Transcriptional inhibition of hypertrophic scars by a gene silencer, pyrrole-imidazole polyamide, targeting the TGF-Β1 promoter

Journal of Investigative Dermatology

Volumn 131, Issue 10, 2011, Pages 1987-1995

  Washio, Hisayo ^a   Fukuda, Noboru ^b   Matsuda, Hiroyuki ^b   Nagase, Hiroki ^a   Watanabe, Takayoshi ^a   Matsumoto, Yoshiaki ^b   Terui, Tadashi ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NIHON UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; IMIDAZOLE DERIVATIVE; PYRROLE IMIDAZOLE POLYAMIDE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG DOSE INCREASE; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROSIS; GENE EXPRESSION; GENE TARGETING; HISTOLOGY; HYPERTROPHIC SCAR; IMMUNOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN INCISION;

EID: 80052822707     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2011.150     Document Type: Article

References (28)

1. Abraham DJ, Shiwen X, Black CM et al. (2000) Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts. J Biol Chem 275:15220-5 (Pubitemid 30337246)
2. Chen M, Matsuda H, Wang L et al. (2010) Pretranscriptional regulation of Tgf-beta1 by PI polyamide prevents scarring and accelerates wound healing of the cornea after exposure to alkali. Mol Ther 18: 519-27
3. Chu Y, Guo F, Li Y et al. (2008) A novel truncated TGF-b receptor II downregulates collagen synthesis and TGF-b1 secretion of keloid fibroblasts. Connect Tissue Res 49:92-8
4. Dervan PB (2001) Molecular recognition of DNA by small molecules. Bioorg Med Chem 9:2215-35 (Pubitemid 32834613)
5. Dervan PB, Doss RM, Marques MA (2005) Programmable DNA binding oligomers for control of transcription. Curr Med Chem Anticancer Agents 5:373-87 (Pubitemid 40974811)
6. Duncan MR, Frazier KS, Abramson S et al. (1999) Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J 13:1774-86 (Pubitemid 29473339)
7. Fukusawa A, Aoyama T, Nagashima T et al. (2009) Pharmacokinetics of pyrrole-imidazole polyamide after intravenous administration in rat. Biopharm Drug Dispos 30:81-9
8. Grotendorst GR, Okochi H, Hayashi N (1996) A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ 7:469-80 (Pubitemid 26362091)
9. Hasegawa T, Nakao A, Sumiyoshi K et al. (2005) SB-431542 inhibits TGF-b-induced contraction of collagen gel by normal and keloid fibroblasts. J Dermatol Sci 39:33-8 (Pubitemid 40835831)
10. Igarashi A, Nashiro K, Kikuchi K et al. (1996) Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J Invest Dermatol 106:729-33 (Pubitemid 26119731)
11. Ito Y, Aten J, Bende RJ et al. (1998) Expression of connective tissue growth factor in human renal fibrosis. Kidney Int 53:853-61 (Pubitemid 28155657)
12. Khoo YT, Ong CT, Mukhopadhyay A et al. (2006) Upregulation of secretory connective tissue growth factor (CTGF) in keratinocyte-fibroblast coculture contributes to keloid pathogenesis. J Cell Physiol 208:336-43 (Pubitemid 43993424)
13. Kryger ZB, Sisco M, Roy NK et al. (2007) Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring. J Am Coll Surg 205:78-88 (Pubitemid 47016969)
14. Lai YM, Fukuda N, Ueno T et al. (2005) Synthetic pyrrole-imidazole polyamide inhibits expression of the human transforming growth factor-beta1 gene. J Pharmacol Exp Ther 315:571-5 (Pubitemid 41500721)
15. Leask A, Abraham D (2006) All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J Cell Sci 119:4803-10 (Pubitemid 46017793)
16. Leask A, Abraham DJ (2004) TGF-beta signaling and the fibrotic response. FASEB J 18:816-27
17. Lu L, Saulis AS, Liu WR et al. (2005) The temporal effects of anti-TGF-beta1, 2, and 3 monoclonal antibody on wound healing and hypertrophic scar formation. J Am Coll Surg 201:391-7 (Pubitemid 41206777)
18. Matsuda H, Fukuda N, Ueno T et al. (2006) Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-b1 promoter for treatment of progressive renal diseases. J Am Soc Nephrol 17:422-32
19. Matsuda H, Fukuda N, Ueno T et al. (2011) Transcriptional regulation of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-b1 promoter. Kidney Int 79:46-56
20. Mori T, Kawara S, Shinozaki M et al. (1999) Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: a mouse fibrosis model. J Cell Physiol 181:153-9 (Pubitemid 29400382)
21. Paradis V, Dargere D, Vidaud M et al. (1999) Expression of connective tissue growth factor in experimental rat and human liver fibrosis. Hepatology 30:968-76 (Pubitemid 29458286)
22. Phan TT, Lim IJ, Aalami O et al. (2005) Smad3 signaling plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions. J Pathol 207:232-42 (Pubitemid 41404154)
23. Roques C, Téot L (2008) The use of corticosteroids to treat keloids: a review. Int J Low Extrem Wounds 7:137-45
24. Shigeki S, Murakami T, Yata N et al. (1997) Treatment of keloid and hypertrophic scars by iontophoretic transdermal delivery of tranilast. Scand J Plast Reconstr Surg Hand Surg 31:151-8
25. Shinozaki M, Kawara S, Hayashi N et al. (1997) Induction of subcutaneous tissue fibrosis in newborn mice by transforming growth factor-b-simultaneous application with basic fibroblast growth factor causes persistent fibrosis. Biochem Biophy Res Commn 237:292-7
26. Trauger JW, Baird EE, Dervan PB (1996) Recognition of DNA by designed ligands at subnanomolar concentrations. Nature 382:559-61 (Pubitemid 26262061)
27. Yao EH, Fukuda N, Ueno T et al. (2009) A pyrrole-imidazole polyamide targeting transforming growth factor-b1 inhibits restenosis and preserves endothelialization in the injured artery. Cardiovasc Res 81:797-804
28. White S, Baird EE, Dervan PB (1997) On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides. Chem Biol 4:569-78 (Pubitemid 27398760)