta-activated Smad complexes. J. Biol. Chem. 280 22 (2005) 21329-21336
    • (2005) J. Biol. Chem. , vol.280 , Issue.22 , pp. 21329-21336
    • Chen, H.B.1    Rud, J.G.2    Lin, K.3    Xu, L.4
  • 14
    • 0142211206 scopus 로고    scopus 로고
    • Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import
    • Xu L., Alarcon C., Col S., and Massague J. Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import. J. Biol. Chem. 278 43 (2003) 42569-42577
    • (2003) J. Biol. Chem. , vol.278 , Issue.43 , pp. 42569-42577
    • Xu, L.1    Alarcon, C.2    Col, S.3    Massague, J.4
  • 15
    • 0029931509 scopus 로고    scopus 로고
    • A human Mad protein acting as a BMP-regulated transcriptional activator
    • Liu F., Hata A., Baker J.C., Doody J., Carcamo J., Harland R.M., and Massague J. A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 381 6583 (1996) 620-623
    • (1996) Nature , vol.381 , Issue.6583 , pp. 620-623
    • Liu, F.1    Hata, A.2    Baker, J.C.3    Doody, J.4    Carcamo, J.5    Harland, R.M.6    Massague, J.7
  • 16
    • 0030911104 scopus 로고    scopus 로고
    • The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
    • Kretzschmar M., Liu F., Hata A., Doody J., and Massague J. The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes. Dev. 11 8 (1997) 984-995
    • (1997) Genes. Dev. , vol.11 , Issue.8 , pp. 984-995
    • Kretzschmar, M.1    Liu, F.2    Hata, A.3    Doody, J.4    Massague, J.5
  • 19
    • 18244362844 scopus 로고    scopus 로고
    • Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling
    • Wu J.W., et al. Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling. Mol. Cell 8 6 (2001) 1277-1289
    • (2001) Mol. Cell , vol.8 , Issue.6 , pp. 1277-1289
    • Wu, J.W.1
  • 20
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMAD proteins in TGFβ signalling pathways
    • Lagna G., Hata A., Hemmati-Brivanlou A., and Massagué J. Partnership between DPC4 and SMAD proteins in TGFβ signalling pathways. Nature 383 (1996) 832-836
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Hemmati-Brivanlou, A.3    Massagué, J.4
  • 21
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi Y., and Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113 6 (2003) 685-700
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 22
    • 0032483544 scopus 로고    scopus 로고
    • Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA-binding in TGF-β signaling
    • Shi Y., Wang Y.-F., Jayaraman L., Yang H., Massagué J., and Pavletich N. Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA-binding in TGF-β signaling. Cell 94 (1998) 585-594
    • (1998) Cell , vol.94 , pp. 585-594
    • Shi, Y.1    Wang, Y.-F.2    Jayaraman, L.3    Yang, H.4    Massagué, J.5    Pavletich, N.6
  • 23
    • 0036670359 scopus 로고    scopus 로고
    • Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus
    • Xu L., Kang Y., Col S., and Massague J. Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Mol. Cell 10 2 (2002) 271-282
    • (2002) Mol. Cell , vol.10 , Issue.2 , pp. 271-282
    • Xu, L.1    Kang, Y.2    Col, S.3    Massague, J.4
  • 24
    • 0036670339 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity
    • Inman G.J., Nicolas F.J., and Hill C.S. Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity. Mol. Cell 10 2 (2002) 283-294
    • (2002) Mol. Cell , vol.10 , Issue.2 , pp. 283-294
    • Inman, G.J.1    Nicolas, F.J.2    Hill, C.S.3
  • 25
    • 33644996932 scopus 로고    scopus 로고
    • Identification of phosphatases for Smad in the BMP/DPP pathway
    • Chen H.B., Shen J., Ip Y.T., and Xu L. Identification of phosphatases for Smad in the BMP/DPP pathway. Genes. Dev. (2006)
    • (2006) Genes. Dev.
    • Chen, H.B.1    Shen, J.2    Ip, Y.T.3    Xu, L.4
  • 26
    • 33646560216 scopus 로고    scopus 로고
    • M. Knockaert, G. Sapkota, C. Alarcon, J. Massague and A.H. Brivanlou, New players in the BMP pathway: small CTD phosphatases dephophorylate Smad1 to attenuate BMP signaling (submitted for publication).
  • 27
    • 23044505285 scopus 로고    scopus 로고
    • Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain
    • Ogunjimi A.A., et al. Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. Mol. Cell 19 3 (2005) 297-308
    • (2005) Mol. Cell , vol.19 , Issue.3 , pp. 297-308
    • Ogunjimi, A.A.1
  • 28
    • 0033257926 scopus 로고    scopus 로고
    • Ubiquitin-dependent degradation of TGF-beta-activated smad2
    • Lo R.S., and Massague J. Ubiquitin-dependent degradation of TGF-beta-activated smad2. Nat. Cell Biol. 1 8 (1999) 472-478
    • (1999) Nat. Cell Biol. , vol.1 , Issue.8 , pp. 472-478
    • Lo, R.S.1    Massague, J.2
  • 29
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-beta signaling
    • Massague J., and Chen Y.G. Controlling TGF-beta signaling. Genes. Dev. 14 6 (2000) 627-644
    • (2000) Genes. Dev. , vol.14 , Issue.6 , pp. 627-644
    • Massague, J.1    Chen, Y.G.2
  • 31
    • 15444348295 scopus 로고    scopus 로고
    • The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
    • Sirard C., et al. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes. Dev. 12 1 (1998) 107-119
    • (1998) Genes. Dev. , vol.12 , Issue.1 , pp. 107-119
    • Sirard, C.1
  • 32
    • 3442894138 scopus 로고    scopus 로고
    • Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1
    • Subramanian G., Schwarz R.E., Higgins L., McEnroe G., Chakravarty S., Dugar S., and Reiss M. Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1. Cancer Res. 64 15 (2004) 5200-5211
    • (2004) Cancer Res. , vol.64 , Issue.15 , pp. 5200-5211
    • Subramanian, G.1    Schwarz, R.E.2    Higgins, L.3    McEnroe, G.4    Chakravarty, S.5    Dugar, S.6    Reiss, M.7
  • 34
    • 33646550118 scopus 로고    scopus 로고
    • He, W., Dorn, D.C., Erdjument-Bromage, H., Tempst, P., Moore, M.A.S. and Massague, J. Hematopoiesis controlled by distinct TIF1ã and Smad4 branches of the TGFâ Pathway, Cell (in press).
  • 35
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R., and Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425 6958 (2003) 577-584
    • (2003) Nature , vol.425 , Issue.6958 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 36
    • 14844364701 scopus 로고    scopus 로고
    • Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
    • Ozdamar B., Bose R., Barrios-Rodiles M., Wang H.R., Zhang Y., and Wrana J.L. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 307 5715 (2005) 1603-1609
    • (2005) Science , vol.307 , Issue.5715 , pp. 1603-1609
    • Ozdamar, B.1    Bose, R.2    Barrios-Rodiles, M.3    Wang, H.R.4    Zhang, Y.5    Wrana, J.L.6
  • 37
    • 0141656297 scopus 로고    scopus 로고
    • Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1
    • Foletta V.C., et al. Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1. J. Cell Biol. 162 6 (2003) 1089-1098
    • (2003) J. Cell Biol. , vol.162 , Issue.6 , pp. 1089-1098
    • Foletta, V.C.1
  • 38
    • 11244313831 scopus 로고    scopus 로고
    • Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis
    • Lee-Hoeflich S.T., Causing C.G., Podkowa M., Zhao X., Wrana J.L., and Attisano L. Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. Embo. J. 23 24 (2004) 4792-4801
    • (2004) Embo. J. , vol.23 , Issue.24 , pp. 4792-4801
    • Lee-Hoeflich, S.T.1    Causing, C.G.2    Podkowa, M.3    Zhao, X.4    Wrana, J.L.5    Attisano, L.6
  • 39
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGF-beta signals
    • Massague J. How cells read TGF-beta signals. Nat. Rev. Mol. Cell Biol. 1 3 (2000) 169-178
    • (2000) Nat. Rev. Mol. Cell Biol. , vol.1 , Issue.3 , pp. 169-178
    • Massague, J.1
  • 40
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and selectivity in TGF-beta signaling through Smads
    • Feng X.H., and Derynck R. Specificity and selectivity in TGF-beta signaling through Smads. Annu. Rev. Cell Dev. Biol. 21 (2005) 659-666
    • (2005) Annu. Rev. Cell Dev. Biol. , vol.21 , pp. 659-666
    • Feng, X.H.1    Derynck, R.2
  • 42
    • 0030872367 scopus 로고    scopus 로고
    • Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
    • Kim J., Johnson K., Chen H.J., Carroll S., and Laughon A. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388 (1997) 304-308
    • (1997) Nature , vol.388 , pp. 304-308
    • Kim, J.1    Johnson, K.2    Chen, H.J.3    Carroll, S.4    Laughon, A.5
  • 43
    • 0037067653 scopus 로고    scopus 로고
    • E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression
    • Chen C.R., Kang Y., Siegel P.M., and Massague J. E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell 110 1 (2002) 19-32
    • (2002) Cell , vol.110 , Issue.1 , pp. 19-32
    • Chen, C.R.1    Kang, Y.2    Siegel, P.M.3    Massague, J.4
  • 44
    • 0029802485 scopus 로고    scopus 로고
    • A transcriptional partner for MAD proteins in TGF-b signalling
    • Chen X., Rubock M.J., and Whitman M. A transcriptional partner for MAD proteins in TGF-b signalling. Nature 383 (1996) 691-696
    • (1996) Nature , vol.383 , pp. 691-696
    • Chen, X.1    Rubock, M.J.2    Whitman, M.3
  • 45
    • 0038369998 scopus 로고    scopus 로고
    • A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
    • Kang Y., Chen C.R., and Massague J. A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol. Cell 11 4 (2003) 915-926
    • (2003) Mol. Cell , vol.11 , Issue.4 , pp. 915-926
    • Kang, Y.1    Chen, C.R.2    Massague, J.3
  • 46
    • 0035970035 scopus 로고    scopus 로고
    • Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program
    • Chen C.R., Kang Y., and Massague J. Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program. Proc. Natl. Acad. Sci. USA 98 3 (2001) 992-999
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , Issue.3 , pp. 992-999
    • Chen, C.R.1    Kang, Y.2    Massague, J.3
  • 48
    • 0033518256 scopus 로고    scopus 로고
    • Synexpression groups in eukaryotes
    • Niehrs C., and Pollet N. Synexpression groups in eukaryotes. Nature 402 6761 (1999) 483-487
    • (1999) Nature , vol.402 , Issue.6761 , pp. 483-487
    • Niehrs, C.1    Pollet, N.2
  • 49
    • 33646593418 scopus 로고    scopus 로고
    • Gomis, R.R., Alarcon, C., Nadal, C., He, W., Wang, Q., Seoane, J., Van Poznak, C., Massague, J. C/EBPbeta at the core of the TGF cytostatic response and its evasion in metastatic breast cancers (submitted for publication).
  • 50
    • 2342496712 scopus 로고    scopus 로고
    • FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
    • Accili D., and Arden K.C. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation,. Cell 117 4 (2004) 421-426
    • (2004) Cell , vol.117 , Issue.4 , pp. 421-426
    • Accili, D.1    Arden, K.C.2
  • 52
    • 1642332084 scopus 로고    scopus 로고
    • Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    • Seoane J., Le H.V., Shen L., Anderson S.A., and Massague J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117 2 (2004) 211-223
    • (2004) Cell , vol.117 , Issue.2 , pp. 211-223
    • Seoane, J.1    Le, H.V.2    Shen, L.3    Anderson, S.A.4    Massague, J.5
  • 53
    • 0035798414 scopus 로고    scopus 로고
    • McBindall - a better name for CCAAT/enhancer binding proteins?
    • McKnight S.L. McBindall - a better name for CCAAT/enhancer binding proteins?. Cell 107 (2001) 259-261
    • (2001) Cell , vol.107 , pp. 259-261
    • McKnight, S.L.1
  • 54
    • 1542539924 scopus 로고    scopus 로고
    • The role of C/EBPbeta in mammary gland development and breast cancer
    • Grimm S.L., and Rosen J.M. The role of C/EBPbeta in mammary gland development and breast cancer. J. Mammary Gland Biol. Neoplasia. 8 2 (2003) 191-204
    • (2003) J. Mammary Gland Biol. Neoplasia. , vol.8 , Issue.2 , pp. 191-204
    • Grimm, S.L.1    Rosen, J.M.2
  • 55
    • 7644219511 scopus 로고    scopus 로고
    • Essential requirement of CCAAT/enhancer binding proteins in embryogenesis
    • Begay V., Smink J., and Leutz A. Essential requirement of CCAAT/enhancer binding proteins in embryogenesis. Mol. Cell Biol. 24 22 (2004) 9744-9751
    • (2004) Mol. Cell Biol. , vol.24 , Issue.22 , pp. 9744-9751
    • Begay, V.1    Smink, J.2    Leutz, A.3
  • 56
    • 0347991862 scopus 로고    scopus 로고
    • Integration of Smad and MAPK pathways: a link and a linker revisited
    • Massague J. Integration of Smad and MAPK pathways: a link and a linker revisited. Genes. Dev. 17 (2003) 2993-2997
    • (2003) Genes. Dev. , vol.17 , pp. 2993-2997
    • Massague, J.1
  • 57
    • 0030773834 scopus 로고    scopus 로고
    • Opposing BMP and EGF signalling pathway converge on the TGFβ family mediator Smad1
    • Kretzschmar M., Doody J., and Massagué J. Opposing BMP and EGF signalling pathway converge on the TGFβ family mediator Smad1. Nature 389 (1997) 618-622
    • (1997) Nature , vol.389 , pp. 618-622
    • Kretzschmar, M.1    Doody, J.2    Massagué, J.3
  • 58
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras
    • Kretzschmar M., Doody J., Timokhina I., and Massague J. A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. Genes. Dev. 13 7 (1999) 804-816
    • (1999) Genes. Dev. , vol.13 , Issue.7 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3    Massague, J.4
  • 59
    • 0033780420 scopus 로고    scopus 로고
    • Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II
    • Wicks S.J., Lui S., Abdel-Wahab N., Mason R.M., and Chantry A. Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II. Mol. Cell Biol. 20 21 (2000) 8103-8111
    • (2000) Mol. Cell Biol. , vol.20 , Issue.21 , pp. 8103-8111
    • Wicks, S.J.1    Lui, S.2    Abdel-Wahab, N.3    Mason, R.M.4    Chantry, A.5
  • 60
    • 3142546336 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate the antiproliferative function of Smads
    • Matsuura I., Denissova N.G., Wang G., He D., Long J., and Liu F. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 430 6996 (2004) 226-231
    • (2004) Nature , vol.430 , Issue.6996 , pp. 226-231
    • Matsuura, I.1    Denissova, N.G.2    Wang, G.3    He, D.4    Long, J.5    Liu, F.6
  • 61
    • 0036301992 scopus 로고    scopus 로고
    • Nuclear exclusion of Smad2 is a mechanism leading to loss of competence
    • Grimm O.H., and Gurdon J.B. Nuclear exclusion of Smad2 is a mechanism leading to loss of competence. Nat. Cell Biol. 4 7 (2002) 519-522
    • (2002) Nat. Cell Biol. , vol.4 , Issue.7 , pp. 519-522
    • Grimm, O.H.1    Gurdon, J.B.2
  • 62
    • 0346594337 scopus 로고    scopus 로고
    • Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction
    • Pera E.M., Ikeda A., Eivers E., and De Robertis E.M. Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes. Dev. 17 24 (2003) 3023-3028
    • (2003) Genes. Dev. , vol.17 , Issue.24 , pp. 3023-3028
    • Pera, E.M.1    Ikeda, A.2    Eivers, E.3    De Robertis, E.M.4
  • 63
    • 11144357466 scopus 로고    scopus 로고
    • IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    • Hu M.C., et al. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117 2 (2004) 225-237
    • (2004) Cell , vol.117 , Issue.2 , pp. 225-237
    • Hu, M.C.1
  • 64
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet A., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 5666 (2004) 2011-2015
    • (2004) Science , vol.303 , Issue.5666 , pp. 2011-2015
    • Brunet, A.1
  • 66
    • 0027318843 scopus 로고
    • Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta
    • Koff A., Ohtsuki M., Polyak K., Roberts J.M., and Massague J. Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. Science 260 5107 (1993) 536-539
    • (1993) Science , vol.260 , Issue.5107 , pp. 536-539
    • Koff, A.1    Ohtsuki, M.2    Polyak, K.3    Roberts, J.M.4    Massague, J.5
  • 67
    • 0029073142 scopus 로고
    • Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
    • Datto M.B., Li Y., Panus J.F., Howe D.J., Xiong Y., and Wang X.F. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA 92 12 (1995) 5545-5549
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , Issue.12 , pp. 5545-5549
    • Datto, M.B.1    Li, Y.2    Panus, J.F.3    Howe, D.J.4    Xiong, Y.5    Wang, X.F.6
  • 68
    • 0028168242 scopus 로고
    • p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
    • Hannon G.J., and Beach D. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 371 6494 (1994) 257-261
    • (1994) Nature , vol.371 , Issue.6494 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 69
    • 0028953810 scopus 로고
    • Transforming growth factor β and cell cycle regulation
    • Alexandrow M.G., and Moses H.L. Transforming growth factor β and cell cycle regulation. Cancer Res. 55 (1995) 1452-1457
    • (1995) Cancer Res. , vol.55 , pp. 1452-1457
    • Alexandrow, M.G.1    Moses, H.L.2
  • 70
    • 6344293545 scopus 로고    scopus 로고
    • Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation
    • Scandura J.M., Boccuni P., Massague J., and Nimer S.D. Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation. Proc. Natl. Acad. Sci. USA. 101 (2004) 15231-15236
    • (2004) Proc. Natl. Acad. Sci. USA. , vol.101 , pp. 15231-15236
    • Scandura, J.M.1    Boccuni, P.2    Massague, J.3    Nimer, S.D.4
  • 71
    • 0028179669 scopus 로고
    • p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
    • Polyak K., Kato J.Y., Solomon M.J., Sherr C.J., Massague J., Roberts J.M., and Koff A. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes. Dev. 8 1 (1994) 9-22
    • (1994) Genes. Dev. , vol.8 , Issue.1 , pp. 9-22
    • Polyak, K.1    Kato, J.Y.2    Solomon, M.J.3    Sherr, C.J.4    Massague, J.5    Roberts, J.M.6    Koff, A.7
  • 72
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Polyak K., Lee M.H., Erdjument-Bromage H., Koff A., Roberts J.M., Tempst P., and Massague J. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78 1 (1994) 59-66
    • (1994) Cell , vol.78 , Issue.1 , pp. 59-66
    • Polyak, K.1    Lee, M.H.2    Erdjument-Bromage, H.3    Koff, A.4    Roberts, J.M.5    Tempst, P.6    Massague, J.7
  • 73
    • 0029153609 scopus 로고
    • Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
    • Reynisdottir I., Polyak K., Iavarone A., and Massague J. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes. Dev. 9 15 (1995) 1831-1845
    • (1995) Genes. Dev. , vol.9 , Issue.15 , pp. 1831-1845
    • Reynisdottir, I.1    Polyak, K.2    Iavarone, A.3    Massague, J.4
  • 74
    • 0034744957 scopus 로고    scopus 로고
    • Repression of p15INK4b expression by Myc through association with Miz-1
    • Staller P., et al. Repression of p15INK4b expression by Myc through association with Miz-1. Nat. Cell Biol. 3 4 (2001) 392-399
    • (2001) Nat. Cell Biol. , vol.3 , Issue.4 , pp. 392-399
    • Staller, P.1
  • 76
    • 0037126303 scopus 로고    scopus 로고
    • Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
    • Seoane J., Le H.V., and Massague J. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419 6908 (2002) 729-734
    • (2002) Nature , vol.419 , Issue.6908 , pp. 729-734
    • Seoane, J.1    Le, H.V.2    Massague, J.3
  • 77
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer, and heritable disorders
    • Massague J., Blain S.W., and Lo R.S. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103 2 (2000) 295-309
    • (2000) Cell , vol.103 , Issue.2 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 78
    • 0029066689 scopus 로고
    • Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
    • Markowitz S., et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268 5215 (1995) 1336-1338
    • (1995) Science , vol.268 , Issue.5215 , pp. 1336-1338
    • Markowitz, S.1
  • 79
    • 0031590968 scopus 로고    scopus 로고
    • Microsatellite instability and mutated type II transforming growth factor-beta receptor gene in gliomas
    • Izumoto S., Arita N., Ohnishi T., Hiraga S., Taki T., Tomita N., Ohue M., and Hayakawa T. Microsatellite instability and mutated type II transforming growth factor-beta receptor gene in gliomas. Cancer Lett. 112 2 (1997) 251-256
    • (1997) Cancer Lett. , vol.112 , Issue.2 , pp. 251-256
    • Izumoto, S.1    Arita, N.2    Ohnishi, T.3    Hiraga, S.4    Taki, T.5    Tomita, N.6    Ohue, M.7    Hayakawa, T.8
  • 80
    • 0033555627 scopus 로고    scopus 로고
    • Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers
    • Grady W.M., et al. Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res. 59 2 (1999) 320-324
    • (1999) Cancer Res. , vol.59 , Issue.2 , pp. 320-324
    • Grady, W.M.1
  • 81
    • 0032213514 scopus 로고    scopus 로고
    • Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer
    • Chen T., Carter D., Garrigue-Antar L., and Reiss M. Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer. Cancer Res. 58 21 (1998) 4805-4810
    • (1998) Cancer Res. , vol.58 , Issue.21 , pp. 4805-4810
    • Chen, T.1    Carter, D.2    Garrigue-Antar, L.3    Reiss, M.4
  • 82
    • 0032404111 scopus 로고    scopus 로고
    • Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas
    • Goggins M., Shekher M., Turnacioglu K., Yeo C.J., Hruban R.H., and Kern S.E. Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res. 58 23 (1998) 5329-5332
    • (1998) Cancer Res. , vol.58 , Issue.23 , pp. 5329-5332
    • Goggins, M.1    Shekher, M.2    Turnacioglu, K.3    Yeo, C.J.4    Hruban, R.H.5    Kern, S.E.6
  • 83
    • 0034662637 scopus 로고    scopus 로고
    • Analysis of specific gene mutations in the transforming growth factor-beta signal transduction pathway in human ovarian cancer
    • Wang D., Kanuma T., Mizunuma H., Takama F., Ibuki Y., Wake N., Mogi A., Shitara Y., and Takenoshita S. Analysis of specific gene mutations in the transforming growth factor-beta signal transduction pathway in human ovarian cancer. Cancer Res. 60 16 (2000) 4507-4512
    • (2000) Cancer Res. , vol.60 , Issue.16 , pp. 4507-4512
    • Wang, D.1    Kanuma, T.2    Mizunuma, H.3    Takama, F.4    Ibuki, Y.5    Wake, N.6    Mogi, A.7    Shitara, Y.8    Takenoshita, S.9
  • 85
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • Derynck R., Akhurst R.J., and Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat. Genet. 29 2 (2001) 117-129
    • (2001) Nat. Genet. , vol.29 , Issue.2 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 86
    • 0042307513 scopus 로고    scopus 로고
    • The two faces of transforming growth factor beta in carcinogenesis
    • Roberts A.B., and Wakefield L.M. The two faces of transforming growth factor beta in carcinogenesis. Proc. Natl. Acad. Sci. USA 100 15 (2003) 8621-8623
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , Issue.15 , pp. 8621-8623
    • Roberts, A.B.1    Wakefield, L.M.2
  • 87
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • Siegel P.M., and Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat. Rev. Cancer 3 11 (2003) 807-821
    • (2003) Nat. Rev. Cancer , vol.3 , Issue.11 , pp. 807-821
    • Siegel, P.M.1    Massague, J.2
  • 89
    • 0030598681 scopus 로고    scopus 로고
    • TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
    • Cui W., Fowlis D.J., Bryson S., Duffie E., Ireland H., Balmain A., and Akhurst R.J. TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 86 4 (1996) 531-542
    • (1996) Cell , vol.86 , Issue.4 , pp. 531-542
    • Cui, W.1    Fowlis, D.J.2    Bryson, S.3    Duffie, E.4    Ireland, H.5    Balmain, A.6    Akhurst, R.J.7
  • 90
    • 0031930657 scopus 로고    scopus 로고
    • The role of transforming growth factor beta in glioma progression
    • Jennings M.T., and Pietenpol J.A. The role of transforming growth factor beta in glioma progression. J. Neurooncol. 36 2 (1998) 123-140
    • (1998) J. Neurooncol. , vol.36 , Issue.2 , pp. 123-140
    • Jennings, M.T.1    Pietenpol, J.A.2
  • 91
    • 0032905311 scopus 로고    scopus 로고
    • Microsatellite instability is uncommon in breast cancer
    • Anbazhagan R., Fujii H., and Gabrielson E. Microsatellite instability is uncommon in breast cancer. Clin. Cancer Res. 5 4 (1999) 839-844
    • (1999) Clin. Cancer Res. , vol.5 , Issue.4 , pp. 839-844
    • Anbazhagan, R.1    Fujii, H.2    Gabrielson, E.3
  • 92
    • 0033381357 scopus 로고    scopus 로고
    • The role for transforming growth factor-beta (TGF-beta) in human cancer
    • Gold L.I. The role for transforming growth factor-beta (TGF-beta) in human cancer. Crit. Rev. Oncog. 10 4 (1999) 303-360
    • (1999) Crit. Rev. Oncog. , vol.10 , Issue.4 , pp. 303-360
    • Gold, L.I.1
  • 93
    • 0036372440 scopus 로고    scopus 로고
    • Transforming growth factor-beta in T-cell biology
    • Gorelik L., and Flavell R.A. Transforming growth factor-beta in T-cell biology. Nat. Rev. Immunol. 2 1 (2002) 46-53
    • (2002) Nat. Rev. Immunol. , vol.2 , Issue.1 , pp. 46-53
    • Gorelik, L.1    Flavell, R.A.2
  • 94
    • 27644457376 scopus 로고    scopus 로고
    • TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
    • Thomas D.A., and Massague J. TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell 8 5 (2005) 369-380
    • (2005) Cancer Cell , vol.8 , Issue.5 , pp. 369-380
    • Thomas, D.A.1    Massague, J.2
  • 95
    • 0038353468 scopus 로고    scopus 로고
    • Reversal of tumor-induced immunosuppression by TGF-beta inhibitors
    • Wojtowicz-Praga S. Reversal of tumor-induced immunosuppression by TGF-beta inhibitors. Invest. New Drugs 21 1 (2003) 21-32
    • (2003) Invest. New Drugs , vol.21 , Issue.1 , pp. 21-32
    • Wojtowicz-Praga, S.1
  • 96
    • 25444479744 scopus 로고    scopus 로고
    • Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
    • Kang Y., et al. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc. Natl. Acad. Sci. USA 102 39 (2005) 13909-13914
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , Issue.39 , pp. 13909-13914
    • Kang, Y.1
  • 97
    • 0038724672 scopus 로고    scopus 로고
    • Targeting the TGF beta signaling network in human neoplasia
    • Dumont N., and Arteaga C.L. Targeting the TGF beta signaling network in human neoplasia. Cancer Cell 3 6 (2003) 531-536
    • (2003) Cancer Cell , vol.3 , Issue.6 , pp. 531-536
    • Dumont, N.1    Arteaga, C.L.2
  • 98
    • 0029808318 scopus 로고    scopus 로고
    • TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein
    • Herrera R.E., Makela T.P., and Weinberg R.A. TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein. Mol. Biol. Cell 7 (1996) 1335-1342
    • (1996) Mol. Biol. Cell , vol.7 , pp. 1335-1342
    • Herrera, R.E.1    Makela, T.P.2    Weinberg, R.A.3
  • 100
    • 0035256772 scopus 로고    scopus 로고
    • Gliomagenesis: genetic alterations and mouse models
    • Holland E.C. Gliomagenesis: genetic alterations and mouse models. Nat. Rev. Genet. 2 2 (2001) 120-129
    • (2001) Nat. Rev. Genet. , vol.2 , Issue.2 , pp. 120-129
    • Holland, E.C.1
  • 101
    • 0029009621 scopus 로고
    • Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres
    • Xuan S., Baptista C.A., Balas G., Tao W., Soares V.C., and Lai E. Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron 14 6 (1995) 1141-1152
    • (1995) Neuron , vol.14 , Issue.6 , pp. 1141-1152
    • Xuan, S.1    Baptista, C.A.2    Balas, G.3    Tao, W.4    Soares, V.C.5    Lai, E.6
  • 102
    • 0036703468 scopus 로고    scopus 로고
    • Brain factor-1 controls the proliferation and differentiation of neocortical progenitor cells through independent mechanisms
    • Hanashima C., Shen L., Li S.C., and Lai E. Brain factor-1 controls the proliferation and differentiation of neocortical progenitor cells through independent mechanisms. J. Neurosci. 22 15 (2002) 6526-6536
    • (2002) J. Neurosci. , vol.22 , Issue.15 , pp. 6526-6536
    • Hanashima, C.1    Shen, L.2    Li, S.C.3    Lai, E.4
  • 103
    • 0345824722 scopus 로고    scopus 로고
    • Foxg1 suppresses early cortical cell fate
    • Hanashima C., Li S.C., Shen L., Lai E., and Fishell G. Foxg1 suppresses early cortical cell fate. Science 303 5654 (2004) 56-59
    • (2004) Science , vol.303 , Issue.5654 , pp. 56-59
    • Hanashima, C.1    Li, S.C.2    Shen, L.3    Lai, E.4    Fishell, G.5
  • 104
    • 0042634444 scopus 로고    scopus 로고
    • The role of transforming growth factor-beta in primary brain tumors
    • Rich J.N. The role of transforming growth factor-beta in primary brain tumors. Front Biosci. 8 (2003) e245-e260
    • (2003) Front Biosci. , vol.8
    • Rich, J.N.1
  • 107
    • 0037816160 scopus 로고    scopus 로고
    • Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
    • Siegel P.M., Shu W., Cardiff R.D., Muller W.J., and Massague J. Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc. Natl. Acad. Sci. USA 100 14 (2003) 8430-8435
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , Issue.14 , pp. 8430-8435
    • Siegel, P.M.1    Shu, W.2    Cardiff, R.D.3    Muller, W.J.4    Massague, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.